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Editorial
July 28, 2023
- A new journey to predict the prognosis of diabetic kidney disease
- Da Woon Kim, Sang Heon Song
- Kidney Res Clin Pract. 2023;42(4):409-411.
- Study Protocol
- Shared Decision Making for Choosing renAl Replacement Therapy in Chronic Kidney Disease Patients (SDM-ART trial): study protocol for randomized clinical trial
- Jae Hyun Chang, Yong Chul Kim, Sang Heon Song, Soojin Kim, Min-Woo Jo, Sejoong Kim
- Received February 1, 2022 Accepted August 4, 2022
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Background: Patients with chronic kidney disease (CKD) should be educated about their condition so that they can initiate dialysis at the optimal time and make an informed choice between dialysis modalities. Shared decision-making (SDM) empowers patients to select their own treatment and improves patient outcomes. This study aimed to evaluate whether SDM affects the choice of renal replacement therapy among... -
DOI: https://doi.org/10.23876/j.krcp.22.019 [Epub ahead of print]
- Editorials
- The new race-free equations for estimating glomerular filtration rate: should they be adopted for Asians?
- Hyoungnae Kim
- Received May 8, 2023 Accepted May 16, 2023
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DOI: https://doi.org/10.23876/j.krcp.23.111 [Epub ahead of print]
- Removal of uremic toxin by dialysis, what is the issue?
- Young-Il Jo
- Received May 14, 2023 Accepted June 11, 2023
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DOI: https://doi.org/10.23876/j.krcp.23.115 [Epub ahead of print]
- C4d Puzzle in ABO-incompatible kidney transplantation
- Beom Jin Lim
- Received June 2, 2023 Accepted June 15, 2023
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DOI: https://doi.org/10.23876/j.krcp.23.139 [Epub ahead of print]
- Optimizing patient outcomes in dialysis patients: the significance of dialysis specialists
- Myung-Gyu Kim
- Received June 6, 2023 Accepted June 15, 2023
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DOI: https://doi.org/10.23876/j.krcp.23.145 [Epub ahead of print]
- Review Articles
- The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism
- Orestes Foresto-Neto, Ana Ruth Paolinetti Alves da Silva, Marcella Cipelli, Fernanda Paula Roncon Santana-Novelli, Niels Olsen Saraiva Camara
- Received January 11, 2023 Accepted March 20, 2023
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Kidneys are sensitive to disturbances in oxygen homeostasis. Hypoxia and activation of the hypoxia-inducible factor (HIF) pathway alter the expression of genes involved in the metabolism of renal and immune cells, interfering with their functioning. Whether the transcriptional activity of HIF protects the kidneys or participates in the pathogenesis of renal diseases is unclear. Several studies have indicated that HIF... -
DOI: https://doi.org/10.23876/j.krcp.23.012 [Epub ahead of print]
- Overview of aristolochic acid nephropathy: an update
- Qingqing Zhou, Lei Jiang, Tao Su, Gang Liu, Li Yang
- Received September 20, 2022 Accepted January 16, 2023
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Aristolochic acid nephropathy (AAN) is a rapidly progressive renal interstitial fibrosis caused by medical or environmental exposure to aristolochic acid (AA). Since the outbreak of AAN in Belgium was reported nearly 30 years ago, the safety of herbal remedies has drawn considerable attention, and AAN has become a global public health problem. Breakthroughs have been made to better understand the... -
DOI: https://doi.org/10.23876/j.krcp.22.211 [Epub ahead of print]
- Review Article s
- Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
- Jihyun Baek, Yu Ho Lee, Hye Yun Jeong, So-Young Lee
- Received October 17, 2022 Accepted January 17, 2023
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Most eukaryotic cells have mitochondrial networks that can change in shape, distribution, and size depending on cellular metabolic demands and environments. Mitochondrial quality control is critical for various mitochondrial functions including energy production, redox homeostasis, intracellular calcium handling, cell differentiation, proliferation, and cell death. Quality control mechanisms within mitochondria consist of antioxidant defenses, protein quality control, DNA damage repair systems,... -
