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Editorial
July 5, 2024
- Brief review for “Machine learning-based 2-year risk prediction tool in immunoglobulin A nephropathy”
- Hae-Ryong Yun, Tae-Hyun Yoo
- Kidney Res Clin Pract. 2024;43(6):697-699.
- Study Protocols
- Study protocol for a consortium linking health medical records, biospecimens, and biosignals in Korean patients with acute kidney injury (LINKA cohort)
- Donghwan Yun, Seung Seok Han, Jeonghwan Lee, Yaerim Kim, Kwangsoo Kim, Kyubok Jin, Ji Eun Kim, Shin Young Ahn, Gang-Jee Ko, Seokwoo Park, Sejoong Kim, Hee-Yeon Jung, Jang-Hee Cho, Sun-Hee Park, Eun Sil Koh, Sungjin Chung, Jung Pyo Lee, Dong Ki Kim, Sung Gyun Kim, Jung Nam An
- Received March 2, 2024 Accepted June 28, 2024
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Background: Acute kidney injury (AKI) may transition into acute kidney disease (AKD) or chronic kidney disease (CKD), leading to subacute and chronic deterioration, respectively. Despite extensive research on AKI, a significant gap exists in understanding the specific biomarkers and development of individualized treatments prior to progression to AKD and CKD. Methods: As a consortium linking health medical records, biospecimens, and biosignals,... -
DOI: https://doi.org/10.23876/j.krcp.24.061 [Epub ahead of print]
- A Pragmatic Randomized clinical trial: twice-weekly vs. thrice-weekly Incident hemoDialysis in Elderly patients (PRIDE): study protocol
- Miyeun Han, Huiwon Jeon, Byung Chul Yu, Sang Heon Song, Sungjin Chung, Chiyeon Lim, Hojoon Sohn, Jin-Won Noh, Soon Hyo Kwon
- Received June 30, 2023 Accepted September 24, 2023
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Background: The optimal frequency for hemodialysis in older adults with end-stage kidney disease (ESKD) has not been established. This study aims to investigate whether a twice-weekly dialysis schedule using an incremental approach can reduce hospitalization rates in the elderly with incident dialysis, compared with conventional thrice-weekly dialysis. Methods: We have designed a pragmatic randomized controlled trial to compare the effects... -
DOI: https://doi.org/10.23876/j.krcp.23.177 [Epub ahead of print]
- Editorial
- Immunoglobulin M nephropathy: requiring more attention
- Kyung Chul Moon
- Received April 15, 2024 Accepted April 28, 2024
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DOI: https://doi.org/10.23876/j.krcp.24.104 [Epub ahead of print]
- Review Articles
- Unveiling the podocyte-protective effect of sodium-glucose cotransporter-2 inhibitors
- Buchun Jiang, Zhiwen Cheng, Dongjie Wang, Fei Liu, Jingjing Wang, Haidong Fu, Jianhua Mao
- Received May 25, 2024 Accepted October 7, 2024
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The renoprotective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors in both diabetic and nondiabetic nephropathy are widely recognized due to results from randomized controlled trials notably the DAPA-CKD and EMPA-KIDNEY trials. Research exploring the mechanisms of renoprotection indicates that SGLT2 inhibitors exert protective effects on podocytes by enhancing autophagy and stabilizing the structure of podocytes and basement membranes. Furthermore, reductions in... -
DOI: https://doi.org/10.23876/j.krcp.24.144 [Epub ahead of print]
- Alport syndrome and eye
- Yeonji Jang, Jae Ho Jung
- Received March 20, 2024 Accepted August 26, 2024
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Alport syndrome, characterized by renal failure, hearing loss, and ocular abnormalities due to collagen type IV gene mutations, exhibits distinctive ocular manifestations in the various ocular tissues including the cornea, lens, and retina. Ophthalmological examinations, providing noninvasive visibility of basement membrane anomalies caused by collagen type IV mutations, can have a role in Alport syndrome diagnostics. Lenticonus, macular fleck, and... -
DOI: https://doi.org/10.23876/j.krcp.24.080 [Epub ahead of print]
- Renal transplantation in Alport syndrome
- Soyeon Kim, Soon Hyo Kwon
- Received June 4, 2024 Accepted August 26, 2024
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Kidney transplantation is recognized as an effective treatment for end-stage renal disease in Alport syndrome, demonstrating outcomes comparable to or even superior to those in other causes of renal failure. When considering living related donor kidney transplantation for Alport syndrome patients, it is crucial to consider genetic factors during the donor selection process. In addition to a comprehensive health check,... -
DOI: https://doi.org/10.23876/j.krcp.24.143 [Epub ahead of print]
- A comprehensive review of Alport syndrome: definition, pathophysiology, clinical manifestations, and diagnostic considerations
- Eunjeong Kang, Byung Hwa Park, Hajeong Lee, Hee Gyung Kang, Ji Hyun Kim, Ye Na Kim, Yeonsoon Jung, Hark Rim, Ho Sik Shin
- Received March 12, 2024 Accepted July 22, 2024
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Alport syndrome, a rare genetic disorder affecting around 1 in 50,000 individuals, primarily presents as microscopic hematuria and chronic kidney disease (CKD) with associated extrarenal complications. The Alport syndrome results from mutations in COL4A3, COL4A4, and COL4A5 genes, disrupting the formation of the α3–α4–α5 chain in the collagen IV network. The etiology involves X chromosome-related, autosomal dominant, autosomal recessive, and... -
DOI: https://doi.org/10.23876/j.krcp.24.065 [Epub ahead of print]
- Donor-derived cell-free DNA-based liquid biopsies to determine future kidney transplant rejection
- Weiwei Wang, Cuello Garcia Haider, Yinfeng Wang, Zhoufan Zhang, Yuelin Liu, Fengcheng Xue, Haitao Liu, Tingya Jiang, Jingyi Cao, Yang Zhou
- Received November 8, 2023 Accepted June 4, 2024
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Donor-derived cell-free DNA (dd-cfDNA) based liquid kidney biopsies have the potential to detect the chances of kidney transplant rejection. Several studies have found that dd-cfDNA can be used to determine the risk of kidney transplant rejection and may correlate with antibody-mediated rejection (ABMR), T cell-mediated rejection (TCMR), and estimated glomerular filtration rate (eGFR). A high concentration of dd-cfDNA in the... -
DOI: https://doi.org/10.23876/j.krcp.23.286 [Epub ahead of print]
- The burden of chronic kidney disease in Asia region: a review of the evidence, current challenges, and future directions
- Afiatin Makmun, Bancha Satirapoj, Do Gia Tuyen, Marjorie W. Y. Foo, Romina Danguilan, Sanjeev Gulati, Sejoong Kim, Sunita Bavanandan, Yi-Wen Chiu, Sydney C.W. Tang
- Received July 28, 2023 Accepted May 7, 2024
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The disease burden of chronic kidney disease (CKD) and its impact on healthcare systems has been poorly studied in Asia, a socioeconomically diverse region with wide variations in availability, access, and quality of CKD care. The high CKD burden in this region is predominantly driven by an increased prevalence of risk factors including diabetes mellitus, hypertension, obesity, and use of... -
DOI: https://doi.org/10.23876/j.krcp.23.194 [Epub ahead of print]
- Pathological diagnosis of Alport syndrome
- Kyoung Bun Lee, Minsun Jung, Beom Jin Lim
- Received March 6, 2024 Accepted April 15, 2024
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Alport syndrome (AS) is a hereditary nephritis characterized by structural abnormalities in the glomerular basement membrane resulting from pathogenic variants in the COL4A3, COL4A4, and COL4A5 genes. Conventional pathological evaluations reveal nonspecific light microscopic changes and diagnostic clues can be obtained through electron microscopy. Type IV collagen staining elucidates distinct patterns based on AS inheritance, aiding in subtype classification. However,... -
DOI: https://doi.org/10.23876/j.krcp.24.063 [Epub ahead of print]
- In silico medicine and -omics strategies in nephrology: contributions and relevance to the diagnosis and prevention of chronic kidney disease
- Ana Checa-Ros, Antonella Locascio, Nelia Steib, Owahabanun-Joshua Okojie, Totte Malte-Weier, Valmore Bermúdez, Luis D’Marco
- Received December 4, 2023 Accepted February 29, 2024
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Chronic kidney disease (CKD) has been increasing over the last years, with a rate between 0.49% to 0.87% new cases per year. Currently, the number of affected people is around 850 million worldwide. CKD is a slowly progressive disease that leads to irreversible loss of kidney function, end-stage kidney disease, and premature death. Therefore, CKD is considered a global health... -
DOI: https://doi.org/10.23876/j.krcp.23.334 [Epub ahead of print]
- Original Articles
- The importance of kidney response over hematologic response in predicting kidney outcome in amyloid light-chain amyloidosis
- Sungmi Kim, Jinyoung Yang, Kyungho Lee, Junseok Jeon, Sang Eun Yoon, Darae Kim, Jin-Oh Choi, Seok Jin Kim, Kihyun Kim, Jung Eun Lee
