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Editorial
March 19, 2025
- Identifying the optimal blood pressure target among Korean hemodialysis patients: current evidence and future directions
- Young Su Joo, Tae-Hyun Yoo
- Kidney Res Clin Pract. 2025;44(2):213-216.
- Special Article
- Novel insights and practical strategies for health professionals to improve the uptake of plant-based diets in people with chronic kidney disease
- Kelly Lambert, Vanessa Cullen, Brian Jones, Amy McAlpine, Brad Rossiter
- Received October 28, 2024 Accepted December 13, 2024
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There has been a significant shift in dietary guidance in the past 5 years for people with chronic kidney disease. Multiple best practice guidelines in nephrology now include nutritional guidance that recommends the adoption of healthy dietary patterns with an emphasis on whole foods and diets with adequate fruit, vegetables, legumes, nuts, wholegrain bread and cereals, with minimal amounts of... -
DOI: https://doi.org/10.23876/j.krcp.24.272 [Epub ahead of print]
- Study Protocols
- Study protocol for a consortium linking health medical records, biospecimens, and biosignals in Korean patients with acute kidney injury (LINKA cohort)
- Donghwan Yun, Seung Seok Han, Jeonghwan Lee, Yaerim Kim, Kwangsoo Kim, Kyubok Jin, Ji Eun Kim, Shin Young Ahn, Gang-Jee Ko, Seokwoo Park, Sejoong Kim, Hee-Yeon Jung, Jang-Hee Cho, Sun-Hee Park, Eun Sil Koh, Sungjin Chung, Jung Pyo Lee, Dong Ki Kim, Sung Gyun Kim, Jung Nam An
- Received March 2, 2024 Accepted June 28, 2024
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Background: Acute kidney injury (AKI) may transition into acute kidney disease (AKD) or chronic kidney disease (CKD), leading to subacute and chronic deterioration, respectively. Despite extensive research on AKI, a significant gap exists in understanding the specific biomarkers and development of individualized treatments prior to progression to AKD and CKD. Methods: As a consortium linking health medical records, biospecimens, and biosignals,... -
DOI: https://doi.org/10.23876/j.krcp.24.061 [Epub ahead of print]
- A Pragmatic Randomized clinical trial: twice-weekly vs. thrice-weekly Incident hemoDialysis in Elderly patients (PRIDE): study protocol
- Miyeun Han, Huiwon Jeon, Byung Chul Yu, Sang Heon Song, Sungjin Chung, Chiyeon Lim, Hojoon Sohn, Jin-Won Noh, Soon Hyo Kwon
- Received June 30, 2023 Accepted September 24, 2023
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Background: The optimal frequency for hemodialysis in older adults with end-stage kidney disease (ESKD) has not been established. This study aims to investigate whether a twice-weekly dialysis schedule using an incremental approach can reduce hospitalization rates in the elderly with incident dialysis, compared with conventional thrice-weekly dialysis. Methods: We have designed a pragmatic randomized controlled trial to compare the effects... -
DOI: https://doi.org/10.23876/j.krcp.23.177 [Epub ahead of print]
- Review Articles
- Protein-energy wasting in chronic kidney disease: mechanisms responsible for loss of muscle mass and function
- S. Russ Price, Xiaonan H. Wang
- Received August 20, 2024 Accepted October 7, 2024
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The worldwide prevalence of chronic kidney disease (CKD) is high and growing, making CKD a leading cause of mortality. Skeletal muscle wasting, sometimes called sarcopenia or protein-energy wasting, is a frequent, serious consequence of CKD that reduces muscle strength and function, diminishes the quality of life of patients, and raises their risk of comorbidities and death. Muscle atrophy results from... -
DOI: https://doi.org/10.23876/j.krcp.24.214 [Epub ahead of print]
- Pathophysiology and potential treatment of uremic sarcopenia
- Shao-Yu Yang, Jia-Huang Chen, Chih-Kang Chiang, Kuan-Yu Hung
- Received July 8, 2024 Accepted October 27, 2024
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Sarcopenia, commonly found in the elderly and characterized by the loss of skeletal muscle mass, decreased muscle strength, and reduced physical performance, draws attention because it often leads to frailty, an increased risk of falls and fractures, and higher morbidity and mortality. Patients with chronic kidney disease (CKD) usually suffer from malnutrition, physical inactivity, inflammation, metabolic acidosis, insulin resistance, and... -
