Editorial

June 27, 2025


Not to be overlooked: persistent chronic kidney disease burden in low-income groups despite global trends
Sarah Soyeon Oh, Jae Il Shin
Kidney Res Clin Pract. 2025;44(4):547-549.

Editorial

May 9, 2025


Revisiting the safety of hypertensive kidney donors: a call for vigilance
Chan-Duck Kim
Kidney Res Clin Pract. 2025;44(4):550-552.

Special Article

June 27, 2025


Steroid-sensitive nephrotic syndrome in children: Korean Society of Pediatric Nephrology clinical practice recommendations
Hyun Kyung Lee, Myung Hyun Cho, Min Hyun Cho, et al.
Kidney Res Clin Pract. 2025;44(4):553-565.

Review Article

September 26, 2024


A comprehensive review of Alport syndrome: definition, pathophysiology, clinical manifestations, and diagnostic considerations
Eunjeong Kang, Byung Hwa Park, Hajeong Lee, et al.
Kidney Res Clin Pract. 2025;44(4):566-575.

Review Article

November 18, 2024


Alport syndrome and eye
Yeonji Jang, Jae Ho Jung
Kidney Res Clin Pract. 2025;44(4):576-582.

Review Article

November 12, 2024


Renal transplantation in Alport syndrome
Soyeon Kim, Soon Hyo Kwon
Kidney Res Clin Pract. 2025;44(4):583-587.

Original Article

July 22, 2024


Global burden and risk factors of chronic kidney disease in adolescents and young adults: a study from 1990 to 2019
Hua Deng, Qin Zou, Zhe Chen, et al.
Kidney Res Clin Pract. 2025;44(4):588-601.

Original Article

August 21, 2024


Comparisons of clinical outcomes between hypertensive and normotensive living kidney donors: a prospective, multicenter nationwide cohort study
Jong Ho Kim, Yu Ho Lee, Dae Kyu Kim, et al.
Kidney Res Clin Pract. 2025;44(4):602-611.

Original Article

September 9, 2024


Evaluation of the novel ALK5 inhibitor EW-7197 on therapeutic efficacy in renal fibrosis using a three-dimensional chip model
So Young Jang, Seong-Hye Hwang, Yunyeong Choi, et al.
Kidney Res Clin Pract. 2025;44(4):612-625.

Original Article

September 11, 2024


NLRP3 inflammasome activation and macrophage distribution in kidney tissues from patients with acute oxalate nephropathy
Daorina Bao, Xu Zhang, Su-xia Wang, et al.
Kidney Res Clin Pract. 2025;44(4):626-637.

Original Article

November 20, 2024


Characteristics of glomerulonephritis with dominant C1q precipitation compared to corresponding glomerulonephritis without C1q staining on immunofluorescent examination
Ji Young Ryu, Giae Yun, Eun-jeong Kwon, et al.
Kidney Res Clin Pract. 2025;44(4):638-650.

Original Article

April 11, 2025


Home care program with telemonitoring for patients undergoing peritoneal dialysis in South Korea: a cost-utility analysis
KyungYi Kim, Tae Hyun Kim, Jaeyong Shin, et al.
Kidney Res Clin Pract. 2025;44(4):651-663.

Original Article

April 25, 2025


Prediction model for 6-month mortality in incident older hemodialysis patients in South Korea
Woo Yeong Park, Eunjin Bae, Hui-Seung Lee, et al.
Kidney Res Clin Pract. 2025;44(4):664-678.

Original Article

September 13, 2024


Framingham risk score is a useful indicator of posttransplant cardiovascular events and survival among Korean kidney transplant recipients: a nationwide, prospective cohort study
Jeonghwan Lee, Hong Suk Chang, Hyejin Mo, et al.
Kidney Res Clin Pract. 2025;44(4):679-692.

Images in Practice

June 11, 2025


Posttransplant lymphoproliferative disorder encasing transplant renal vein in patient with kidney transplantation
Sang Heon Song
Kidney Res Clin Pract. 2025;44(4):693-694.

Correspondence

June 16, 2025


Hereditary focal segmental glomerulosclerosis associated with an LMX1B mutation in the absence of extrarenal manifestations
Dae Kyu Kim, Geon Woo Kim, Kyung Hwan Jeong, et al.
Kidney Res Clin Pract. 2025;44(4):695-698.

