Editorial

May 28, 2024


Unveiling the genetic architecture of kidney function in the Korean population
Sehoon Park
Kidney Res Clin Pract. 2024;43(3):257-259.

Editorial

May 28, 2024


Does the primary cilium elongation play a role in urine concentration?
Tae-Hwan Kwon
Kidney Res Clin Pract. 2024;43(3):260-262.

Special Article

May 28, 2024


Trends in clinical outcomes of older hemodialysis patients: data from the 2023 Korean Renal Data System (KORDS)
Hyunglae Kim, Seon A Jeong, Kyeong Min Kim, et al.
Kidney Res Clin Pract. 2024;43(3):263-273.

Review Article

February 6, 2024


Urinary podocyte markers in diabetic kidney disease
Chuanlei Li, Cheuk-Chun Szeto
Kidney Res Clin Pract. 2024;43(3):274-286.

Review Article

March 18, 2024


School urinary screening program in Japan: history, outcomes, perspectives
Masataka Honda, Takeshi Yanagihara, Yoshimitsu Gotoh
Kidney Res Clin Pract. 2024;43(3):287-298.

Original Article

November 3, 2023


Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants
Dong-Jin Lee, Jong-Seok Moon, Dae Kwon Song, et al.
Kidney Res Clin Pract. 2024;43(3):299-312.

Original Article

November 7, 2023


High water intake induces primary cilium elongation in renal tubular cells
Min Jung Kong, Sang Jun Han, Sung Young Seu, et al.
Kidney Res Clin Pract. 2024;43(3):313-325.

Original Article

February 19, 2024


Anti-SARS-CoV-2 spike antibody response to the third dose of BNT162b2 mRNA COVID-19 vaccine and associated factors in Japanese hemodialysis patients
Keiji Hirai, Masako Shimotashiro, Toshiaki Okumura, et al.
Kidney Res Clin Pract. 2024;43(3):326-336.

Original Article

February 8, 2024


Mortality associated with the neutrophil-lymphocyte ratio in septic acute kidney injury requiring continuous renal replacement therapy
Jinwoo Lee, Jeongin Song, Seong Geun Kim, et al.
Kidney Res Clin Pract. 2024;43(3):337-347.

Original Article

September 1, 2023


Clinical relevance of blood urea nitrogen to serum albumin ratio for predicting bacteremia in very young children with febrile urinary tract infection
Hyesun Hyun, Yeon hee Lee, Na Yoon Kang, et al.
Kidney Res Clin Pract. 2024;43(3):348-357.

Original Article

December 18, 2023


Association between hearing loss and physical performance in patients on maintenance hemodialysis
Weifeng Fan, Xiaojing Zhong, Qing Wu, et al.
Kidney Res Clin Pract. 2024;43(3):358-368.

Original Article

January 23, 2024


Efficacy and cost-effectiveness of darbepoetin alfa once every 4 weeks versus continuous erythropoietin receptor activator once every 4 weeks for anemia correction in patients with chronic kidney disease not on dialysis
Geo Neul Park, Kyung Ho Lee, Ji Eun Moon, et al.
Kidney Res Clin Pract. 2024;43(3):369-380.

Original Article

March 18, 2024


Triglyceride-glucose index is an independent predictor of coronary artery calcification progression in patients with chronic kidney disease
Ye Eun Ko, Hyung Woo Kim, Jung Tak Park, et al.
Kidney Res Clin Pract. 2024;43(3):381-390.