DOI: https://doi.org/10.23876/j.krcp.24.176 [Epub ahead of print]
- Renal fibrosis: research progress on mechanisms and therapeutic strategies
- Cheng-Xiao Yin, Jia-Rui Fan, Xiao-Gang Du
- Received June 19, 2024 Accepted October 27, 2024
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Renal fibrosis (RF) is a prevalent clinical symptom of numerous chronic kidney illnesses and a significant pathological alteration in end-stage renal disease resulting from various mechanisms, such as abnormally activated signaling pathways, microRNAs, aging, autophagy disorders, and fibrotic ecological niches, all of which contribute to RF development. Inhibiting, blocking, or delaying the aforementioned mechanisms may yield novel approaches for treating... -
DOI: https://doi.org/10.23876/j.krcp.24.158 [Epub ahead of print]
- Sarcopenia, sarcopenic obesity, and frailty in individuals with chronic kidney disease: a comprehensive review
- Chia-Ter Chao, Csaba P. Kovesdy, Reshma Aziz Merchant
- Received August 17, 2024 Accepted October 27, 2024
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Population aging is a global challenge that increases the burden of chronic kidney disease (CKD) and geriatric syndromes such as sarcopenia, sarcopenic obesity, and frailty. These conditions affect almost half of older CKD individuals and are associated with poor outcomes, including CKD progression, cardiometabolic complications, increased health and social care costs, and mortality. They can be both the cause and... -
DOI: https://doi.org/10.23876/j.krcp.24.207 [Epub ahead of print]
- The role of extracellular vesicles in kidney disease progression
- Ran Kim, Tae Min Kim
- Received July 29, 2024 Accepted October 20, 2024
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Extracellular vesicles (EVs) are nanosized membranous particles released by nearly all cell types, playing a crucial role in mediating cell-to-cell communication. The molecular profile of EVs often reflects that of their originating cells, rendering them valuable for therapeutic and diagnostic purposes. The kidney comprises various cell types, and urinary EVs are predominantly produced from tubular, glomerular, and urinary bladder cells.... -
DOI: https://doi.org/10.23876/j.krcp.24.201 [Epub ahead of print]
- Alport syndrome and eye
- Yeonji Jang, Jae Ho Jung
- Received March 20, 2024 Accepted August 26, 2024
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Alport syndrome, characterized by renal failure, hearing loss, and ocular abnormalities due to collagen type IV gene mutations, exhibits distinctive ocular manifestations in the various ocular tissues including the cornea, lens, and retina. Ophthalmological examinations, providing noninvasive visibility of basement membrane anomalies caused by collagen type IV mutations, can have a role in Alport syndrome diagnostics. Lenticonus, macular fleck, and... -
DOI: https://doi.org/10.23876/j.krcp.24.080 [Epub ahead of print]
- Renal transplantation in Alport syndrome
- Soyeon Kim, Soon Hyo Kwon
- Received June 4, 2024 Accepted August 26, 2024
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Kidney transplantation is recognized as an effective treatment for end-stage renal disease in Alport syndrome, demonstrating outcomes comparable to or even superior to those in other causes of renal failure. When considering living related donor kidney transplantation for Alport syndrome patients, it is crucial to consider genetic factors during the donor selection process. In addition to a comprehensive health check,... -
DOI: https://doi.org/10.23876/j.krcp.24.143 [Epub ahead of print]
- A comprehensive review of Alport syndrome: definition, pathophysiology, clinical manifestations, and diagnostic considerations
- Eunjeong Kang, Byung Hwa Park, Hajeong Lee, Hee Gyung Kang, Ji Hyun Kim, Ye Na Kim, Yeonsoon Jung, Hark Rim, Ho Sik Shin
- Received March 12, 2024 Accepted July 22, 2024
