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Editorial
April 30, 2025
- Blood pressure targets for the prevention of chronic kidney disease: the discrepancies between observational studies and randomized controlled trials
- Hong Sang Choi, Eun Hui Bae
- Kidney Res Clin Pract. 2025;44(3):399-401.
- Editorials
- Blood pressure targets for the prevention of chronic kidney disease: the discrepancies between observational studies and randomized controlled trials
- Hong Sang Choi, Eun Hui Bae
- Kidney Res Clin Pract. 2025;44(3):399-401. Published online April 30, 2025
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- “Back to the future” of the medical care payment system for hemodialysis patients in South Korea over the past 20 years
- Jae won Yang
- Kidney Res Clin Pract. 2025;44(3):402-405. Published online April 30, 2025
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- Review Articles
- Pathological diagnosis of Alport syndrome
- Kyoung Bun Lee, Minsun Jung, Beom Jin Lim
- Kidney Res Clin Pract. 2025;44(3):406-410. Published online August 23, 2024
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Alport syndrome (AS) is a hereditary nephritis characterized by structural abnormalities in the glomerular basement membrane resulting from pathogenic variants in the COL4A3, COL4A4, and COL4A5 genes. Conventional pathological evaluations reveal nonspecific light microscopic changes and diagnostic clues can be obtained through electron microscopy. Type IV collagen staining elucidates distinct patterns based on AS inheritance, aiding in subtype classification. However,...
- The burden of chronic kidney disease in Asia region: a review of the evidence, current challenges, and future directions
- Afiatin Makmun, Bancha Satirapoj, Do Gia Tuyen, Marjorie W. Y. Foo, Romina Danguilan, Sanjeev Gulati, Sejoong Kim, Sunita Bavanandan, Yi-Wen Chiu, Sydney C.W. Tang
- Kidney Res Clin Pract. 2025;44(3):411-433. Published online September 9, 2024
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The disease burden of chronic kidney disease (CKD) and its impact on healthcare systems has been poorly studied in Asia, a socioeconomically diverse region with wide variations in availability, access, and quality of CKD care. The high CKD burden in this region is predominantly driven by an increased prevalence of risk factors including diabetes mellitus, hypertension, obesity, and use of...
- Original Articles
- Association of systolic blood pressure with incident chronic kidney disease estimated by marginal structural model: a nationwide population-based study
- Hyunsun Lim, Youn Nam Kim, Tae Ik Chang, Jae Young Kim
- Kidney Res Clin Pract. 2025;44(3):434-443. Published online November 7, 2023
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Background: We aimed to investigate the association between systolic blood pressure (SBP) and risk of incident chronic kidney disease (CKD) using marginal structural model (MSM) to reflect mutual effects of exposure and confounders on the outcome. Methods: A total of 195,970 adults with an estimated glomerular filtration rate (eGFR) of >60 mL/min/1.73 m2 and no proteinuria were included from a...
- Preliminary evaluation of the effect of revised reimbursement scheme in outpatient hemodialysis for medical aid recipients in Korea
- Heenyun Kim, Yongseok Choi, Soontack Kwon, Kook Young Jang, Do Kyung Ryuk, Hyejin Lee, Jin Yong Lee
- Kidney Res Clin Pract. 2025;44(3):444-451. Published online February 13, 2024
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Background: South Korea has universal health coverage guaranteeing equitable healthcare for all. However, equity issues have been raised regarding hemodialysis reimbursement for medical aid recipients with chronic kidney disease. Physicians and civic groups demanded a revision of the discriminatory policy, and in response, the Ministry of Health and Welfare amended the hemodialysis case payment scheme. This study aims to evaluate...
- Smoking amplifies the risk of albuminuria in individuals with high sodium intake: the Korea National Health and
Nutrition Examination Survey (KNHANES) 2008–2011 and 2014–2018
- Young-Bin Son, Tae-Bum Kim, Hyeon-Jin Min, Jihyun Yang, Myung-Gyu Kim, Sang Kyung Jo, Won Yong Cho, Se Won Oh
- Kidney Res Clin Pract. 2025;44(3):452-460. Published online October 24, 2023
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Background: Smoking and sodium intake (SI) have been evaluated as risk factors for kidney disease; however, the data are inconsistent. We assessed the association between SI and cotinine-verified smoking status and the risk of albuminuria. Methods: An observational study using the Korea National Health and Nutrition Examination Survey (2008–2011 and 2014– 2018) was performed. We included 37,410 adults with an...
- Exploring new horizons: angiotensin II, angiotensin II type 1 receptor, and renal outer medullary potassium channel interaction in distal convoluted tubule
- Kun Zhao, Tiantian Han, Linzhen Jia, Libo Wen, Renjun Gao, Xue Li
- Kidney Res Clin Pract. 2025;44(3):461-480. Published online September 19, 2024
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Background: This study investigates angiotensin II (Ang II)’s regulatory mechanism on renal outer medullary potassium channel (ROMK) activity in the distal convoluted tubule (DCT) during low potassium intake, focusing on the janus kinase 2 (JAK2) pathway activation mediated by the Ang II type 1 receptor (AT1R). Methods: Utilizing a low potassium diet mouse model, various methods including patch clamping, reverse...