APAC2023 AKI-CRRTs
Validation of prediction model for successful discontinuation of continuous renal replacement therapy: a multicenter cohort study
Junseok Jeon, Eun Jeong Ko, Hyejeong Park, Song In Baeg, Hyung Duk Kim, Ji-Won Min, Eun Sil Koh, Kyungho Lee, Danbee Kang, Juhee Cho, Jung Eun Lee, Wooseong Huh, Byung Ha Chung, Hye Ryoun Jang
Received November 23, 2023  Accepted April 8, 2024  
Background: Continuous renal replacement therapy (CRRT) has become the standard modality of renal replacement therapy (RRT) in critically ill patients. However, consensus is lacking regarding the criteria for discontinuing CRRT. Here we validated the usefulness of the prediction model for successful discontinuation of CRRT in a multicenter retrospective cohort. Methods: One temporal cohort and four external cohorts included 1,517 patients with...
DOI: https://doi.org/10.23876/j.krcp.23.308    [Epub ahead of print]
APAC 2023 AKI-CRRTs
Artificial intelligence and machine learning’s role in sepsis-associated acute kidney injury
Wisit Cheungpasitporn, Charat Thongprayoon, Kianoush B. Kashani
Received November 13, 2023  Accepted May 8, 2024  
Sepsis-associated acute kidney injury (SA-AKI) is a serious complication in critically ill patients, resulting in higher mortality, morbidity, and cost. The intricate pathophysiology of SA-AKI requires vigilant clinical monitoring and appropriate, prompt intervention. While traditional statistical analyses have identified severe risk factors for SA-AKI, the results have been inconsistent across studies. This has led to growing interest in leveraging artificial...
DOI: https://doi.org/10.23876/j.krcp.23.298    [Epub ahead of print]
The effect of pharmacist-led medication therapy management in the multidisciplinary care of acute kidney injury survivors
Ting Wang, Hao-Cheng Kang, Chien-Chih Wu, Tsung-Lin Wu, Chih-Fen Huang, Vin-Cent Wu
Received November 22, 2023  Accepted May 8, 2024  
Background: The Acute Disease Quality Initiative advocates multidisciplinary care for the survivors of acute kidney injury (AKI). The bundled care strategy recognizes the role of pharmacists. However, their specific contributions in this context remain underexplored. Methods: This retrospective study examined the effecicacy of pharmacist-led post-AKI pharmaceutical care in outpatient settings at a single center. Adults with recent AKI during hospitalization,...
DOI: https://doi.org/10.23876/j.krcp.23.306    [Epub ahead of print]
APAC2023 AKI-CRRTs
A machine learning-based approach for predicting renal function recovery in general ward patients with acute kidney injury
Nam-Jun Cho, Inyong Jeong, Yeongmin Kim, Dong Ok Kim, Se-Jin Ahn, Sang-Hee Kang, Hyo-Wook Gil, Hwamin Lee
Received December 4, 2023  Accepted April 23, 2024  
Background: Acute kidney injury (AKI) is a significant challenge in healthcare, imposing a significant social burden. While there are considerable researches dedicated to AKI and the recovery of AKI patients, a crucial factor in their prognosis, is often overlooked. Thus, our study aims to address this issue through the development of a machine learning-based approach to predict restoration of kidney...
DOI: https://doi.org/10.23876/j.krcp.23.330    [Epub ahead of print]
APAC 2023 AKI-CRRTs
Differences in the incidence, characteristics, and outcomes of patients with acute kidney injury in the medical and surgical intensive care units
Yeji Lee, Taeil Kim, Dong Eon Kim, Eun Mi Jo, Da Woon Kim, Hyo Jin Kim, Eun Young Seong, Sang Heon Song, Harin Rhee
Received November 26, 2023  Accepted March 28, 2024  
Background: Though acute kidney injury (AKI) is a prevalent complication in critically ill patients, knowledge on the epidemiological differences and clinical characteristics of patients with AKI admitted to medical and surgical intensive care units (ICUs) remains limited. Methods: Electronic medical records of patients in ICUs in Pusan National University Hospital and Pusan National University Hospital Yangsan, from January 2011 to December...
DOI: https://doi.org/10.23876/j.krcp.23.312    [Epub ahead of print]
APAC2023 AKI-CRRTs
Association between systemic inflammation biomarkers and mortality in patients with sepsis-associated acute kidney injury receiving intensive care and continuous kidney replacement therapy: results from the RENERGY (REsearches for NEphRology and epidemioloGY) study
Chan-Young Jung, Jiyun Jung, Jeong-Hoon Lim, Jin Hyuk Paek, Kipyo Kim, Tae Hyun Ban, Jae Yoon Park, Hyosang Kim, Yong Chul Kim, Chung Hee Baek
Received November 27, 2023  Accepted February 1, 2024  
Background: Identifying risk factors and improving prognostication for mortality among patients with sepsis-associated acute kidney injury (AKI) undergoing continuous kidney replacement therapy (CKRT) is important in improving the adverse prognosis of this patient population. This study aimed to compare the prognostic value of existing systemic inflammation biomarkers and determine the optimal systemic inflammation biomarker in patients with sepsis-associated AKI receiving...
DOI: https://doi.org/10.23876/j.krcp.23.321    [Epub ahead of print]
APAC 2023 AKI-CRRTs
Mortality of elderly patients with acute kidney injury undergoing continuous renal replacement therapy: is age a risk factor?
Ji Hye Kim, Sang Hun Eum, Hyoung Woo Kim, Ji Won Min, Eun Sil Koh, Eun Jeong Ko, Hyung Duk Kim, Byung Ha Chung, Seok Joon Shin, Chul Woo Yang, Hye Eun Yoon
Received November 25, 2023  Accepted March 18, 2024  
Background: Whether advanced age is associated with poor outcomes of elderly patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is controversial. This study aimed to evaluate age effect and predictors for mortality in elderly AKI patients undergoing CRRT. Methods: Data of 480 elderly AKI patients who underwent CRRT were retrospectively analyzed. Subjects were stratified into two groups...
DOI: https://doi.org/10.23876/j.krcp.23.313    [Epub ahead of print]
Phosphate level predicts mortality in acute kidney injury patients undergoing continuous kidney replacement therapy and has a U-shaped association with mortality in patients with high disease severity: a multicenter retrospective study
Young Hwan Lee, Soyoung Lee, Yu Jin Seo, Jiyun Jung, Jangwook Lee, Jae Yoon Park, Tae Hyun Ban, Woo Yeong Park, Sung Woo Lee, Kipyo Kim, Kyeong Min Kim, Hyosang Kim, Ji-Young Choi, Jang-Hee Cho, Yong Chul Kim, Jeong-Hoon Lim
Received November 24, 2023  Accepted March 8, 2024  
Background: This study investigated the association between serum phosphate level and mortality in acute kidney injury (AKI) patients undergoing continuous kidney replacement therapy (CKRT) and evaluated whether this association differed according to disease severity. Methods: Data from eight tertiary hospitals in Korea were retrospectively analyzed. The patients were classified into four groups (low, normal, high, and very high) based on their...
DOI: https://doi.org/10.23876/j.krcp.23.311    [Epub ahead of print]
The role of nafamostat mesylate anticoagulation in continuous kidney replacement therapy for critically ill patients with bleeding tendencies: a retrospective study on patient outcomes and safety
Taeil Kim, Dong Eon Kim, Eun Mi Jo, Yeji Lee, Da Woon Kim, Hyo Jin Kim, Eun Young Seong, Sang Heon Song, Harin Rhee
Received November 24, 2023  Accepted February 23, 2024  
Background: Continuous kidney replacement therapy (CKRT) is crucial in the management of acute kidney injury in intensive care units (ICUs). Nonetheless, the optimal anticoagulation strategy for patients with bleeding tendencies remains debated. This study aimed to evaluate patient outcomes and safety of nafamostat mesylate (NM) compared with no anticoagulation (NA) in critically ill patients with bleeding tendencies who were undergoing...
