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| 성인의 (成人) 소병변성신증후군 (小病性腎症候群) |
| 김대중 (金大重) , 이후(李厚) , 이상구 (李相求) , 안규리 (安圭里) , 한진석 (韓鎭錫) , 김성권 (金聖權) , 이정상 (李正相) , 김용일 (金勇一) |
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| Abstract |
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It is well known that there are some differences in clinical and laboratory findings between minor change nephrotic syndrome in adults and children. But little is known about minor change nephrotic syndrome in adults of our country except that it constitutes moderate proportion of nephrotic syn- drome due to primary glomerular disease. There- fore we reviewed patier.ts records and biopsv specimens of 126 patients with minor change nep- hrotic syndrome who were admitted to department of internal medicine of Seoul National University Hospital from January 1979 to June 1985. The results obtained were as follows: 1) The patients with minor change nephrotic syndrome constituted 46. 8 percents of patients with nephrotic syndrome due to primary glom- erular disease. Major proportion of the patients were young patients, patients of ages between 15 and 24 constituting 57. 9 percents. Male to female ratio was 2. 32: 1 with male predom- inance. 2) The clinical and laboratory findings of the patients were as follows; the proporation of pa- tients with hypertension was 37 4 Q, azotemia 34. 1%, selectivity index above 0. 2, 50. 8%, RA factor 1. 0 %', antinuclear antibody 9. 1%. 3) The proportions of the patients according to the subclassification of light microscopic biopsy findings were as follows; nil change 27. O%, focal glomerular obsolescence 12. 7%, mild mesangial thickening 30.2% fcal tubular chang'e 25.4%, mild mesangial hypercellularity 4. 8 %'. 4) Immunofluorescence findings of the patients revealed deposits of IgG in 11. G p of patients, IgM in 33, 9 %, C in 25. 4 Fo, fibrinogen in 40. 1 %' o patients. There was no significant difference bet- ween patients with immunoglobulin deposits in glomeruli and patients without deposits, in regard to the incidences of hypertension, azotemia, and hematuria. 5) When treated with steroid only, 7 7 .6percents of the patients experienced complete remission in 8 weeks and 93. 9 percents of the patients experi- enced complete remission in 26 weeks with relapse rate of 71. 7 percents. 6) We observed various complications in the pa- tients including pleural effusion, various infections and thrombosis in veins and femoral artery. The above findings of adult minor change nep- hrotic syndrome was consistent with various re- ports of adult minor char.ge nephrotic syndrome till now. |
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