DOI: https://doi.org/10.23876/j.krcp.22.233 [Epub ahead of print]
- Review Articles
- Acute kidney disease: an overview of the epidemiology, pathophysiology, and management
- Chin-Wei Kung, Yu-Hsiang Chou
- Received January 2, 2023 Accepted February 20, 2023
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Acute kidney injury (AKI) increases the risk of chronic kidney disease (CKD), and AKI and CKD are seen as interconnected syndromes. Acute kidney disease (AKD) is defined as subacute damage and/or loss of kidney function occurring 7 to 90 days after AKI, during which period key interventions may be initiated to hinder the development of CKD. While AKD is usually... -
DOI: https://doi.org/10.23876/j.krcp.23.001 [Epub ahead of print]
- Autophagy and regulation of aquaporins in the kidneys
- Xiangdong Guo, Yonglun Kong, Tae-Hwan Kwon, Chunling Li, Weidong Wang
- Received October 30, 2022 Accepted December 20, 2022
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Aquaporins (AQPs) are water channel proteins that facilitate the transport of water molecules across cell membranes. To date, seven AQPs have been found to be expressed in mammal kidneys. The cellular localization and regulation of the transport properties of AQPs in the kidney have been widely investigated. Autophagy is known as a highly conserved lysosomal pathway, which degrades cytoplasmic components.... -
DOI: https://doi.org/10.23876/j.krcp.22.247 [Epub ahead of print]
- Original Articles
- A comparative study of epidemiological characteristics, treatment outcomes, and mortality among patients undergoing hemodialysis by health insurance types: data from the Korean Renal Data System
- Kyeong Min Kim, Soyoung Lee, Jong Ho Shin, Mira Park
- Received September 29, 2022 Accepted May 11, 2023
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Background: The prevalence of end-stage renal disease (ESRD) requiring dialysis has progressively increased. Therefore, to achieve financial stability by managing the increasing numbers of patients undergoing hemodialysis (HD), a fixed-payment system was introduced in 2001 for medical aid (MA) beneficiaries receiving HD in Korea. Methods: We identified patients in the Korean Renal Data System that received HD between 2001 and 2017... -
DOI: https://doi.org/10.23876/j.krcp.22.220 [Epub ahead of print]
- Nephrology consultation improves the clinical outcomes of patients with acute kidney injury
- Harin Rhee, Meeyoung Park, Il Young Kim
- Received February 22, 2023 Accepted March 26, 2023
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Background: Acute kidney injury (AKI) is prevalent in critically ill patients and is associated with an increased risk of in-hospital mortality. Nephrology consultation may be protective, but this has rarely been evaluated in South Korea. Methods: This multicenter retrospective study was based on the electronic medical records (EMRs) of two third-affiliated hospitals. We extracted the records of patients admitted to intensive... -
DOI: https://doi.org/10.23876/j.krcp.23.039 [Epub ahead of print]
- Effect of immunosuppressive agents on clinical outcomes in idiopathic membranous nephropathy
- Ji-Young Choi, Ho Jun Chin, Hajeong Lee, Yena Jeon, Jeong-Hoon Lim, Hee-Yeon Jung, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
- Received November 3, 2022 Accepted February 25, 2023
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Background: Few comparative studies on the effects of immunosuppressants in patients with idiopathic membranous nephropathy have been conducted. Methods: Data from 489 patients who received conservative treatment or immunosuppressants were retrospectively analyzed by propensity score matching. Primary outcomes were complete or partial remission (CR or PR) of proteinuria, and secondary outcomes were renal survival and infection. Results: Of the 489 patients,... -
DOI: https://doi.org/10.23876/j.krcp.22.255 [Epub ahead of print]
- Loss of Cutibacterium is responsible for chronic kidney disease-associated pruritus in patients on dialysis