DOI: https://doi.org/10.23876/j.krcp.23.310    [Epub ahead of print]
Long-term outcomes of acute kidney injury in acute decompensated heart failure: identifying true cardiorenal syndrome and unveiling prognostic significance
Peerapat Thanapongsatorn, Atiwat Tanomchartchai, Jarin Assavahanrit
Received November 29, 2023  Accepted February 24, 2024  
Introduction: Cardiorenal syndrome (CRS) type 1 defined as acute kidney injury (AKI) in acute decompensated heart failure (ADHF), is complicated due to diverse definitions. Recently, a more precise CRS type 1 definition was proposed, mandating concurrent AKI and signs of unimproved heart failure (HF). Our study explores the incidence, predictors, and long-term outcomes of AKI in ADHF under this new...
DOI: https://doi.org/10.23876/j.krcp.23.323    [Epub ahead of print]
Plasma presepsin for mortality prediction in patients with sepsis-associated acute kidney injury requiring continuous kidney replacement therapy
Gi-Beop Lee, Ji Won Lee, Se-Hee Yoon, Won Min Hwang, Sung-Ro Yun, Dong Hoon Koh, Yohan Park
Received November 15, 2023  Accepted February 20, 2024  
Background: The reliability of presepsin as a biomarker of sepsis may be reduced in patients with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT). This study analyzed the utility of plasma presepsin values in predicting mortality in patients with AKI requiring CKRT, particularly those with sepsis-associated AKI. Methods: This single-center retrospective study included 57 patients who underwent CKRT, with...
DOI: https://doi.org/10.23876/j.krcp.23.301    [Epub ahead of print]
Time-restricted feeding protects against cisplatin-induced acute kidney injury in mice
Kyu Won Jang, Young Suk Kim, Min Jeong Kim, Seo Rin Kim, Dong Won Lee, Soo Bong Lee, Il Young Kim
Received December 13, 2023  Accepted February 4, 2024  
Background: Time-restricted feeding (TRF), devoid of calorie restriction, is acknowledged for promoting metabolic health and mitigating various chronic metabolic diseases. While TRF exhibits widespread benefits across multiple tissues, there is limited exploration into its impact on kidney function. In this study, our aim was to investigate the potential ameliorative effects of TRF on kidney damage in a mouse model of...
DOI: https://doi.org/10.23876/j.krcp.23.351    [Epub ahead of print]
Special Article
Asymptomatic hematuria in children: Korean Society of Pediatric Nephrology recommendations for diagnosis and management
Eujin Park, Sang Woon Kim, Su Jin Kim, Minki Baek, Yo Han Ahn, Eun Mi Yang, Myung Hyun Cho, Hyun Kyung Lee, Kyoung Hee Han, Yae Lim Kim, Miyoung Choi, Hee Gyung Kang, Jin-Soon Suh
Received September 1, 2023  Accepted November 12, 2023  
Hematuria is a relatively common condition among school-aged children. Because international guidelines for asymptomatic hematuria in children are unavailable, developing practical guidelines for the diagnosis and management of asymptomatic hematuria based on scientific evidence while considering real-world practice settings, values, and patient and physician preferences is essential. The Korean Society of Pediatric Nephrology developed clinical guidelines to address key questions...
DOI: https://doi.org/10.23876/j.krcp.23.231    [Epub ahead of print]
Study Protocol
A Pragmatic Randomized clinical trial: twice-weekly vs. thrice-weekly Incident hemoDialysis in Elderly patients (PRIDE): study protocol
Miyeun Han, Huiwon Jeon, Byung Chul Yu, Sang Heon Song, Sungjin Chung, Chiyeon Lim, Hojoon Sohn, Jin-Won Noh, Soon Hyo Kwon
Received June 30, 2023  Accepted September 24, 2023  
Background: The optimal frequency for hemodialysis in older adults with end-stage kidney disease (ESKD) has not been established. This study aims to investigate whether a twice-weekly dialysis schedule using an incremental approach can reduce hospitalization rates in the elderly with incident dialysis, compared with conventional thrice-weekly dialysis. Methods: We have designed a pragmatic randomized controlled trial to compare the effects...
DOI: https://doi.org/10.23876/j.krcp.23.177    [Epub ahead of print]
Editorial
The current state of life expectancy of hemodialysis patients in Korea
Seyoung Ryou, Hye Eun Yoon
Received April 6, 2024  Accepted April 28, 2024  
DOI: https://doi.org/10.23876/j.krcp.24.099    [Epub ahead of print]
Review Articles
Personalized nutritional management in the transition from non-dialysis dependent chronic kidney disease to dialysis
Yoko Narasaki, Man Kit Siu, Matthew Nguyen, Kamyar Kalantar-Zadeh, Connie M. Rhee
Received June 3, 2023  Accepted November 10, 2023  
Dialysis has been the dominant treatment regimen in end-stage kidney disease as a means to remove uremic waste products and to maintain electrolyte, acid base, and fluid balance. However, given that dialysis may not always provide a survival benefit nor improved quality of life in certain subpopulations, there is growing recognition of the need for conservative and preservative management as...
DOI: https://doi.org/10.23876/j.krcp.23.142    [Epub ahead of print]
Precision medicine for focal segmental glomerulosclerosis
Yi Xie, Fei Liu
Received August 24, 2023  Accepted November 15, 2023  
Focal segmental glomerulosclerosis (FSGS) is one of the common causes of nephrotic syndrome in adults and children worldwide. FSGS consists of a group of kidney diseases classified based on specific histopathological features. The current classification of FSGS makes it difficult to distinguish individual differences in pathogenesis, disease progression, and response to treatment. In recent years, the spread of next-generation sequencing,...
DOI: https://doi.org/10.23876/j.krcp.23.227    [Epub ahead of print]
Pathogenesis and management of renal fibrosis induced by unilateral ureteral obstruction
Qi Yan Nan, Shang Guo Piao, Ji Zhe Jin, Byung Ha Chung, Chul Woo Yang, Can Li
Received June 15, 2023  Accepted November 10, 2023  
Regardless of the underlying etiology, renal fibrosis is the final histological outcome of progressive kidney disease. Unilateral ureteral obstruction (UUO) is an ideal and reproducible experimental rodent model of renal fibrosis, which is characterized by tubulointerstitial inflammatory responses, accumulation of extracellular matrix, tubular dilatation and atrophy, and fibrosis. The magnitude of UUO-induced renal fibrosis is experimentally manipulated by the species...
DOI: https://doi.org/10.23876/j.krcp.23.156    [Epub ahead of print]
Original Articles
Single-cell RNA sequencing revealed the role of the Th17 pathway in the development of anti- human leukocyte antigen antibodies in a highly sensitized mouse model
Hanbi Lee, Yoo-Jin Shin, Xianying Fang, Sheng Cui, Sun Woo Lim, Seon-Yeong Lee, Sang Hun Eum, Ji-Won Min, Chang-Won Hong, Hae-Ock Lee, Mi-La Cho, Eun-Jee Oh, Chul Woo Yang, Byung Ha Chung
Received November 26, 2023  Accepted February 28, 2024  
Background: The aim of this study is to investigate the specific pathway involved in human leukocyte antigen (HLA) sensitization using single-cell RNA-sequencing analysis and an allo-sensitized mouse model developed with an HLA.A2 transgenic mouse. Methods: For sensitization, wild-type C57BL/6 mouse received two skin grafts from C57BL/6-Tg(HLA-A2.1)1Enge/J mouse (allogeneic mouse, ALLO). For syngeneic control (SYN), skin grafts were transferred from C57BL/6...
DOI: https://doi.org/10.23876/j.krcp.23.317    [Epub ahead of print]
