Prevalence of Primary Glomerulonephritis - A Single Center Analysis

Korean Journal of Nephrology 2011;30(5):498-505.

Ki Hyun Kim, M.D.1, Young Ki Son, M.D.1, Su Mi Lee, M.D.1, Won Suk An, M.D.1, Seong Eun Kim, M.D.1 and Seo Hee Rha, M.D.2

Department of Internal Medicine¹
Department of Pathology²
Dong-A University College of Medicine, Busan, Korea

원저 : 원발성 사구체질환의 발생 빈도-단일병원분석

김기현1 , 손영기1 , 이수미1 , 안원석1 , 김성은1 , 나서희2

동아대학교 의료원 내과학교실1 , 해부병리학교실2

Abstract

Purpose: To evaluate the exact prevalence of primary glomerular diseases in Korea. Methods: We analyzed a retrospective cohort of biopsy proven 1,100 patients with primary glomerular disease in OO Hospital from April 1990 to March 2010. Results: Pathologic diagnosises of 1,100 cases were as follows: IgA nephropathy (IgAN) , 557 cases (50.6%), was the most common followed by 200 cases (18.1%) of minor glomerular abnormalities (MGA), 168 cases (15.2%) of focal segmental glomerulosclerosis (FSGS), 93 cases (8.0%) of membranous nephropathy (MN), 31 cases (2.8%) of membranoproliferative glomerulonephritis type I (MPGN), 17 cases (1.5%) of focal glomerulonephritis and 7 cases (0.6%) of diffuse mesangial proliferative glomerulonephritis (DMGN) in order. In idiopathic nephrotic syndrome, the most common pathologic diagnosis was minimal change nephrotic syndrome (MCNS) (40.2%), followed by FSGS (27.5%), MN (24.2%), MPGN (8.1%) and DMGN (0.5%). When the incidence rates between 1990-1992 and 2008-2010 were compared, IgAN and FSGS increased from 34.7, 12.5 to 47.8%, 30.4%, but MCNS (from 33.3 to 6.5 %) decreased significantly Conclusion: IgAN was the most common primary glomerulonephritis. During the past 20 years, the prevalence of IgAN and FSGS were increased, while MCNS and MN were decreased.

Key Words: Biopsy, Glomerulonephritis, Prevalenc