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| 낭창성 신염 환자의 임상추적 고찰 |
| 양진모 , 이여민 , 강숙영 , 윤영석 , 김호연 , 방병기 |
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| Abstract |
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Systemic lupus erythematosus is a disease of un- known origin, characterized by major alterations of hurnoral or cellular immunity. Lupus nephritis, one of most critical manifestations of outcome in systemic lupus erythematosus, is characterized by various clinical course, histologic and immunologic patterns. 1) In 156 patients with systemic lupus erythematosus, 11 patients were men and 145 patients were women (M: F=l:13.2). Their age at onset of the disease ranged mainly in the 2nd and 3rd decades. 2) In 156 patients systemic lupus erythematosus, lu pus nephritis occurred in 96 patients(61.5%). 3) On admission, positive rates of anti-DNA antibody showed 68.4%, ANA: 71.8%, and ENA antibody: 63.3%. 4) On the basis of morphologic features, the renal lesions were categorized as follows: mesangial prolifer- ative lupus nephritis 2, tocal proliferative lupus nephri- tis 8, diffuse proliferative lupus nephritis 14, mem- branons lupus nephritis 5 and interstitial nephriti a one. 5) In the only steroid therapeutic group, rate of com- plete remission and no-response were 53.6%, 46.4% respectively. In the steroid and cyclophosphamide com- bination therapeutic group, rate of complete remission and no-response were 60.9%, 39.1% respectively. 6) The cause of death in 10 patients with lupus nephri- tis were reviewed. Unknown (30%), renal failure (20%), suicide (20%), sepsis (10%), pulmonary hemorrage (10%), CUA (10%) were noted. |
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