Editorials
Not to be overlooked: persistent chronic kidney disease burden in low-income groups despite global trends
Sarah Soyeon Oh, Jae Il Shin
Kidney Res Clin Pract. 2025;44(4):547-549.   Published online June 27, 2025
Revisiting the safety of hypertensive kidney donors: a call for vigilance
Chan-Duck Kim
Kidney Res Clin Pract. 2025;44(4):550-552.   Published online May 9, 2025
Special Article
Steroid-sensitive nephrotic syndrome in children: Korean Society of Pediatric Nephrology clinical practice recommendations
Hyun Kyung Lee, Myung Hyun Cho, Min Hyun Cho, Yeon Hee Lee, Jeong Yeon Kim, Joo Hoon Lee, Hee Gyung Kang, Eujin Park, Jin-Soon Suh, Dong Ah Park, Heeyeon Cho
Kidney Res Clin Pract. 2025;44(4):553-565.   Published online June 27, 2025
Pediatric nephrotic syndrome is a clinical condition characterized by severe proteinuria, hypoalbuminemia, hyperlipidemia, and generalized edema, most commonly affecting children aged 2 and 6 years. Although standard oral steroid therapy is effective in managing most cases, relapses are common during childhood. Nephrotic syndrome presents significant challenges due to frequent relapses and the potential side effects of long-term drug therapy. In...
Review Articles
A comprehensive review of Alport syndrome: definition, pathophysiology, clinical manifestations, and diagnostic considerations
Eunjeong Kang, Byung Hwa Park, Hajeong Lee, Hee Gyung Kang, Ji Hyun Kim, Ye Na Kim, Yeonsoon Jung, Hark Rim, Ho Sik Shin
Kidney Res Clin Pract. 2025;44(4):566-575.   Published online September 26, 2024
Alport syndrome, a rare genetic disorder affecting around 1 in 50,000 individuals, primarily presents as microscopic hematuria and chronic kidney disease (CKD) with associated extrarenal complications. The Alport syndrome results from mutations in COL4A3, COL4A4, and COL4A5 genes, disrupting the formation of the α3–α4–α5 chain in the collagen IV network. The etiology involves X chromosome- related, autosomal dominant, autosomal recessive,...
Alport syndrome and eye
Yeonji Jang, Jae Ho Jung
Kidney Res Clin Pract. 2025;44(4):576-582.   Published online November 18, 2024
Alport syndrome, characterized by renal failure, hearing loss, and ocular abnormalities due to collagen type IV gene mutations, exhibits distinctive ocular manifestations in the various ocular tissues including the cornea, lens, and retina. Ophthalmological examinations, providing noninvasive visibility of basement membrane anomalies caused by collagen type IV mutations, can have a role in Alport syndrome diagnostics. Lenticonus, macular fleck, and...
Renal transplantation in Alport syndrome
Soyeon Kim, Soon Hyo Kwon
Kidney Res Clin Pract. 2025;44(4):583-587.   Published online November 12, 2024
Kidney transplantation is recognized as an effective treatment for end-stage renal disease in Alport syndrome, demonstrating outcomes comparable to or even superior to those in other causes of renal failure. When considering living related donor kidney transplantation for Alport syndrome patients, it is crucial to consider genetic factors during the donor selection process. In addition to a comprehensive health check,...
Original Articles
Global burden and risk factors of chronic kidney disease in adolescents and young adults: a study from 1990 to 2019

Hua Deng, Qin Zou, Zhe Chen, Bo Hu, Xiangping Liao
Kidney Res Clin Pract. 2025;44(4):588-601.   Published online July 22, 2024
Background: Few studies have evaluated the global burden of chronic kidney disease (CKD) in adolescents and young adults (AYAs). Methods: Age-standardized rates of incidence (ASIR), mortality (ASMR), and disability-adjusted life-years (ASDR) were used to describe the CKD burden in AYAs. The estimated annual percentage changes (EAPCs) were calculated to evaluate the temporal trends from 1990 to 2019. Risk factors were...
Comparisons of clinical outcomes between hypertensive and normotensive living kidney donors: a prospective, multicenter nationwide cohort study

Jong Ho Kim, Yu Ho Lee, Dae Kyu Kim, Jin Sug Kim, Kyung Hwan Jeong, Ku Yong Chung, Jong Cheol Jeong, Soo Jin Na Choi, Jaeseok Yang, Myoung Soo Kim, Hyeon Seok Hwang
Kidney Res Clin Pract. 2025;44(4):602-611.   Published online August 21, 2024
Background: Living kidney donors with hypertension are potential candidates for solving the donor shortages in renal transplantation. However, the safety of donors with hypertension after nephrectomy has not been sufficiently confirmed. Methods: A total of 642 hypertensive and 4,848 normotensive living kidney donors who were enrolled in the Korean Organ Transplantation Registry between May 2014 and December 2020 were included...
Original Article s
Evaluation of the novel ALK5 inhibitor EW-7197 on therapeutic efficacy in renal fibrosis using a three-dimensional chip model

So Young Jang, Seong-Hye Hwang, Yunyeong Choi, Wan-Young Kim, Sung Hyuk Park, Won Mook Kim, Eun-Jeong Kwon, Sejoong Kim
Kidney Res Clin Pract. 2025;44(4):612-625.   Published online September 9, 2024
Background: EW-7197, a potent oral ALK5 inhibitor, was assessed for its impact on transforming growth factor beta 1 (TGF-β1)–induced fibrosis in a three-dimensional (3D) renal fibrosis-on-a-chip and a mouse model. The evaluation included tubular epithelial- mesenchymal transition, angiogenesis, and inflammatory cytokine expression. Methods: In a 3D renal fibrosis-on-a-chip model, three cell types(kidney fibroblasts, human proximal tubular cells, and human umbilical...
Original Articles
NLRP3 inflammasome activation and macrophage distribution in kidney tissues from patients with acute oxalate nephropathy

