Korean Journal of Nephrology 2010;29(2):241-246.
Renal and Gastrointestinal Amyloidosis in Castleman’s Disease
So Young Choi, M.D.1, Dong Young Lee, M.D.1, Kyung Hwan Jeong, M.D.1, Joo Young Moon, M.D.1, Sang Ho Lee, M.D.1, Tea Won Lee, M.D.1, Kyung Sam Cho, M.D.1, Ju Hee Lee, M.D.2, and Chun Gyoo Ihm, M.D.1
Department of Internal Medicine1
Department of Pathology2 Kyung-Hee University College of Medicine, Seoul, Korea
증례 : Castleman병에 동반된 신장 및 위장관 유전분증 1예
최소영1, 이동영1, 정경환1, 문주영1, 이상호1, 이태원1, 조경삼1, 이주희2, 임천규1
경희대학교 의과대학 내과학교실1 , 병리학교실2
Abstract
Castleman’s disease is a rare disorder and thought to occur as a result of chronic antigenic stimulation due to an unknown infectious or inflammatory etiology. It has a heterogenous course: the symptoms persist in some cases for many years and have a progressive fatal course in others. Renal dysfunction in the form of nephrotic syndrome is quite a rare occurrence. Secondary amyloidosis due to Castleman’s disease has also been reported in a few case reports. A 46-year-old female who had asymptomatic abdominal lymphadenopathy was diagnosed with Castleman’s disease-plasma cell type in our hospital in 2006. Three years after diagnosis, she developed chronic diarrhea, weight loss, anemia and nephrotic range proteinuria. The etiology of symptom was found to be secondary amyloidosis based on renal and gastrointestinal biopsies. She was discharged with steroid therapy. Unfortunately, she had a progressive fatal course. One month after the treatment, she developed thrombocytopenia and died due to cerebral hemorrhage.
Key Words: Castleman’s disease, Plasma cells, Amyloidosis, Kidney
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