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Editorial
March 31, 2023
- Updates in renal pathology
- Hyeon Joo Jeong
- Kidney Res Clin Pract. 2023;42(2):153-154.
- Editorial
- Updates in renal pathology
- Hyeon Joo Jeong
- Kidney Res Clin Pract. 2023;42(2):153-154. Published online March 31, 2023
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- Review Article
- Recent advances in electron microscopy for the diagnosis and research of glomerular diseases
- Kazuho Honda, Takashi Takaki, Dedong Kang
- Kidney Res Clin Pract. 2023;42(2):155-165. Published online May 4, 2022
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Recent technical advances in the detection of backscattered electrons during scanning electron microscopy (SEM) have improved resolution and have provided several new technologies for research and clinical practice in kidney disease. The advances include three-dimensional (3D) electron microscopy (3D-EM), correlative light and electron microscopy (CLEM), low-vacuum SEM (LVSEM), and scanning transmission electron microscopy (STEM). 3D-EM analysis used to be laborious,...
- Histologic evaluation of activity and chronicity of lupus nephritis and its clinical significance
- Sung-Eun Choi, Agnes B. Fogo, Beom Jin Lim
- Kidney Res Clin Pract. 2023;42(2):166-173. Published online March 15, 2023
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The National Institutes of Health (NIH) lupus nephritis activity and chronicity indices, which comprise six activity scores and four chronicity scores, have a long development history. The 2018 revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification for lupus nephritis adopted the most recent NIH indices to replace subclasses A, C, and A/C. Although an evidence-based approach should further evaluate...
- An update on renal fibrosis: from mechanisms to therapeutic strategies with a focus on extracellular vesicles
- Cui Wang, Shang-Wei Li, Xin Zhong, Bi-Cheng Liu, Lin-Li Lv
- Kidney Res Clin Pract. 2023;42(2):174-187. Published online March 31, 2023
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The increasing prevalence of chronic kidney disease (CKD) is a major global public health concern. Despite the complicated pathogenesis of CKD, renal fibrosis represents the most common pathological condition, comprised of progressive accumulation of extracellular matrix in the diseased kidney. Over the last several decades, tremendous progress in understanding the mechanism of renal fibrosis has been achieved, and corresponding potential...
- Original Article
- Diminazene aceturate exacerbates renal fibrosis after unilateral ureteral obstruction in female mice
- Yosep Kim, Jongwan Kim, Sang Jun Han
- Kidney Res Clin Pract. 2023;42(2):188-201. Published online March 22, 2023
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Background: Diminazene aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, exerts anti-inflammatory and antifibrotic effects in a variety of human chronic diseases. However, the role of DIZE in kidney fibrosis and the underlying mechanism remain unclear. Therefore, we investigated the effects of DIZE on the progression of renal fibrosis after unilateral ureteral obstruction (UUO), a well-established model of chronic kidney...
- Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis
- Tae-Sun Ha, Su-Bin Seong, Dong-Soo Ha, Seung Jung Kim
- Kidney Res Clin Pract. 2023;42(2):202-215. Published online March 31, 2023
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Background: Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development of glomerular injury and proteinuria. We studied the role of oxidative stress in angiotensin II-induced podocyte apoptosis. Methods: Mouse podocytes were incubated in media containing various concentrations of...
- Evaluating the Safety and effectivenesS in adult KorEaN patients treated with Tolvaptan for management of autosomal domInAnt poLycystic kidney disease (ESSENTIAL): short-term outcomes during the titration period
- Hyuk Huh, Yong Soo Kim, Wookyung Chung, Yong Lim Kim, Yaerim Kim, Seungyeup Han, Yeonsoon Jung, Ki Young Na, Kyu Beck Lee, Yun Kyu Oh, Hyeong Cheon Park, Seung Hyeok Han, Tae Hyun Yoo, Yeong Hoon Kim, Soo Wan Kim, Kang Wook Lee, Hayne Cho Park, Sung Gyun Kim, Hyunsuk Kim, Chang Hwa Lee, Kyongtae T. Bae, Kook Hwan Oh, Curie Ahn, Hyun Jin Ryu, Yong Chul Kim
- Kidney Res Clin Pract. 2023;42(2):216-228. Published online January 13, 2023
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Background: Tolvaptan reduces height-adjusted total kidney volume (htTKV) and renal function decline in autosomal dominant polycystic kidney disease (ADPKD). This study was aimed at investigating the efficacy and safety of tolvaptan in Korean patients with ADPKD during the titration period. Methods: This study is a multicenter, single-arm, open-label phase 4 study. We enrolled 108 patients with ADPKD (age, 19–50 years)...
