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| 소아 신질환 환자의 신기능 평가에 있어서 Cimetidine 효과에 대한 연구 |
| 임애연 , 피대훈 , 유기환 , 이주원 , 김순겸 |
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| Abstract |
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To investigate whether the creatinine clearances using cimetidine approximate to true glomerular filtration rate, serum ceatinine concentration, creatinine clearance were analyzed in 33 children with renal diseases except acute diseases influencing on glomerular filtration rate, before and after cimetidine administra- tion. Also, we evaluated that the ratios of the creatinine clearance (C ) to the glomerular filtration rate using Tc-DTPA scan (D+) approximate to unity. All patients had stable renal function and were received cimetidine 20 mg/kg p.o. four times daily for six days. The results were as follows. 1) Administration of cimetidine resulted in a significant increase (p<0.01) in mean serum creatinine con centration and a significant reduction (p<0.05) In mean creatinine clearance. 2) The mean ratio of C to Dpvp after ingestion of cimetidine approximated to unity significantly (p<0.05). In conclusion, the cimetidine-aided creatinine clearance can be used as a reliable technique to evaluate renal function in children with various renal diseases. |
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