Korean Journal of Nephrology 1996;15(2):123-135.

아데노신 A1 수용체 길항제에 의한 신장효과의 신성고혈압 가토에서의 감약

조용범 , 김선희 , 조경우

Abstract

It has been suggested that the endogenous adenosine is the mediator for the intercellular communication in the regulation of tubuloglomerular feedback control and renin release. Eventhough two subclasses of adenosine receptors, Al and A2, have been described in the kidney, their functional roles are controversial. The adenosine contents in the left and right renal vein have been reported to be markedly increased during the early phase of two- kidney on clip hypertension of the rat. The present study was undertaken to clarify the role of the adenosine system in the experimental hypertension. Experiments were performed in two-kidney one clip Goldblatt hypertensive rabbits (2KICGHR) and sharn-operated normotensive rabbits. S-phenyltheo- phylline (8-PT), 1, 3-diethyl-8-phnylxanthine (DPX), and theophylline were infused into the untouched renal artery. The adenosine receptor antagonists increased renal hemodynamic parameters and excretory functions in dose-dependent manner in both hypertensive and normotensive rabbits. The increases in urine volume, renal blood flow, glo- merular filtration rate and excreted amounts of electrolyte caused hy 8-PT and DPX were significantly attenuated in the 2KICGHR. However, changes in urine volume, glornerular filtration rate, and fractional excretion of sodium caused by theophylline were not significantly different from those in sham-operate'. Rabbits. Increases in excreted amount of sodium and fractional excretion of sodium caused by theophylline were significantly attenuated in the 2K1CGHR. These results suggest that the attenuation of renal effects of adenosine receptor antagonists may be due to the modification of adenosine receptor in the hypertensive rabbit.