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Editorial
January 31, 2023
- Deep learning outperforms kidney organoid experts
- Seyoung Yu, Heon Yung Gee
- Kidney Res Clin Pract. 2023;42(1):1-3.
- Review Articles
- How should we treat acute kidney injury caused by renal congestion?
- Masanori Abe, Seiichiro Hemmi, Hiroki Kobayashi
- Received September 30, 2022 Accepted October 29, 2022
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Decreased kidney function is associated with increased risk of cardiovascular events and mortality, and heart failure (HF) is a well-known risk factor for renal dysfunction. Acute kidney injury (AKI) in patients with HF often is attributed to prerenal factors, such as renal hypoperfusion and ischemia as a result of decreased cardiac output. Another such factor is reduction of absolute or... -
DOI: https://doi.org/10.23876/j.krcp.22.224 [Epub ahead of print]
- Histologic evaluation of activity and chronicity of lupus nephritis and its clinical significance
- Sung-Eun Choi, Agnes B. Fogo, Beom Jin Lim
- Received April 23, 2022 Accepted May 8, 2022
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The National Institutes of Health (NIH) lupus nephritis activity and chronicity indices, which comprise six activity scores and four chronicity scores, have a long development history. The 2018 revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification for lupus nephritis adopted the most recent NIH indices to replace subclasses A, C, and A/C. Although an evidence-based approach should further evaluate... -
DOI: https://doi.org/10.23876/j.krcp.22.083 [Epub ahead of print]
- Recent advances in electron microscopy for the diagnosis and research of glomerular diseases
- Kazuho Honda, Takashi Takaki, Dedong Kang
- Received November 19, 2021 Accepted December 26, 2021
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Recent technical advances in the detection of backscattered electrons during scanning electron microscopy (SEM) have improved resolution and have provided several new technologies for research and clinical practice in kidney disease. The advances include three-dimensional (3D) electron microscopy (3D-EM), correlative light and electron microscopy (CLEM), low-vacuum SEM (LVSEM), and scanning transmission electron microscopy (STEM). 3D-EM analysis used to be laborious,... -
DOI: https://doi.org/10.23876/j.krcp.21.270 [Epub ahead of print]
- Original Articles
- Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease
- Ji Hye Kim, Minjung Kang, Eunjeong Kang, Hyunjin Ryu, Yujin Jeong, Jayoun Kim, Sue K. Park, Jong Cheol Jeong, Tae-Hyun Yoo, Yaeni Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Kook-Hwan Oh
- Received September 12, 2022 Accepted November 9, 2022
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Background: The 2009 Chronic Kidney Disease Epidemiology Collaboration creatinine-based estimated glomerular filtration rate (eGFRcr) equation contains a race component that is not based on biology and may cause a bias in results. Therefore, the 2021 eGFRcr and creatinine-cystatin C–based eGFR (eGFRcr-cysC) equations were developed with no consideration of race. This study compared the cardiovascular event (CVE) and all-cause mortality and... -
DOI: https://doi.org/10.23876/j.krcp.22.206 [Epub ahead of print]
- Predictive performance of the new race-free Chronic Kidney Disease Epidemiology Collaboration equations for kidney outcome in Korean patients with chronic kidney disease
- Hyoungnae Kim, Young Youl Hyun, Hae-Ryong Yun, Young Su Joo, Yaeni Kim, Ji Yong Jung, Jong Cheol Jeong, Jayoun Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Kook-Hwan Oh, Seung Hyeok Han
- Received July 18, 2022 Accepted September 25, 2022
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Background: The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations without a race coefficient have gained recognition across the United States. We aimed to test whether these new equations performed well in Korean patients with chronic kidney disease (CKD). Methods: This study included 2,149 patients with CKD G1–G5 without kidney replacement therapy from the Korean Cohort Study for Outcome in Patients... -
DOI: https://doi.org/10.23876/j.krcp.22.158 [Epub ahead of print]
