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Editorial
July 24, 2024
- Immunoglobulin M nephropathy: requiring more attention
- Kyung Chul Moon
- Kidney Res Clin Pract. 2025;44(1):1-3.
- Editorials
- Immunoglobulin M nephropathy: requiring more attention
- Kyung Chul Moon
- Kidney Res Clin Pract. 2025;44(1):1-3. Published online July 24, 2024
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- The overlooked tool: kidney biopsy in progressive renal decline of type 2 diabetes patients
- Sang Youb Han
- Kidney Res Clin Pract. 2025;44(1):4-5. Published online December 11, 2024
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- Special Articles
- Mind the gap in kidney care: translating what we know into what we do
- Valerie A. Luyckx, Katherine R. Tuttle, Dina Abdellatif, Ricardo Correa-Rotter, Winston W.S. Fung, Agnès Haris, Li-Li Hsiao, Makram Khalife, Latha A. Kumaraswami, Fiona Loud, Vasundhara Raghavan, Stefanos Roumeliotis, Marianella Sierra, Ifeoma Ulasi, Bill Wang, Siu-Fai Lui, Vassilios Liakopoulos, Alessandro Balducci
- Kidney Res Clin Pract. 2025;44(1):6-19. Published online January 15, 2025
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Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the...
- Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension
- Se Jin Park, Hyo Soon An, Sung Hye Kim, Seong Heon Kim, Hee Yeon Cho, Jae Hyun Kim, Anna Cho, Ji Hee Kwak, Jae IL Shin, Keum Hwa Lee, Jin-Hee Oh, Jung Won Lee, Hae Soon Kim, Hye-Jung Shin, Mi Young Han, Myung Chul Hyun, Tae Sun Ha, Young Hwan Song
- Kidney Res Clin Pract. 2025;44(1):20-48. Published online January 31, 2025
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Pediatric hypertension (HTN) is a significant, growing health concern worldwide and also in Korea. Diagnosis, evaluation, and treatment of HTN in Korean children and adolescents are uncertain due to limitations in using the current international guidelines, since the recommendations by the American Academy of Pediatrics (AAP) and European Society of Hypertension (ESH) guidelines differ. Furthermore, these are guidelines for Western...
- Review Articles
- In silico medicine and -omics strategies in nephrology: contributions and relevance to the diagnosis and prevention of chronic kidney disease
- Ana Checa-Ros, Antonella Locascio, Nelia Steib, Owahabanun-Joshua Okojie, Totte Malte-Weier, Valmore Bermúdez, Luis D’Marco
- Kidney Res Clin Pract. 2025;44(1):49-57. Published online July 5, 2024
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Chronic kidney disease (CKD) has been increasing over the last years, with a rate between 0.49% to 0.87% new cases per year. Currently, the number of affected people is around 850 million worldwide. CKD is a slowly progressive disease that leads to irreversible loss of kidney function, end-stage kidney disease, and premature death. Therefore, CKD is considered a global health...
- Management of high-flow arteriovenous access
- Hoon Suk Park, Seok Joon Shin
- Kidney Res Clin Pract. 2025;44(1):58-68. Published online January 31, 2025
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An arteriovenous fistula or graft is essential for hemodialysis (HD). It involves connecting a high-resistance artery to a low-resistance vein, which increases cardiac output (CO). In the early days of HD, patients with end-stage kidney disease (ESKD) were typically younger, and their HD access was located in the distal forearm. However, in the modern era, ESKD patients are often the...
- Unveiling the podocyte-protective effect of sodium-glucose cotransporter-2 inhibitors
- Buchun Jiang, Zhiwen Cheng, Dongjie Wang, Fei Liu, Jingjing Wang, Haidong Fu, Jianhua Mao
- Kidney Res Clin Pract. 2025;44(1):69-78. Published online December 5, 2024
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The renoprotective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors in both diabetic and nondiabetic nephropathy are widely recognized due to results from randomized controlled trials notably the DAPA-CKD and EMPA-KIDNEY trials. Research exploring the mechanisms of renoprotection indicates that SGLT2 inhibitors exert protective effects on podocytes by enhancing autophagy and stabilizing the structure of podocytes and basement membranes. Furthermore, reductions in...
