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| IgA 신증에서 신간질내 세포성 면역의 임상적 의의 |
| 정태시 , 권영주 , 조원용 , 김형규 , 원남희 |
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| Abstract |
Background
, IgA nephropathy is one of the most common glomerulonephritis characterized by prominent mesangial IgA deposits. But its pathogenesis is still uncertain. We made a comparative study of elinical features and infiltrating cells in renal interstitium, then assessed clinical significance of cellular immunity in the interstitium of this disease. Me'thods. We examined laboratory and pathological findings in interstitial tissues by immunochemistry from a series of 17 cases to be proven by clinical features and renal biopsy specimens. In interstitial tissues, we aver- aged the positive brown-colored cells in cytoplasm and nucleus each HPF by naked eye through light mi- croscope. Results. At the time of evaluation, the most common chief complaint was hematuria(93.8%), the case more than 1.8 mg/dl of serum creatinine was 1(5.9%), and 4 cases(25.0%) of 24 hrs. urine protein excretion were more than 1 gm/day. The histologic grading in glomer- ular change was that 9 cases(52.9%) were III/V and it was more than others. However, there were no signifi- cant relationships between serum creatinine, 24 hrs. urine protein excretion and the histologic gradings in glomerular change. There were significant correlations between serum creatinine, 24 hrs. Urine protein excre- tiori and UCHL 1(r=0.55, p<0.05, and r=0.60, p<0, 05). In addition, correlation between IgA and T cells in interstitium was 0.57(p<0.05). The mean value of UCHL 1 was 6.43±6.07(p<0.0005) larger than that of L 26. Conclasions. These findings suggest that cell- mediated immunity is a part of pathogenesis of IgA nephropathy and interstitial change in kidney is helpful to prognostic evaluation. |
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