A novel allocation scheme for deceased donor kidneys to balance equity and utility
Jin Hyeog Lee, Jun Hye Seo, Tai Yeon Koo, Jang Hee Cho, Kyung Pyo Kang, Jung Eun Lee, Kook Hwan Oh, Beom Seok Kim, Jaeseok Yang
Received February 2, 2024  Accepted March 26, 2024  
Background: Patients with sensitization and blood type O experience increased waiting times for deceased-donor kidney transplantation (DDKT). While allocation benefits are needed to resolve inequity in DDKT opportunity, whether DDKT has comparable outcomes in this disadvantaged population requires further study. This study assessed these outcomes and developed a new allocation system that balances equity and utility. Methods: Patients from national and...
DOI: https://doi.org/10.23876/j.krcp.24.033    [Epub ahead of print]
Comparative analysis of the incidence and mortality of COVID-19 in Korean end-stage kidney disease patients: hemodialysis, peritoneal dialysis, and transplantation
AJin Cho, Seon A Jeong, Hayne Cho Park, Do Hyoung Kim, Kyung Don Yoo, Hye Eun Yoon, Yang Gyun Kim, Young-Ki Lee
Received November 8, 2023  Accepted December 26, 2023  
Background: Patients with end-stage kidney disease (ESKD) are more susceptible to viral epidemics and are known to have higher incidence and death rates of coronavirus disease 2019 (COVID-19) compared to the general population. We determined COVID-19 incidence and mortality among chronic hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) patients in Korea. Methods: We conducted a retrospective cohort study and...
DOI: https://doi.org/10.23876/j.krcp.23.287    [Epub ahead of print]
COVID-19 infection in patients with end-stage kidney disease undergoing renal replacement therapies in Korea
Heejung Choi, Ah-Young Kim, Inwhee Park, Hankil Lee, Min-Jeong Lee
Received November 2, 2023  Accepted January 18, 2024  
Background: The global coronavirus disease 2019 (COVID-19) pandemic has placed patients with end-stage kidney disease (ESKD) at heightened risk owing to their vulnerability to infections. Our study focused on patients with ESKD, examining COVID-19 incidence, hospitalization, and mortality in relation to their renal replacement therapy (RRT) type and identifying factors influencing COVID-19 hospitalization. Methods: We conducted a retrospective cohort study...
DOI: https://doi.org/10.23876/j.krcp.23.280    [Epub ahead of print]
The association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease
Eunmi Jo, Hyo Jin Kim, Jayoun Kim, Tae-Hyun Yoo, Yaeni Kim, Soo Wan Kim, Kook-Hwan Oh, Eun Young Seong, Sang Heon Song
Received September 1, 2023  Accepted January 6, 2024  
Background: Transferrin saturation (TSAT) has been used as an indicator of iron deficiency. However, there is no consensus regarding its optimal range for patient with chronic kidney disease (CKD). We aimed to analyze the effect of TSAT on the prognosis of patients with non-dialysis CKD (NDCKD). Methods: From 2011 to 2016, 2157 NDCKD patients with baseline TSAT measurements were followed...
DOI: https://doi.org/10.23876/j.krcp.23.278    [Epub ahead of print]
Sarcopenia is independently associated with mortality and recovery from dialysis in critically ill patients with sepsis-induced acute kidney injury receiving continuous renal replacement therapy
Il Young Kim, Byung Min Ye, Seo Rin Kim, Dong Won Lee, Soo Bong Lee
Received January 10, 2024  Accepted February 20, 2024  
Background: Sarcopenia upon admission to the intensive care unit (ICU) consistently correlates with adverse outcomes, including heightened mortality, in critically ill patients. This study aims to investigate the independent association of sarcopenia with both mortality and recovery from dialysis in critically ill patients with sepsis-induced acute kidney injury (SIAKI) undergoing continuous renal replacement therapy (CRRT). Methods: This retrospective study included 618...
DOI: https://doi.org/10.23876/j.krcp.24.015    [Epub ahead of print]
Obesity exacerbates ischemia-reperfusion injury and senescence in murine kidneys and perirenal adipose tissues
Seo Rin Kim, Young-Suk Kim, Je Min Hyeon, Su Ji Kim, Byung Min Ye, Min Jeong Kim, Byung Hyun Choi, Dongwon Yi, Il Young Kim, Soo Bong Lee, Dong Won Lee
Received August 25, 2022  Accepted February 3, 2023  
Background: Obesity is a major worldwide health problem and can be related to cellular senescence. Along with the rise in obesity, the comorbidity of renal ischemia-reperfusion (IR) injury is increasing. Whether obesity accelerates the severity of IR injury and whether senescence contributes to these conditions remain unclear. We studied the degree of injury and cellular senescence in the IR kidneys...
DOI: https://doi.org/10.23876/j.krcp.22.193    [Epub ahead of print]
Longitudinal progression trajectory of estimated glomerular filtration rate in children with chronic kidney disease: results from the KNOW-Ped CKD (KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease)
Eun Mi Yang, Jayoun Kim, Eujin Park, Kyoung Hee Han, Seong Heon Kim, Heeyeon Cho, Jae Il Shin, Min Hyun Cho, Joo Hoon Lee, Ji Hyun Kim, Hee Gyung Kang, Il-Soo Ha, Yo Han Ahn
Received July 24, 2023  Accepted December 1, 2023  
Background: The natural course of chronic kidney disease (CKD) progression in children varies according to their underlying conditions. This study aims to identify different patterns of subsequent decline in kidney function and investigate factors associated with different patterns of estimated glomerular filtration rate (eGFR) trajectories. Methods: We analyzed data from the KNOW-Ped CKD (KoreaN cohort study for Outcomes in patients With...
DOI: https://doi.org/10.23876/j.krcp.23.198    [Epub ahead of print]
Impact of obesity on renal function in elderly Korean adults: a national population-based cohort study
Jihyun Yang, Hui Seung Lee, Chi-Yeon Lim, Hyunsuk Kim, Sungjin Chung, Soon Hyo Kwon, Jang-Hee Cho, Kyung Don Yoo, Woo Yeong Park, In O Sun, Byung Chul Yu, Gang-Jee Ko, Jae Won Yang, Won Min Hwang, Sang Heon Song, Sung Joon Shin, Yu Ah Hong, Eunjin Bae, Young Youl Hyun
Received July 14, 2023  Accepted December 1, 2023  
Background: Obesity is a well-known risk factor for chronic kidney disease and its progression. However, the impact of obesity on the renal function of the elderly population is uncertain. We investigated the association between obesity and renal outcomes in the elderly. Methods: We analyzed 130,504 participants from the Korean National Health Insurance Service-Senior cohort. Obesity was classified according to body...
DOI: https://doi.org/10.23876/j.krcp.23.187    [Epub ahead of print]
Remaining life expectancy of Korean hemodialysis patients: how much longer can they live?
Hayne Cho Park, Do Hyoung Kim, AJin Cho, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Jinseog Kim, Young-Ki Lee
Received September 11, 2023  Accepted November 9, 2023  
Background: Hemodialysis (HD) patients have a higher mortality rate compared to the general population. However, no study has investigated life expectancy in Korean HD patients so far. Therefore, this study aimed to calculate the remaining life expectancy among Korean maintenance HD patients and compare it to those of the general population as well as HD patients from other countries. Methods: Baseline...
DOI: https://doi.org/10.23876/j.krcp.23.241    [Epub ahead of print]
Intradialytic hypotension and worse outcomes in patients with acute kidney injury requiring intermittent hemodialysis
Yeong-Won Park, Donghwan Yun, Yeojin Yu, Sang Hyun Kim, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seong Geun Kim, Seung Seok Han
Received July 16, 2023  Accepted November 9, 2023  
