|
| Baralgin 에 의한 혈소판 감소증을 동반한 급성 신부전 1예 |
| 김갑식 , 한남익 , 이흥현 , 윤영석 , 김호연 , 방병기 |
|
|
| Abstract |
|
We present here a case of acute renal failure aaaociated with thrombocytopenia developed after an intramuscular injection of Baralgin. A 59-year-old female waa admitted to the hoa- pitsl becauae of jaundice, oliguria, thrombocytope- nia, and generalized purpurae, especially at the in- jection eite of Baralgin4'. The hemoglobin was 12. 1 g/dl, the hemstocrit 33%, the platelet count 32, 000/mm, and the white cell count 19,200/mm with 81% segmented neutr- ophils, 5% 8tab neutrophils, 12% lymphocytes, and 2% monocytes. The BUN was 113.8mg/dl, the cr- eatinine 9. 3 mg/dl, the bilirbin 3. 6 mg/dl(the dir- ect 2. Omg and the indirect 1.6 mg), the SGOT 105 unit, and the SGPT 101unit. The 'direct and indi- rect Coomb's tests were all negative. The clot retraction inhibition test using the pa- tient's whole blood and Baralgin was done for seeking the causative agent of thrombocytopenia. Clot retraction was inhibited at the 1: 1 diluted mixture with the patient's whole blood and Bara- 1gin4. The test suggested that Baralgin might be the causative agent of thrombocytopenia. The patient recovered 'with good result after 10 days CAPD. The mechanism of acute renal failure is yet un- certain. But it is conceivsble that the hypersensitivity reaction to,Baralgin induced the acute interstitial nephritis and thrombocytopenia such as that in the case of rifampicin-induced acute renal failure. The possibility of drug allargies should always be investigated in cases of acute renal failure ass- ociated with thrombocytopenia of unknown origin. |
|
PDF Links
Download Citation