- Jeong Geon Lee, Hoonhee Seo, Seung Seob Son, Hee Seul Jeong, Kyung Mi Lee, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hyun-A Park, Sukyung Kim, Eun Young Lee
- Received March 9, 2023 Accepted May 4, 2023
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Background: Chronic kidney disease (CKD)-associated pruritus is a severe distressing condition that frequently occurs in patients undergoing dialysis. In this study, the profile of the skin microbiome was analyzed to understand the underlying etiology and potential treatments. Methods: Seventy-six end-stage kidney disease (ESKD) patients (hemodialysis, 40; peritoneal dialysis, 36) and 15 healthy controls were enrolled and swabbed at three sites:... -
DOI: https://doi.org/10.23876/j.krcp.23.057 [Epub ahead of print]
- Clinical relevance of blood urea nitrogen to serum albumin ratio for predicting bacteremia in very young children with febrile urinary tract infection
- Hyesun Hyun, Yeon hee Lee, Na Yoon Kang, Jin-Soon Suh
- Received December 15, 2022 Accepted May 7, 2023
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Background: Urinary tract infections (UTIs) are one of the most common bacterial infections in febrile children and a common cause of hospitalization, especially in very young children. We examined the clinical characteristics and predictive factors of concomitant bacteremia in pediatric patients with febrile UTI aged ≤24 months. Methods: This retrospective multicenter study reviewed medical data from 2,141 patients from three centers... -
DOI: https://doi.org/10.23876/j.krcp.22.289 [Epub ahead of print]
- The impact of severe depression on the survival of older patients with end-stage kidney disease
- You Hyun Jeon, Jeong-Hoon Lim, Yena Jeon, Yu-Kyung Chung, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
- Received November 13, 2022 Accepted May 4, 2023
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Background: Incidence of depression increases in patients with end-stage kidney disease (ESKD). We evaluated the association between depression and mortality among older patients with ESKD, which has not been studied previously. Methods: This nationwide prospective cohort study included 487 patients with ESKD aged >65 years, who were categorized into minimal, mild-to-moderate, and severe depression groups based on their Beck Depression Inventory-II... -
DOI: https://doi.org/10.23876/j.krcp.22.268 [Epub ahead of print]
- Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes
- Seung-Hyun Jeong, Samel Park, Jae-sung Choi, Nam-Jun Cho, Jong-Seok Moon, Hyo-Wook Gil
- Received December 29, 2022 Accepted April 19, 2023
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Background: Neurologic complications, such as cognitive and emotional dysfunction, have frequently been observed in chronic kidney disease (CKD) patients. Previous research shows that uremic toxins play a role in the pathogenesis of CKD-associated cognitive impairment. Since astrocytes contribute to the protection and survival of neurons, astrocyte function and brain metabolism may contribute to the pathogenesis of neurodegeneration. Indoxyl sulfate (IS)... -
DOI: https://doi.org/10.23876/j.krcp.23.005 [Epub ahead of print]
- Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys
- Jeong Hoon Park, Sung Gi Yoon, Jung Yeon Ghee, Ji Ae Yoo, Jin Joo Cha, Young Sun Kang, Sang Youb Han, Yun Jae Seol, Jee Young Han, Dae Ryong Cha
- Received January 4, 2023 Accepted April 22, 2023
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Background: Aging is a risk factor for development of chronic kidney disease and diabetes mellitus with commonly shared features of chronic inflammation and increased oxidative stress. Here, we investigated the effect of pan-Nox-inhibitor, APX-115, on renal function in aging diabetic mice. Methods: Diabetes was induced by intraperitoneal injection of streptozotocin at 50 mg/kg/day for 5 days in 52-week-old C57BL/6J mice.... -
DOI: https://doi.org/10.23876/j.krcp.23.004 [Epub ahead of print]
- Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease
- Kang Min Park, Chang Min Heo, Dong Ah Lee, Hyuk Huh, Sihyung Park, Yang Wook Kim, Yoo Jin Lee, Hyeok Jin Yoon, Bong Soo Park