- Received April 15, 2024 Accepted October 9, 2024
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Background: Light chain amyloidosis, characterized by amyloid fibril deposition in multiple organs, often leads to progression to endstage kidney disease. This study aimed to identify predictors of kidney survival in patients with kidney amyloidosis, focusing on hematologic and kidney response. Methods: This retrospective study included 138 patients diagnosed with kidney amyloidosis between 2011 and 2019. Palladini criteria were applied to... -
DOI: https://doi.org/10.23876/j.krcp.24.111 [Epub ahead of print]
- Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series
- So Hyun Ki, Min Hwa Son, Hyung Eun Yim
- Received July 10, 2024 Accepted September 25, 2024
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Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions. Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed. NCS was diagnosed with renal Doppler ultrasonography, abdominal computed tomography,... -
DOI: https://doi.org/10.23876/j.krcp.24.178 [Epub ahead of print]
- Characteristics of glomerulonephritis with dominant C1q precipitation compared to corresponding glomerulonephritis without C1q staining on immunofluorescent examination
- Ji Young Ryu, Giae Yun, Eun-jeong Kwon, Hyung Eun Son, Kipyo Kim, Sang-Ho Lee, Kyung Pyo Kang, Young-Joo Kwon, Ho Jun Chin
- Received September 19, 2023 Accepted July 14, 2024
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Background: The clinical significance and renal outcomes of C1q nephropathy (C1qN) are unclear; therefore, the implications of C1qN as a new pathological entity are uncertain. We compared the clinical characteristics of glomerulonephritis reclassified into cases that meet the definition of C1qN and glomerulonephritis not included in the definition of C1qN. Methods: In total, 21,697 patients who underwent native kidney biopsy... -
DOI: https://doi.org/10.23876/j.krcp.23.238 [Epub ahead of print]
- Effectiveness and safety of denosumab on osteoporosis treatment in kidney transplant recipients
- Jin Kyung Kwon, Yaerim Kim, Jin Hyuk Paek, Kyubok Jin, Seungyeup Han, Woo Yeong Park
- Received June 26, 2024 Accepted September 17, 2024
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Background: Denosumab has been reported to improve bone mineral density (BMD), but the clinical impact of denosumab on osteoporosis in kidney transplant recipients (KTRs) remains controversial. Methods: We analyzed 98 KTRs who used denosumab from 2018 to 2023. We investigated the change in BMD, laboratory findings, complications of denosumab, fracture risk assessment tool (FRAX) score, acute rejection within 1 year, and... -
DOI: https://doi.org/10.23876/j.krcp.24.168 [Epub ahead of print]
- Circulating osteoprotegerin and progression of coronary artery calcification in patients with chronic kidney disease: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD)
- Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Tae-Hyun Yoo, Soo Wan Kim
- Received February 7, 2024 Accepted August 29, 2024
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Background: Coronary artery calcification (CAC) is a surrogate of cardiovascular events in patients with chronic kidney disease (CKD). To establish the role of circulating osteoprotegerin (OPG) as a cardiovascular biomarker in patients with CKD, we investigated whether an increase in serum OPG levels is associated with the risk of CAC progression. Methods: A total of 1,130 patients with CKD stage... -
DOI: https://doi.org/10.23876/j.krcp.24.039 [Epub ahead of print]
- Hearing loss phenotypes in Alport syndrome: experience in a tertiary referral center
- Sang-Yoon Han, Myung-Whan Suh, Moo Kyun Park, Jun Ho Lee, Hee Gyung Kang, Sang-Yeon Lee
- Received April 2, 2024 Accepted August 19, 2024
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Background: Despite previous reports of auditory phenotypes in Alport syndrome (AS), there have been no studies specifically addressing audiological phenotypes in South Korea. Herein, we elaborated on the audiological characteristics associated with AS based on their genotypes. Methods: We reviewed data from in-house AS patients between March 2014 and February 2023, excluding those without audiological documentation or genetic diagnoses. We... -
DOI: https://doi.org/10.23876/j.krcp.24.091 [Epub ahead of print]
- Effects of dietary fatty acid on all-cause mortality according to the kidney function based on the nationwide population study
- Yaerim Kim, Kyungho Ha, Jeonghwan Lee, Eunjin Bae, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Dong Ki Kim, Chun Soo Lim, Jung Pyo Lee
- Received May 6, 2024 Accepted August 2, 2024
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Background: Although the relationship between fatty acids (FAs) and the risk of all-cause mortality has been long discussed, there is little evidence about the impact of each FA component on all-cause mortality by kidney function status. Methods: We used data from the U.S. National Health and Nutrition Examination Survey 1999–2016. The intake of FAs was estimated as a percentage of... -
DOI: https://doi.org/10.23876/j.krcp.24.121 [Epub ahead of print]
- Risk of cardiovascular events following hemodialysis initiation: a self-controlled case series study
- Minyoul Baik, Jimin Jeon, Joonsang Yoo, Hyo Suk Nam, Ji Hoe Heo, Jinkwon Kim, Young Dae Kim
- Received April 9, 2024 Accepted July 23, 2024
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Background: Patients with chronic kidney disease (CKD) are at high risk for cardiovascular disease (CVD). We aimed to evaluate whether hemodialysis (HD) initiation is associated with CVD risk in patients with CKD. Methods: This self-controlled case series, using data from a nationwide Korean health claims database, included patients with CKD who initiated HD between 2007 and 2019 and experienced CVD,... -
DOI: https://doi.org/10.23876/j.krcp.24.097 [Epub ahead of print]
- Comparison of clinical outcomes based on dialysis modality and icodextrin usage in patients on peritoneal dialysis
- Seok Hui Kang, Jun Young Do
- Received January 5, 2024 Accepted July 8, 2024
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Background: There is no conclusive evidence regarding the survival benefits of automated peritoneal dialysis (APD) or the use of icodextrin. This study aimed to evaluate patient and technique survival among four groups divided based on peritoneal dialysis modality and icodextrin use over 1 year. Methods: We specifically included patients who underwent a single peritoneal dialysis modality for at least 1 year... -
DOI: https://doi.org/10.23876/j.krcp.24.017 [Epub ahead of print]
- Blood osteoprotegerin is associated with arteriovenous access thrombosis in hemodialysis patients
- Tung-Ling Chung, Yi-Hsueh Liu, Pei-Yu Wu, Jiun-Chi Huang, Yi-Chun Tsai, Ya-Ling Hsu, Mei-Chuan Kuo, Yi-Wen Chiu, Ping-Hsun Wu, Szu-Chia Chen
- Received June 3, 2024 Accepted July 21, 2024
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Background: A functioning arteriovenous (AV) access is essential for hemodialysis efficiency and the quality of life in hemodialysis patients. Blood osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappa B ligand (RANKL) have been linked to cardiovascular diseases and vascular calcification. This study investigated the relationship between blood OPG, RANKL, and the occurrence of AV access thrombosis. Methods: This... -
DOI: https://doi.org/10.23876/j.krcp.24.153 [Epub ahead of print]
- Patient-reported mental health problems and clinical outcomes in adults with non-dialysis chronic kidney disease
- Jihyun Yang, Young Youl Hyun, Kyu-Beck Lee, Hyo Jin Kim, Sang Heon Suh, Hayne Cho Park, Yun Kyu Oh, Sue Kyung Park, Kook-Hwan Oh
- Received January 31, 2024 Accepted June 17, 2024
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Background: Mental health affects well-being and physical health. Among adults with chronic kidney disease (CKD), mental health (MH) problems are common and can induce adverse clinical outcomes. We examined the association between patient-reported MH problems and clinical outcomes in adults with non-dialysis CKD. Methods: This prospective observational study included 1,879 participants from the KNOW-CKD (KoreaN Cohort Study for Outcomes in Patients... -
DOI: https://doi.org/10.23876/j.krcp.24.034 [Epub ahead of print]
- Safety of the reduced fixed dose of mycophenolate mofetil confirmed via therapeutic drug monitoring in de novo kidney transplant recipients
- Hee-Yeon Jung, Yu Jin Seo, Deokbi Hwang, Woo-Sung Yun, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Jeong-Hoon Lim, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Dong Il Won, Jang-Hee Cho, Chan-Duck Kim
- Received October 26, 2023 Accepted January 3, 2024
