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Editorial
April 28, 2026
- Hearing loss and truncating variants in Alport syndrome
- Hyung Eun Yim
- Kidney Res Clin Pract. 2026;45(3):289-292.
- Editorials
- Hearing loss and truncating variants in Alport syndrome
- Hyung Eun Yim
- Kidney Res Clin Pract. 2026;45(3):289-292. Published online April 28, 2026
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- Unmet needs and challenges in the development of noninvasive diagnostics for kidney disease
- Kootae Park, Soon Hyo Kwon
- Kidney Res Clin Pract. 2026;45(3):293-295. Published online September 30, 2025
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- Review Articles
- Role of urate transporters in the kidneys and intestine in uric acid homeostasis
- Su Hyun Kim, Jungho Shin, Hyung-Eun Son, Duk-Hee Kang
- Kidney Res Clin Pract. 2026;45(3):296-313. Published online June 18, 2025
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Hyperuricemia is frequently observed in patients with chronic kidney disease and is recognized as a significant contributor to the progression of renal dysfunction. On the other hand, hypouricemia, although less thoroughly studied, has been implicated in exercise-induced acute kidney injury and urolithiasis. Uric acid (UA), the final product of purine metabolism, is predominantly synthesized in the liver and excreted through...
- Epitranscriptomics in kidney disease: insights and therapeutic potential
- Yu-Cheng Tsai, Ming-Tsun Tsai, Shuo-Ming Ou, Chih-Ching Lin, Szu-Yuan Li
- Kidney Res Clin Pract. 2026;45(3):314-326. Published online December 12, 2025
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Epitranscriptomic regulation, particularly N6-methyladenosine (m⁶A) RNA methylation, has emerged as a pivotal layer of gene expression control, complementing traditional epigenetic mechanisms. As the most prevalent internal modification in eukaryotic messenger RNA, m⁶A dynamically modulates RNA splicing, stability, translation, and localization through the coordinated actions of writer, eraser, and reader proteins. Recent studies have illuminated the critical role of m⁶A in...
- Medical treatment for diabetic acute kidney disease from 2012 to 2024: advances, prescription trends, and future directions
- Heng-Chih Pan, Chung-An Wang, Jui-Yi Chen, Vin-Cent Wu
- Kidney Res Clin Pract. 2026;45(3):327-342. Published online February 6, 2026
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Diabetic acute kidney disease (AKD) represents a pivotal transitional phase between acute kidney injury (AKI) and chronic kidney disease (CKD), carrying a high risk of progression to end-stage kidney disease. Effective medical management is crucial during this phase. Renin-angiotensin-aldosterone system inhibitors remain the foundation of therapy, and newer agents have expanded the armamentarium. Sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor...
- Original Articles
- A noninvasive method of diagnosing membranous nephropathy using exosomes derived from urine
- Giae Yun, Taewoon Kim, Kwang Sik Kim, Kyusoon Shin, Jin-Ho Paik, Jee Yoon Park, Luke P. Lee, Jong Wook Hong, Sejoong Kim
- Kidney Res Clin Pract. 2026;45(3):343-356. Published online September 26, 2024
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Background: Membranous nephropathy (MN) is a specific autoimmune disease affecting kidneys. It is characterized by the accumulation of immune complexes in the glomerular basement membrane. Renal biopsy is currently the standard procedure to confirm the diagnosis, although the presence of autoantibodies against the phospholipase A2 receptor (PLA2R) can also help diagnose. In this study, we aimed to investigate the potential...
- Hearing loss phenotypes in Alport syndrome: experience in a tertiary referral center
- Sang-Yoon Han, Myung-Whan Suh, Moo Kyun Park, Jun Ho Lee, Hee Gyung Kang, Sang-Yeon Lee
- Kidney Res Clin Pract. 2026;45(3):357-372. Published online November 13, 2024
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Background: Despite previous reports of auditory phenotypes in Alport syndrome (AS), there have been no studies specifically addressing audiological phenotypes in South Korea. Herein, we elaborated on the audiological characteristics associated with AS based on their genotypes. Methods: We reviewed data from in-house AS patients between March 2014 and February 2023, excluding those without audiological documentation or genetic diagnoses. We...
- Disaster preparedness and awareness among medical staff in Korean dialysis units
- Kyung Don Yoo, Sang Hun Lee, Dai Hai Choi, Jung Eon Kim, Hidehiro Sugisawa, Young-Ki Lee, Hayne Cho Park
- Kidney Res Clin Pract. 2026;45(3):373-382. Published online September 25, 2025
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Background: The patients receiving hemodialysis (HD) are especially vulnerable during disasters since disasters can destroy the infrastructure necessary for proper HD treatment. This study aimed to investigate disaster experience, disaster preparedness, and cognition among medical staff in Korean HD units. Methods: The survey instrument was adapted and modified from a validated questionnaire developed by the Japanese Association of Dialysis Physicians and...