- Original Articles
- Comparison between characteristics of immunoglobulin M nephropathy and other glomerular diseases
- Giae Yun, Eun Jeong Kwon, Seokwoo Park, Jong Cheol Jeong, Sejoong Kim, Ki Young Na, Ho Jun Chin
- Kidney Res Clin Pract. 2025;44(1):79-90. Published online February 15, 2024
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Background: Immunoglobulin M (IgM) nephropathy (IgMN) is characterized by the IgM deposition in the kidney’s mesangium. We assessed the impact of electron-dense deposits (EDDs) on IgMN and compared it to other kidney diseases. Methods: We enrolled 63 adult patients with IgMN who underwent renal biopsy from May 2003 to June 2017. We compared clinicopathological features of IgMN based on EDD...
- Kidney biopsy can help to predict renal outcomes of patients with type 2 diabetes mellitus
- Wook-Joon Kim, Taehoon Oh, Nam Hun Heo, Kyungsup Kwon, Ga-Eun Shin, Se-Hwi Jeong, Ji Hye Lee, Samel Park, Nam-Jun Cho, Hyo-Wook Gil, Eun Young Lee
- Kidney Res Clin Pract. 2025;44(1):91-101. Published online January 12, 2024
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Background: In patients with type 2 diabetes mellitus (T2DM), diabetic kidney disease (DKD) is diagnosed based on clinical features. A kidney biopsy is used only in selected cases. This study aimed to reconsider the role of a biopsy in predicting renal outcomes. Methods: Clinical and laboratory parameters and renal biopsy results were obtained from 237 patients with T2DM who underwent...
- Nephrology consultation improves the clinical outcomes of patients with acute kidney injury
- Harin Rhee, Meeyoung Park, Il Young Kim
- Kidney Res Clin Pract. 2025;44(1):102-110. Published online September 8, 2023
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Background: Acute kidney injury (AKI) is prevalent in critically ill patients and is associated with an increased risk of in-hospital mortality. Nephrology consultation may be protective, but this has rarely been evaluated in South Korea. Methods: This multicenter retrospective study was based on the electronic medical records (EMRs) of two third-affiliated hospitals. We extracted the records of patients admitted to...
- Bowman capsule rupture in children with myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis predicts poor renal survival
- Pei Zhang, Li-li Jia, Meng-zhen Fu, Kai-li Shi, Chun-lin Gao, Zheng-kun Xia
- Kidney Res Clin Pract. 2025;44(1):111-122. Published online November 1, 2023
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Background: Recent developments indicated that Bowman capsule rupture (BCR) is observed in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN). We aimed to explore the relationship between BCR and clinical manifestations, pathological changes, and prognosis in children with myeloperoxidase (MPO)-AAGN. Methods: A total of 56 children with MPO-AAGN were divided into BCR (+) and BCR (–) groups according to the status of...
- Clinical consequence of hypophosphatemia during antiviral therapy for chronic hepatitis B
- Mee Yeon Park, Hojin Jeon, Kyungho Park, Junseok Jeon, Minsu Park, Sang Ah Chi, Kyunga Kim, Dong Hyun Sinn, Jung Eun Lee, Geum-Youn Gwak, Wooseong Huh, Yoon-Goo Kim, Hye Ryoun Jang
- Kidney Res Clin Pract. 2025;44(1):123-131. Published online January 17, 2025
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Background: Antiviral therapy is an essential treatment for chronic hepatitis B (CHB) infection. Although hypophosphatemia is an important adverse effect of antiviral agents, its clinical significance remains unclear. We investigated the incidence and clinical consequences of hypophosphatemia in a large cohort of CHB patients. Methods: This retrospective cohort study included CHB patients who started antiviral therapy between 2005 and 2015...
- Atherogenic indices and risk of chronic kidney disease in metabolic derangements: Gangnam Severance Medical Cohort
- Donghwan Oh, Seoyoung Lee, Eunji Yang, Hoon Young Choi, Hyeong Cheon Park, Jong Hyun Jhee
- Kidney Res Clin Pract. 2025;44(1):132-144. Published online December 1, 2023
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Background: The effects of atherogenic indices on kidney function remain unclear. This study evaluated the association between atherogenic indices and risk of chronic kidney disease (CKD) in adults with metabolic derangements. Methods: A total of 4,176 participants from the Gangnam Severance Medical Cohort (2006–2021), which consisted of participants who had at least one disease related to metabolic derangements including diabetes...
- Clinical influencing factors affecting pulmonary hypertension in hemodialysis patients
- Xu Zhang, Kun Xiao, Longkai Li, Nan Wang, Tao Cong, Yushan Wei, Shengji Cao, Xinyu Wen, Qingyang Meng, Hongli Lin, Taihua Wu
- Kidney Res Clin Pract. 2025;44(1):145-154. Published online December 5, 2023
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Background: The fluid status and rate of blood flow through the arteriovenous fistula (AVF) are two important factors affecting hemodynamic in hemodialysis patients; however, their effects on pulmonary hypertension have rarely been studied. Hence, we aimed to evaluate the effects of these factors in hemodialysis patients with pulmonary hypertension. Methods: This single-center cross-sectional survey included 219 maintenance hemodialysis patients (139...