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Background: Mycophenolate mofetil (MMF) is usually prescribed with a reduced fixed dose in Asian kidney transplant recipients (KTRs). However, the clinical efficacy and safety of the fixed dose have not yet been investigated via therapeutic drug monitoring. We evaluated whether reduced fixed-dose MMF is an optimal dosing strategy to achieve the therapeutic target of mycophenolic acid (MPA) exposure in Korean... -
DOI: https://doi.org/10.23876/j.krcp.23.274 [Epub ahead of print]
- Baseline characteristics and associated factors for hypertension in children with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Pediatric Chronic Kidney Disease study
- Ji Yeon Song, Keum Hwa Lee, Jae Il Shin, Hee Gyung Kang, Yo Han Ahn, Hee Sun Baek, Min Hyun Cho, Jiwon Jung, Joo Hoon Lee, Heeyeon Cho, Kyoung Hee Han, Eujin Park, Eun Mi Yang, Seong Heon Kim
- Received December 31, 2023 Accepted March 25, 2024
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Background: Hypertension is one of the most important complications of chronic kidney disease (CKD) as it exacerbates disease progression in children. The aim of this study is to identify characteristics and factors associated with hypertension in children with CKD. Methods: This is a cross-sectional study using baseline data from the 10-year ongoing cohort study named KNOW-PedCKD (Korean Cohort Study for Outcome... -
DOI: https://doi.org/10.23876/j.krcp.24.006 [Epub ahead of print]
- Predicting long-term mortality of patients with postoperative acute kidney injury following noncardiac general anesthesia surgery using machine learning
- Bo Yeon Choi, Wona Choi, Jiwon Min, Byung Ha Chung, Eun Sil Koh, Su Yeon Hong, Tae Hyun Ban, Yong Kyun Kim, Hye Eun Yoon, In Young Choi
- Received April 12, 2024 Accepted July 1, 2024
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Background: This study addresses the gap in knowledge regarding the long-term mortality implications of postoperative acute kidney injury (PO-AKI) utilizing advanced machine learning techniques to predict outcomes more accurately than traditional statistical models. Methods: A retrospective cohort study was conducted using data from seven institutions between March 2009 and December 2019. Machine learning models were developed to predict all-cause mortality of... -
DOI: https://doi.org/10.23876/j.krcp.24.106 [Epub ahead of print]
- Artificial intelligence-powered chest computed tomography analysis unveils prognostic insights for COVID-19 mortality among prevalent hemodialysis patients
- Eunji Kim, Soo-Jin Yoon, Sungbong Yu, Eunsil Ko, Kyungjun Shon, Jooyeon Yoon, Youn Kyung Kee, Do Hyoung Kim, AJin Cho, Hayne Cho Park, Young-Ki Lee
- Received March 22, 2024 Accepted July 2, 2024
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Background: Coronavirus disease 2019 (COVID-19) has led to severe pneumonia and mortality worldwide, however, clinical outcomes in end-stage renal disease patients remain unclear. This study evaluates the prognostic value of chest computed tomography (CT) findings in predicting COVID-19-related outcomes in prevalent hemodialysis patients. Methods: We retrospectively analyzed 326 prevalent hemodialysis patients diagnosed with COVID-19 who underwent chest CT scans. Characteristics assessed... -
DOI: https://doi.org/10.23876/j.krcp.24.079 [Epub ahead of print]
- A noninvasive method of diagnosing membranous nephropathy using exosomes derived from urine
- Giae Yun, Taewoon Kim, Kwang Sik Kim, Kyusoon Shin, Jin-Ho Paik, Jee Yoon Park, Luke P. Lee, Jong Wook Hong, Sejoong Kim
- Received August 8, 2023 Accepted May 2, 2024
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Background: Membranous nephropathy (MN) is a specific autoimmune disease affecting kidneys. It is characterized by the accumulation of immune complexes in the glomerular basement membrane. Renal biopsy is currently the standard procedure to confirm the diagnosis, although the presence of autoantibodies against the phospholipase A2 receptor (PLA2R) can also help diagnose. In this study, we aimed to investigate the potential... -
DOI: https://doi.org/10.23876/j.krcp.23.208 [Epub ahead of print]
- Exploring new horizons: angiotensin II, angiotensin II type 1 receptor, and renal outer medullary potassium channel interaction in distal convoluted tubule
- Kun Zhao, Tiantian Han, Linzhen Jia, Libo Wen, Renjun Gao, Xue Li
- Received January 17, 2024 Accepted May 9, 2024
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Background: This study investigates angiotensin II (Ang II)’s regulatory mechanism on renal outer medullary potassium channel (ROMK) activity in the distal convoluted tubule (DCT) during low potassium intake, focusing on the Janus kinase 2 (JAK2) pathway activation mediated by the Ang II type 1 receptor (AT1R). Methods: Utilizing a low potassium diet mouse model, various methods including patch clamping, reverse... -
DOI: https://doi.org/10.23876/j.krcp.24.023 [Epub ahead of print]
- Framingham risk score is a useful indicator of posttransplant cardiovascular events and survival among Korean kidney transplant recipients: a nationwide, prospective cohort study
- Jeonghwan Lee, Hong Suk Chang, Hyejin Mo, In Mok Jung, Boram Weon, Soie Kwon, Chun Soo Lim, Yon Su Kim, Sang-Ho Lee, Yu Ho Lee, Jeong-Hoon Lee, Jaeseok Yang, Myoung Soo Kim, Jung Pyo Lee
- Received September 10, 2023 Accepted June 3, 2024
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Background: Cardiovascular disease is an important risk factor for mortality among kidney transplant recipients. In this study, we aimed to investigate the association between cardiovascular risk score at kidney transplantation and long-term outcomes of patients. Methods: In this prospective, observational cohort study, we enrolled kidney transplant recipients who participated in the Korean Organ Transplantation Registry and underwent transplantation between April... -
DOI: https://doi.org/10.23876/j.krcp.23.237 [Epub ahead of print]
- Conventional machine learning-based prediction models did not outperform the International IgA Nephropathy Prediction Tool
- Sehoon Park, Yisak Kim, Chung Hee Baek, Hyunjeong Cho, Ji In Park, Eun Sil Koh, Jung Pyo Lee, Sun-Hee Park, Hyung Woo Kim, Seung Hyeok Han, Ho Jun Chin, Dong Ki Kim, Kyung Chul Moon, Young-Gon Kim, Hajeong Lee
- Received August 10, 2023 Accepted March 21, 2024
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Background: Immunoglobulin A nephropathy (IgAN) is a major cause of end-stage kidney disease (ESKD). The International IgA Nephropathy Prediction Tool (IIgAN-PT) predicts IgAN prognosis, but improvement in the prediction performance using machine learning (ML)-based methods is needed. Methods: We analyzed 4,425 biopsy-confirmed patients with IgAN and ≥6 months of follow-up from nine tertiary university hospitals in Korea. The study population... -
DOI: https://doi.org/10.23876/j.krcp.23.212 [Epub ahead of print]
- Impact of sex on clinical outcomes according to immunologic risk in spousal donor kidney transplantation
- Seunghyeok Choi, Hanbi Lee, Sang Hun Eum, Ji-Won Min, Hye Eun Yoon, Chul Woo Yang, Byung Ha Chung
- Received May 9, 2024 Accepted June 23, 2024
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Background: The aim of this study is to investigate the impact of sex on the clinical outcomes of spousal donor kidney transplantation. Methods: We analyzed 456 spousal donor kidney transplantation recipients and categorized them into standard or high immunological risk groups according to panel-reactive antibody ≥50% or less. There were 366 recipients in the standard-risk group and 89 recipients in... -
DOI: https://doi.org/10.23876/j.krcp.24.128 [Epub ahead of print]
- Evaluating the Safety and effectivenesS in adult KorEaN patients treated with Tolvaptan for management of autosomal domInAnt poLycystic kidney disease (ESSENTIAL): final report
- Hayne Cho Park, Yong Chul Kim, Hyunsuk Kim, Yaerim Kim, Hyun Jin Ryu, Yong Soo Kim, Wookyung Chung, Yong-Lim Kim, Seungyeup Han, Yeonsoon Jung, Ho Sik Shin, Ki Young Na, Kyu Beck Lee, Hyeong Cheon Park, Seung Hyeok Han, Tae-Hyun Yoo, Yeong Hoon Kim, Soo Wan Kim, Kang Wook Lee, Sung Gyun Kim, Chang Hwa Lee, Kyongtae T. Bae, Kook Hwan Oh, Curie Ahn, Yun Kyu Oh
- Received March 10, 2024 Accepted June 7, 2024
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Background: Tolvaptan, a selective vasopressin V2 receptor antagonist, was first approved by the Korean Ministry of Food and Drug Safety in 2015 as a treatment option for autosomal dominant polycystic kidney disease (ADPKD). To prescribe tolvaptan safely and effectively, we designed the phase 4 clinical trial among Korean ADPKD patients with chronic kidney disease stages 1 to 3. Methods: A total... -
DOI: https://doi.org/10.23876/j.krcp.24.067 [Epub ahead of print]
- Medical costs in the peridiagnosis period of various biopsy-confirmed kidney diseases in South Korea