- Received December 20, 2022 Accepted March 24, 2023
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Background: This study aimed to investigate differences in intrinsic prefrontal functional connectivity according to the presence of cognitive impairment in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS). Methods: We prospectively enrolled 37 patients with ESRD who had been undergoing hemodialysis for more than 6 months and had no history of neurological or psychiatric disorders. All patients... -
DOI: https://doi.org/10.23876/j.krcp.22.291 [Epub ahead of print]
- The feasibility of incremental peritoneal dialysis for older patients on peritoneal dialysis
- Ruihua Liu, Jing Guo, Hongjian Ye, Yuan Peng, Haishan Wu, Haiping Mao, Qunying Guo, Fengxian Huang, Xiao Yang
- Received September 2, 2022 Accepted April 3, 2023
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Background: This study was performed to investigate the feasibility of incremental peritoneal dialysis (iPD) in older patients. Methods: In this retrospective cohort study, we enrolled peritoneal dialysis (PD) patients with age ≥ 60 years old at our center from 2008 to 2017. The patients were divided into two groups based on the daily PD exchanges: iPD group (≤3 × 2... -
DOI: https://doi.org/10.23876/j.krcp.22.202 [Epub ahead of print]
- Acute kidney injury in hospitalized adults with chronic kidney disease: comparing the reference change value of the serum creatinine optimized criteria for acute kidney injury in chronic kidney disease (cROCK), Kidney Disease Improving Global Outcomes (KDIGO), and combined criteria
- Ling Sun, Rui-Xue Hua, Yu Wu, Lu-Xi Zou
- Received July 17, 2022 Accepted April 1, 2023
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Background: Acute-on-chronic kidney disease (ACKD) increases the risk of progression of chronic kidney disease (CKD), major adverse cardiovascular events (MACEs), and all-cause mortality. This study aimed to evaluate the ability of a novel criteria of reference change value of the serum creatinine optimized criteria for acute kidney injury (AKI) in CKD (cROCK) to detect ACKD patients and then compared the... -
DOI: https://doi.org/10.23876/j.krcp.22.161 [Epub ahead of print]
- Factors associated with gait speed: results from the RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients (RECOVERY) study
- Miyeun Han, Sang Heon Song, Su Hyun Kim, Ran-hui Cha, Seock Hui Kang, Won Suk An, Jun Chul Kim
- Received July 6, 2022 Accepted December 25, 2022
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Background: Gait speed is an important measure of functional ability. This study aimed to investigate the factors associated with gait speed in patients with chronic kidney disease. The study focused on sarcopenic components, plasma uremic or inflammatory marker levels, and quality of life effects. Methods: The RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients is... -
DOI: https://doi.org/10.23876/j.krcp.22.143 [Epub ahead of print]
- Prediction of diabetes mellitus after kidney transplantation using patient-specific induced pluripotent stem cells
- Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
- Received November 4, 2022 Accepted February 20, 2023
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Background: Multiple risk factors are involved in new-onset diabetes mellitus (DM) after organ transplantation; however, their ability to predict clinical prognosis remains unclear. Therefore, we investigated whether patient-specific induced pluripotent stem cells (iPSCs) could help predict DM development before performing kidney transplantation (KT). Methods: We first performed whole transcriptome and functional enrichment analyses of KT patient-derived iPSCs. Our results revealed... -
DOI: https://doi.org/10.23876/j.krcp.22.251 [Epub ahead of print]
- A questionnaire survey on the diagnosis and treatment of Fabry nephropathy in clinical practice
- Soo Jeong Choi, Su Hyun Kim, Min Sung Lee, Samel Park, Eunjung Cho, Seung Seok Han, Eun Sil Koh, Byung Ha Chung, Kyung Hwan Jeong, EunHui Bae, Eun Young Lee, Young Joo Kwon
- Received October 16, 2022 Accepted February 6, 2023
