Crohn’s Disease in a Patient Undergoing Hemodialysis Caused by IgA Nephropathy

Korean Journal of Nephrology 2009;28(5):519-524.

Biro Kim, M.D., Jae Won Yang, M.D., Joung Wook Choi, M.D., Young Sub Kim, M.D., Jong Myeong Yu, M.D., Seung Ok Choi, M.D. and Byoung Geun Han, M.D.

Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea

증례 : Crohn’s Disease in a Patient Undergoing Hemodialysis Caused by IgA Nephropathy

Biro Kim, M.D., Jae Won Yang, M.D., Joung Wook Choi, M.D., Young Sub Kim, M.D., Jong Myeong Yu, M.D., Seung Ok Choi, M.D. and Byoung Geun Han, M.D.

Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea

Abstract

IgA nephropathy is usually localized to the kidney, however, it can accompany systemic disease, including gastrointestinal disease, skin disease, connective tissue disease, and malignant tumor. In some patients with IgA nephropathy which manifested as an extraintestinal symptom of Crohn’s disease, recovery of renal function was achieved following treatment of Crohn’s disease. The pathophysiology of each disease remains unclear. According to some studies, however, immunological, genetic, and environmental factors may be involved in a complex manner. In patients receiving renal replacement therapy for treatment of renal dysfunction due to IgA nephropathy, occurrence of Crohn’s disease as an extrarenal symptom has not been reported. We experienced a case of Crohn’s disease which developed in a patient receiving hemodialysis for treatment of end-stage renal disease due to IgA nephropathy.

Key Words: IgA nephropathy, Crohn’s disease, End-stage renal disease, Hemodialysis