Korean Journal of Nephrology 2011;30(1):94-97.
A Case of Adult Minimal Change Nephrotic Syndrome Associated with Thin Basement Membrane Nephropathy
Ji Eun Song1, Ki Hoi Kim1, Jeong Gwan Kim1, Wang Guk Oh1, Sung Hyun Park1, Kyung Chul Moon2, Jung Hwa Kim1 and Kwang Young Lee1
Department of Internal Medicine1
Presbyterian Medical Center, Jeonju, Korea Department of Pathology2
Seoul National University College of Medicine, Seoul, Korea
증례 : 박기저막 질환에 동반된 성인 미세변화 신증후군 1예
송지은1, 김기회1, 김정관1, 박성현1, 오왕국1, 문경철2, 김정화1, 이광영1
전주 예수병원 신장내과1, 서울대학교 병리학교실2
Thin basement membrane nephropathy (TBMN) is characterized by persistent hematuria, mild proteinuria, normal renal function and family history of hematuria. Many studies report that TBMN commonly occurs together with other glomerular diseases such as minimal change nephrotic syndrome, membranous nephropathy, IgA nephropathy and focal segmental glomerulosclerosis. Especially, the case of TBMN with minimal change nephrotic syndrome has been rare. We report a case of adult minimal change nephrotic syndrome with TBMN in a 44-year-old female with general edema and microscopic hematuria. On renal biopsy, electron microscopic examination demonstrated diffuse thinning of glomerular basement membrane with the thickness less than 250nm and diffuse foot process effacement. Treatment with corticosteroid resulted in complete remission of proteinuria.
Key Words: Minimal change nephrotic syndrome, Glomerular basement membrane, Hematuria

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