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| 천식이 없는 환자에서 발생한 급성 신부전이 동반된 Churg - Strauss 증후군 |
| 정윤철 , 한주용 , 김동완 , 임춘수 , 진호준 , 안규리 , 한진석 , 김성권 , 이정상 , 이현순 |
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| Abstract |
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Churg-Strauss syndrome(allergic granulomatosis and angiitis) is a distinct entity composed of fever, eosinophilia, systemic vasculitis of multiple organ sy- stems, and pathologically eosinophilic infiltration, gra- nuloma and necrotizing vasculitis. In most cases it develops in patients with asthma, and renal involve- ment is characteristically mild and acute renal failure is rare in contrast to other systemic vasculitides. We report an unusual case of Churg-Strauss syndrome manifested by acute renal failure as well as fever, rash, eosinophilia, and nonfixed pulmonary infiltrates in a patient without history of asthma but with that of allergic contact dermatitis. Renal biopsy revealed interstitial eosinophil infiltration, glomerular, vascular and perivascular granulomas containing giant cells. Fever, eosinophilia, and acute renal failure impro- ved immediately after prednisolone 1mg/kg/day de- monstrating good response to steroid as in previous reports. |
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