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Alport syndrome, a rare genetic disorder affecting around 1 in 50,000 individuals, primarily presents as microscopic hematuria and chronic kidney disease (CKD) with associated extrarenal complications. The Alport syndrome results from mutations in COL4A3, COL4A4, and COL4A5 genes, disrupting the formation of the α3–α4–α5 chain in the collagen IV network. The etiology involves X chromosome-related, autosomal dominant, autosomal recessive, and... -
DOI: https://doi.org/10.23876/j.krcp.24.065 [Epub ahead of print]
- Donor-derived cell-free DNA-based liquid biopsies to determine future kidney transplant rejection
- Weiwei Wang, Cuello Garcia Haider, Yinfeng Wang, Zhoufan Zhang, Yuelin Liu, Fengcheng Xue, Haitao Liu, Tingya Jiang, Jingyi Cao, Yang Zhou
- Received November 8, 2023 Accepted June 4, 2024
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Donor-derived cell-free DNA (dd-cfDNA) based liquid kidney biopsies have the potential to detect the chances of kidney transplant rejection. Several studies have found that dd-cfDNA can be used to determine the risk of kidney transplant rejection and may correlate with antibody-mediated rejection (ABMR), T cell-mediated rejection (TCMR), and estimated glomerular filtration rate (eGFR). A high concentration of dd-cfDNA in the... -
DOI: https://doi.org/10.23876/j.krcp.23.286 [Epub ahead of print]
- The burden of chronic kidney disease in Asia region: a review of the evidence, current challenges, and future directions
- Afiatin Makmun, Bancha Satirapoj, Do Gia Tuyen, Marjorie W. Y. Foo, Romina Danguilan, Sanjeev Gulati, Sejoong Kim, Sunita Bavanandan, Yi-Wen Chiu, Sydney C.W. Tang
- Received July 28, 2023 Accepted May 7, 2024
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The disease burden of chronic kidney disease (CKD) and its impact on healthcare systems has been poorly studied in Asia, a socioeconomically diverse region with wide variations in availability, access, and quality of CKD care. The high CKD burden in this region is predominantly driven by an increased prevalence of risk factors including diabetes mellitus, hypertension, obesity, and use of... -
DOI: https://doi.org/10.23876/j.krcp.23.194 [Epub ahead of print]
- Pathological diagnosis of Alport syndrome
- Kyoung Bun Lee, Minsun Jung, Beom Jin Lim
- Received March 6, 2024 Accepted April 15, 2024
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Alport syndrome (AS) is a hereditary nephritis characterized by structural abnormalities in the glomerular basement membrane resulting from pathogenic variants in the COL4A3, COL4A4, and COL4A5 genes. Conventional pathological evaluations reveal nonspecific light microscopic changes and diagnostic clues can be obtained through electron microscopy. Type IV collagen staining elucidates distinct patterns based on AS inheritance, aiding in subtype classification. However,... -
DOI: https://doi.org/10.23876/j.krcp.24.063 [Epub ahead of print]
- Original Articles
- Referral to nephrologists is associated with the slow progression of kidney dysfunction in patients with type 2 diabetes mellitus
- Donghwan Yun, Sohyun Bae, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seung Seok Han
- Received August 26, 2024 Accepted December 9, 2024
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Background: Although treatment guidelines exist, referrals and discussions among clinicians about the disease can lead to more appropriate treatment for the patient. This study evaluated the effects of referrals from diabetes clinics to nephrologists on kidney function in type 2 diabetic patients through causal inference analysis. Methods: This study included patients with type 2 diabetes who initially visited the diabetes clinic... -
DOI: https://doi.org/10.23876/j.krcp.24.217 [Epub ahead of print]
- Quality of life, socioeconomic impact, and medical consideration of living kidney donors: a comprehensive survey in Korea
- Eunjeong Kang, Yaerim Kim, Jang Wook Lee, Seungyeup Han, Hyeong Dong Yuk, Chang Wook Jeong, Ahram Han, Sangil Min, Sehoon Park, Yong Chul Kim, Yon Su Kim, Jongwon Ha, Hajeong Lee
- Received July 15, 2024 Accepted November 8, 2024
