A Case of Focal Segmental Glomerulosclerosis Associated with Renal Cell Carcinoma

Korean Journal of Nephrology 2008;27(1):127-132.

Hun Jeong, M.D.1, Stephen YongGu Lee, M.D.1, Hyo Young Kim, M.D.1, Sang Hoon Kim, M.D.1 Myung Su Son, M.D.1, Yang Hyun Cho, M.D.1, Hyung-Jong Kim, M.D.1 Dong Ho Yang, M.D.1, Yong Hee Lee, M.D.2 and Sun Won Hong, M.D.3

Department of Internal Mecidine¹
Pathology²
College of Medicine, Pochon CHA University, Sungnam Department of Pathology³
College of Medicine, Yonsei University, Seoul, Korea

증례 : 신세포암에 동반된 국소성 분절성 사구체신염 1예

정 훈1•이용구1•김효영1•김상훈1•손명수1•조양현1•김형종1•양동호1•이용희2•홍순원3

포천중문의과대학교 분당차병원 내과학교실1, 병리학교실2, 연세대학교 의과대학 병리학교실3

Abstract

The association between malignancy and glomerular disease has been reported in older patients. Although the relationship between membranous glomerulonephritis or minimal change disease and solid tumors or hematologic malignancies, respectively, are known widely, focal segmental glomerulosclerosis have been described rarely in patients with solid tumors. We describe a patient with renal cell carcinoma who presented to nephrotic syndrome, volume overload and renal failure. On renal biopsy at contra-lateral kidney of renal cell carcinoma, the patient was diagnosed at focal segmental glomerulosclerosis. The proteinuria and renal function were ameliorated after resection renal cell carcinoma. We suggest that the focal segmental glomerulosclerosis is associated with renal cell carcinoma. This is the first case of the clinical cause of focal segmental glomerulosclerosis associated with renal cell carcinoma of papillary type.

Key Words: Focal segmental glomerulosclerosis, Renal cell carcinoma, Nephrotic syndrome