- Young Sun Shin, Kyungdo Han, Kwon Wook Joo, Jeong Min Cho, Yeojin Yu, Soojin Lee, Yaerim Kim, Semin Cho, Hyuk Huh, Seong Geun Kim, Eun Jeong Kang, Dong Ki Kim, Sehoon Park
- Received November 21, 2023 Accepted April 28, 2024
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Background: In-depth investigation is imperative to scrutinize medical costs associated with the periods before and after biopsies for diverse kidney diseases in South Korea. Long-term epidemiological data, including follow-up information, is essential for comparing risks linked to various kidney diseases and their adverse outcomes. Methods: Patients diagnosed with glomerulonephritis (GN), tubulointerstitial nephritis (TIN), and acute tubular necrosis (ATN) at Seoul... -
DOI: https://doi.org/10.23876/j.krcp.23.300 [Epub ahead of print]
- Effect of the geometry and severity of left ventricular hypertrophy on cardiovascular mortality in dialysis patients
- Yi-Chen Huang, Chung-Kuan Wu
- Received November 9, 2023 Accepted April 5, 2024
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Background: Left ventricular hypertrophy (LVH) is a vital risk factor for mortality of dialysis patients. The association of the geometry and severity of LVH with cardiovascular and all-cause mortality in hemodialysis (HD) patients remains unknown. This study investigated clinical outcomes among HD patients with different LVH geometric patterns and severity. Methods: The monocentric retrospective cohort study enrolled chronic HD patients who... -
DOI: https://doi.org/10.23876/j.krcp.23.290 [Epub ahead of print]
- NLRP3 inflammasome activation and macrophage distribution in kidney tissues from patients with acute oxalate nephropathy
- Daorina Bao, Xu Zhang, Su-xia Wang, Yu Wang, Ming-hui Zhao
- Received October 17, 2023 Accepted April 24, 2024
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Background: The current study was initiated to evaluate renal nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome pathway activation and macrophage subtype distribution and their clinicopathological significance in a cohort of oxalate-induced acute kidney injury. Methods: Twelve patients with biopsy-proven acute oxalate nephropathy (AON) from January 2016 to October 2022 were retrospectively enrolled, with estimated glomerular filtration... -
DOI: https://doi.org/10.23876/j.krcp.23.266 [Epub ahead of print]
- Original Article s
- Impact of hemodialysis center accreditation on patient mortality: Korean nationwide cohort study
- Hayne Cho Park, Do Hyoung Kim, AJin Cho, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Won-Min Hwang, Jinseog Kim, Dae Joong Kim, Young-Ki Lee
- Received March 5, 2024 Accepted May 20, 2024
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Background: Since hemodialysis (HD) patients are prone to various complications and high mortality, they need to be treated in HD units with professional personnel, proper equipment, and facilities. The Korean Society of Nephrology has been conducting an HD unit accreditation program since 2016. This study was performed to evaluate whether a qualified dialysis center (QDC) reduced the mortality of HD... -
DOI: https://doi.org/10.23876/j.krcp.24.059 [Epub ahead of print]
- Evaluation of the novel ALK5 inhibitor EW-7197 on therapeutic efficacy in renal fibrosis using a three-dimensional chip model
- So Young Jang, Seong-Hye Hwang, Yunyeong Choi, Wan-Young Kim, Sung Hyuk Park, Won Mook Kim, Eun-Jeong Kwon, Sejoong Kim
- Received November 29, 2023 Accepted April 28, 2024
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Background: EW-7197, a potent oral ALK5 inhibitor, was assessed for its impact on transforming growth factor beta 1 (TGF-β1)–induced fibrosis in a three-dimensional (3D) renal fibrosis-on-a-chip and a mouse model. The evaluation included tubular epithelial-mesenchymal transition, angiogenesis, and inflammatory cytokine expression. Methods: In a 3D renal fibrosis-on-a-chip model, three cell types (kidney fibroblasts, human proximal tubular cell line, and human umbilical... -
DOI: https://doi.org/10.23876/j.krcp.23.324 [Epub ahead of print]
- Original Articles
- Investigation of current clinical practices and perceptions of patients and caregivers regarding Alport syndrome in South Korea
- Dabin Kim, Yo Han Ahn, Eunjeong Kang, Hajeong Lee, Min Hyun Cho, Hee Gyung Kang, Ji Hyun Kim
- Received October 12, 2023 Accepted March 18, 2024
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Background: Alport syndrome (AS) is a highly prevalent inherited kidney disease. Early diagnosis and intervention are crucial for improved kidney outcomes. This study evaluated awareness among Korean clinicians about AS and assessed the understanding of AS patients and caregivers. Methods: An online survey targeting registered members of the Korean Society of Nephrology, the Korean Society of Pediatric Nephrology, AS patients,... -
DOI: https://doi.org/10.23876/j.krcp.23.260 [Epub ahead of print]
- GAIT-CKD (Gait Analysis using Artificial Intelligence for digital Therapeutics of patients with Chronic Kidney Disease): design and methods
- Youngjin Song, In cheol Jeong, Semin Ryu, Sunghan Lee, Jeonghwan Koh, Seokjue Jeong, Seongmin Park, Munsang Kim, Wonjun Lee, Okhyeon Rye, Yeojin Kim, Sanggyu Lee, Mooeob Ahn, Hyunsuk Kim
- Received October 22, 2023 Accepted February 13, 2024
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Background: Digital therapeutics are emerging as treatments for diseases and disabilities. In chronic kidney disease (CKD), gait is a potential biomarker for health status and intervention effectiveness. This study aims to analyze gait characteristics in CKD patients, providing baseline data for digital therapeutics development. Methods: At baseline and after an 8-week intervention, we performed bioimpedance analysis measurements, the Timed Up and... -
DOI: https://doi.org/10.23876/j.krcp.23.273 [Epub ahead of print]
- Comparisons of clinical outcomes between hypertensive and normotensive living kidney donors: a prospective, multicenter nationwide cohort study
- Jong Ho Kim, Yu Ho Lee, Dae Kyu Kim, Jin Sug Kim, Kyung Hwan Jeong, Ku Yong Chung, Jong Cheol Jeong, Soo Jin Na Choi, Jaeseok Yang, Myoung Soo Kim, Hyeon Seok Hwang
- Received October 30, 2023 Accepted February 2, 2024
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Background: Living kidney donors with hypertension are potential candidates for solving the donor shortages in renal transplantation. However, the safety of donors with hypertension after nephrectomy has not been sufficiently confirmed. Methods: A total of 642 hypertensive and 4,848 normotensive living kidney donors who were enrolled in the Korean Organ Transplantation Registry between May 2014 and December 2020 were included in... -
DOI: https://doi.org/10.23876/j.krcp.23.283 [Epub ahead of print]
- Clinical effects of a home care program for patients with peritoneal dialysis in a tertiary care hospital
- KyungYi Kim, Hyung Woo Kim, Beom Seok Kim, Suk-Yong Jang, Jaeyong Shin, Tae Hyun Kim, Sang Gyu Lee
- Received June 12, 2023 Accepted January 3, 2024
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Background: Digital health technologies have been rapidly adopted during the coronavirus disease 2019 pandemic. In Korea, a home care program, including face-to-face educational consultation and remote patient monitoring, was initiated to improve patients’ quality of life. This study focused on patients with end-stage renal disease undergoing peritoneal dialysis to verify the long-term clinical effectiveness of this home care program. Methods: This... -
DOI: https://doi.org/10.23876/j.krcp.23.160 [Epub ahead of print]
- Hospitalization among adults with chronic kidney disease: results from the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD) study
- Yeong-Won Park, Jaeseung Hwang, Minsang Kim, Seon-Mi Kim, Yujin Jeong, Minjung Kang, Eunjeong Kang, Hyunjin Ryu, Sue K. Park, Yaeni Kim, Jong Cheol Jeong, Seung Hyeok Han, Kook-Hwan Oh
- Received October 20, 2023 Accepted February 6, 2024
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Background: Chronic kidney disease (CKD) patients are hospitalized for various conditions. Hospitalization increases the readmission rate and mortality rate, seriously deteriorating patients’ quality of life. Consequently, it is crucial to analyze the reasons for hospitalization in CKD patients from a broader perspective according to CKD grade. Methods: This is a prospective cohort study of CKD patients entitled the KoreaN Cohort Study... -
DOI: https://doi.org/10.23876/j.krcp.23.263 [Epub ahead of print]
- Mortality in patients receiving renal replacement therapy in South Korea
- BeongWoo Kim, Chan Il Park, Yu Ah Hong, Hye Eun Yoon, Yong Kyun Kim, Hyunglae Kim, Kyeong Min Kim, Seun Deuk Hwang, Sun Ryoung Choi, Hajeong Lee, Ji Hyun Kim, Su Hyun Kim, Ho-Seok Koo, Chang-Yun Yoon, Kiwon Kim, Seon Ho Ahn, Seon A Jeong, Tae Hee Kim
- Received January 30, 2024 Accepted April 6, 2024