- Impact of health insurance status on hospitalization and mortality from emergency department admission in patients with end-stage kidney disease: a Korean nationwide registry analysis
- AJin Cho, Kyung Don Yoo, Hye Eun Yoon, Seon A Jeong, Wookjin Choi, Dai Hai Choi, Jungeon Kim, Hayne Cho Park, Young-Ki Lee
- Kidney Res Clin Pract. 2026;45(3):383-392. Published online September 25, 2025
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Background: Health insurance plays a critical role in healthcare accessibility and outcomes, particularly for patients with end-stage kidney disease (ESKD). This retrospective observational study evaluated the relationships between health insurance status and rates of hospitalization and in-hospital mortality among patients with ESKD visiting the emergency department (ED). Methods: We retrospectively analyzed data from the National Emergency Department Information System in South...
- Zinc alpha-2-glycoprotein in peritoneal dialysis effluent correlates with peritoneal transport characteristics, peritonitis rate, and outcome
- Gordon Chun-Kau Chan, Win Hlaing Than, Bonnie Ching-Ha Kwan, Ka-Bik Lai, Ronald Cheong-Kin Chan, Jeremy Yuen-Chun Teoh, Jack Kit-Chung Ng, Kai-Ming Chow, Phyllis Mei-Shan Cheng, Man-Ching Law, Chi-Bon Leung, Philip Kam-Tao Li, Cheuk-Chun Szeto
- Kidney Res Clin Pract. 2026;45(3):393-403. Published online March 11, 2026
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Background: There were limited data on zinc alpha-2-glycoprotein (ZAG) levels and their association with peritoneal characteristics and clinical outcomes in patients undergoing peritoneal dialysis (PD). We aimed to quantify and explore the correlation between ZAG levels in PD effluent (PDE), adipose, and serum samples from PD patients, and to evaluate their association with peritoneal characteristics and outcome. Methods: Incident adult PD...
- Mortality in patients receiving renal replacement therapy in South Korea
- BeongWoo Kim, Chan Il Park, Yu Ah Hong, Hye Eun Yoon, Yong Kyun Kim, Hyunglae Kim, Kyeong Min Kim, Seun Deuk Hwang, Sun Ryoung Choi, Hajeong Lee, Ji Hyun Kim, Su Hyun Kim, Ho-Seok Koo, Chang-Yun Yoon, Kiwon Kim, Seon Ho Ahn, Seon A Jeong, Tae Hee Kim
- Kidney Res Clin Pract. 2026;45(3):404-415. Published online July 24, 2024
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Background: This study analyzed data from the end-stage renal disease patient registry collected by the Korean Society of Nephrology to explore trends in mortality among dialysis patients from 2001 to 2022. Methods: Mortality was analyzed in two ways: firstly, using the annual mortality rate; and secondly, by assessing survivability after a certain period of time since the initiation of dialysis. Additionally,...
- Factors associated with gait speed: results from the RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients (RECOVERY) study
- Miyeun Han, Sang Heon Song, Su Hyun Kim, Ran-hui Cha, Seock Hui Kang, Won Suk An, Jun Chul Kim
- Kidney Res Clin Pract. 2026;45(3):416-425. Published online July 10, 2023
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Background: Gait speed is an important measure of functional ability. This study aimed to investigate the factors associated with gait speed in patients with chronic kidney disease. The study focused on sarcopenic components, plasma uremic or inflammatory marker levels, and quality of life effects. Methods: The RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients is...
- The feasibility of incremental peritoneal dialysis for older patients on peritoneal dialysis
- Ruihua Liu, Jing Guo, Hongjian Ye, Yuan Peng, Haishan Wu, Haiping Mao, Qunying Guo, Fengxian Huang, Xiao Yang
- Kidney Res Clin Pract. 2026;45(3):426-437. Published online August 10, 2023
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Background: This study was performed to investigate the feasibility of incremental peritoneal dialysis (iPD) in older patients. Methods: In this retrospective cohort study, we enrolled peritoneal dialysis (PD) patients with age ≥ 60 years old at our center from 2008 to 2017. The patients were divided into two groups based on the daily PD exchanges: iPD group (≤3 × 2...
- Correspondence
- Targeting intestinal zinc transporters: a novel therapeutic approach for zinc deficiency in chronic kidney disease
- Itsuro Kazama
- Kidney Res Clin Pract. 2026;45(3):438-440. Published online April 9, 2026
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