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Editorial
July 5, 2024
- Brief review for “Machine learning-based 2-year risk prediction tool in immunoglobulin A nephropathy”
- Hae-Ryong Yun, Tae-Hyun Yoo
- Kidney Res Clin Pract. 2024;43(6):697-699.
- Editorials
- Brief review for “Machine learning-based 2-year risk prediction tool in immunoglobulin A nephropathy”
- Hae-Ryong Yun, Tae-Hyun Yoo
- Kidney Res Clin Pract. 2024;43(6):697-699. Published online July 5, 2024
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- What is the final destination of hemodialysis membrane?
- Jae Won Yang
- Kidney Res Clin Pract. 2024;43(6):700-702. Published online August 12, 2024
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- Special Article
- Pathological and functional significance of aging mouse kidneys: clinical implications to reduce the risk of hyper- or hypokalemia in the elderly
- Itsuro Kazama
- Kidney Res Clin Pract. 2024;43(6):703-708. Published online August 7, 2024
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Elderly patients are prone to develop hyper- or hypokalemia, since they are susceptible to drugs or diets that affect the urinary or fecal potassium (K+) excretion. In aging mouse kidneys, in addition to glomerulosclerosis, proximal tubular atrophy, and atherosclerosis in renal arterioles, there was diffuse tubulointerstitial fibrosis with a number of inflammatory leukocytes infiltrating into the cortical interstitium. Since these...
- Review Articles
- Precision medicine for focal segmental glomerulosclerosis
- Yi Xie, Fei Liu
- Kidney Res Clin Pract. 2024;43(6):709-723. Published online February 6, 2024
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Focal segmental glomerulosclerosis (FSGS) is one of the common causes of nephrotic syndrome in adults and children worldwide. FSGS consists of a group of kidney diseases classified based on specific histopathological features. The current classification of FSGS makes it difficult to distinguish individual differences in pathogenesis, disease progression, and response to treatment. In recent years, the spread of next-generation sequencing,...
- The crosstalk of Wnt/β-catenin signaling and p53 in acute kidney injury and chronic kidney disease
- Wen-Hua Ming, Lin Wen, Wen-Juan Hu, Rong-Fang Qiao, Yang Zhou, Bo-Wei Su, Ya-Nan Bao, Ping Gao, Zhi-Lin Luan
- Kidney Res Clin Pract. 2024;43(6):724-738. Published online November 18, 2024
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Wnt/β-catenin is a signaling pathway associated with embryonic development, organ formation, cancer, and fibrosis. Its activation can repair kidney damage during acute kidney injury (AKI) and accelerate the occurrence of renal fibrosis after chronic kidney disease (CKD). Interestingly, p53 has also been found as a key modulator in AKI and CKD in recent years. Meantime, some studies have found crosstalk...
- Original Articles
- Machine learning-based 2-year risk prediction tool in immunoglobulin A nephropathy
- Yujeong Kim, Jong Hyun Jhee, Chan Min Park, Donghwan Oh, Beom Jin Lim, Hoon Young Choi, Dukyong Yoon, Hyeong Cheon Park
- Kidney Res Clin Pract. 2024;43(6):739-752. Published online October 27, 2023
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Background: This study aimed to develop a machine learning-based 2-year risk prediction model for early identification of patients with rapid progressive immunoglobulin A nephropathy (IgAN). We also assessed the model’s performance to predict the long-term kidney-related outcome of patients. Methods: A retrospective cohort of 1,301 patients with biopsy-proven IgAN from two tertiary hospitals was used to derive and externally validate...
- Medium cut-off dialyzer improves reduction ratios of large middle molecules associated with vascular calcification
- Hyo Jin Kim, Eun Young Seong, Sang Heon Song
- Kidney Res Clin Pract. 2024;43(6):753-762. Published online January 25, 2024
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Background: We aimed to investigate the change in the large middle molecule (>15 kDa) removal rate, which is associated with vascular calcification, when using a medium cut-off (MCO) dialyzer compared to a high-flux (HF) dialyzer. Methods: Twenty patients with clinically stable maintenance hemodialysis were investigated over a 15-week study period. Dialyzer efficacies were evaluated during the last midweek hemodialysis treatment...
- Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys
- Jeong Hoon Park, Sung Gi Yoon, Jung Yeon Ghee, Ji Ae Yoo, Jin Joo Cha, Young Sun Kang, Sang Youb Han, Yun Jae Seol, Jee Young Han, Dae Ryong Cha
- Kidney Res Clin Pract. 2024;43(6):763-773. Published online August 10, 2023
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Background: Aging is a risk factor for development of chronic kidney disease and diabetes mellitus with commonly shared features of chronic inflammation and increased oxidative stress. Here, we investigated the effect of pan-Nox-inhibitor, APX-115, on renal function in aging diabetic mice. Methods: Diabetes was induced by intraperitoneal injection of streptozotocin at 50 mg/kg/day for 5 days in 52-week-old C57BL/6J mice....
- Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes
- Seung-Hyun Jeong, Samel Park, Jae-sung Choi, Nam-Jun Cho, Jong-Seok Moon, Hyo-Wook Gil
- Kidney Res Clin Pract. 2024;43(6):774-784. Published online August 10, 2023
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Background: Neurologic complications, such as cognitive and emotional dysfunction, have frequently been observed in chronic kidney disease (CKD) patients. Previous research shows that uremic toxins play a role in the pathogenesis of CKD-associated cognitive impairment. Since astrocytes contribute to the protection and survival of neurons, astrocyte function and brain metabolism may contribute to the pathogenesis of neurodegeneration. Indoxyl sulfate (IS)...
- The association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease
- Eunmi Jo, Hyo Jin Kim, Jayoun Kim, Tae-Hyun Yoo, Yaeni Kim, Soo Wan Kim, Kook-Hwan Oh, Eun Young Seong, Sang Heon Song
- Kidney Res Clin Pract. 2024;43(6):785-796. Published online May 29, 2024
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Background: Transferrin saturation (TSAT) has been used as an indicator of iron deficiency. However, there is no consensus regarding its optimal range for patient with chronic kidney disease (CKD). We aimed to analyze the effect of TSAT on the prognosis of patients with non-dialysis CKD (NDCKD). Methods: From 2011 to 2016, 2157 NDCKD patients with baseline TSAT measurements were followed...
- Circulating microRNAs as markers for scrub typhus-associated acute kidney injury
- Haeun Lee, Jung Min Kim, A Young Cho, Ju Hwan Oh, Kwang Young Lee, Chang-Seop Lee, In O Sun
- Kidney Res Clin Pract. 2024;43(6):797-806. Published online November 28, 2024
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Background: Circulating microRNAs (miRNAs) are potential biomarkers for various kidney diseases. In this study, we aimed to identify a circulating miRNA signature for detecting acute kidney injury (AKI) in scrub typhus. Methods: We prospectively enrolled 40 patients with scrub typhus (20 with AKI, AKI group; 20 without AKI, non-AKI group) and 20 healthy volunteers (the HV group). Thereafter, we performed...
- Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease
- Kang Min Park, Chang Min Heo, Dong Ah Lee, Hyuk Huh, Sihyung Park, Yang Wook Kim, Yoo Jin Lee, Hyeok Jin Yoon, Bong Soo Park
- Kidney Res Clin Pract. 2024;43(6):807-817. Published online August 10, 2023
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Background: This study aimed to investigate differences in intrinsic prefrontal functional connectivity according to the presence of cognitive impairment in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS). Methods: We prospectively enrolled 37 patients with ESRD who had been undergoing hemodialysis for more than 6 months and had no history of neurological or psychiatric disorders. All patients...
- The impact of severe depression on the survival of older patients with end-stage kidney disease
- You Hyun Jeon, Jeong-Hoon Lim, Yena Jeon, Yu-Kyung Chung, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
- Kidney Res Clin Pract. 2024;43(6):818-828. Published online August 30, 2023
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Background: Incidence of depression increases in patients with end-stage kidney disease (ESKD). We evaluated the association between depression and mortality among older patients with ESKD, which has not been studied previously. Methods: This nationwide prospective cohort study included 487 patients with ESKD aged >65 years, who were categorized into minimal, mild-to-moderate, and severe depression groups based on their Beck Depression...
- Images in Practice
- Unilateral polycystic kidney with PKHD1 gene mutation
- Joung-Hyun Park, Hye-Won Woo, Bum-Sang Cho, Hye-Young Kim
- Kidney Res Clin Pract. 2024;43(6):829-831. Published online November 18, 2024
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- Correspondence
- Fostering international coordination in renal disaster preparedness: a collaboration between the Renal Disaster Preparedness Working Group of the International Society of Nephrology and the Disaster Preparedness and Response Committee of the Korean Society of Nephrology
- Kyung Don Yoo, Sunhwa Lee, Hayne Cho Park, Won Min Hwang, Jung Pyo Lee, Adrian Liew, Ali Abu-Alfa, Hyeong Cheon Park, Young-Ki Lee
- Kidney Res Clin Pract. 2024;43(6):832-835. Published online November 28, 2024
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