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| 신이식 환자에서의 임신이 이식신의 기능 및 Cyclosporin 농도에 미치는 영향 |
| 박철수 , 이승헌 , 양철우 , 김용수 , 김석영 , 윤영석 , 방병기 |
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| Abstract |
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Renal allograft recipients in pregnancy are regarded as high risk group. To evaluate the influence of pregnancy on graft function, blood pressure, and blood cyclosporin(CsA) levels in renal allograft recipients, 14 pregnancies in 12 renal transplant recipients were evaluated. Most of patients(11/13, 85%) showed stable serum creatinine but 2 cases(15%) showed increase in serum crea- tinine due to acute rejection and preeclampsia. Acute rejection was noted in 1 patient(7%) and was unresponsive to OKT3 therapy. 9 cases(82%) kept blood pressure to the level of before pregnancy. But 2 normotensive cases(18%) before pregnancy develo- ped hypertension and one of whom had to take a antihypertensive drug even after delivery. Maternal blood CsA levels were lower during pregnancy(273± 73 vs. 129±73 ng/mL p<0.01) than before pregnancy and normalized after delivery(273±73 vs. 214±61 ng/mL p
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