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Background: South Korea stands out as a prominent nation relying heavily on living-donor transplants, with a high incidence of living-donor kidney transplants. This study aimed to obtain objective data on the psychological, social, and mental health status of living kidney donors in South Korea. Methods: A questionnaire was administered to living kidney donors at two tertiary hospitals between June 2020 and... -
DOI: https://doi.org/10.23876/j.krcp.24.191 [Epub ahead of print]
- A novel approach to the relation of multi-pollutant effect and kidney dysfunction: data analysis from the Korean National Environmental Health Survey Cycle 3 (2015–2017)
- Inae Lee, Junhyug Noh, Yaerim Kim, Jung Nam An, Jae Yoon Park, Yong Chul Kim, Jeonghwan Lee, Jung Pyo Lee, Jong Soo Lee, Kyungho Choi, Kyung Don Yoo
- Received July 1, 2024 Accepted December 23, 2024
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Background: Traditional statistical models for estimating the impact of multiple environmental chemicals on kidney outcomes have limitations. This study aimed to evaluate the risk prediction of kidney disease in the general population using innovative methodologies. Methods: Serum persistent organic pollutant (POP), urinary chemical, serum creatinine, and urinary albumin levels were measured in a subpopulation of adults (n = 1,266) drawn from... -
DOI: https://doi.org/10.23876/j.krcp.24.173 [Epub ahead of print]
- Clinical outcomes of bortezomib-based desensitization in highly sensitized living and deceased donor kidney transplantation
- Hyeran Park, Hanbi Lee, Sang Hun Eum, Ji-Won Min, Hye Eun Yoon, Eun-Jee Oh, Chul Woo Yang, Byung Ha Chung
- Received March 19, 2024 Accepted May 20, 2024
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Background: Sensitization acts as an immunological barrier to successful kidney transplantation (KT). We aim to investigate the efficacy and safety of bortezomib-based desensitization (BOZ-DSZ) in both highly sensitized living donor KT (LDKT) and deceased donor KT (DDKT). Methods: We applied BOZ-DSZ to 20 highly sensitized patients—14 LDKT and six DDKT candidates—and analyzed the change in anti-human leukocyte antigen (HLA) antibody,... -
DOI: https://doi.org/10.23876/j.krcp.24.077 [Epub ahead of print]
- Emergency department visits for patients with end-stage kidney disease in Korea: registry data from the National Emergency Department Information System 2019–2021
- AJin Cho, Seon A Jeong, Hayne Cho Park, Hye Eun Yoon, Jungeon Kim, Young-Ki Lee, Kyung Don Yoo
- Received June 27, 2024 Accepted November 29, 2024
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Background: Patients with end-stage kidney disease (ESKD) frequently visit the emergency department (ED) due to complications from comorbidities and dialysis. This study aimed to investigate the clinical outcomes and patterns of ED visits, hospitalizations, and in-hospital mortality among ED visits by ESKD patients in South Korea. Methods: This study utilized data from the National Emergency Department Information System from 2019... -
DOI: https://doi.org/10.23876/j.krcp.24.170 [Epub ahead of print]
- Microstructural and functional connectivity changes of decision-related brain networks in end-stage kidney disease patients undergoing peritoneal dialysis
- Jingjing Yin, Dongxue Luo, Shuhua Ma, Chudan Cai, Xiaoyan Shi, Yanqiang Peng, Jianwei Peng, Lingyu Chen, Yanmin Zheng, Ruiwei Guo, Zelin Zhuang, Zhirong Lin, Lei Xie
- Received May 27, 2024 Accepted October 16, 2024
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Background: We aimed to explore changes in decision-related brain microstructure, brain functional activities, and functional connectivity, and their correlations with cognitive function in end-stage kidney disease (ESKD) patients undergoing peritoneal dialysis (PD). Furthermore, the impact of dialysis on these changes was examined. Methods: Thirty ESKD patients undergoing PD, 20 chronic kidney disease (CKD) stage 5 patients without dialysis (predialysis CKD... -
DOI: https://doi.org/10.23876/j.krcp.24.146 [Epub ahead of print]
- Methylcrotonyl-CoA carboxylase 2 supports leucine catabolism to promote mitochondrial biogenesis and alleviate cisplatin-induced acute kidney injury
- Hu Li, Kangqiang Weng, Hao Qi, Huiyue Qi, Linlu She, Junliang Qiu, Yingbo Dai
- Received June 26, 2024 Accepted September 16, 2024
