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Editorial
July 3, 2024
- The 5th Asia Pacific AKI CRRT 2023: Best Movement to Critical Care, Save Lives
- Kyung Pyo Kang
- Kidney Res Clin Pract. 2024;43(4):391-392.
- Editorial
- The 5th Asia Pacific AKI CRRT 2023: Best Movement to Critical Care, Save Lives
- Kyung Pyo Kang
- Kidney Res Clin Pract. 2024;43(4):391-392. Published online July 3, 2024
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- Review Articles
- Biomarkers in pursuit of precision medicine for acute kidney injury: hard to get rid of customs
- Kun-Mo Lin, Ching-Chun Su, Jui-Yi Chen, Szu-Yu Pan, Min-Hsiang Chuang, Cheng-Jui Lin, Chih-Jen Wu, Heng-Chih Pan, Vin-Cent Wu
- Kidney Res Clin Pract. 2024;43(4):393-405. Published online June 25, 2024
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Traditional acute kidney injury (AKI) classifications, which are centered around semi-anatomical lines, can no longer capture the complexity of AKI. By employing strategies to identify predictive and prognostic enrichment targets, experts could gain a deeper comprehension of AKI’s pathophysiology, allowing for the development of treatment-specific targets and enhancing individualized care. Subphenotyping, which is enriched with AKI biomarkers, holds insights into...
- Unveiling the enigma of acute kidney disease: predicting prognosis, exploring interventions, and embracing a multidisciplinary approach
- Szu-Yu Pan, Thomas Tao-Min Huang, Zheng-Hong Jiang, Li-Chun Lin, I-Jung Tsai, Tsung-Lin Wu, Chih-Yi Hsu, Ting Wang, Hui-Chuen Chen, Yu-Feng Lin, Vin-Cent Wu
- Kidney Res Clin Pract. 2024;43(4):406-416. Published online June 25, 2024
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Acute kidney disease (AKD) is a critical transitional period between acute kidney injury and chronic kidney disease. The incidence of AKD following acute kidney injury is approximately 33.6%, and it can occur without identifiable preceding acute kidney injury. The development of AKD is associated with increased risks of chronic kidney disease, dialysis, and mortality. Biomarkers and subphenotypes are promising tools...
- Artificial intelligence and machine learning’s role in sepsis-associated acute kidney injury
- Wisit Cheungpasitporn, Charat Thongprayoon, Kianoush B. Kashani
- Kidney Res Clin Pract. 2024;43(4):417-432. Published online June 20, 2024
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Sepsis-associated acute kidney injury (SA-AKI) is a serious complication in critically ill patients, resulting in higher mortality, morbidity, and cost. The intricate pathophysiology of SA-AKI requires vigilant clinical monitoring and appropriate, prompt intervention. While traditional statistical analyses have identified severe risk factors for SA-AKI, the results have been inconsistent across studies. This has led to growing interest in leveraging artificial...
- Original Articles
- Association between systemic inflammation biomarkers and mortality in patients with sepsis-associated acute kidney injury receiving intensive care and continuous kidney replacement therapy: results from the RENERGY (REsearches for NEphRology and epidemioloGY) study
- Chan-Young Jung, Jiyun Jung, Jeong-Hoon Lim, Jin Hyuk Paek, Kipyo Kim, Tae Hyun Ban, Jae Yoon Park, Hyosang Kim, Yong Chul Kim, Chung Hee Baek
- Kidney Res Clin Pract. 2024;43(4):433-443. Published online June 13, 2024
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Background: Identifying risk factors and improving prognostication for mortality among patients with sepsis-associated acute kidney injury (AKI) undergoing continuous kidney replacement therapy (CKRT) is important in improving the adverse prognosis of this patient population. This study aimed to compare the prognostic value of existing systemic inflammation biomarkers and determine the optimal systemic inflammation biomarker in patients with sepsis-associated AKI receiving...