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Background: Fabry nephropathy is characterized by a deficiency of lysosomal alpha-galactosidase A, which results in proteinuria and kidney disease. The ineffectiveness of enzyme replacement therapy (ERT) for severe kidney failure highlights the need for early detection and meaningful markers. However, because the diagnosis and treatment of Fabry disease can vary according to the expertise of physicians, we evaluated the opinions... -
DOI: https://doi.org/10.23876/j.krcp.22.235 [Epub ahead of print]
- Comparison of the medium cutoff dialyzer and postdilution hemodiafiltration on the removal of small and middle molecule uremic toxins
- Chang Seong Kim, Soo Yeon Joo, Hong Sang Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
- Received December 1, 2021 Accepted July 4, 2022
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Background: The medium cutoff (MCO) dialyzer increases the removal of several middle molecules more effectively than high-flux hemodialysis (HD). However, comparative data addressing the efficacy and safety of MCO dialyzers vs. postdilution hemodiafiltration (HDF) in Korean patients are lacking. Methods: Nine patients with chronic HD were included in this pre-post study. Patients underwent HD with an MCO dialyzer for 4... -
DOI: https://doi.org/10.23876/j.krcp.21.287 [Epub ahead of print]
- Role of APE1/Ref-1 in hydrogen peroxide-induced apoptosis in human renal HK-2 cells
- Ha Yeon Kim, Jung Sun Park, Byeong Hwa Jeon, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
- Received August 4, 2022 Accepted November 11, 2022
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Background: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multipotent protein that plays essential roles in cellular responses to oxidative stress. However, the role of APE1/Ref-1 for kidney injuries has yet to be identified. Methods: To examine the role of APE1/Ref-1 in ischemia-reperfusion (I/R) injuries and hydrogen peroxide (H2O2)-induced renal tubular apoptosis, we studied male C57BL6 mice and human proximal tubular... -
DOI: https://doi.org/10.23876/j.krcp.22.171 [Epub ahead of print]
- The roles of interleukin-17A in risk stratification and prognosis of patients with sepsis-associated acute kidney injury
- Heng Jin, Wei Wei, Yibo Zhao, Ai Ma, Keke Sun, Xiaoxi Lin, Qihui Liu, Songtao Shou, Yan Zhang
- Received March 27, 2022 Accepted July 1, 2022
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Background: The aim of this study was to evaluate the roles of interleukin (IL)-17A in risk stratification and prognosis of patients with sepsis-associated acute kidney injury (SAKI). Methods: We enrolled 146 sepsis patients (84 non-SAKI and 62 SAKI patients) admitted to the emergency department from November 2020 to November 2021. Patients with SAKI were differentiated based on the severity of... -
DOI: https://doi.org/10.23876/j.krcp.22.063 [Epub ahead of print]
- Serum and urine metabolomic biomarkers for predicting prognosis in patients with immunoglobulin A nephropathy
- You Hyun Jeon, Sujin Lee, Da Woon Kim, Suhkmann Kim, Sun Sik Bae, Miyeun Han, Eun Young Seong, Sang Heon Song
- Received July 7, 2022 Accepted November 28, 2022
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Background: Immunoglobulin A nephropathy (IgAN) is the most prevalent form of glomerulonephritis worldwide. Prediction of disease progression in IgAN can help to provide individualized treatment based on accurate risk stratification. Methods: We performed proton nuclear magnetic resonance-based metabolomics analyses of serum and urine samples from healthy controls, non-progressor (NP), and progressor (P) groups to identify metabolic profiles of IgAN disease... -
DOI: https://doi.org/10.23876/j.krcp.22.146 [Epub ahead of print]
- Significance of C4d expression in peritubular capillaries concurrent with microvascular inflammation in for-cause biopsies of ABO-incompatible renal allografts
- Haeyon Cho, Chung Hee Baek, Su-Kil Park, Hyosang Kim, Heounjeong Go
- Received September 28, 2022 Accepted January 20, 2023