Background: Intradialytic hypotension (IDH) is a critical complication related to worse outcomes in patients undergoing maintenance hemodialysis. Herein, we addressed the impact of IDH on mortality and other outcomes in patients with severe acute kidney injury (AKI) requiring intermittent hemodialysis. Methods: We retrospectively reviewed 1,009 patients who underwent intermittent hemodialysis due to severe AKI. IDH was defined as either dialysis discontinuation...
DOI: https://doi.org/10.23876/j.krcp.23.188    [Epub ahead of print]
Immediate-start peritoneal dialysis without break-in-period: an 18-year retrospective cohort study on patient survival
Jee Young Lee, Hyun-Jin Cho, Yoo-Sun Joo, Hye-Jin Na, Jung-Hwan Park, Young-Il Jo
Received April 28, 2023  Accepted November 8, 2023  
Background: Immediate-start peritoneal dialysis (ISPD) is an effective renal replacement therapy that can prevent central venous catheterization due to its immediate initiation of peritoneal dialysis (PD) after catheter insertion without a break-in period. This study aimed to investigate the effect of ISPD on long-term patient survival. Methods: In this retrospective single-center cohort study, 178 consecutive patients who started PD from August...
DOI: https://doi.org/10.23876/j.krcp.23.103    [Epub ahead of print]
Comparison between characteristics of immunoglobulin M nephropathy and other glomerular diseases
Giae Yun, Eun Jeong Kwon, Seokwoo Park, Jong Cheol Jeong, Sejoong Kim, Ki Young Na, Ho Jun Chin
Received June 14, 2023  Accepted August 5, 2023  
Background: Immunoglobulin M (IgM) nephropathy (IgMN) is characterized by the IgM deposition in the kidney’s mesangium. We assessed the impact of electron-dense deposits (EDDs) on IgMN and compared it to other kidney diseases. Methods: We enrolled 63 adult patients with IgMN who underwent renal biopsy from May 2003 to June 2017. We compared clinicopathological features of IgMN based on EDD presence;...
DOI: https://doi.org/10.23876/j.krcp.23.159    [Epub ahead of print]
Preliminary evaluation of the effect of revised reimbursement scheme in outpatient hemodialysis for medical aid recipients in Korea
Heenyun Kim, Yongseok Choi, Soontack Kwon, Kook Young Jang, Do Kyung Ryuk, Hyejin Lee, Jin Yong Lee
Received February 17, 2023  Accepted July 26, 2023  
Background: South Korea has universal health coverage guaranteeing equitable healthcare for all. However, equity issues have been raised regarding hemodialysis reimbursement for medical aid recipients with chronic kidney disease. Physicians and civic groups demanded a revision of the discriminatory policy, and in response, the Ministry of Health and Welfare amended the hemodialysis case payment scheme. This study aims to evaluate...
DOI: https://doi.org/10.23876/j.krcp.23.038    [Epub ahead of print]
Association between dementia diagnosis at dialysis initiation and mortality in older patients with end-stage kidney disease in South Korea
Byung Min Ye, Seongmin Kang, Woo Yeong Park, Jang-Hee Cho, Byung Chul Yu, Miyeun Han, Sang Heon Song, Gang-Jee Ko, Jae Won Yang, Sungjin Chung, Yu Ah Hong, Young Youl Hyun, Eunjin Bae, In O Sun, Hyunsuk Kim, Won Min Hwang, Sung Joon Shin, Soon Hyo Kwon, Seo Rin Kim, Kyung Don Yoo
Received June 9, 2023  Accepted October 22, 2023  
Background: The prevalence of dementia is 2- to 7-fold higher among patients with end-stage kidney disease (ESKD) than among the general population; however, its clinical implications in this population remain unclear. Therefore, this study aimed to determine whether comorbid dementia increases mortality among older patients with ESKD undergoing newly initiated hemodialysis. Methods: We analyzed data from the Korean Society...
DOI: https://doi.org/10.23876/j.krcp.23.151    [Epub ahead of print]
Efficacy of intradialytic neuromuscular electrical stimulation and oral nutritional supplementation in hemodialysis patients: a multicenter, randomized controlled trial
Jae Hyeon Park, Jae Yoon Park, Geum Sil Lee, Ran-hui Cha
Received June 2, 2023  Accepted October 2, 2023  
Background: Sarcopenia is common in hemodialysis patients. This study aimed to evaluate the effect of simultaneous nutritional support and intradialytic neuromuscular electrical stimulation (NMES) in hemodialysis patients. Methods: We performed a 12-week, multicenter, randomized controlled trial. The participants were randomly assigned to the control group, the protein group (25 g of protein at every dialysis session), the NMES group (intradialytic...
DOI: https://doi.org/10.23876/j.krcp.23.146    [Epub ahead of print]
Performance evaluation of Chronic Kidney Disease Epidemiology Collaboration equations for estimated glomerular filtration rate compared to inulin clearance in Koreans
Jeong Min Cho, Ran-hui Cha, Dong Ki Kim, Ho Jun Chin
Received May 17, 2023  Accepted September 12, 2023  
Background: A race-free glomerular filtration rate (GFR) estimation equation has recently been developed. However, the performance of the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations needs to be evaluated in Asian populations. Methods: We performed a cross-sectional study at a single center in South Korea. The measured GFR (mGFR) was determined based on systemic inulin clearance. The GFR was...
DOI: https://doi.org/10.23876/j.krcp.23.124    [Epub ahead of print]
Pericyte activation accompanied by peritubular capillaries dysfunction and pericyte-to-myofibroblast transition is associated with renal fibrosis in diabetic nephropathy
Yiduo Feng, Dongli Tian, Yu Bai, Yan Li, Liling Zhang, Yiru Wu, Wenhu Liu, Zongli Diao
Received April 19, 2023  Accepted October 2, 2023  
Background: Tubulointerstitial renal fibrosis is an essential feature of diabetic nephropathy (DN). Pericytes play a critical role in microvascular diseases and renal fibrogenesis. However, the role of pericytes in DN remains unclear. Herein, we aimed to explore the properties and possible mechanisms of pericytes in renal fibrosis in DN. Methods: We used multiplex immunofluorescence staining to evaluate the location and...
DOI: https://doi.org/10.23876/j.krcp.23.099    [Epub ahead of print]
Fasting blood glucose and the risk of all-cause mortality in patients with diabetes mellitus undergoing hemodialysis
Soo-Young Yoon, Jin Sug Kim, Gang Jee Ko, Yun Jin Choi, Ju Young Moon, Kyunghwan Jeong, Hyeon Seok Hwang
Received January 15, 2023  Accepted January 15, 2023  
Background: Glycemic control is particularly important in hemodialysis (HD) patients with diabetes mellitus (DM). Although fasting blood glucose (FBG) level is an important indicator of glycemic control, a clear target for reducing mortality in HD patients with DM is lacking. Methods: A total of 26,162 maintenance HD patients with DM were recruited from the National Health Insurance Database of Korea between...
DOI: https://doi.org/10.23876/j.krcp.23.098    [Epub ahead of print]
Medium cut-off dialyzer improves reduction ratios of large middle molecules associated with vascular calcification
Hyo Jin Kim, Eun Young Seong, Sang Heon Song
Received March 15, 2023  Accepted July 31, 2023  
Background: We aimed to investigate the change in the large middle molecule (>15 kDa) removal rate, which is associated with vascular calcification, when using a medium cut-off (MCO) dialyzer compared to a high-flux (HF) dialyzer. Methods: Twenty patients with clinically stable maintenance hemodialysis were investigated over a 15-week study period. Dialyzer efficacies were evaluated during the last midweek hemodialysis treatment...
DOI: https://doi.org/10.23876/j.krcp.23.061    [Epub ahead of print]
