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| 스테로이드에 반응하는 IgA 신증에 동반된 신증후군 |
| 김현철 , 조성수 , 이수형 , 박성배 , 박관규 , 장은숙 |
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| Abstract |
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We are reporting four cases of steroid responsive nephrotic syndrome which showed mesangial IgA deposition at immunofluorescence. In IgA nephropathy severe proteinuria is rare and more often associated with hypertension, steroid resistance, and a tendency to renal insufficiency with severe renal histopathologic changes such as advanced glomerular sclerosis and crescent formation. But these cases exhibited minor glomerular alterations at light microscopy despite of massive proteinuria. Furthermore, these cases took a clinical course mimicking that of minimal change ne- phrotic syndrome, characterized by steroid responsive proteinuria, infrequent relapses (in case 2), absence of hematuria, and absence of renal insufficiency during the follow-up period. However, we could diagnose these cases by presence of mesangial IgA deposits at immunofluorescence. In conclusion, we could recommend the use of corticoster- oid particularly in case of the nephrotic syndrome associated with IgA nephropathy with minor histopath- ologic change. |
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