Spontaneous Remission of Nephrotic Syndrome in IgA Nephropathy

Korean Journal of Nephrology 2010;29(3):371-375.

Jeong Ho Kim, M.D.1, Hana Kim, M.D.1, Seok Min Hong, M.D.1, Jeong Hae Kie, M.D.2, Ea Wha Kang, M.D.1, Suk Kyun Shin, M.D.1 and Seung Hyeok Han, M.D.1, 3

Department of Internal Medicine¹
Department of Pathology²
NHIC Ilsan Hospital, Goyangshi, Gyeonggi-do, Korea, Department of Internal Medicine³
Yonsei University College of Medicine, Korea

증례 : IgA 신병증에 합병된 신증후군의 자연관해를 보인 증례보고

김정호1 , 김하나1 , 홍석민1 , 기정혜2 , 강이화1 , 신석균1 , 한승혁1, 3

국민건강 보험공단 일산병원 신장내과1 , 병리과2 , 연세대학교 의과대학 신장내과3

Abstract

Although a moderate degree of proteinuria is common in patients with IgA nephropathy (IgAN), nephritic syndrome combined with IgAN is rare. It has been reported that approximately 5% of all patients with IgAN are complicated by minimal change disease and these patients respond well to corticosteroid therapy. However, spontaneous remission is uncommon in heavy proteinuric patients with IgAN. Recently, we experienced two cases of spontaneous remission of nephrotic syndrome combined with IgAN without use of corticosteroid. In these patients, heavy proteinuria disappeared in 1 month after the onset and no recurrence occurred during follow-up. With such limited number of cases, factors associated with spontaneous remission in these patients could not be explored. Further study with a larger number of patients is required and careful attention should be paid to these complicated cases.

Key Words: IgA nephropathy, Nephrotic syndrome, Spontaneous remission