Glyphosate Induced Severe Tubulointerstitial Nephritis Requiring Hemodialysis

Korean Journal of Nephrology 2010;29(1):158-161.

Sun Hong Yoo, M.D., Byung Soo Kim, M.D., Hye Yun Lee, M.D. Ja Young Lee, M.D., Jae Ki Choi, M.D., Young Soo Kim, M.D. Sun Ae Yoon, M.D., Yeong Jin Choi, M.D. and Young Ok Kim, M.D.

Department of Internal Medicine and Pathology, College of Medicine The Catholic University of Korea, Seoul, Korea

증례 : Glyphosate Induced Severe Tubulointerstitial Nephritis Requiring Hemodialysis

Sun Hong Yoo, M.D., Byung Soo Kim, M.D., Hye Yun Lee, M.D. Ja Young Lee, M.D., Jae Ki Choi, M.D., Young Soo Kim, M.D. Sun Ae Yoon, M.D., Yeong Jin Choi, M.D. and Young Ok Kim, M.D.

Department of Internal Medicine and Pathology, College of Medicine The Catholic University of Korea, Seoul, Korea

Abstract

This is the first case of glyphosate induced severe tubulointerstitial nephritis requiring hemodialysis without cardiovascular collapse. A 67-year-old man presented to the hospital 30 minutes after ingesting 90 mL of glyphosate herbicide. On arrival, his serum creatinine was 0.8 mg/dL and other laboratory findings including liver, cardiac, and muscle enzymes were all normal. Two days after admission, although his vital signs were stable, his creatinine abruptly increased to 8.2 mg/dL and oliguria developed. As a result, we started hemodialysis treatment and two weeks after initiation of hemodialysis, his renal function started to improve slowly. After discontinuation of hemodialysis, his renal function gradually recovered and serum creatinine level decreased to 1.6 mg/dL three weeks after admission.

Key Words: Glyphosate, Tubulointerstitial nephritis, Hemodialysis