- Vitamin D and narrowband ultraviolet B phototherapy for chronic kidney disease-associated pruritus
- Youn Kyung Kee, Hee Jung Jeon, Jieun Oh, Dong Ho Shin
- Received July 11, 2022 Accepted October 18, 2022
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Background: In addition to improving the serum vitamin D balance, narrowband ultraviolet B (NB-UVB) phototherapy can effectively treat chronic kidney disease-associated pruritus (CKD-aP). We investigated the degree of CKD-aP amelioration according to changes in the serum vitamin D level after NB-UVB phototherapy. Methods: This was a before–after clinical study in patients with refractory CKD-aP on hemodialysis. NB-UVB phototherapy was administered thrice... -
DOI: https://doi.org/10.23876/j.krcp.22.153 [Epub ahead of print]
- Sex disparity in dialysis and kidney transplantation over 20 years in Korea
- Miyeun Han, Jong Cheol Jeong, Yun Yung Cho, Curie Ahn, Yeong Hoon Kim
- Received July 4, 2022 Accepted November 1, 2022
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Background: Sex disparity is prevalent in organ transplantations worldwide. This study aimed to understand sex disparities in dialysis and kidney transplantation in Korea over the last 20 years. Methods: Data for incident dialysis, waiting list registration, and donors and recipients were retrospectively collected between January 2000 and December 2020 from the Korean Society of Nephrology end-stage renal disease registry and the... -
DOI: https://doi.org/10.23876/j.krcp.22.138 [Epub ahead of print]
- Dialysis specialist care and patient survival in hemodialysis facilities: a Korean nationwide cohort study
- Hayne Cho Park, Do Hyoung Kim, Ajin Cho, Young Eun Kwon, Dong-Ryeol Ryu, Jinseog Kim, Ki Hwa Yang, Ji Hyeon Shin, Eun Jung Son, Young-Ki Lee
- Received May 18, 2022 Accepted August 11, 2022
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Background: It is important for the dialysis specialist to provide essential and safe care to hemodialysis (HD) patients. However, little is known about the actual effect of dialysis specialist care on the survival of HD patients. We therefore investigated the influence of dialysis specialist care on patient mortality in a nationwide Korean dialysis cohort. Methods: We used an HD quality assessment... -
DOI: https://doi.org/10.23876/j.krcp.22.103 [Epub ahead of print]
- Risk of ventricular tachycardia and its outcomes in patients undergoing continuous renal replacement therapy due to acute kidney injury
- Seong Geun Kim, Donghwan Yun, Jayoun Kim, Jinwoo Lee, Min Woo Kang, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Hoseok Koo, Yon Su Kim, Seung Seok Han
- Received May 15, 2022 Accepted August 3, 2022
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Background: Despite efforts to treat critically ill patients who require continuous renal replacement therapy (CRRT) due to acute kidney injury (AKI), their mortality risk remains high. This condition may be attributable to complications of CRRT, such as arrhythmias. Here, we addressed the occurrence of ventricular tachycardia (VT) during CRRT and its relationship with patient outcomes. Methods: This study retrospectively enrolled... -
DOI: https://doi.org/10.23876/j.krcp.22.101 [Epub ahead of print]
- The flavonoid fisetin ameliorates renal fibrosis by inhibiting SMAD3 phosphorylation, oxidative damage, and inflammation in ureteral obstructed kidney in mice
- Ha Young Ju, Jongwan Kim, Sang Jun Han
- Received February 15, 2022 Accepted June 28, 2022
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Background: Renal fibrosis is characterized by the accumulation of extracellular matrix and inflammatory cells and kidney dysfunction, which is a major pathway in the progression of chronic kidney disease (CKD). Accumulating evidence indicates that oxidative stress plays a critical role in the initiation and progression of CKD via proinflammatory and profibrotic signaling pathways. Fisetin (3,3′,4′,7-tetrahydroxyflavone) has biological activities including antioxidant,... -
DOI: https://doi.org/10.23876/j.krcp.22.034 [Epub ahead of print]
- Diminazene aceturate exacerbates renal fibrosis after unilateral ureteral obstruction in female mice
- Yosep Kim, Jongwan Kim, Sang Jun Han
