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| Metallothionein 유도가 Aminoglycoside계 항생물질의 신독성 경감작용에 관한 연구 |
| 정해영 , 김정선 , 노영재 , 김종덕 , 정한영 |
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| Abstract |
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Gentamicin is an aminoglycoside antibiotic widely used in the treatment of Gram ( ) bacteria infections. Both nephrotoxicity and ototoxicity (primarily eighth nerve damage) are prominent side effects of gentamicin. The present study is designed to confirm the mecha- nism through which bismuth nitrate reduce the ne- phrotoxicity of gentamicin. Bismuth nitrate markedly induced the renal metal- lothionein. Moreover, the treatment with gentamicin in the presence of pretreatment with bismuth nitrate signi- ficantly reduced blood urea nitrogen and urinary y- glutamyltransferase, glutathione S-transferase activity and urinary glucose content compared with mice of given gentamicin alone, which showed the protective effects of bismuth nitrate against the nephrotoxicity of gentamicin. On the other hand, dimethylthiourea (sca- venger of hydroxyl radical) did not cause the synergistic action on the protective effects of bismuth nitrate. However, the amelioration of gentamicin-induced ne- phrotoxicity by bismuth nitrate was abolished by pretreatment with indomethacin that is cyclooxygenase inhibitor, which suggests the prostaglandin system is involved in the ameliorating action of bismuth nitrate. Therefore, these results suggest that bismuth nitrate can show a protective effect against gentamicin-induced nephrotoxicity via prostaglandin system which may play an important role in ameliorating the nephrotox- icity of gentamicin as a defense mechanism of kidney damage. |
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