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Background: Cisplatin is widely used in clinical practice, but its nephrotoxicity severely limits its use. Previous studies have shown that cisplatin-induced acute kidney injury (AKI) is closely related to mitochondrial damage and that alleviating mitochondrial dysfunction can alleviate cisplatin-induced AKI. Methylcrotonyl‑CoA carboxylase 2 (MCCC2) is mainly located in mitochondria, where it catalyzes the catabolism of leucine and maintains mitochondrial function;... -
DOI: https://doi.org/10.23876/j.krcp.24.169 [Epub ahead of print]
- Validation of an acute kidney injury prediction model as a clinical decision support system
- Giae Yun, Jinyeong Yi, Sangyub Han, Jihyeon Seong, Enver Menadjiev, Hyunkyung Han, Jaesik Choi, Ji Hyun Kim, Sejoong Kim
- Received June 21, 2024 Accepted October 21, 2024
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Background: Acute kidney injury (AKI) is a critical clinical condition that requires immediate intervention. We developed an artificial intelligence (AI) model called PRIME Solution to predict AKI and evaluated its ability to enhance clinicians’ predictions. Methods: The PRIME Solution was developed using convolutional neural networks with residual blocks on 183,221 inpatient admissions from a tertiary hospital (2013−2017) and externally validated with... -
DOI: https://doi.org/10.23876/j.krcp.24.163 [Epub ahead of print]
- Safety of direct oral anticoagulants in hemodialysis patients with venous thromboembolism: an analysis using the Korean National Health Insurance Service database
- Hyejin Mo, Hyangkyoung Kim, Seung Boo Yang, Young joo Kwon
- Received April 4, 2024 Accepted October 27, 2024
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Background: Limited data exist regarding the safety of direct oral anticoagulants in hemodialysis patients with venous thromboembolic disease. This study aims to investigate the safety of direct oral anticoagulants in hemodialysis patients using national data. Methods: The National Health Insurance Service database was retrospectively queried to identify chronic kidney disease patients who took direct oral anticoagulants for venous thromboembolism from 2008... -
DOI: https://doi.org/10.23876/j.krcp.24.093 [Epub ahead of print]
- Association between obstructive sleep apnea and albuminuria in Korean adults: a nationwide populationbased study
- Yeojin Yu, Kyungdo Han, Kyu-na Lee, Jung Hun Koh, Young Sun Shin, Jeong Min Cho, Minsang Kim, Min Woo Kang, Seong Geun Kim, Sehyun Jung, Semin Cho, Hyuk Huh, Eunjeong Kang, Sehoon Park, Yaerim Kim, Kwon Wook Joo, Dong Ki Kim, Soojin Lee
- Received June 10, 2024 Accepted October 18, 2024
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Background: Obstructive sleep apnea (OSA) is a sleep disorder associated with an increased risk of cardiovascular and metabolic complications. Albuminuria, an early marker of kidney damage, is a proposed risk factor for OSA and its adverse outcomes. The study explored the association between OSA and albuminuria in Korean adults. Methods: We screened participants from the cross-sectional Korean National Health and... -
DOI: https://doi.org/10.23876/j.krcp.24.159 [Epub ahead of print]
- Clinical features and outcomes of immune complex-membranoproliferative glomerulonephritis and C3 glomerulopathy: a multicenter observational cohort study analyzing kidney biopsy cases
- SungYeon Kim, Young Eun Choi, Sung Gyun Kim, Dong-Ryeol Ryu, Sun-Hee Park, Tai Yeon Koo, Myung-Gyu Kim, Sang Kyung Jo, Se Won Oh
- Received May 12, 2024 Accepted September 20, 2024
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Background: Membranoproliferative glomerulonephritis (MPGN) has two subtypes based on immunofluorescence findings: complement 3 glomerulopathy (C3G) and immune complex-mediated MPGN (IC-MPGN). This study investigated the characteristics and prognosis of patients with MPGN. Methods: This retrospective study analyzed data from 18 hospitals between 1979 and 2018. Among 21,697 patients, 620 were diagnosed with MPGN, 570 with IC-MPGN, and 50 with C3G. Results: The C3G... -
DOI: https://doi.org/10.23876/j.krcp.24.129 [Epub ahead of print]