- The effects of socioeconomic status on major adverse cardiovascular events: a nationwide population-based cohort study
- Eun Hui Bae, Sang Yup Lim, Eun Mi Yang, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Bongseong Kim, Kyung-Do Han, Soo Wan Kim
- Kidney Res Clin Pract. 2023;42(2):229-242. Published online March 31, 2023
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Background: Although multiple factors influence the risk of major adverse cardiovascular events (MACE), the effects of socioeconomic status on MACE in the presence and absence of renal dysfunction (RD) have not been comprehensively explored in Korea. Methods: We examined the effects of socioeconomic status on MACE in individuals with and without RD. The data of 44,473 Koreans from 2008 to...
- Serum copeptin as a predictor of risk of hyponatremia after transurethral prostatectomy
- Katarzyna Bryc-Walczak, Władysław Bryc, Michał Nowicki
- Kidney Res Clin Pract. 2023;42(2):243-250. Published online March 31, 2023
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Background: Transurethral resection of the prostate gland (TURP) frequently leads to the de-velopment of dilutional serum sodium decrease. Copeptin has been established as a surrogate marker of vasopressin and is measured for clinical assessment of various sodium and water dis-turbances. This study aims to assess the utility of serum concentration of copeptin and N-terminal prohormone of brain natriuretic peptide (NT-proBNP)...
- Association between urinary chloride excretion and progression of coronary artery calcification in patients with nondialysis chronic kidney disease: results from the KNOW-CKD study
- Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Tae-Hyun Yoo, Dong-Wan Chae, Soo Wan Kim
- Kidney Res Clin Pract. 2023;42(2):251-261. Published online March 13, 2023
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Background: Urine chloride has recently been suggested as a biomarker of renal tubule function in patients with nondialysis chronic kidney disease (CKD), as low urinary chloride concentration is associated with an increased risk of CKD progression. We investigate the association between urinary chloride excretion and the progression of coronary artery calcification (CAC). Methods: A total of 1,065 patients with nondialysis...
- Serum calcification propensity and its association with biochemical parameters and bone mineral density in hemodialysis patients
- Hyunsook Kim, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Wookyung Chung, Ji Yong Jung
- Kidney Res Clin Pract. 2023;42(2):262-271. Published online October 25, 2022
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Background: T50 is a novel serum-based marker that assesses the propensity for calcification in serum. A shorter T50 indicates a greater propensity to calcify and has been associated with cardiovascular disease and mortality among patients with chronic kidney disease. The factors associated with T50 and the correlation between T50 and bone mineral density (BMD) are unknown in hemodialysis (HD) patients....
- Images in Practice
- Rejection of a kidney graft revealed by positron emission tomography
- Aidana Barrera-Herrera, Ángela Gonzalez-Rojas, Andrés Perissinotti, Ana Belen Larque, Frederic Cofan, Fritz Diekmann, David Cucchiari
- Kidney Res Clin Pract. 2023;42(2):272-274. Published online March 31, 2023
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- Correspondence
- Safety and efficiency of molnupiravir for COVID-19 patients with advanced chronic kidney disease
- Inès Dufour, Arnaud Devresse, Anais Scohy, Caroline Briquet, Hélène Georgery, Philippe Delaey, Julien De Greef, Eric Goffin, Laura Labriola
- Kidney Res Clin Pract. 2023;42(2):275-278. Published online March 31, 2023
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