Associations of metabolic variabilities and cardiovascular outcomes according to estimated glomerular filtration rate in chronic kidney disease: a nationwide observational cohort study
Jeong Min Cho, Kyungdo Han, Kwon Wook Joo, Soojin Lee, Yaerim Kim, Semin Cho, Hyuk Huh, Seong Geun Kim, Minsang Kim, Eunjeong Kang, Dong Ki Kim, Sehoon Park
Received May 24, 2023  Accepted August 16, 2023  
Background: The impact of baseline estimated glomerular filtration rate (eGFR) on the risk of adverse outcomes according to metabolic parameter variabilities in chronic kidney disease has rarely been investigated. Methods: We conducted a retrospective nationwide cohort study using the National Health Insurance System data in Korea from 2007 to 2013 to identify individuals with three or more health screenings. The metabolic...
DOI: https://doi.org/10.23876/j.krcp.23.135    [Epub ahead of print]
Association of metformin with cardiovascular and graft outcomes in kidney transplant recipients with posttransplantation diabetes mellitus
Dongyeon Lee, Jiyun Jung, Sichan Kim, Jaeyun Lee, Jangwook Lee, Chung Hee Baek, Hyunwook Kwon, Sung Shin, Younghoon Kim, Sung Joon Shin, Su-Kil Park, Jae Yoon Park, Hyosang Kim
Received April 10, 2023  Accepted August 28, 2023  
Background: Posttransplantation diabetes mellitus (PTDM) is a crucial problem after kidney transplantation. We aimed to determine whether metformin affects cardiovascular and graft outcomes in patients with PTDM. Methods: This retrospective cohort study included 1,663 kidney transplant recipients without preexisting diabetes mellitus. The patients were divided into metformin and non-metformin groups, with matched propensity scores. We also estimated metformin’s effect on percutaneous...
DOI: https://doi.org/10.23876/j.krcp.23.085    [Epub ahead of print]
Kidney biopsy can help to predict renal outcomes of patients with type 2 diabetes mellitus
Wook-Joon Kim, Taehoon Oh, Nam Hun Heo, Kyungsup Kwon, Ga-Eun Shin, Se-Hwi Jeong, Ji Hye Lee, Samel Park, Nam-Jun Cho, Hyo-Wook Gil, Eun Young Lee
Received March 13, 2023  Accepted July 30, 2023  
Background: In patients with type 2 diabetes mellitus (T2DM), diabetic kidney disease (DKD) is diagnosed based on clinical features. A kidney biopsy is used only in selected cases. This study aimed to reconsider the role of a biopsy in predicting renal outcomes. Methods: Clinical and laboratory parameters and renal biopsy results were obtained from 237 patients with T2DM who underwent renal...
DOI: https://doi.org/10.23876/j.krcp.23.059    [Epub ahead of print]
Maternal exposure to airborne particulate matter during pregnancy and lactation induces kidney injury in rat dams and their male offspring: the role of vitamin D in pregnancy and beyond
Min Hwa Son, Eujin Park, Hyung Eun Yim, Yoon Jeong Nam, Yu-Seon Lee, Eui Kyung Choi, Sang Hoon Jeong, Ju‑Han Lee
Received May 3, 2023  Accepted August 6, 2023  
Background: Little is known about the transgenerational effects of maternal exposure to fine particulate matter (PM2.5) on offspring kidney health. This study investigated the effect of maternal administration of PM2.5 or PM2.5 with vitamin D during pregnancy and lactation on renal injury in rat dams and their offspring. Methods: Nine pregnant Sprague-Dawley rats received oral administration of normal saline, airborne PM2.5,...
DOI: https://doi.org/10.23876/j.krcp.23.106    [Epub ahead of print]
Long-term outcomes and associated prognostic risk factors of childhood-onset lupus nephritis
Eujin Park, Jiwon Jung, Jeesu Min, Hyeonju Lee, Min Ji Park, Ji Yeon Song, Ji Hyun Kim, Kyung Mi Jang, Eun Mi Yang, Yo Han Ahn, Min Hyun Cho, Joo Hoon Lee, Young Seo Park, Soon Chul Kim, Se Jin Park, Jung Won Lee, Kee Hyuck Kim, Ki Soo Pai, Hee Gyung Kang, Seong Heon Kim
Received February 15, 2023  Accepted August 14, 2023  
Background: This study investigated the clinical characteristics and kidney outcomes of childhood-onset lupus nephritis (LN), and risk factors associated with prognosis. Methods: We enrolled 216 patients with histologically diagnosed LN during childhood. The Korean Society of Pediatric Nephrology organized a retrospective cohort study of childhood-onset LN in 13 major pediatric nephrology centers in South Korea. Results: The mean age at...
DOI: https://doi.org/10.23876/j.krcp.23.032    [Epub ahead of print]
Insulin resistance is associated with incident chronic kidney disease in population with normal renal function
Su Hyun Song, Young Jin Goo, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Received December 23, 2022  Accepted June 20, 2023  
Background: Insulin resistance is prevalent in chronic kidney disease and may accelerate the progression of chronic kidney disease. This study aimed to investigate whether insulin resistance is associated with the development of incident chronic kidney disease in a population with normal renal function. Methods: A total of 3,331 participants from a community-based cohort with normal renal function were prospectively analyzed....
DOI: https://doi.org/10.23876/j.krcp.22.298    [Epub ahead of print]
Long non-coding RNA MEG3 silencing weakens high glucose-induced mesangial cell injury by decreasing LIN28B expression by sponging and sequestering miR-23c
Lu Rong, Huanzhou Xue, Jianwei Hao, Jianjun Liu, Hao Xu
Received April 11, 2023  Accepted July 20, 2023  
Background: Diabetic nephropathy (DN) is a common kidney disease in diabetic patients. Long non-coding RNA maternally expressed gene 3 (MEG3) and microRNA (miR)-23c are reported to be implicated in DN development. Nevertheless, it is unclear that the molecular mechanism between MEG3 and miR-23c in DN remains unclear. Methods: Human mesangial cells (HMCs) were treated with high glucose (HG) to simulate...
DOI: https://doi.org/10.23876/j.krcp.23.090    [Epub ahead of print]
Impact of albuminuria on early-onset type 2 diabetes mellitus: a nationwide population-based study
Soojin Lee, Semin Cho, Geum Nae Nam, Jeongmin Cho, Seong Geun Kim, Minsang Kim, Hyuk Huh, Eunjeong Kang, Sehoon Park, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Kwon Wook Joo, Kyungdo Han, Dong Ki Kim, Yaerim Kim
Received November 25, 2022  Accepted July 11, 2023  
Background: Early-onset diabetes mellitus has a significant lifetime burden and is associated with higher morbidity and mortality. Since insulin resistance is one of the mechanisms of podocyte injury, we aimed to evaluate the effect of albuminuria on newly developed early-onset type 2 diabetes mellitus (T2DM). Methods: We screened 6,891,399 subjects aged ≥20 and <40 years without a history of prediabetes...
DOI: https://doi.org/10.23876/j.krcp.22.278    [Epub ahead of print]
Clinical influencing factors affecting pulmonary hypertension in hemodialysis patients
Xu Zhang, Kun Xiao, Longkai Li, Nan Wang, Tao Cong, Yushan Wei, Shengji Cao, Xinyu Wen, Qingyang Meng, Hongli Lin, Taihua Wu
Received February 2, 2023  Accepted May 4, 2023  
Background: The fluid status and rate of blood flow through the arteriovenous fistula (AVF) are two important factors affecting hemodynamic in hemodialysis patients; however, their effects on pulmonary hypertension have rarely been studied. Hence, we aimed to evaluate the effects of these factors in hemodialysis patients with pulmonary hypertension. Methods: This single-center cross-sectional survey included 219 maintenance hemodialysis patients (139...
DOI: https://doi.org/10.23876/j.krcp.23.021    [Epub ahead of print]
Atherogenic indices and risk of chronic kidney disease in metabolic derangements: Gangnam Severance Medical Cohort
