Minimal Change Nephrotic Syndrome Developed after Thymectomy in a Patient with Thymoma

Korean Journal of Nephrology 2011;30(4):404-408.

Fa Mee Doh, M.D., Seon Jung Jang, M.D., Hyang Mo Koo, M.D., Eun Jin Kim, M.D., Hye Sun Shin, M.D., Seung Hyeok Han, M.D., Shin-Wook Kang, M.D., Kyu Hun Choi, M.D. and Tae-Hyun Yoo, M.D.

Department of Internal Medicine, Yonsei University College of Medicine

증례 : 흉선종 절제술 후 발생한 미세변화병 1예

도화미, 장선정, 구향모, 김은진, 신혜선, 한승혁, 강신욱, 최규헌, 유태현

연세대학교 의과대학 내과학교실 신장내과

Abstract

We report a case of patient with malignant thymoma, who developed nephrotic syndrome several years after thymectomy. This 38-year-old man was diagnosed as myasthenia gravis and malignant thymoma and underwent thymectomy in 2004. Tumor resection and systemic chemotherapy were performed after recurrence in pleura in 2006. He also took pyridostigmine to control his symptoms of myasthenia gravis after thymectomy. Four years later, even though there was no evidence of recurrence of thymoma, he developed a nephrotic syndrome and was diagnosed as a minimal change disease on renal biopsy. After pulse therapy with methylprednisolone followed by oral administration of prednisolone therapy, nephrotic syndrome was improved.

Key Words: Minimal change nephrotic syndrome, Portal vein, Thrombosis, Acute kidney injury