- Impact of glycemic control on residual kidney function and technique failure associated with volume overload in diabetic patients on peritoneal dialysis
- Dong Eon Kim, Da Woon Kim, Hyo Jin Kim, Harin Rhee, Eun Young Seong, Yewon Choi, Sang Heon Song
- Kidney Res Clin Pract. 2025;44(3):481-490. Published online July 24, 2024
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Background: It is unclear whether poor glycemic control contributes to residual kidney function (RKF) decline and consequent volume overload in diabetic patients on peritoneal dialysis (PD). Methods: This retrospective analysis included 80 diabetic patients who started PD at a single center. The first 2 years of patient data were collected to investigate the impact of glycemic control on RKF and...
- Insulin resistance is associated with incident chronic kidney disease in population with normal renal function
- Su Hyun Song, Young Jin Goo, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
- Kidney Res Clin Pract. 2025;44(3):491-499. Published online December 13, 2023
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Background: Insulin resistance is prevalent in chronic kidney disease and may accelerate the progression of chronic kidney disease. This study aimed to investigate whether insulin resistance is associated with the development of incident chronic kidney disease in a population with normal renal function. Methods: A total of 3,331 participants from a community-based cohort with normal renal function were prospectively analyzed....
- Comparative analysis of the incidence and mortality of COVID-19 in Korean end-stage kidney disease patients: hemodialysis, peritoneal dialysis, and transplantation
- AJin Cho, Seon A Jeong, Hayne Cho Park, Do Hyoung Kim, Kyung Don Yoo, Hye Eun Yoon, Yang Gyun Kim, Young-Ki Lee
- Kidney Res Clin Pract. 2025;44(3):500-509. Published online May 29, 2024
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Background: Patients with end-stage kidney disease (ESKD) are more susceptible to viral epidemics and are known to have higher incidence and death rates of coronavirus disease 2019 (COVID-19) compared to the general population. We determined COVID-19 incidence and mortality among chronic hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) patients in Korea. Methods: We conducted a retrospective cohort study...
- Clinical effects of a home care program for patients with peritoneal dialysis in a tertiary care hospital
- KyungYi Kim, Hyung Woo Kim, Beom Seok Kim, Suk-Yong Jang, Jaeyong Shin, Tae Hyun Kim, Sang Gyu Lee
- Kidney Res Clin Pract. 2025;44(3):510-521. Published online August 7, 2024
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Background: Digital health technologies have been rapidly adopted during the coronavirus disease 2019 pandemic. In Korea, a home care program, including face-to-face educational consultation and remote patient monitoring, was initiated to improve patients’ quality of life. This study focused on patients with end-stage renal disease undergoing peritoneal dialysis to verify the long-term clinical effectiveness of this home care program. Methods:...
- COVID-19 infection in patients with end-stage kidney disease undergoing renal replacement therapies in Korea
- Heejung Choi, Ah-Young Kim, Inwhee Park, Hankil Lee, Min-Jeong Lee
- Kidney Res Clin Pract. 2025;44(3):522-534. Published online May 29, 2024
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Background: The global coronavirus disease 2019 (COVID-19) pandemic has placed patients with end-stage kidney disease (ESKD) at heightened risk owing to their vulnerability to infections. Our study focused on patients with ESKD, examining COVID-19 incidence, hospitalization, and mortality in relation to their renal replacement therapy (RRT) type and identifying factors influencing COVID-19 hospitalization. Methods: We conducted a retrospective cohort study...
- Hospitalization among adults with chronic kidney disease: results from the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD) study
- Yeong-Won Park, Jaeseung Hwang, Minsang Kim, Seon-Mi Kim, Yujin Jeong, Minjung Kang, Eunjeong Kang, Hyunjin Ryu, Sue K. Park, Yaeni Kim, Jong Cheol Jeong, Seung Hyeok Han, Kook-Hwan Oh
- Kidney Res Clin Pract. 2025;44(3):535-544. Published online July 25, 2024
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Background: Chronic kidney disease (CKD) patients are hospitalized for various conditions. Hospitalization increases the readmission rate and mortality rate, seriously deteriorating patients’ quality of life. Consequently, it is crucial to analyze the reasons for hospitalization in CKD patients from a broader perspective according to CKD grade. Methods: This is a prospective cohort study of CKD patients entitled the KoreaN cohort...
- Images in Practice
- Striped noncrystalline deposits within the expanded subendothelial space
- Hiroki Ito, Atsuhiro Kannno, Takuo Hirose, Takefumi Mori
- Kidney Res Clin Pract. 2025;44(3):545-547. Published online April 11, 2025
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