Donghwan Oh, Seoyoung Lee, Eunji Yang, Hoon Young Choi, Hyeong Cheon Park, Jong Hyun Jhee
Received February 21, 2023  Accepted July 3, 2023  
Background: The effects of atherogenic indices on kidney function remain unclear. This study evaluated the association between atherogenic indices and risk of chronic kidney disease (CKD) in adults with metabolic derangements. Methods: A total of 4,176 participants from the Gangnam Severance Medical Cohort (2006–2021), which consisted of participants who had at least one disease related to metabolic derangements including diabetes mellitus,...
DOI: https://doi.org/10.23876/j.krcp.23.043    [Epub ahead of print]
Association of systolic blood pressure with incident chronic kidney disease estimated by marginal structural model: a nationwide population-based study
Hyunsun Lim, Youn Nam Kim, Tae Ik Chang, Jae Young Kim
Received March 28, 2023  Accepted July 30, 2023  
Background: We aimed to investigate the association between systolic blood pressure (SBP) and risk of incident chronic kidney disease (CKD) using marginal structural model (MSM) to reflect mutual effects of exposure and confounders on the outcome. Methods: A total of 195,970 adults with an estimated glomerular filtration rate (eGFR) of >60 mL/min/1.73 m2 and no proteinuria were included from...
DOI: https://doi.org/10.23876/j.krcp.23.073    [Epub ahead of print]
Necessity of induction agent modification for old age kidney transplant recipients
Kyeong Deok Kim, Kyo Won Lee, Jae Berm Park, Woo Sung Sim, Manuel Lim, Eun Sung Jeong, Jieun Kwon, Jaehun Yang
Received March 21, 2023  Accepted July 4, 2023  
Background: Immunosenescence gradually deteriorates the function of the immune system, making elderly patients susceptible to infection, while reducing rejection of organ transplants. Therefore, age-adaptive immunosuppression is necessary in the elderly. We evaluated clinical outcomes such as rejection and infection rate when using basiliximab and rabbit anti-thymocyte globulin (r-ATG) as induction agents in elderly and young organ transplant recipients. Methods: We...
DOI: https://doi.org/10.23876/j.krcp.23.068    [Epub ahead of print]
Bowman capsule rupture in children with myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis predicts poor renal survival
Pei Zhang, Li-li Jia, Meng-zhen Fu, Kai-li Shi, Chun-lin Gao, Zheng-kun Xia
Received March 6, 2023  Accepted May 25, 2023  
Background: Recent developments indicated that Bowman capsule rupture (BCR) is observed in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN). We aimed to explore the relationship between BCR and clinical manifestations, pathological changes, and prognosis in children with myeloperoxidase (MPO)-AAGN. Methods: A total of 56 children with MPO-AAGN were divided into BCR (+) and BCR (–) groups according to the status of Bowman’s...
DOI: https://doi.org/10.23876/j.krcp.23.051    [Epub ahead of print]
Target blood pressure in Korean hemodialysis patients for optimal survival
Ji Eun Kim, Yun Jin Choi, Soon-Young Hwang, Hyeon Seok Hwang, Kyung Hwan Jeong, Eunjung Cho, Shin Young Ahn, Young Joo Kwon, Ju-Young Moon, Gang-Jee Ko
Received October 12, 2022  Accepted March 23, 2023  
Background: Hypertension is a major cardiovascular risk factor in hemodialysis patients. This study identified the optimal blood pressure (BP) target for Korean hemodialysis patients using the Korean Renal Dialysis System (KORDS) dataset from the Korean Society of Nephrology and a pooled analysis for previous studies. Methods: Hemodialysis patients were classified according to their systolic (SBP) and diastolic BP (DBP) at intervals...
DOI: https://doi.org/10.23876/j.krcp.22.241    [Epub ahead of print]
Machine learning-based 2-year risk prediction tool in immunoglobulin A nephropathy
Yujeong Kim, Jong Hyun Jhee, Chan Min Park, Donghwan Oh, Beom Jin Lim, Hoon Young Choi, Dukyong Yoon, Hyeong Cheon Park
Received March 22, 2023  Accepted July 17, 2023  
Background: This study aimed to develop a machine learning-based 2-year risk prediction model for early identification of patients with rapid progressive immunoglobulin A nephropathy (IgAN). We also assessed the model’s performance to predict the long-term kidney-related outcome of patients. Methods: A retrospective cohort of 1,301 patients with biopsy-proven IgAN from two tertiary hospitals was used to derive and externally validate a...
DOI: https://doi.org/10.23876/j.krcp.23.076    [Epub ahead of print]
Smoking amplifies the risk of albuminuria in individuals with high sodium intake: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011 and 2014–2018
Young-Bin Son, Tae-Bum Kim, Hyeon-Jin Min, Jihyun Yang, Myung-Gyu Kim, Sang Kyung Jo, Won Yong Cho, Se Won Oh
Received June 30, 2022  Accepted April 10, 2023  
Background: Smoking and sodium intake (SI) have been evaluated as risk factors for kidney disease; however, the data are inconsistent. We assessed the association between SI and cotinine-verified smoking status and the risk of albuminuria. Methods: An observational study using the Korea National Health and Nutrition Examination Survey (2008–2011 and 2014–2018) was performed. We included 37,410 adults with an estimated...
DOI: https://doi.org/10.23876/j.krcp.22.133    [Epub ahead of print]
Clinical significance of the living kidney donor profile index for predicting long-term posttransplant outcomes: results from the Korean Organ Transplantation Registry
Jong Ho Kim, Sang Ho Lee, Jin Sug Kim, Hyeon Seok Hwang, Hyunmin Ko, Cheol-Woong Jung, Deok Gie Kim, Yeong Hoon Kim, Jaeseok Yang, Curie Ahn, Kyung Hwan Jeong
Received November 17, 2022  Accepted March 11, 2023  
Background: The usefulness of the living kidney donor profile index (LKDPI) has not been widely demonstrated; therefore, it requires verification before clinical application. We analyzed the LKDPI using data from the Korean Organ Transplantation Registry (KOTRY) to confirm whether the LKDPI can be used to predict the survival of allografts in living donor kidney transplantation (LDKT) patients in Korea. Methods:...
DOI: https://doi.org/10.23876/j.krcp.22.266    [Epub ahead of print]
Examine the optimal multidisciplinary care teams for patients with chronic kidney disease from a nationwide cohort study
Masanori Abe, Tsuguru Hatta, Yoshihiko Imamura, Tsutomu Sakurada, Shinya Kaname
Received February 12, 2023  Accepted March 31, 2023  
Background: Multidisciplinary team-based integrated care (MDC) has been recommended for patients with chronic kidney disease (CKD). However, team-based specific structured care systems are not yet established. Therefore, we investigated the efficacy of MDC system and the optimal number of professionals that make up the team for maintaining kidney function and improving prognosis. Methods: This nationwide, multicenter, observational study included 2,957...
DOI: https://doi.org/10.23876/j.krcp.23.026    [Epub ahead of print]
A comparative study of epidemiological characteristics, treatment outcomes, and mortality among patients undergoing hemodialysis by health insurance types: data from the Korean Renal Data System
Kyeong Min Kim, Soyoung Lee, Jong Ho Shin, Mira Park
Received September 29, 2022  Accepted May 11, 2023  
Background: The prevalence of end-stage renal disease (ESRD) requiring dialysis has progressively increased. Therefore, to achieve financial stability by managing the increasing numbers of patients undergoing hemodialysis (HD), a fixed-payment system was introduced in 2001 for medical aid (MA) beneficiaries receiving HD in Korea. Methods: We identified patients in the Korean Renal Data System that received HD between 2001 and 2017...