- Constipation and risk of death and cardiovascular events in patients on hemodialysis
- Sang Cheol Park, Juyoung Jung, Young Eun Kwon, Song In Baeg, Dong-Jin Oh, Do Hyoung Kim, Young-Ki Lee, Hye Min Choi
- Kidney Res Clin Pract. 2025;44(1):155-163. Published online January 9, 2025
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Background: Constipation is a common gastrointestinal disorder and is often accompanied by alteration in the gut microbiota. Recently, several studies have disclosed its association with an increased risk of cardiovascular disease and mortality in the general population. Despite the high prevalence of constipation, data on the clinical impact of constipation in patients with chronic kidney disease are limited. We aimed...
- A comparative study of epidemiological characteristics, treatment outcomes, and mortality among patients undergoing hemodialysis by health insurance types: data from the Korean Renal Data System
- Kyeong Min Kim, Soyoung Lee, Jong Ho Shin, Mira Park
- Kidney Res Clin Pract. 2025;44(1):164-175. Published online September 12, 2023
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Background: The prevalence of end-stage renal disease (ESRD) requiring dialysis has progressively increased. Therefore, to achieve financial stability by managing the increasing numbers of patients undergoing hemodialysis (HD), a fixed-payment system was introduced in 2001 for medical aid (MA) beneficiaries receiving HD in Korea. Methods: We identified patients in the Korean Renal Data System that received HD between 2001 and...
- Loss of Cutibacterium is responsible for chronic kidney disease-associated pruritus in patients on dialysis
- Jeong Geon Lee, Hoonhee Seo, Seung Seob Son, Hee Seul Jeong, Kyung Mi Lee, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hyun-A Park, Sukyung Kim, Eun Young Lee
- Kidney Res Clin Pract. 2025;44(1):176-188. Published online September 6, 2023
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Background: Chronic kidney disease (CKD)-associated pruritus is a severe distressing condition that frequently occurs in patients undergoing dialysis. In this study, the profile of the skin microbiome was analyzed to understand the underlying etiology and potential treatments. Methods: Seventy-six end-stage kidney disease (ESKD) patients (hemodialysis, 40; peritoneal dialysis, 36) and 15 healthy controls were enrolled and swabbed at three sites:...
- Clinical significance of the living kidney donor profile index for predicting long-term posttransplant outcomes: results from the Korean Organ Transplantation Registry
- Jong Ho Kim, Sang Ho Lee, Jin Sug Kim, Hyeon Seok Hwang, Hyunmin Ko, Cheol-Woong Jung, Deok Gie Kim, Yeong Hoon Kim, Jaeseok Yang, Curie Ahn, Kyung Hwan Jeong
- Kidney Res Clin Pract. 2025;44(1):189-199. Published online October 19, 2023
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Background: The usefulness of the living kidney donor profile index (LKDPI) has not been widely demonstrated; therefore, it requires verification before clinical application. We analyzed the LKDPI using data from the Korean Organ Transplantation Registry (KOTRY) to confirm whether the LKDPI can be used to predict the survival of allografts in living donor kidney transplantation (LDKT) patients in Korea. Methods:...
- Safety of the reduced fixed dose of mycophenolate mofetil confirmed via therapeutic drug monitoring in de novo kidney transplant recipients
- Hee-Yeon Jung, Yu Jin Seo, Deokbi Hwang, Woo-Sung Yun, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Jeong-Hoon Lim, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Dong Il Won, Jang-Hee Cho, Chan-Duck Kim
- Kidney Res Clin Pract. 2025;44(1):200-209. Published online October 24, 2024
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Background: Mycophenolate mofetil (MMF) is usually prescribed with a reduced fixed dose in Asian kidney transplant recipients (KTRs). However, the clinical efficacy and safety of the fixed dose have not yet been investigated via therapeutic drug monitoring. We evaluated whether reduced fixed-dose MMF is an optimal dosing strategy to achieve the therapeutic target of mycophenolic acid (MPA) exposure in Korean...
- Images in Practice
- Zebra bodies in lupus nephritis without Fabry disease or hydroxychloroquine therapy
- Yaning Wang, Rongdan Cai, Yunqi Liu, Ning Yu, Mingfeng Zhao
- Kidney Res Clin Pract. 2025;44(1):210-212. Published online January 17, 2025
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