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Background: This study analyzed data from the end-stage renal disease patient registry collected by the Korean Society of Nephrology to explore trends in mortality among dialysis patients from 2001 to 2022. Methods: Mortality was analyzed in two ways: firstly, using the annual mortality rate; and secondly, by assessing survivability after a certain period of time since the initiation of dialysis. Additionally,... -
DOI: https://doi.org/10.23876/j.krcp.24.035 [Epub ahead of print]
- Impact of glycemic control on residual kidney function and technique failure associated with volume overload in diabetic patients on peritoneal dialysis
- Dong Eon Kim, Da Woon Kim, Hyo Jin Kim, Harin Rhee, Eun Young Seong, Yewon Choi, Sang Heon Song
- Received September 25, 2023 Accepted December 14, 2023
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Background: It is unclear whether poor glycemic control contributes to residual kidney function (RKF) decline and consequent volume overload in diabetic patients on peritoneal dialysis (PD). Methods: This retrospective analysis included 80 diabetic patients who started PD at a single center. The first 2 years of patient data were collected to investigate the impact of glycemic control on RKF and volume... -
DOI: https://doi.org/10.23876/j.krcp.23.251 [Epub ahead of print]
- The impact of donor hepatitis B virus infection on transplant outcomes in deceased donor kidney transplantation recipients
- You Luo, Rui Zhang, Xiao Hu, Zuofu Tang, Jinhua Zhang, Jiaqing Wu, Ning Na, Hengjun Xiao
- Received September 3, 2023 Accepted November 26, 2023
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Background: The use of hepatitis B virus (HBV)-positive donor kidneys to expand the donor pool has been implemented, but limited evidence exists regarding their impact on transplant outcomes. This study aimed to investigate the effects of donor HBV infection on transplant outcomes. Methods: Donor and recipient data between 2015 and 2021 were collected. A total of 743 kidney transplant cases were... -
DOI: https://doi.org/10.23876/j.krcp.23.233 [Epub ahead of print]
- Global burden and risk factors of chronic kidney disease in adolescents and young adults: a study from 1990 to 2019
- Hua Deng, Qin Zou, Zhe Chen, Bo Hu, Xiangping Liao
- Received November 28, 2023 Accepted March 11, 2024
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Background: Few studies have evaluated the global burden of chronic kidney disease (CKD) in adolescents and young adults (AYAs). Methods: Age-standardized rates of incidence (ASIR), mortality (ASMR), and disability-adjusted life-years (ASDR) were used to describe the CKD burden in AYAs. The estimated annual percentage changes (EAPCs) were calculated to evaluate the temporal trends from 1990 to 2019. Risk factors were... -
DOI: https://doi.org/10.23876/j.krcp.23.331 [Epub ahead of print]
- Early single session of hyperbaric oxygen therapy mitigates renal apoptosis in lipopolysaccharides-induced endotoxemia in rats
- Hyoung Youn Lee, In Jin Kim, Hong Sang Choi, Yong Hun Jung, Kyung Woon Jeung, Najmiddin Mamadjonov, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
- Received November 15, 2023 Accepted February 13, 2024
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Background: Sepsis-associated acute kidney injury (SA-AKI) is a prominent sepsis complication, often resulting in adverse clinical outcomes. Hyperbaric oxygen therapy (HBOT), known for its anti-inflammatory characteristics, antioxidant effects, and ability to deliver high oxygen tension to hypo-perfused tissues, offers potential benefits for SA-AKI. This study investigated whether HBOT improved renal injury in sepsis and elucidated its underlying mechanisms. Methods: A lipopolysaccharide... -
DOI: https://doi.org/10.23876/j.krcp.23.294 [Epub ahead of print]
- Systematic metabolomics study in the serum and urine of a mouse model of Fabry disease
- Chang Seong Kim, Songjin Oh, Moongi Ji, Byeongchan Choi, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Eun Hui Bae, Seong Kwon Ma, Man-Jeong Paik, Soo Wan Kim
- Received August 14, 2023 Accepted January 2, 2024
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Background: Fabry disease (FD) is an X-linked lysosomal disorder caused by α-galactosidase A enzyme activity deficiency. Although glycosphingolipid analogs have been identified in the plasma or urine of patients with FD, there is a limited understanding of altered metabolomics profiles beyond the globotriaosylceramide accumulation in FD. Methods: Metabolomics study was performed for monitoring of biomarker and altered metabolism related with disease... -
DOI: https://doi.org/10.23876/j.krcp.23.218 [Epub ahead of print]
- Single-cell RNA sequencing revealed the role of the Th17 pathway in the development of anti- human leukocyte antigen antibodies in a highly sensitized mouse model
- Hanbi Lee, Yoo-Jin Shin, Xianying Fang, Sheng Cui, Sun Woo Lim, Seon-Yeong Lee, Sang Hun Eum, Ji-Won Min, Chang-Won Hong, Hae-Ock Lee, Mi-La Cho, Eun-Jee Oh, Chul Woo Yang, Byung Ha Chung
- Received November 26, 2023 Accepted February 28, 2024
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Background: The aim of this study is to investigate the specific pathway involved in human leukocyte antigen (HLA) sensitization using single-cell RNA-sequencing analysis and an allo-sensitized mouse model developed with an HLA.A2 transgenic mouse. Methods: For sensitization, wild-type C57BL/6 mouse received two skin grafts from C57BL/6-Tg(HLA-A2.1)1Enge/J mouse (allogeneic mouse, ALLO). For syngeneic control (SYN), skin grafts were transferred from C57BL/6... -
DOI: https://doi.org/10.23876/j.krcp.23.317 [Epub ahead of print]
- A novel allocation scheme for deceased donor kidneys to balance equity and utility
- Jin Hyeog Lee, Jun Hye Seo, Tai Yeon Koo, Jang Hee Cho, Kyung Pyo Kang, Jung Eun Lee, Kook Hwan Oh, Beom Seok Kim, Jaeseok Yang
- Received February 2, 2024 Accepted March 26, 2024
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Background: Patients with sensitization and blood type O experience increased waiting times for deceased-donor kidney transplantation (DDKT). While allocation benefits are needed to resolve inequity in DDKT opportunity, whether DDKT has comparable outcomes in this disadvantaged population requires further study. This study assessed these outcomes and developed a new allocation system that balances equity and utility. Methods: Patients from national and... -
DOI: https://doi.org/10.23876/j.krcp.24.033 [Epub ahead of print]
- Comparative analysis of the incidence and mortality of COVID-19 in Korean end-stage kidney disease patients: hemodialysis, peritoneal dialysis, and transplantation
- AJin Cho, Seon A Jeong, Hayne Cho Park, Do Hyoung Kim, Kyung Don Yoo, Hye Eun Yoon, Yang Gyun Kim, Young-Ki Lee
- Received November 8, 2023 Accepted December 26, 2023
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Background: Patients with end-stage kidney disease (ESKD) are more susceptible to viral epidemics and are known to have higher incidence and death rates of coronavirus disease 2019 (COVID-19) compared to the general population. We determined COVID-19 incidence and mortality among chronic hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) patients in Korea. Methods: We conducted a retrospective cohort study and... -
DOI: https://doi.org/10.23876/j.krcp.23.287 [Epub ahead of print]
- COVID-19 infection in patients with end-stage kidney disease undergoing renal replacement therapies in Korea
- Heejung Choi, Ah-Young Kim, Inwhee Park, Hankil Lee, Min-Jeong Lee
- Received November 2, 2023 Accepted January 18, 2024
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Background: The global coronavirus disease 2019 (COVID-19) pandemic has placed patients with end-stage kidney disease (ESKD) at heightened risk owing to their vulnerability to infections. Our study focused on patients with ESKD, examining COVID-19 incidence, hospitalization, and mortality in relation to their renal replacement therapy (RRT) type and identifying factors influencing COVID-19 hospitalization. Methods: We conducted a retrospective cohort study... -
DOI: https://doi.org/10.23876/j.krcp.23.280 [Epub ahead of print]
- Sarcopenia is independently associated with mortality and recovery from dialysis in critically ill patients with sepsis-induced acute kidney injury receiving continuous renal replacement therapy
- Il Young Kim, Byung Min Ye, Seo Rin Kim, Dong Won Lee, Soo Bong Lee
- Received January 10, 2024 Accepted February 20, 2024
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Background: Sarcopenia upon admission to the intensive care unit (ICU) consistently correlates with adverse outcomes, including heightened mortality, in critically ill patients. This study aims to investigate the independent association of sarcopenia with both mortality and recovery from dialysis in critically ill patients with sepsis-induced acute kidney injury (SIAKI) undergoing continuous renal replacement therapy (CRRT). Methods: This retrospective study included 618... -