DOI: https://doi.org/10.23876/j.krcp.22.220    [Epub ahead of print]
Nephrology consultation improves the clinical outcomes of patients with acute kidney injury
Harin Rhee, Meeyoung Park, Il Young Kim
Received February 22, 2023  Accepted March 26, 2023  
Background: Acute kidney injury (AKI) is prevalent in critically ill patients and is associated with an increased risk of in-hospital mortality. Nephrology consultation may be protective, but this has rarely been evaluated in South Korea. Methods: This multicenter retrospective study was based on the electronic medical records (EMRs) of two third-affiliated hospitals. We extracted the records of patients admitted to intensive...
DOI: https://doi.org/10.23876/j.krcp.23.039    [Epub ahead of print]
Effect of immunosuppressive agents on clinical outcomes in idiopathic membranous nephropathy
Ji-Young Choi, Ho Jun Chin, Hajeong Lee, Yena Jeon, Jeong-Hoon Lim, Hee-Yeon Jung, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Received November 3, 2022  Accepted February 25, 2023  
Background: Few comparative studies on the effects of immunosuppressants in patients with idiopathic membranous nephropathy have been conducted. Methods: Data from 489 patients who received conservative treatment or immunosuppressants were retrospectively analyzed by propensity score matching. Primary outcomes were complete or partial remission (CR or PR) of proteinuria, and secondary outcomes were renal survival and infection. Results: Of the 489 patients,...
DOI: https://doi.org/10.23876/j.krcp.22.255    [Epub ahead of print]
Loss of Cutibacterium is responsible for chronic kidney disease-associated pruritus in patients on dialysis
Jeong Geon Lee, Hoonhee Seo, Seung Seob Son, Hee Seul Jeong, Kyung Mi Lee, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hyun-A Park, Sukyung Kim, Eun Young Lee
Received March 9, 2023  Accepted May 4, 2023  
Background: Chronic kidney disease (CKD)-associated pruritus is a severe distressing condition that frequently occurs in patients undergoing dialysis. In this study, the profile of the skin microbiome was analyzed to understand the underlying etiology and potential treatments. Methods: Seventy-six end-stage kidney disease (ESKD) patients (hemodialysis, 40; peritoneal dialysis, 36) and 15 healthy controls were enrolled and swabbed at three sites:...
DOI: https://doi.org/10.23876/j.krcp.23.057    [Epub ahead of print]
The impact of severe depression on the survival of older patients with end-stage kidney disease
You Hyun Jeon, Jeong-Hoon Lim, Yena Jeon, Yu-Kyung Chung, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Received November 13, 2022  Accepted May 4, 2023  
Background: Incidence of depression increases in patients with end-stage kidney disease (ESKD). We evaluated the association between depression and mortality among older patients with ESKD, which has not been studied previously. Methods: This nationwide prospective cohort study included 487 patients with ESKD aged >65 years, who were categorized into minimal, mild-to-moderate, and severe depression groups based on their Beck Depression Inventory-II...
DOI: https://doi.org/10.23876/j.krcp.22.268    [Epub ahead of print]
Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes
Seung-Hyun Jeong, Samel Park, Jae-sung Choi, Nam-Jun Cho, Jong-Seok Moon, Hyo-Wook Gil
Received December 29, 2022  Accepted April 19, 2023  
Background: Neurologic complications, such as cognitive and emotional dysfunction, have frequently been observed in chronic kidney disease (CKD) patients. Previous research shows that uremic toxins play a role in the pathogenesis of CKD-associated cognitive impairment. Since astrocytes contribute to the protection and survival of neurons, astrocyte function and brain metabolism may contribute to the pathogenesis of neurodegeneration. Indoxyl sulfate (IS)...
DOI: https://doi.org/10.23876/j.krcp.23.005    [Epub ahead of print]
Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys
Jeong Hoon Park, Sung Gi Yoon, Jung Yeon Ghee, Ji Ae Yoo, Jin Joo Cha, Young Sun Kang, Sang Youb Han, Yun Jae Seol, Jee Young Han, Dae Ryong Cha
Received January 4, 2023  Accepted April 22, 2023  
Background: Aging is a risk factor for development of chronic kidney disease and diabetes mellitus with commonly shared features of chronic inflammation and increased oxidative stress. Here, we investigated the effect of pan-Nox-inhibitor, APX-115, on renal function in aging diabetic mice. Methods: Diabetes was induced by intraperitoneal injection of streptozotocin at 50 mg/kg/day for 5 days in 52-week-old C57BL/6J mice....
DOI: https://doi.org/10.23876/j.krcp.23.004    [Epub ahead of print]
Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease
Kang Min Park, Chang Min Heo, Dong Ah Lee, Hyuk Huh, Sihyung Park, Yang Wook Kim, Yoo Jin Lee, Hyeok Jin Yoon, Bong Soo Park
Received December 20, 2022  Accepted March 24, 2023  
Background: This study aimed to investigate differences in intrinsic prefrontal functional connectivity according to the presence of cognitive impairment in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS). Methods: We prospectively enrolled 37 patients with ESRD who had been undergoing hemodialysis for more than 6 months and had no history of neurological or psychiatric disorders. All patients...
DOI: https://doi.org/10.23876/j.krcp.22.291    [Epub ahead of print]
The feasibility of incremental peritoneal dialysis for older patients on peritoneal dialysis
Ruihua Liu, Jing Guo, Hongjian Ye, Yuan Peng, Haishan Wu, Haiping Mao, Qunying Guo, Fengxian Huang, Xiao Yang
Received September 2, 2022  Accepted April 3, 2023  
Background: This study was performed to investigate the feasibility of incremental peritoneal dialysis (iPD) in older patients. Methods: In this retrospective cohort study, we enrolled peritoneal dialysis (PD) patients with age ≥ 60 years old at our center from 2008 to 2017. The patients were divided into two groups based on the daily PD exchanges: iPD group (≤3 × 2...
DOI: https://doi.org/10.23876/j.krcp.22.202    [Epub ahead of print]
Factors associated with gait speed: results from the RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients (RECOVERY) study
Miyeun Han, Sang Heon Song, Su Hyun Kim, Ran-hui Cha, Seock Hui Kang, Won Suk An, Jun Chul Kim
Received July 6, 2022  Accepted December 25, 2022  
Background: Gait speed is an important measure of functional ability. This study aimed to investigate the factors associated with gait speed in patients with chronic kidney disease. The study focused on sarcopenic components, plasma uremic or inflammatory marker levels, and quality of life effects. Methods: The RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients is...
DOI: https://doi.org/10.23876/j.krcp.22.143    [Epub ahead of print]
Vitamin D and narrowband ultraviolet B phototherapy for chronic kidney disease-associated pruritus

Youn Kyung Kee, Hee Jung Jeon, Jieun Oh, Dong Ho Shin
Kidney Res Clin Pract. 2024;43(2):177-185.   Published online March 22, 2023
Background: In addition to improving the serum vitamin D balance, narrowband ultraviolet B (NB-UVB) phototherapy can effectively treat chronic kidney disease-associated pruritus (CKD-aP). We investigated the degree of CKD-aP amelioration according to changes in the serum vitamin D level after NB-UVB phototherapy. Methods: This was a before–after clinical study in patients with refractory CKD-aP on hemodialysis. NB-UVB phototherapy was administered...
DOI: https://doi.org/10.23876/j.krcp.22.153    [Epub ahead of print]
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