Daorina Bao, Xu Zhang, Su-xia Wang, Yu Wang, Ming-hui Zhao
Kidney Res Clin Pract. 2025;44(4):626-637.   Published online September 11, 2024
Background: The current study was initiated to evaluate renal nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome pathway activation and macrophage subtype distribution and their clinicopathological significance in a cohort of oxalate-induced acute kidney injury. Methods: Twelve patients with biopsy-proven acute oxalate nephropathy (AON) from January 2016 to October 2022 were retrospectively enrolled, with estimated glomerular filtration...
Characteristics of glomerulonephritis with dominant C1q precipitation compared to corresponding glomerulonephritis without C1q staining on immunofluorescent examination

Ji Young Ryu, Giae Yun, Eun-jeong Kwon, Hyung Eun Son, Kipyo Kim, Sang-Ho Lee, Kyung Pyo Kang, Young-Joo Kwon, Ho Jun Chin
Kidney Res Clin Pract. 2025;44(4):638-650.   Published online November 20, 2024
Background: The clinical significance and renal outcomes of C1q nephropathy (C1qN) are unclear; therefore, the implications of C1qN as a new pathological entity are uncertain. We compared the clinical characteristics of glomerulonephritis reclassified into cases that meet the definition of C1qN and glomerulonephritis not included in the definition of C1qN. Methods: In total, 21,697 patients who underwent native kidney biopsy...
Home care program with telemonitoring for patients undergoing peritoneal dialysis in South Korea: a cost-utility analysis

KyungYi Kim, Tae Hyun Kim, Jaeyong Shin, Suk-Yong Jang, Hyung Woo Kim, Beom Seok Kim, Sang Gyu Lee
Kidney Res Clin Pract. 2025;44(4):651-663.   Published online April 11, 2025
Background: The COVID-19 pandemic accelerated the use of digital health technologies to improve care access and quality of life. The Korean Ministry of Health and Welfare introduced a home care program for end-stage renal disease patients on peritoneal dialysis (PD), incorporating educational consultations and remote monitoring. This study evaluates the long-term economic effectiveness of this digital health-based home care program....
Prediction model for 6-month mortality in incident older hemodialysis patients in South Korea

Woo Yeong Park, Eunjin Bae, Hui-Seung Lee, Chi-Yeon Lim, Jang-Hee Cho, Byung Chul Yu, Miyeun Han, Sang Heon Song, Gang-Jee Ko, Jae Won Yang, Sungjin Chung, Yu Ah Hong, Young Youl Hyun, In O Sun, Hyunsuk Kim, Won Min Hwang, Sung Joon Shin, Soon Hyo Kwon, Kyung Don Yoo
Kidney Res Clin Pract. 2025;44(4):664-678.   Published online April 25, 2025
Background: Early mortality following hemodialysis initiation hinders survival improvement in older patients. This study aimed to develop a clinical risk model for predicting 6-month mortality after dialysis initiation in older Korean hemodialysis patients. Methods: We analyzed data from incident hemodialysis patients aged >70 years from the Korean Society of Geriatric Nephrology (KSGN) database. A prediction model was developed using multivariate...
Framingham risk score is a useful indicator of posttransplant cardiovascular events and survival among Korean kidney transplant recipients: a nationwide, prospective cohort study

Jeonghwan Lee, Hong Suk Chang, Hyejin Mo, In Mok Jung, Boram Weon, Soie Kwon, Chun Soo Lim, Yon Su Kim, Sang-Ho Lee, Yu Ho Lee, Jeong-Hoon Lee, Jaeseok Yang, Myoung Soo Kim, Jung Pyo Lee
Kidney Res Clin Pract. 2025;44(4):679-692.   Published online September 13, 2024
Background: Cardiovascular disease is an important risk factor for mortality among kidney transplant recipients. In this study, we aimed to investigate the association between cardiovascular risk score at kidney transplantation and long-term outcomes of patients. Methods: In this prospective, observational cohort study, we enrolled kidney transplant recipients who participated in the Korean Organ Transplantation Registry and underwent transplantation between April...
Images in Practice
Posttransplant lymphoproliferative disorder encasing transplant renal vein in patient with kidney transplantation
Sang Heon Song
Kidney Res Clin Pract. 2025;44(4):693-694.   Published online June 11, 2025
Correspondence
Hereditary focal segmental glomerulosclerosis associated with an LMX1B mutation in the absence of extrarenal manifestations
Dae Kyu Kim, Geon Woo Kim, Kyung Hwan Jeong, Hyeon Seok Hwang, Ji-Youn Sung, Jin Sug Kim
Kidney Res Clin Pract. 2025;44(4):695-698.   Published online June 16, 2025

Kidney Research
and
Clinical Practice

Print ISSN: 2211-9132
Online ISSN: 2211-9140


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
#301, (Miseung Bldg.) 23, Apgujenog-ro 30-gil, Gangnam-gu, Seoul 06022, Korea
Tel: +82-2-3486-8736    Fax: +82-2-3486-8737    E-mail: registry@ksn.or.kr                

Copyright © 2025 by The Korean Society of Nephrology.

Developed in M2PI

Close layer