Korean Journal of Nephrology 1987;6(2):329-333.

IgA 신증환자의 피부내 IgA 침착

안명주 , 김홍근 , 박찬현 , 강종명 , 박한철 , 이창우

Abstract

Granular deposits of IgA are known to occur in the walls of superficial vessels in apparently healthy skin of patients with primary IgA nephropathy and Henoch- Schonlein purpura, but the specificity of the finding is still a matter of debate. We investigated the disease specificity and sensitivity of these deposits in the skin of patients with glomer- ulonephritis. In 45 patients with various glomerulone- phritis, the sensitivity of the finding for the diagnosis of IgA nephropathy was only 38%, the specificity being also 38%. We conclude that IgA deposits in the skin are not diagnostic for IgA nephropathy. However, this finding may help one in the understanding of the pathogenesis of the IgA nephropathy.