DOI: https://doi.org/10.23876/j.krcp.24.015 [Epub ahead of print]
- Obesity exacerbates ischemia-reperfusion injury and senescence in murine kidneys and perirenal adipose tissues
- Seo Rin Kim, Young-Suk Kim, Je Min Hyeon, Su Ji Kim, Byung Min Ye, Min Jeong Kim, Byung Hyun Choi, Dongwon Yi, Il Young Kim, Soo Bong Lee, Dong Won Lee
- Received August 25, 2022 Accepted February 3, 2023
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Background: Obesity is a major worldwide health problem and can be related to cellular senescence. Along with the rise in obesity, the comorbidity of renal ischemia-reperfusion (IR) injury is increasing. Whether obesity accelerates the severity of IR injury and whether senescence contributes to these conditions remain unclear. We studied the degree of injury and cellular senescence in the IR kidneys... -
DOI: https://doi.org/10.23876/j.krcp.22.193 [Epub ahead of print]
- Longitudinal progression trajectory of estimated glomerular filtration rate in children with chronic kidney disease: results from the KNOW-Ped CKD (KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease)
- Eun Mi Yang, Jayoun Kim, Eujin Park, Kyoung Hee Han, Seong Heon Kim, Heeyeon Cho, Jae Il Shin, Min Hyun Cho, Joo Hoon Lee, Ji Hyun Kim, Hee Gyung Kang, Il-Soo Ha, Yo Han Ahn
- Received July 24, 2023 Accepted December 1, 2023
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Background: The natural course of chronic kidney disease (CKD) progression in children varies according to their underlying conditions. This study aims to identify different patterns of subsequent decline in kidney function and investigate factors associated with different patterns of estimated glomerular filtration rate (eGFR) trajectories. Methods: We analyzed data from the KNOW-Ped CKD (KoreaN cohort study for Outcomes in patients With... -
DOI: https://doi.org/10.23876/j.krcp.23.198 [Epub ahead of print]
- Impact of obesity on renal function in elderly Korean adults: a national population-based cohort study
- Jihyun Yang, Hui Seung Lee, Chi-Yeon Lim, Hyunsuk Kim, Sungjin Chung, Soon Hyo Kwon, Jang-Hee Cho, Kyung Don Yoo, Woo Yeong Park, In O Sun, Byung Chul Yu, Gang-Jee Ko, Jae Won Yang, Won Min Hwang, Sang Heon Song, Sung Joon Shin, Yu Ah Hong, Eunjin Bae, Young Youl Hyun
- Received July 14, 2023 Accepted December 1, 2023
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Background: Obesity is a well-known risk factor for chronic kidney disease and its progression. However, the impact of obesity on the renal function of the elderly population is uncertain. We investigated the association between obesity and renal outcomes in the elderly. Methods: We analyzed 130,504 participants from the Korean National Health Insurance Service-Senior cohort. Obesity was classified according to body... -
DOI: https://doi.org/10.23876/j.krcp.23.187 [Epub ahead of print]
- Intradialytic hypotension and worse outcomes in patients with acute kidney injury requiring intermittent hemodialysis
- Yeong-Won Park, Donghwan Yun, Yeojin Yu, Sang Hyun Kim, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seong Geun Kim, Seung Seok Han
- Received July 16, 2023 Accepted November 9, 2023
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Background: Intradialytic hypotension (IDH) is a critical complication related to worse outcomes in patients undergoing maintenance hemodialysis. Herein, we addressed the impact of IDH on mortality and other outcomes in patients with severe acute kidney injury (AKI) requiring intermittent hemodialysis. Methods: We retrospectively reviewed 1,009 patients who underwent intermittent hemodialysis due to severe AKI. IDH was defined as either dialysis discontinuation... -
DOI: https://doi.org/10.23876/j.krcp.23.188 [Epub ahead of print]
- Immediate-start peritoneal dialysis without break-in-period: an 18-year retrospective cohort study on patient survival
- Jee Young Lee, Hyun-Jin Cho, Yoo-Sun Joo, Hye-Jin Na, Jung-Hwan Park, Young-Il Jo
- Received April 28, 2023 Accepted November 8, 2023
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Background: Immediate-start peritoneal dialysis (ISPD) is an effective renal replacement therapy that can prevent central venous catheterization due to its immediate initiation of peritoneal dialysis (PD) after catheter insertion without a break-in period. This study aimed to investigate the effect of ISPD on long-term patient survival. Methods: In this retrospective single-center cohort study, 178 consecutive patients who started PD from August... -
DOI: https://doi.org/10.23876/j.krcp.23.103 [Epub ahead of print]
- Comparison between characteristics of immunoglobulin M nephropathy and other glomerular diseases
- Giae Yun, Eun Jeong Kwon, Seokwoo Park, Jong Cheol Jeong, Sejoong Kim, Ki Young Na, Ho Jun Chin
- Received June 14, 2023 Accepted August 5, 2023
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Background: Immunoglobulin M (IgM) nephropathy (IgMN) is characterized by the IgM deposition in the kidney’s mesangium. We assessed the impact of electron-dense deposits (EDDs) on IgMN and compared it to other kidney diseases. Methods: We enrolled 63 adult patients with IgMN who underwent renal biopsy from May 2003 to June 2017. We compared clinicopathological features of IgMN based on EDD presence;... -
DOI: https://doi.org/10.23876/j.krcp.23.159 [Epub ahead of print]
- Preliminary evaluation of the effect of revised reimbursement scheme in outpatient hemodialysis for medical aid recipients in Korea
- Heenyun Kim, Yongseok Choi, Soontack Kwon, Kook Young Jang, Do Kyung Ryuk, Hyejin Lee, Jin Yong Lee
- Received February 17, 2023 Accepted July 26, 2023
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Background: South Korea has universal health coverage guaranteeing equitable healthcare for all. However, equity issues have been raised regarding hemodialysis reimbursement for medical aid recipients with chronic kidney disease. Physicians and civic groups demanded a revision of the discriminatory policy, and in response, the Ministry of Health and Welfare amended the hemodialysis case payment scheme. This study aims to evaluate... -
DOI: https://doi.org/10.23876/j.krcp.23.038 [Epub ahead of print]
- Association between dementia diagnosis at dialysis initiation and mortality in older patients with end-stage kidney disease in South Korea
- Byung Min Ye, Seongmin Kang, Woo Yeong Park, Jang-Hee Cho, Byung Chul Yu, Miyeun Han, Sang Heon Song, Gang-Jee Ko, Jae Won Yang, Sungjin Chung, Yu Ah Hong, Young Youl Hyun, Eunjin Bae, In O Sun, Hyunsuk Kim, Won Min Hwang, Sung Joon Shin, Soon Hyo Kwon, Seo Rin Kim, Kyung Don Yoo
- Received June 9, 2023 Accepted October 22, 2023
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Background: The prevalence of dementia is 2- to 7-fold higher among patients with end-stage kidney disease (ESKD) than among the general population; however, its clinical implications in this population remain unclear. Therefore, this study aimed to determine whether comorbid dementia increases mortality among older patients with ESKD undergoing newly initiated hemodialysis. Methods: We analyzed data from the Korean Society... -
DOI: https://doi.org/10.23876/j.krcp.23.151 [Epub ahead of print]
- Efficacy of intradialytic neuromuscular electrical stimulation and oral nutritional supplementation in hemodialysis patients: a multicenter, randomized controlled trial
- Jae Hyeon Park, Jae Yoon Park, Geum Sil Lee, Ran-hui Cha
- Received June 2, 2023 Accepted October 2, 2023
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Background: Sarcopenia is common in hemodialysis patients. This study aimed to evaluate the effect of simultaneous nutritional support and intradialytic neuromuscular electrical stimulation (NMES) in hemodialysis patients. Methods: We performed a 12-week, multicenter, randomized controlled trial. The participants were randomly assigned to the control group, the protein group (25 g of protein at every dialysis session), the NMES group (intradialytic... -
DOI: https://doi.org/10.23876/j.krcp.23.146 [Epub ahead of print]
- Performance evaluation of Chronic Kidney Disease Epidemiology Collaboration equations for estimated glomerular filtration rate compared to inulin clearance in Koreans
- Jeong Min Cho, Ran-hui Cha, Dong Ki Kim, Ho Jun Chin
- Received May 17, 2023 Accepted September 12, 2023
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Background: A race-free glomerular filtration rate (GFR) estimation equation has recently been developed. However, the performance of the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations needs to be evaluated in Asian populations. Methods: We performed a cross-sectional study at a single center in South Korea. The measured GFR (mGFR) was determined based on systemic inulin clearance. The GFR was... -
