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Editorial
June 27, 2025
- Not to be overlooked: persistent chronic kidney disease burden in low-income groups despite global trends
- Sarah Soyeon Oh, Jae Il Shin
- Kidney Res Clin Pract. 2025;44(4):547-549.
- Editorials
- Not to be overlooked: persistent chronic kidney disease burden in low-income groups despite global trends
- Sarah Soyeon Oh, Jae Il Shin
- Kidney Res Clin Pract. 2025;44(4):547-549. Published online June 27, 2025
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- Revisiting the safety of hypertensive kidney donors: a call for vigilance
- Chan-Duck Kim
- Kidney Res Clin Pract. 2025;44(4):550-552. Published online May 9, 2025
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- Special Article
- Steroid-sensitive nephrotic syndrome in children: Korean Society of Pediatric Nephrology clinical practice recommendations
- Hyun Kyung Lee, Myung Hyun Cho, Min Hyun Cho, Yeon Hee Lee, Jeong Yeon Kim, Joo Hoon Lee, Hee Gyung Kang, Eujin Park, Jin-Soon Suh, Dong Ah Park, Heeyeon Cho
- Kidney Res Clin Pract. 2025;44(4):553-565. Published online June 27, 2025
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Pediatric nephrotic syndrome is a clinical condition characterized by severe proteinuria, hypoalbuminemia, hyperlipidemia, and generalized edema, most commonly affecting children aged 2 and 6 years. Although standard oral steroid therapy is effective in managing most cases, relapses are common during childhood. Nephrotic syndrome presents significant challenges due to frequent relapses and the potential side effects of long-term drug therapy. In...
- Review Articles
- A comprehensive review of Alport syndrome: definition, pathophysiology, clinical manifestations, and diagnostic considerations
- Eunjeong Kang, Byung Hwa Park, Hajeong Lee, Hee Gyung Kang, Ji Hyun Kim, Ye Na Kim, Yeonsoon Jung, Hark Rim, Ho Sik Shin
- Kidney Res Clin Pract. 2025;44(4):566-575. Published online September 26, 2024
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Alport syndrome, a rare genetic disorder affecting around 1 in 50,000 individuals, primarily presents as microscopic hematuria and chronic kidney disease (CKD) with associated extrarenal complications. The Alport syndrome results from mutations in COL4A3, COL4A4, and COL4A5 genes, disrupting the formation of the α3–α4–α5 chain in the collagen IV network. The etiology involves X chromosome- related, autosomal dominant, autosomal recessive,...
- Alport syndrome and eye
- Yeonji Jang, Jae Ho Jung
- Kidney Res Clin Pract. 2025;44(4):576-582. Published online November 18, 2024
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Alport syndrome, characterized by renal failure, hearing loss, and ocular abnormalities due to collagen type IV gene mutations, exhibits distinctive ocular manifestations in the various ocular tissues including the cornea, lens, and retina. Ophthalmological examinations, providing noninvasive visibility of basement membrane anomalies caused by collagen type IV mutations, can have a role in Alport syndrome diagnostics. Lenticonus, macular fleck, and...
- Renal transplantation in Alport syndrome
- Soyeon Kim, Soon Hyo Kwon
- Kidney Res Clin Pract. 2025;44(4):583-587. Published online November 12, 2024
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Kidney transplantation is recognized as an effective treatment for end-stage renal disease in Alport syndrome, demonstrating outcomes comparable to or even superior to those in other causes of renal failure. When considering living related donor kidney transplantation for Alport syndrome patients, it is crucial to consider genetic factors during the donor selection process. In addition to a comprehensive health check,...
- Original Articles
- Global burden and risk factors of chronic kidney disease in adolescents and young adults: a study from 1990 to 2019
- Hua Deng, Qin Zou, Zhe Chen, Bo Hu, Xiangping Liao
- Kidney Res Clin Pract. 2025;44(4):588-601. Published online July 22, 2024
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Background: Few studies have evaluated the global burden of chronic kidney disease (CKD) in adolescents and young adults (AYAs). Methods: Age-standardized rates of incidence (ASIR), mortality (ASMR), and disability-adjusted life-years (ASDR) were used to describe the CKD burden in AYAs. The estimated annual percentage changes (EAPCs) were calculated to evaluate the temporal trends from 1990 to 2019. Risk factors were...
- Comparisons of clinical outcomes between hypertensive and normotensive living kidney donors: a prospective, multicenter nationwide cohort study
- Jong Ho Kim, Yu Ho Lee, Dae Kyu Kim, Jin Sug Kim, Kyung Hwan Jeong, Ku Yong Chung, Jong Cheol Jeong, Soo Jin Na Choi, Jaeseok Yang, Myoung Soo Kim, Hyeon Seok Hwang
- Kidney Res Clin Pract. 2025;44(4):602-611. Published online August 21, 2024
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Background: Living kidney donors with hypertension are potential candidates for solving the donor shortages in renal transplantation. However, the safety of donors with hypertension after nephrectomy has not been sufficiently confirmed. Methods: A total of 642 hypertensive and 4,848 normotensive living kidney donors who were enrolled in the Korean Organ Transplantation Registry between May 2014 and December 2020 were included...