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Background: Pathologic diagnosis of antibody-mediated rejection (ABMR) in ABO-incompatible (ABOi) transplantation patients is often challenging because patients without ABMR are frequently immunopositive for C4d. The aim of this study was to determine whether C4d positivity with microvascular inflammation (MVI), in the absence of any detectable donor-specific antibodies (DSAs) in ABOi patients, could be considered as ABMR. Methods: A retrospective study of... -
DOI: https://doi.org/10.23876/j.krcp.22.221 [Epub ahead of print]
- A collaborative model between dialysis clinics and a hospital center improves the quality of vascular access care and intervention for hemodialysis patients
- Chung-Kuan Wu, Yu-Wei Fang, Chia-Hsun Lin
- Received August 10, 2022 Accepted December 19, 2022
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Background: This study reports the outcomes of a collaborative program between dialysis clinics and a referral hospital, which consisted of clinical monitoring and supplementary routine surveillance, for improving the quality of vascular access care. Methods: This retrospective observational study was performed at five dialysis clinics as part of a 2-year collaborative program (2019–2020) in conjunction with a hospital-based dialysis access... -
DOI: https://doi.org/10.23876/j.krcp.22.175 [Epub ahead of print]
- Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease
- Ji Hye Kim, Minjung Kang, Eunjeong Kang, Hyunjin Ryu, Yujin Jeong, Jayoun Kim, Sue K. Park, Jong Cheol Jeong, Tae-Hyun Yoo, Yaeni Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Kook-Hwan Oh
- Received September 12, 2022 Accepted November 9, 2022
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Background: The 2009 Chronic Kidney Disease Epidemiology Collaboration creatinine-based estimated glomerular filtration rate (eGFRcr) equation contains a race component that is not based on biology and may cause a bias in results. Therefore, the 2021 eGFRcr and creatinine-cystatin C–based eGFR (eGFRcr-cysC) equations were developed with no consideration of race. This study compared the cardiovascular event (CVE) and all-cause mortality and... -
DOI: https://doi.org/10.23876/j.krcp.22.206 [Epub ahead of print]
- Vitamin D and narrowband ultraviolet B phototherapy for chronic kidney disease-associated pruritus
- Youn Kyung Kee, Hee Jung Jeon, Jieun Oh, Dong Ho Shin
- Received July 11, 2022 Accepted October 18, 2022
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Background: In addition to improving the serum vitamin D balance, narrowband ultraviolet B (NB-UVB) phototherapy can effectively treat chronic kidney disease-associated pruritus (CKD-aP). We investigated the degree of CKD-aP amelioration according to changes in the serum vitamin D level after NB-UVB phototherapy. Methods: This was a before–after clinical study in patients with refractory CKD-aP on hemodialysis. NB-UVB phototherapy was administered thrice... -
DOI: https://doi.org/10.23876/j.krcp.22.153 [Epub ahead of print]
- Validation of operational definitions of mortality in a nationwide hemodialysis population using the Health
Insurance Review and Assessment Service databases of Korea
- Dong Hee Lee, Ye-Jee Kim, Hyangkyoung Kim, Hyung Seok Lee
- Received April 13, 2022 Accepted September 9, 2022
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Background: Health Insurance Review and Assessment Service’s (HIRA) claims data have been used in studies of hemodialysis patients even though information about mortality is not provided in this database. Mortality analysis using HIRA data has been conducted using various operational definitions that have not been validated. This study aimed to validate operational definitions of mortality for maintenance hemodialysis patients that... -
DOI: https://doi.org/10.23876/j.krcp.22.077 [Epub ahead of print]
- Correspondence
- Acute pancreatitis after trimethoprim/sulfamethoxazole exposure during desensitization for kidney transplantation
- Hanbi Lee, Hyung Duk Kim, Chul Woo Yang, Sook Young Lee, Hwa Young Lee, Byung Ha Chung
- Received May 8, 2023 Accepted May 16, 2023
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DOI: https://doi.org/10.23876/j.krcp.23.112 [Epub ahead of print]
