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| 증례 : Waldenstrom`s Macroglobulinemia 에 의해 유발된 사구체 신염 1 예 (Case Reports : A Case of Glomerulonephritis in Waldenstrom`s Macroglobulinemia ( WM ) Characterized by Hyaline Thrombi in
Glomerulocapillary Lumen) |
| 박창근(Chang Keun Park),신태원(Tae Won Sin),권대식(Dae Sik Kwon),김지섭(Ji Sub Kim),정재성(Jae Sung Chung),공진민(Jin Min Kong),김호균(Ho Gun Kim),김병창(Byung Chang Kim),김혜숙(Hae Sook Kim),김용진(Yong Jin Kim) |
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| Abstract |
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Waldenstrom's macroglobulinemia(WM) is a disorder of malignant proliferation of plasmacyoid lymphocytes and monoclonal immunoglobulin M. The renal complications of WM are less common and severe than that of multiple myeloma. We present a case of WM which involved the kidney as massive proteinuria, hematuria and renal failure. A biopy specimen of the kidney reveals the intraglomerular hyaline thrombi of immunoglobulin M paraprotein. Three cycles of plasmapheresis and systemic chemotherapy with chlorambucil and prednisolone show improvement in his renal manifestations. We suppose the glomerulonephritis caused by hyaline thrombi in WM may be reversible, at least in its early stage. |
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