- Interobserver agreement analysis among renal pathologists in classification of lupus nephritis using a digital pathology image dataset: after a third evaluation
- Ju Yeon Pyo, Nara Jeon, Su-Jin Shin, Minsun Jung, Beom Jin Lim, Minseob Eom, Sung-Eun Choi
- Received July 11, 2024 Accepted October 11, 2024
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Background: Lupus nephritis is well-known for low concordance in classification. Furthermore, there has been no agreement analysis among Korean renal pathologists regarding lupus nephritis. Inconsistent diagnosis leads to confusion and increases medical costs, as well as failure of appropriate therapeutic interventions. This study aimed to assess the level of agreement among Korean renal pathologists regarding classification. Methods: Representative glomerular images... -
DOI: https://doi.org/10.23876/j.krcp.24.185 [Epub ahead of print]
- The importance of kidney response over hematologic response in predicting kidney outcome in amyloid light-chain amyloidosis
- Sungmi Kim, Jinyoung Yang, Kyungho Lee, Junseok Jeon, Sang Eun Yoon, Darae Kim, Jin-Oh Choi, Seok Jin Kim, Kihyun Kim, Jung Eun Lee
- Received April 15, 2024 Accepted October 9, 2024
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Background: Light chain amyloidosis, characterized by amyloid fibril deposition in multiple organs, often leads to progression to endstage kidney disease. This study aimed to identify predictors of kidney survival in patients with kidney amyloidosis, focusing on hematologic and kidney response. Methods: This retrospective study included 138 patients diagnosed with kidney amyloidosis between 2011 and 2019. Palladini criteria were applied to... -
DOI: https://doi.org/10.23876/j.krcp.24.111 [Epub ahead of print]
- Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series
- So Hyun Ki, Min Hwa Son, Hyung Eun Yim
- Received July 10, 2024 Accepted September 25, 2024
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Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions. Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed. NCS was diagnosed with renal Doppler ultrasonography, abdominal computed tomography,... -
DOI: https://doi.org/10.23876/j.krcp.24.178 [Epub ahead of print]
- Characteristics of glomerulonephritis with dominant C1q precipitation compared to corresponding glomerulonephritis without C1q staining on immunofluorescent examination
- Ji Young Ryu, Giae Yun, Eun-jeong Kwon, Hyung Eun Son, Kipyo Kim, Sang-Ho Lee, Kyung Pyo Kang, Young-Joo Kwon, Ho Jun Chin
- Received September 19, 2023 Accepted July 14, 2024
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Background: The clinical significance and renal outcomes of C1q nephropathy (C1qN) are unclear; therefore, the implications of C1qN as a new pathological entity are uncertain. We compared the clinical characteristics of glomerulonephritis reclassified into cases that meet the definition of C1qN and glomerulonephritis not included in the definition of C1qN. Methods: In total, 21,697 patients who underwent native kidney biopsy... -
DOI: https://doi.org/10.23876/j.krcp.23.238 [Epub ahead of print]
- Effectiveness and safety of denosumab on osteoporosis treatment in kidney transplant recipients
- Jin Kyung Kwon, Yaerim Kim, Jin Hyuk Paek, Kyubok Jin, Seungyeup Han, Woo Yeong Park
- Received June 26, 2024 Accepted September 17, 2024
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Background: Denosumab has been reported to improve bone mineral density (BMD), but the clinical impact of denosumab on osteoporosis in kidney transplant recipients (KTRs) remains controversial. Methods: We analyzed 98 KTRs who used denosumab from 2018 to 2023. We investigated the change in BMD, laboratory findings, complications of denosumab, fracture risk assessment tool (FRAX) score, acute rejection within 1 year, and... -
DOI: https://doi.org/10.23876/j.krcp.24.168 [Epub ahead of print]
- Circulating osteoprotegerin and progression of coronary artery calcification in patients with chronic kidney disease: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD)
- Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Tae-Hyun Yoo, Soo Wan Kim
- Received February 7, 2024 Accepted August 29, 2024
