Korean Journal of Nephrology 2010;29(1):46-53.
Neutrophil-to-lymphocyte Ratio as a Risk Factor for Severe Acute Kidney Injury
Hyun Woo Kim, M.D. and Eun Hee Jang, M.D
Divison of Nephrology, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea
원저 : Neutrophil-to-lymphocyte Ratio as a Risk Factor for Severe Acute Kidney Injury
Hyun Woo Kim, M.D. and Eun Hee Jang, M.D
Divison of Nephrology, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea
Abstract
Purpose : To evaluate whether neutrophil-to-lymphocyte ratio (NLR) as a marker of inflammation correlates with the severity of ischemic acute kidney injury (AKI). Methods : Between January 2003 and December 2008, 84 patients were diagnosed with ischemic AKI. Patients were divided into two groups (prerenal azotemia and acute tubular necrosis; ATN) and analyzed. Results : Of 84 ischemic AKI patients studied, 49 (58%) presented with ATN. NLR on admission was significantly greater in patients with ATN than that in those with prerenal azotemia (7.8±7.7 vs. 5.1± 3.7; p=0.034). There was a significant and positive correlation between NLR and age (r=0.283; p= 0.009), log C-reactive protein (r=0.409; p=0.001), and log initial and peak serum creatinine (SCr) (r= 0.242; p=0.026 and r=0.294; p=0.007, respectively). Body mass index, hemoglobin and serum albumin concentration were negatively correlated with NLR (r=-0.291; p=0.031, r=-0.254; p=0.020, and r= -0.236; p=0.032, respectively). Thirty-four (41%) patients had severe AKI (RIFLE-F, defined as an absolute increase in SCr of either ≥0.5 mg/dL or a threefold increase from baseline, or a SCr of more than 4 mg/dL) during hospitalization. A high NLR (>7.5) was associated with the development of severe AKI in multivariate logistic regression analysis. Conclusion : High levels of inflammation, as demonstrated by a high NLR, are associated with the severity of ischemic AKI.
Key Words: Acute renal failure, Inflammation, Neutrophil, Lymphocyte
TOOLS
METRICS Graph View
  • 977 View
  • 20 Download
Related articles


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
#301, (Miseung Bldg.) 23, Apgujenog-ro 30-gil, Gangnam-gu, Seoul 06022, Korea
Tel: +82-2-3486-8736    Fax: +82-2-3486-8737    E-mail: registry@ksn.or.kr                

Copyright © 2025 by The Korean Society of Nephrology.

Developed in M2PI

Close layer