- Original Article s
- Evaluation of the novel ALK5 inhibitor EW-7197 on therapeutic efficacy in renal fibrosis using a three-dimensional chip model
- So Young Jang, Seong-Hye Hwang, Yunyeong Choi, Wan-Young Kim, Sung Hyuk Park, Won Mook Kim, Eun-Jeong Kwon, Sejoong Kim
- Kidney Res Clin Pract. 2025;44(4):612-625. Published online September 9, 2024
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Background: EW-7197, a potent oral ALK5 inhibitor, was assessed for its impact on transforming growth factor beta 1 (TGF-β1)–induced fibrosis in a three-dimensional (3D) renal fibrosis-on-a-chip and a mouse model. The evaluation included tubular epithelial- mesenchymal transition, angiogenesis, and inflammatory cytokine expression. Methods: In a 3D renal fibrosis-on-a-chip model, three cell types(kidney fibroblasts, human proximal tubular cells, and human umbilical...
- Original Articles
- NLRP3 inflammasome activation and macrophage distribution in kidney tissues from patients with acute oxalate nephropathy
- Daorina Bao, Xu Zhang, Su-xia Wang, Yu Wang, Ming-hui Zhao
- Kidney Res Clin Pract. 2025;44(4):626-637. Published online September 11, 2024
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Background: The current study was initiated to evaluate renal nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome pathway activation and macrophage subtype distribution and their clinicopathological significance in a cohort of oxalate-induced acute kidney injury. Methods: Twelve patients with biopsy-proven acute oxalate nephropathy (AON) from January 2016 to October 2022 were retrospectively enrolled, with estimated glomerular filtration...
- Characteristics of glomerulonephritis with dominant C1q precipitation compared to corresponding glomerulonephritis without C1q staining on immunofluorescent examination
- Ji Young Ryu, Giae Yun, Eun-jeong Kwon, Hyung Eun Son, Kipyo Kim, Sang-Ho Lee, Kyung Pyo Kang, Young-Joo Kwon, Ho Jun Chin
- Kidney Res Clin Pract. 2025;44(4):638-650. Published online November 20, 2024
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Background: The clinical significance and renal outcomes of C1q nephropathy (C1qN) are unclear; therefore, the implications of C1qN as a new pathological entity are uncertain. We compared the clinical characteristics of glomerulonephritis reclassified into cases that meet the definition of C1qN and glomerulonephritis not included in the definition of C1qN. Methods: In total, 21,697 patients who underwent native kidney biopsy...
- Home care program with telemonitoring for patients undergoing peritoneal dialysis in South Korea: a cost-utility analysis
- KyungYi Kim, Tae Hyun Kim, Jaeyong Shin, Suk-Yong Jang, Hyung Woo Kim, Beom Seok Kim, Sang Gyu Lee
- Kidney Res Clin Pract. 2025;44(4):651-663. Published online April 11, 2025
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Background: The COVID-19 pandemic accelerated the use of digital health technologies to improve care access and quality of life. The Korean Ministry of Health and Welfare introduced a home care program for end-stage renal disease patients on peritoneal dialysis (PD), incorporating educational consultations and remote monitoring. This study evaluates the long-term economic effectiveness of this digital health-based home care program....
- Prediction model for 6-month mortality in incident older hemodialysis patients in South Korea
- Woo Yeong Park, Eunjin Bae, Hui-Seung Lee, Chi-Yeon Lim, Jang-Hee Cho, Byung Chul Yu, Miyeun Han, Sang Heon Song, Gang-Jee Ko, Jae Won Yang, Sungjin Chung, Yu Ah Hong, Young Youl Hyun, In O Sun, Hyunsuk Kim, Won Min Hwang, Sung Joon Shin, Soon Hyo Kwon, Kyung Don Yoo
- Kidney Res Clin Pract. 2025;44(4):664-678. Published online April 25, 2025
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Background: Early mortality following hemodialysis initiation hinders survival improvement in older patients. This study aimed to develop a clinical risk model for predicting 6-month mortality after dialysis initiation in older Korean hemodialysis patients. Methods: We analyzed data from incident hemodialysis patients aged >70 years from the Korean Society of Geriatric Nephrology (KSGN) database. A prediction model was developed using multivariate...
- Framingham risk score is a useful indicator of posttransplant cardiovascular events and survival among Korean kidney transplant recipients: a nationwide, prospective cohort study
- Jeonghwan Lee, Hong Suk Chang, Hyejin Mo, In Mok Jung, Boram Weon, Soie Kwon, Chun Soo Lim, Yon Su Kim, Sang-Ho Lee, Yu Ho Lee, Jeong-Hoon Lee, Jaeseok Yang, Myoung Soo Kim, Jung Pyo Lee
- Kidney Res Clin Pract. 2025;44(4):679-692. Published online September 13, 2024
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Background: Cardiovascular disease is an important risk factor for mortality among kidney transplant recipients. In this study, we aimed to investigate the association between cardiovascular risk score at kidney transplantation and long-term outcomes of patients. Methods: In this prospective, observational cohort study, we enrolled kidney transplant recipients who participated in the Korean Organ Transplantation Registry and underwent transplantation between April...
- Images in Practice
- Posttransplant lymphoproliferative disorder encasing transplant renal vein in patient with kidney transplantation
- Sang Heon Song
- Kidney Res Clin Pract. 2025;44(4):693-694. Published online June 11, 2025
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- Correspondence
- Hereditary focal segmental glomerulosclerosis associated with an LMX1B mutation in the absence of extrarenal manifestations
- Dae Kyu Kim, Geon Woo Kim, Kyung Hwan Jeong, Hyeon Seok Hwang, Ji-Youn Sung, Jin Sug Kim
- Kidney Res Clin Pract. 2025;44(4):695-698. Published online June 16, 2025
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