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Background: Coronary artery calcification (CAC) is a surrogate of cardiovascular events in patients with chronic kidney disease (CKD). To establish the role of circulating osteoprotegerin (OPG) as a cardiovascular biomarker in patients with CKD, we investigated whether an increase in serum OPG levels is associated with the risk of CAC progression. Methods: A total of 1,130 patients with CKD stage... -
DOI: https://doi.org/10.23876/j.krcp.24.039 [Epub ahead of print]
- Hearing loss phenotypes in Alport syndrome: experience in a tertiary referral center
- Sang-Yoon Han, Myung-Whan Suh, Moo Kyun Park, Jun Ho Lee, Hee Gyung Kang, Sang-Yeon Lee
- Received April 2, 2024 Accepted August 19, 2024
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Background: Despite previous reports of auditory phenotypes in Alport syndrome (AS), there have been no studies specifically addressing audiological phenotypes in South Korea. Herein, we elaborated on the audiological characteristics associated with AS based on their genotypes. Methods: We reviewed data from in-house AS patients between March 2014 and February 2023, excluding those without audiological documentation or genetic diagnoses. We... -
DOI: https://doi.org/10.23876/j.krcp.24.091 [Epub ahead of print]
- Effects of dietary fatty acid on all-cause mortality according to the kidney function based on the nationwide population study
- Yaerim Kim, Kyungho Ha, Jeonghwan Lee, Eunjin Bae, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Dong Ki Kim, Chun Soo Lim, Jung Pyo Lee
- Received May 6, 2024 Accepted August 2, 2024
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Background: Although the relationship between fatty acids (FAs) and the risk of all-cause mortality has been long discussed, there is little evidence about the impact of each FA component on all-cause mortality by kidney function status. Methods: We used data from the U.S. National Health and Nutrition Examination Survey 1999–2016. The intake of FAs was estimated as a percentage of... -
DOI: https://doi.org/10.23876/j.krcp.24.121 [Epub ahead of print]
- Risk of cardiovascular events following hemodialysis initiation: a self-controlled case series study
- Minyoul Baik, Jimin Jeon, Joonsang Yoo, Hyo Suk Nam, Ji Hoe Heo, Jinkwon Kim, Young Dae Kim
- Received April 9, 2024 Accepted July 23, 2024
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Background: Patients with chronic kidney disease (CKD) are at high risk for cardiovascular disease (CVD). We aimed to evaluate whether hemodialysis (HD) initiation is associated with CVD risk in patients with CKD. Methods: This self-controlled case series, using data from a nationwide Korean health claims database, included patients with CKD who initiated HD between 2007 and 2019 and experienced CVD,... -
DOI: https://doi.org/10.23876/j.krcp.24.097 [Epub ahead of print]
- Comparison of clinical outcomes based on dialysis modality and icodextrin usage in patients on peritoneal dialysis
- Seok Hui Kang, Jun Young Do
- Received January 5, 2024 Accepted July 8, 2024
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Background: There is no conclusive evidence regarding the survival benefits of automated peritoneal dialysis (APD) or the use of icodextrin. This study aimed to evaluate patient and technique survival among four groups divided based on peritoneal dialysis modality and icodextrin use over 1 year. Methods: We specifically included patients who underwent a single peritoneal dialysis modality for at least 1 year... -
DOI: https://doi.org/10.23876/j.krcp.24.017 [Epub ahead of print]
- Blood osteoprotegerin is associated with arteriovenous access thrombosis in hemodialysis patients
- Tung-Ling Chung, Yi-Hsueh Liu, Pei-Yu Wu, Jiun-Chi Huang, Yi-Chun Tsai, Ya-Ling Hsu, Mei-Chuan Kuo, Yi-Wen Chiu, Ping-Hsun Wu, Szu-Chia Chen
- Received June 3, 2024 Accepted July 21, 2024
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Background: A functioning arteriovenous (AV) access is essential for hemodialysis efficiency and the quality of life in hemodialysis patients. Blood osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappa B ligand (RANKL) have been linked to cardiovascular diseases and vascular calcification. This study investigated the relationship between blood OPG, RANKL, and the occurrence of AV access thrombosis. Methods: This... -