- Time-restricted feeding protects against cisplatin-induced acute kidney injury in mice
- Kyu Won Jang, Young Suk Kim, Min Jeong Kim, Seo Rin Kim, Dong Won Lee, Soo Bong Lee, Il Young Kim
- Kidney Res Clin Pract. 2024;43(4):444-456. Published online June 5, 2024
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Background: Time-restricted feeding (TRF), devoid of calorie restriction, is acknowledged for promoting metabolic health and mitigating various chronic metabolic diseases. While TRF exhibits widespread benefits across multiple tissues, there is limited exploration into its impact on kidney function. In this study, our aim was to investigate the potential ameliorative effects of TRF on kidney damage in a mouse model of...
- Plasma presepsin for mortality prediction in patients with sepsis-associated acute kidney injury requiring continuous kidney replacement therapy
- Gi-Beop Lee, Ji Won Lee, Se-Hee Yoon, Won Min Hwang, Sung-Ro Yun, Dong Hoon Koh, Yohan Park
- Kidney Res Clin Pract. 2024;43(4):457-468. Published online June 11, 2024
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Background: The reliability of presepsin as a biomarker of sepsis may be reduced in patients with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT). This study analyzed the utility of plasma presepsin values in predicting mortality in patients with AKI requiring CKRT, particularly those with sepsis-associated AKI. Methods: This single-center retrospective study included 57 patients who underwent CKRT,...
- The role of nafamostat mesylate anticoagulation in continuous kidney replacement therapy for critically ill patients with bleeding tendencies: a retrospective study on patient outcomes and safety
- Taeil Kim, Dong Eon Kim, Eun Mi Jo, Yeji Lee, Da Woon Kim, Hyo Jin Kim, Eun Young Seong, Sang Heon Song, Harin Rhee
- Kidney Res Clin Pract. 2024;43(4):469-479. Published online June 13, 2024
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Background: Continuous kidney replacement therapy (CKRT) is crucial in the management of acute kidney injury in intensive care units (ICUs). Nonetheless, the optimal anticoagulation strategy for patients with bleeding tendencies remains debated. This study aimed to evaluate patient outcomes and safety of nafamostat mesylate (NM) compared with no anticoagulation (NA) in critically ill patients with bleeding tendencies who were undergoing...
- Long-term outcomes of acute kidney injury in acute decompensated heart failure: identifying true cardiorenal syndrome and unveiling prognostic significance
- Peerapat Thanapongsatorn, Atiwat Tanomchartchai, Jarin Assavahanrit
- Kidney Res Clin Pract. 2024;43(4):480-491. Published online June 11, 2024
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Background: Cardiorenal syndrome (CRS) type 1 defined as acute kidney injury (AKI) in acute decompensated heart failure (ADHF), is complicated due to diverse definitions. Recently, a more precise CRS type 1 definition was proposed, mandating concurrent AKI and signs of unimproved heart failure (HF). Our study explores the incidence, predictors, and long-term outcomes of AKI in ADHF under this new...
- Phosphate level predicts mortality in acute kidney injury patients undergoing continuous kidney replacement therapy and has a U-shaped association with mortality in patients with high disease severity: a multicenter retrospective study
- Young Hwan Lee, Soyoung Lee, Yu Jin Seo, Jiyun Jung, Jangwook Lee, Jae Yoon Park, Tae Hyun Ban, Woo Yeong Park, Sung Woo Lee, Kipyo Kim, Kyeong Min Kim, Hyosang Kim, Ji-Young Choi, Jang-Hee Cho, Yong Chul Kim, Jeong-Hoon Lim
- Kidney Res Clin Pract. 2024;43(4):492-504. Published online June 13, 2024
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Background: This study investigated the association between serum phosphate level and mortality in acute kidney injury (AKI) patients undergoing continuous kidney replacement therapy (CKRT) and evaluated whether this association differed according to disease severity. Methods: Data from eight tertiary hospitals in Korea were retrospectively analyzed. The patients were classified into four groups (low, normal, high, and very high) based on...