- Received February 15, 2022 Accepted June 7, 2022
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Background: Diminazene aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, exerts anti-inflammatory and antifibrotic effects in a variety of human chronic diseases. However, the role of DIZE in kidney fibrosis and the underlying mechanism remain unclear. Therefore, we investigated the effects of DIZE on the progression of renal fibrosis after unilateral ureteral obstruction (UUO), a well-established model of chronic kidney... -
DOI: https://doi.org/10.23876/j.krcp.22.033 [Epub ahead of print]
- Association between urinary chloride excretion and progression of coronary artery calcification in patients with nondialysis chronic kidney disease: results from the KNOW-CKD study
- Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Tae-Hyun Yoo, Dong-Wan Chae, Soo Wan Kim
- Received April 10, 2022 Accepted May 19, 2022
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Background: Urine chloride has recently been suggested as a biomarker of renal tubule function in patients with nondialysis chronic kidney disease (CKD), as low urinary chloride concentration is associated with an increased risk of CKD progression. We investigate the association between urinary chloride excretion and the progression of coronary artery calcification (CAC). Methods: A total of 1,065 patients with nondialysis... -
DOI: https://doi.org/10.23876/j.krcp.22.072 [Epub ahead of print]
- Validation of operational definitions of mortality in a nationwide hemodialysis population using the Health
Insurance Review and Assessment Service databases of Korea
- Dong Hee Lee, Ye-Jee Kim, Hyangkyoung Kim, Hyung Seok Lee
- Received April 13, 2022 Accepted September 9, 2022
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Background: Health Insurance Review and Assessment Service’s (HIRA) claims data have been used in studies of hemodialysis patients even though information about mortality is not provided in this database. Mortality analysis using HIRA data has been conducted using various operational definitions that have not been validated. This study aimed to validate operational definitions of mortality for maintenance hemodialysis patients that... -
DOI: https://doi.org/10.23876/j.krcp.22.077 [Epub ahead of print]
- Evaluating the Safety and effectivenesS in adult KorEaN patients treated with Tolvaptan for management of autosomal domInAnt poLycystic kidney disease (ESSENTIAL): short-term outcomes during the titration period
- Hyuk Huh, Yong Soo Kim, Wookyung Chung, Yong Lim Kim, Yaerim Kim, Seungyeup Han, Yeonsoon Jung, Ki Young Na, Kyu Beck Lee, Yun Kyu Oh, Hyeong Cheon Park, Seung Hyeok Han, Tae Hyun Yoo, Yeong Hoon Kim, Soo Wan Kim, Kang Wook Lee, Hayne Cho Park, Sung Gyun Kim, Hyunsuk Kim, Chang Hwa Lee, Kyongtae T. Bae, Kook Hwan Oh, Curie Ahn, Hyun Jin Ryu, Yong Chul Kim
- Received February 3, 2022 Accepted May 30, 2022
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Background: Tolvaptan reduces height-adjusted total kidney volume (htTKV) and renal function decline in autosomal dominant polycystic kidney disease (ADPKD). This study was aimed at investigating the efficacy and safety of tolvaptan in Korean patients with ADPKD during the titration period. Methods: This study is a multicenter, single-arm, open-label phase 4 study. We enrolled 108 patients with ADPKD (age, 19–50 years)... -
DOI: https://doi.org/10.23876/j.krcp.22.024 [Epub ahead of print]
- Serum calcification propensity and its association with biochemical parameters and bone mineral density in hemodialysis patients
- Hyunsook Kim, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Wookyung Chung, Ji Yong Jung
- Received March 29, 2022 Accepted June 3, 2022
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Background: T50 is a novel serum-based marker that assesses the propensity for calcification in serum. A shorter T50 indicates a greater propensity to calcify and has been associated with cardiovascular disease and mortality among patients with chronic kidney disease. The factors associated with T50 and the correlation between T50 and bone mineral density (BMD) are unknown in hemodialysis (HD) patients.... -
DOI: https://doi.org/10.23876/j.krcp.22.059 [Epub ahead of print]