DOI: https://doi.org/10.23876/j.krcp.23.124 [Epub ahead of print]
- Pericyte activation accompanied by peritubular capillaries dysfunction and pericyte-to-myofibroblast transition is associated with renal fibrosis in diabetic nephropathy
- Yiduo Feng, Dongli Tian, Yu Bai, Yan Li, Liling Zhang, Yiru Wu, Wenhu Liu, Zongli Diao
- Received April 19, 2023 Accepted October 2, 2023
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Background: Tubulointerstitial renal fibrosis is an essential feature of diabetic nephropathy (DN). Pericytes play a critical role in microvascular diseases and renal fibrogenesis. However, the role of pericytes in DN remains unclear. Herein, we aimed to explore the properties and possible mechanisms of pericytes in renal fibrosis in DN. Methods: We used multiplex immunofluorescence staining to evaluate the location and... -
DOI: https://doi.org/10.23876/j.krcp.23.099 [Epub ahead of print]
- Associations of metabolic variabilities and cardiovascular outcomes according to estimated glomerular filtration rate in chronic kidney disease: a nationwide observational cohort study
- Jeong Min Cho, Kyungdo Han, Kwon Wook Joo, Soojin Lee, Yaerim Kim, Semin Cho, Hyuk Huh, Seong Geun Kim, Minsang Kim, Eunjeong Kang, Dong Ki Kim, Sehoon Park
- Received May 24, 2023 Accepted August 16, 2023
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Background: The impact of baseline estimated glomerular filtration rate (eGFR) on the risk of adverse outcomes according to metabolic parameter variabilities in chronic kidney disease has rarely been investigated. Methods: We conducted a retrospective nationwide cohort study using the National Health Insurance System data in Korea from 2007 to 2013 to identify individuals with three or more health screenings. The metabolic... -
DOI: https://doi.org/10.23876/j.krcp.23.135 [Epub ahead of print]
- Association of metformin with cardiovascular and graft outcomes in kidney transplant recipients with posttransplantation diabetes mellitus
- Dongyeon Lee, Jiyun Jung, Sichan Kim, Jaeyun Lee, Jangwook Lee, Chung Hee Baek, Hyunwook Kwon, Sung Shin, Younghoon Kim, Sung Joon Shin, Su-Kil Park, Jae Yoon Park, Hyosang Kim
- Received April 10, 2023 Accepted August 28, 2023
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Background: Posttransplantation diabetes mellitus (PTDM) is a crucial problem after kidney transplantation. We aimed to determine whether metformin affects cardiovascular and graft outcomes in patients with PTDM. Methods: This retrospective cohort study included 1,663 kidney transplant recipients without preexisting diabetes mellitus. The patients were divided into metformin and non-metformin groups, with matched propensity scores. We also estimated metformin’s effect on percutaneous... -
DOI: https://doi.org/10.23876/j.krcp.23.085 [Epub ahead of print]
- Kidney biopsy can help to predict renal outcomes of patients with type 2 diabetes mellitus
- Wook-Joon Kim, Taehoon Oh, Nam Hun Heo, Kyungsup Kwon, Ga-Eun Shin, Se-Hwi Jeong, Ji Hye Lee, Samel Park, Nam-Jun Cho, Hyo-Wook Gil, Eun Young Lee
- Received March 13, 2023 Accepted July 30, 2023
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Background: In patients with type 2 diabetes mellitus (T2DM), diabetic kidney disease (DKD) is diagnosed based on clinical features. A kidney biopsy is used only in selected cases. This study aimed to reconsider the role of a biopsy in predicting renal outcomes. Methods: Clinical and laboratory parameters and renal biopsy results were obtained from 237 patients with T2DM who underwent renal... -
DOI: https://doi.org/10.23876/j.krcp.23.059 [Epub ahead of print]
- Long-term outcomes and associated prognostic risk factors of childhood-onset lupus nephritis
- Eujin Park, Jiwon Jung, Jeesu Min, Hyeonju Lee, Min Ji Park, Ji Yeon Song, Ji Hyun Kim, Kyung Mi Jang, Eun Mi Yang, Yo Han Ahn, Min Hyun Cho, Joo Hoon Lee, Young Seo Park, Soon Chul Kim, Se Jin Park, Jung Won Lee, Kee Hyuck Kim, Ki Soo Pai, Hee Gyung Kang, Seong Heon Kim
- Received February 15, 2023 Accepted August 14, 2023
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Background: This study investigated the clinical characteristics and kidney outcomes of childhood-onset lupus nephritis (LN), and risk factors associated with prognosis. Methods: We enrolled 216 patients with histologically diagnosed LN during childhood. The Korean Society of Pediatric Nephrology organized a retrospective cohort study of childhood-onset LN in 13 major pediatric nephrology centers in South Korea. Results: The mean age at... -
DOI: https://doi.org/10.23876/j.krcp.23.032 [Epub ahead of print]
- Insulin resistance is associated with incident chronic kidney disease in population with normal renal function
- Su Hyun Song, Young Jin Goo, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
- Received December 23, 2022 Accepted June 20, 2023
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Background: Insulin resistance is prevalent in chronic kidney disease and may accelerate the progression of chronic kidney disease. This study aimed to investigate whether insulin resistance is associated with the development of incident chronic kidney disease in a population with normal renal function. Methods: A total of 3,331 participants from a community-based cohort with normal renal function were prospectively analyzed.... -
DOI: https://doi.org/10.23876/j.krcp.22.298 [Epub ahead of print]
- Impact of albuminuria on early-onset type 2 diabetes mellitus: a nationwide population-based study
- Soojin Lee, Semin Cho, Geum Nae Nam, Jeongmin Cho, Seong Geun Kim, Minsang Kim, Hyuk Huh, Eunjeong Kang, Sehoon Park, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Kwon Wook Joo, Kyungdo Han, Dong Ki Kim, Yaerim Kim
- Received November 25, 2022 Accepted July 11, 2023
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Background: Early-onset diabetes mellitus has a significant lifetime burden and is associated with higher morbidity and mortality. Since insulin resistance is one of the mechanisms of podocyte injury, we aimed to evaluate the effect of albuminuria on newly developed early-onset type 2 diabetes mellitus (T2DM). Methods: We screened 6,891,399 subjects aged ≥20 and <40 years without a history of prediabetes... -
DOI: https://doi.org/10.23876/j.krcp.22.278 [Epub ahead of print]
- Clinical influencing factors affecting pulmonary hypertension in hemodialysis patients
- Xu Zhang, Kun Xiao, Longkai Li, Nan Wang, Tao Cong, Yushan Wei, Shengji Cao, Xinyu Wen, Qingyang Meng, Hongli Lin, Taihua Wu
- Received February 2, 2023 Accepted May 4, 2023
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Background: The fluid status and rate of blood flow through the arteriovenous fistula (AVF) are two important factors affecting hemodynamic in hemodialysis patients; however, their effects on pulmonary hypertension have rarely been studied. Hence, we aimed to evaluate the effects of these factors in hemodialysis patients with pulmonary hypertension. Methods: This single-center cross-sectional survey included 219 maintenance hemodialysis patients (139... -
DOI: https://doi.org/10.23876/j.krcp.23.021 [Epub ahead of print]
- Atherogenic indices and risk of chronic kidney disease in metabolic derangements: Gangnam Severance Medical Cohort
- Donghwan Oh, Seoyoung Lee, Eunji Yang, Hoon Young Choi, Hyeong Cheon Park, Jong Hyun Jhee
- Received February 21, 2023 Accepted July 3, 2023
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Background: The effects of atherogenic indices on kidney function remain unclear. This study evaluated the association between atherogenic indices and risk of chronic kidney disease (CKD) in adults with metabolic derangements. Methods: A total of 4,176 participants from the Gangnam Severance Medical Cohort (2006–2021), which consisted of participants who had at least one disease related to metabolic derangements including diabetes mellitus,... -
DOI: https://doi.org/10.23876/j.krcp.23.043 [Epub ahead of print]
- Association of systolic blood pressure with incident chronic kidney disease estimated by marginal structural model: a nationwide population-based study
- Hyunsun Lim, Youn Nam Kim, Tae Ik Chang, Jae Young Kim
- Received March 28, 2023 Accepted July 30, 2023
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Background: We aimed to investigate the association between systolic blood pressure (SBP) and risk of incident chronic kidney disease (CKD) using marginal structural model (MSM) to reflect mutual effects of exposure and confounders on the outcome. Methods: A total of 195,970 adults with an estimated glomerular filtration rate (eGFR) of >60 mL/min/1.73 m2 and no proteinuria were included from... -
DOI: https://doi.org/10.23876/j.krcp.23.073 [Epub ahead of print]
- Necessity of induction agent modification for old age kidney transplant recipients
- Kyeong Deok Kim, Kyo Won Lee, Jae Berm Park, Woo Sung Sim, Manuel Lim, Eun Sung Jeong, Jieun Kwon, Jaehun Yang
