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Editorial
August 12, 2024
- Air pollution can affect kidney disease? Scientific evidence from epidemiology to experimental studies
- Jiwoo Park, Whanhee Lee
- Kidney Res Clin Pract. 2024;43(5):559-561.
- Editorials
- Air pollution can affect kidney disease? Scientific evidence from epidemiology to experimental studies
- Jiwoo Park, Whanhee Lee
- Kidney Res Clin Pract. 2024;43(5):559-561. Published online August 12, 2024
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- The current state of life expectancy of hemodialysis patients in Korea
- Seyoung Ryou, Hye Eun Yoon
- Kidney Res Clin Pract. 2024;43(5):562-564. Published online May 29, 2024
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- Special Article
- Asymptomatic hematuria in children: Korean Society of Pediatric Nephrology recommendations for diagnosis and management
- Eujin Park, Sang Woon Kim, Su Jin Kim, Minki Baek, Yo Han Ahn, Eun Mi Yang, Myung Hyun Cho, Hyun Kyung Lee, Kyoung Hee Han, Yae Lim Kim, Miyoung Choi, Hee Gyung Kang, Jin-Soon Suh
- Kidney Res Clin Pract. 2024;43(5):565-574. Published online March 7, 2024
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Hematuria is a relatively common condition among school-aged children. Because international guidelines for asymptomatic hematuria in children are unavailable, developing practical guidelines for the diagnosis and management of asymptomatic hematuria based on scientific evidence while considering real-world practice settings, values, and patient and physician preferences is essential. The Korean Society of Pediatric Nephrology developed clinical guidelines to address key questions...
- Review Articles
- Personalized nutritional management in the transition from non-dialysis dependent chronic kidney disease to dialysis
- Yoko Narasaki, Man Kit Siu, Matthew Nguyen, Kamyar Kalantar-Zadeh, Connie M. Rhee
- Kidney Res Clin Pract. 2024;43(5):575-585. Published online May 10, 2024
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Dialysis has been the dominant treatment regimen in end-stage kidney disease as a means to remove uremic waste products and to maintain electrolyte, acid base, and fluid balance. However, given that dialysis may not always provide a survival benefit nor improved quality of life in certain subpopulations, there is growing recognition of the need for conservative and preservative management as...
- Pathogenesis and management of renal fibrosis induced by unilateral ureteral obstruction
- Qi Yan Nan, Shang Guo Piao, Ji Zhe Jin, Byung Ha Chung, Chul Woo Yang, Can Li
- Kidney Res Clin Pract. 2024;43(5):586-599. Published online February 6, 2024
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Regardless of the underlying etiology, renal fibrosis is the final histological outcome of progressive kidney disease. Unilateral ureteral obstruction (UUO) is an ideal and reproducible experimental rodent model of renal fibrosis, which is characterized by tubulointerstitial inflammatory responses, accumulation of extracellular matrix, tubular dilatation and atrophy, and fibrosis. The magnitude of UUO-induced renal fibrosis is experimentally manipulated by the species...
- Original Articles
- Long non-coding RNA MEG3 silencing weakens high glucose-induced mesangial cell injury by decreasing LIN28B expression by sponging and sequestering miR-23c
- Lu Rong, Huanzhou Xue, Jianwei Hao, Jianjun Liu, Hao Xu
- Kidney Res Clin Pract. 2024;43(5):600-613. Published online December 11, 2023
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Background: Diabetic nephropathy (DN) is a common kidney disease in diabetic patients. Long non-coding RNA maternally expressed gene 3 (MEG3) and microRNA (miR)-23c are reported to be implicated in DN development. Nevertheless, it is unclear that the molecular mechanism between MEG3 and miR-23c in DN remains unclear. Methods: Human mesangial cells (HMCs) were treated with high glucose (HG) to simulate...
- Cardiac and kidney outcomes after sacubitril-valsartan therapy: recovery of cardiac function relative to kidney function decline
- Hyo Jeong Kim, Eunji Yang, Hee Byung Koh, Jong Hyun Jhee, Hyeong Cheon Park, Hoon Young Choi
- Kidney Res Clin Pract. 2024;43(5):614-625. Published online September 30, 2024
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Background: Sacubitril-valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction (HFrEF). However, its long-term protective effects on cardiac function with concurrent acute kidney injury (AKI) remain unclear. This study investigated the recovery of cardiac function relative to kidney function decline. Methods: A total of 512 patients with HFrEF who started sacubitril-valsartan or valsartan...
- Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy
- Yooujin Kwak, Jun Young Lee, Jae Seok Kim, Jae Won Yang, Kyu-Hee Hwang, Seung-Kuy Cha, Minseob Eom
- Kidney Res Clin Pract. 2024;43(5):626-634. Published online August 7, 2024
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Background: Targeted therapies for diabetic nephropathy (DN) are lacking, partly due to their irreversible nature. The role of Orai1, a store-operated Ca2+ channel, in DN remains debated, with conflicting evidence on its effect on proteinuria in animal models. We aimed to elucidate the functional relevance of Orai1 expression for clinicopathological parameters in patients with DN. Methods: In this study, we...
- Effect of immunosuppressive agents on clinical outcomes in idiopathic membranous nephropathy
- Ji-Young Choi, Ho Jun Chin, Hajeong Lee, Yena Jeon, Jeong-Hoon Lim, Hee-Yeon Jung, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
- Kidney Res Clin Pract. 2024;43(5):635-647. Published online September 8, 2023
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Background: Few comparative studies on the effects of immunosuppressants in patients with idiopathic membranous nephropathy have been conducted. Methods: Data from 489 patients who received conservative treatment or immunosuppressants were retrospectively analyzed by propensity score matching. Primary outcomes were complete or partial remission (CR or PR) of proteinuria, and secondary outcomes were renal survival and infection. Results: Of the 489...
- Maternal exposure to airborne particulate matter during pregnancy and lactation induces kidney injury in rat dams and their male offspring: the role of vitamin D in pregnancy and beyond
- Min Hwa Son, Eujin Park, Hyung Eun Yim, Yoon Jeong Nam, Yu-Seon Lee, Eui Kyung Choi, Sang Hoon Jeong, Ju‑Han Lee
- Kidney Res Clin Pract. 2024;43(5):648-662. Published online January 2, 2024
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Background: Little is known about the transgenerational effects of maternal exposure to fine particulate matter (PM2.5) on offspring kidney health. This study investigated the effect of maternal administration of PM2.5 or PM2.5 with vitamin D during pregnancy and lactation on renal injury in rat dams and their offspring. Methods: Nine pregnant Sprague-Dawley rats received oral administration of normal saline, airborne...
- To treat or not to treat: CUBN-associated persistent proteinuria
- Yun Young Choi, Yo Han Ahn, Eujin Park, Ji Hyun Kim, Hee Gyung Kang, Hyun Kyung Lee
- Kidney Res Clin Pract. 2024;43(5):663-670. Published online August 24, 2024
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Background: Persistent proteinuria is an important indicator of kidney damage and requires active evaluation and intervention. However, tubular proteinuria of genetic origin typically does not improve with immunosuppression or antiproteinuric treatment. Recently, defects in CUBN were found to cause isolated proteinuria (mainly albuminuria) due to defective tubular albumin reuptake. Unlike most other genetically caused persistent albuminuria, CUBN C-terminal variants have...
- Remaining life expectancy of Korean hemodialysis patients: how much longer can they live?
- Hayne Cho Park, Do Hyoung Kim, AJin Cho, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Jinseog Kim, Young-Ki Lee
- Kidney Res Clin Pract. 2024;43(5):671-679. Published online February 19, 2024
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Background: Hemodialysis (HD) patients have a higher mortality rate compared to the general population. However, no study has investigated life expectancy in Korean HD patients so far. Therefore, this study aimed to calculate the remaining life expectancy among Korean maintenance HD patients and compare it to those of the general population as well as HD patients from other countries. Methods:...
- Fasting blood glucose and the risk of all-cause mortality in patients with diabetes mellitus undergoing hemodialysis
- Soo-Young Yoon, Jin Sug Kim, Gang Jee Ko, Yun Jin Choi, Ju Young Moon, Kyunghwan Jeong, Hyeon Seok Hwang
- Kidney Res Clin Pract. 2024;43(5):680-689. Published online January 26, 2024
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Background: Glycemic control is particularly important in hemodialysis (HD) patients with diabetes mellitus (DM). Although fasting blood glucose (FBG) level is an important indicator of glycemic control, a clear target for reducing mortality in HD patients with DM is lacking. Methods: A total of 26,162 maintenance HD patients with DM were recruited from the National Health Insurance Database of Korea...
- Images in Practice
- Chronic cholesterol crystal embolism: the value of kidney biopsy
- Izabela Silva e Silva, Marcos Adriano Garcia Campos, Ricardo Ferreira Santos, Gyl Eanes Barros Silva
- Kidney Res Clin Pract. 2024;43(5):690-692. Published online September 30, 2024
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- Correspondence
- Gelsolin amyloidosis associated with the p.D214N gelsolin gene mutation in a Chinese family
- Shuang Wang, Dan-yang Li, Jin Xu, Wen-jing Song, Su-xia Wang
- Kidney Res Clin Pract. 2024;43(5):693-696. Published online September 24, 2024
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