- Mortality of elderly patients with acute kidney injury undergoing continuous renal replacement therapy: is age a risk factor?
- Ji Hye Kim, Sang Hun Eum, Hyoung Woo Kim, Ji Won Min, Eun Sil Koh, Eun Jeong Ko, Hyung Duk Kim, Byung Ha Chung, Seok Joon Shin, Chul Woo Yang, Hye Eun Yoon
- Kidney Res Clin Pract. 2024;43(4):505-517. Published online June 13, 2024
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Background: Whether advanced age is associated with poor outcomes of elderly patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is controversial. This study aimed to evaluate age effect and predictors for mortality in elderly AKI patients undergoing CRRT. Methods: Data of 480 elderly AKI patients who underwent CRRT were retrospectively analyzed. Subjects were stratified into two...
- Differences in the incidence, characteristics, and outcomes of patients with acute kidney injury in the medical and surgical intensive care units
- Yeji Lee, Taeil Kim, Dong Eon Kim, Eun Mi Jo, Da Woon Kim, Hyo Jin Kim, Eun Young Seong, Sang Heon Song, Harin Rhee
- Kidney Res Clin Pract. 2024;43(4):518-527. Published online June 17, 2024
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Background: Though acute kidney injury (AKI) is a prevalent complication in critically ill patients, knowledge on the epidemiological differences and clinical characteristics of patients with AKI admitted to medical and surgical intensive care units (ICUs) remains limited. Methods: Electronic medical records of patients in ICUs in Pusan National University Hospital and Pusan National University Hospital Yangsan, from January 2011 to...
- Validation of prediction model for successful discontinuation of continuous renal replacement therapy: a multicenter cohort study
- Junseok Jeon, Eun Jeong Ko, Hyejeong Park, Song In Baeg, Hyung Duk Kim, Ji-Won Min, Eun Sil Koh, Kyungho Lee, Danbee Kang, Juhee Cho, Jung Eun Lee, Wooseong Huh, Byung Ha Chung, Hye Ryoun Jang
- Kidney Res Clin Pract. 2024;43(4):528-537. Published online June 20, 2024
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Background: Continuous renal replacement therapy (CRRT) has become the standard modality of renal replacement therapy (RRT) in critically ill patients. However, consensus is lacking regarding the criteria for discontinuing CRRT. Here we validated the usefulness of the prediction model for successful discontinuation of CRRT in a multicenter retrospective cohort. Methods: One temporal cohort and four external cohorts included 1,517 patients...
- A machine learning-based approach for predicting renal function recovery in general ward patients with acute kidney injury
- Nam-Jun Cho, Inyong Jeong, Yeongmin Kim, Dong Ok Kim, Se-Jin Ahn, Sang-Hee Kang, Hyo-Wook Gil, Hwamin Lee
- Kidney Res Clin Pract. 2024;43(4):538-547. Published online June 17, 2024
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Background: Acute kidney injury (AKI) is a significant challenge in healthcare. While there are considerable researches dedicated to AKI patients, a crucial factor in their renal function recovery, is often overlooked. Thus, our study aims to address this issue through the development of a machine learning model to predict restoration of kidney function in patients with AKI. Methods: Our study...
- The effect of pharmacist-led medication therapy management in the multidisciplinary care of acute kidney injury survivors
- Ting Wang, Hao-Cheng Kang, Chien-Chih Wu, Tsung-Lin Wu, Chih-Fen Huang, Vin-Cent Wu
- Kidney Res Clin Pract. 2024;43(4):548-558. Published online June 18, 2024
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Background: The Acute Disease Quality Initiative advocates multidisciplinary care for the survivors of acute kidney injury (AKI). The bundled care strategy recognizes the role of pharmacists. However, their specific contributions in this context remain underexplored. Methods: This retrospective study examined the efficacy of pharmacist-led post-AKI pharmaceutical care in outpatient settings at a single center. Adults with recent AKI during hospitalization,...