- Received March 21, 2023 Accepted July 4, 2023
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Background: Immunosenescence gradually deteriorates the function of the immune system, making elderly patients susceptible to infection, while reducing rejection of organ transplants. Therefore, age-adaptive immunosuppression is necessary in the elderly. We evaluated clinical outcomes such as rejection and infection rate when using basiliximab and rabbit anti-thymocyte globulin (r-ATG) as induction agents in elderly and young organ transplant recipients. Methods: We... -
DOI: https://doi.org/10.23876/j.krcp.23.068 [Epub ahead of print]
- Bowman capsule rupture in children with myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis predicts poor renal survival
- Pei Zhang, Li-li Jia, Meng-zhen Fu, Kai-li Shi, Chun-lin Gao, Zheng-kun Xia
- Received March 6, 2023 Accepted May 25, 2023
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Background: Recent developments indicated that Bowman capsule rupture (BCR) is observed in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN). We aimed to explore the relationship between BCR and clinical manifestations, pathological changes, and prognosis in children with myeloperoxidase (MPO)-AAGN. Methods: A total of 56 children with MPO-AAGN were divided into BCR (+) and BCR (–) groups according to the status of Bowman’s... -
DOI: https://doi.org/10.23876/j.krcp.23.051 [Epub ahead of print]
- Target blood pressure in Korean hemodialysis patients for optimal survival
- Ji Eun Kim, Yun Jin Choi, Soon-Young Hwang, Hyeon Seok Hwang, Kyung Hwan Jeong, Eunjung Cho, Shin Young Ahn, Young Joo Kwon, Ju-Young Moon, Gang-Jee Ko
- Received October 12, 2022 Accepted March 23, 2023
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Background: Hypertension is a major cardiovascular risk factor in hemodialysis patients. This study identified the optimal blood pressure (BP) target for Korean hemodialysis patients using the Korean Renal Dialysis System (KORDS) dataset from the Korean Society of Nephrology and a pooled analysis for previous studies. Methods: Hemodialysis patients were classified according to their systolic (SBP) and diastolic BP (DBP) at intervals... -
DOI: https://doi.org/10.23876/j.krcp.22.241 [Epub ahead of print]
- Smoking amplifies the risk of albuminuria in individuals with high sodium intake: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011 and 2014–2018
- Young-Bin Son, Tae-Bum Kim, Hyeon-Jin Min, Jihyun Yang, Myung-Gyu Kim, Sang Kyung Jo, Won Yong Cho, Se Won Oh
- Received June 30, 2022 Accepted April 10, 2023
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Background: Smoking and sodium intake (SI) have been evaluated as risk factors for kidney disease; however, the data are inconsistent. We assessed the association between SI and cotinine-verified smoking status and the risk of albuminuria. Methods: An observational study using the Korea National Health and Nutrition Examination Survey (2008–2011 and 2014–2018) was performed. We included 37,410 adults with an estimated... -
DOI: https://doi.org/10.23876/j.krcp.22.133 [Epub ahead of print]
- Clinical significance of the living kidney donor profile index for predicting long-term posttransplant outcomes: results from the Korean Organ Transplantation Registry
- Jong Ho Kim, Sang Ho Lee, Jin Sug Kim, Hyeon Seok Hwang, Hyunmin Ko, Cheol-Woong Jung, Deok Gie Kim, Yeong Hoon Kim, Jaeseok Yang, Curie Ahn, Kyung Hwan Jeong
- Received November 17, 2022 Accepted March 11, 2023
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Background: The usefulness of the living kidney donor profile index (LKDPI) has not been widely demonstrated; therefore, it requires verification before clinical application. We analyzed the LKDPI using data from the Korean Organ Transplantation Registry (KOTRY) to confirm whether the LKDPI can be used to predict the survival of allografts in living donor kidney transplantation (LDKT) patients in Korea. Methods:... -
DOI: https://doi.org/10.23876/j.krcp.22.266 [Epub ahead of print]
- Examine the optimal multidisciplinary care teams for patients with chronic kidney disease from a nationwide cohort study
- Masanori Abe, Tsuguru Hatta, Yoshihiko Imamura, Tsutomu Sakurada, Shinya Kaname
- Received February 12, 2023 Accepted March 31, 2023
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Background: Multidisciplinary team-based integrated care (MDC) has been recommended for patients with chronic kidney disease (CKD). However, team-based specific structured care systems are not yet established. Therefore, we investigated the efficacy of MDC system and the optimal number of professionals that make up the team for maintaining kidney function and improving prognosis. Methods: This nationwide, multicenter, observational study included 2,957... -
DOI: https://doi.org/10.23876/j.krcp.23.026 [Epub ahead of print]
- A comparative study of epidemiological characteristics, treatment outcomes, and mortality among patients undergoing hemodialysis by health insurance types: data from the Korean Renal Data System
- Kyeong Min Kim, Soyoung Lee, Jong Ho Shin, Mira Park
- Received September 29, 2022 Accepted May 11, 2023
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Background: The prevalence of end-stage renal disease (ESRD) requiring dialysis has progressively increased. Therefore, to achieve financial stability by managing the increasing numbers of patients undergoing hemodialysis (HD), a fixed-payment system was introduced in 2001 for medical aid (MA) beneficiaries receiving HD in Korea. Methods: We identified patients in the Korean Renal Data System that received HD between 2001 and 2017... -
DOI: https://doi.org/10.23876/j.krcp.22.220 [Epub ahead of print]
- Nephrology consultation improves the clinical outcomes of patients with acute kidney injury
- Harin Rhee, Meeyoung Park, Il Young Kim
- Received February 22, 2023 Accepted March 26, 2023
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Background: Acute kidney injury (AKI) is prevalent in critically ill patients and is associated with an increased risk of in-hospital mortality. Nephrology consultation may be protective, but this has rarely been evaluated in South Korea. Methods: This multicenter retrospective study was based on the electronic medical records (EMRs) of two third-affiliated hospitals. We extracted the records of patients admitted to intensive... -
DOI: https://doi.org/10.23876/j.krcp.23.039 [Epub ahead of print]
- Loss of Cutibacterium is responsible for chronic kidney disease-associated pruritus in patients on dialysis
- Jeong Geon Lee, Hoonhee Seo, Seung Seob Son, Hee Seul Jeong, Kyung Mi Lee, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hyun-A Park, Sukyung Kim, Eun Young Lee
- Received March 9, 2023 Accepted May 4, 2023
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Background: Chronic kidney disease (CKD)-associated pruritus is a severe distressing condition that frequently occurs in patients undergoing dialysis. In this study, the profile of the skin microbiome was analyzed to understand the underlying etiology and potential treatments. Methods: Seventy-six end-stage kidney disease (ESKD) patients (hemodialysis, 40; peritoneal dialysis, 36) and 15 healthy controls were enrolled and swabbed at three sites:... -
DOI: https://doi.org/10.23876/j.krcp.23.057 [Epub ahead of print]
- The feasibility of incremental peritoneal dialysis for older patients on peritoneal dialysis
- Ruihua Liu, Jing Guo, Hongjian Ye, Yuan Peng, Haishan Wu, Haiping Mao, Qunying Guo, Fengxian Huang, Xiao Yang
- Received September 2, 2022 Accepted April 3, 2023
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Background: This study was performed to investigate the feasibility of incremental peritoneal dialysis (iPD) in older patients. Methods: In this retrospective cohort study, we enrolled peritoneal dialysis (PD) patients with age ≥ 60 years old at our center from 2008 to 2017. The patients were divided into two groups based on the daily PD exchanges: iPD group (≤3 × 2... -
DOI: https://doi.org/10.23876/j.krcp.22.202 [Epub ahead of print]
- Factors associated with gait speed: results from the RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients (RECOVERY) study
- Miyeun Han, Sang Heon Song, Su Hyun Kim, Ran-hui Cha, Seock Hui Kang, Won Suk An, Jun Chul Kim
- Received July 6, 2022 Accepted December 25, 2022
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Background: Gait speed is an important measure of functional ability. This study aimed to investigate the factors associated with gait speed in patients with chronic kidney disease. The study focused on sarcopenic components, plasma uremic or inflammatory marker levels, and quality of life effects. Methods: The RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients is... -
DOI: https://doi.org/10.23876/j.krcp.22.143 [Epub ahead of print]