DOI: https://doi.org/10.23876/j.krcp.24.153 [Epub ahead of print]
- Patient-reported mental health problems and clinical outcomes in adults with non-dialysis chronic kidney disease
- Jihyun Yang, Young Youl Hyun, Kyu-Beck Lee, Hyo Jin Kim, Sang Heon Suh, Hayne Cho Park, Yun Kyu Oh, Sue Kyung Park, Kook-Hwan Oh
- Received January 31, 2024 Accepted June 17, 2024
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Background: Mental health affects well-being and physical health. Among adults with chronic kidney disease (CKD), mental health (MH) problems are common and can induce adverse clinical outcomes. We examined the association between patient-reported MH problems and clinical outcomes in adults with non-dialysis CKD. Methods: This prospective observational study included 1,879 participants from the KNOW-CKD (KoreaN Cohort Study for Outcomes in Patients... -
DOI: https://doi.org/10.23876/j.krcp.24.034 [Epub ahead of print]
- Baseline characteristics and associated factors for hypertension in children with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Pediatric Chronic Kidney Disease study
- Ji Yeon Song, Keum Hwa Lee, Jae Il Shin, Hee Gyung Kang, Yo Han Ahn, Hee Sun Baek, Min Hyun Cho, Jiwon Jung, Joo Hoon Lee, Heeyeon Cho, Kyoung Hee Han, Eujin Park, Eun Mi Yang, Seong Heon Kim
- Received December 31, 2023 Accepted March 25, 2024
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Background: Hypertension is one of the most important complications of chronic kidney disease (CKD) as it exacerbates disease progression in children. The aim of this study is to identify characteristics and factors associated with hypertension in children with CKD. Methods: This is a cross-sectional study using baseline data from the 10-year ongoing cohort study named KNOW-PedCKD (Korean Cohort Study for Outcome... -
DOI: https://doi.org/10.23876/j.krcp.24.006 [Epub ahead of print]
- Predicting long-term mortality of patients with postoperative acute kidney injury following noncardiac general anesthesia surgery using machine learning
- Bo Yeon Choi, Wona Choi, Jiwon Min, Byung Ha Chung, Eun Sil Koh, Su Yeon Hong, Tae Hyun Ban, Yong Kyun Kim, Hye Eun Yoon, In Young Choi
- Received April 12, 2024 Accepted July 1, 2024
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Background: This study addresses the gap in knowledge regarding the long-term mortality implications of postoperative acute kidney injury (PO-AKI) utilizing advanced machine learning techniques to predict outcomes more accurately than traditional statistical models. Methods: A retrospective cohort study was conducted using data from seven institutions between March 2009 and December 2019. Machine learning models were developed to predict all-cause mortality of... -
DOI: https://doi.org/10.23876/j.krcp.24.106 [Epub ahead of print]
- Artificial intelligence-powered chest computed tomography analysis unveils prognostic insights for COVID-19 mortality among prevalent hemodialysis patients
- Eunji Kim, Soo-Jin Yoon, Sungbong Yu, Eunsil Ko, Kyungjun Shon, Jooyeon Yoon, Youn Kyung Kee, Do Hyoung Kim, AJin Cho, Hayne Cho Park, Young-Ki Lee
- Received March 22, 2024 Accepted July 2, 2024
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Background: Coronavirus disease 2019 (COVID-19) has led to severe pneumonia and mortality worldwide, however, clinical outcomes in end-stage renal disease patients remain unclear. This study evaluates the prognostic value of chest computed tomography (CT) findings in predicting COVID-19-related outcomes in prevalent hemodialysis patients. Methods: We retrospectively analyzed 326 prevalent hemodialysis patients diagnosed with COVID-19 who underwent chest CT scans. Characteristics assessed... -
DOI: https://doi.org/10.23876/j.krcp.24.079 [Epub ahead of print]
- A noninvasive method of diagnosing membranous nephropathy using exosomes derived from urine
- Giae Yun, Taewoon Kim, Kwang Sik Kim, Kyusoon Shin, Jin-Ho Paik, Jee Yoon Park, Luke P. Lee, Jong Wook Hong, Sejoong Kim
- Received August 8, 2023 Accepted May 2, 2024
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Background: Membranous nephropathy (MN) is a specific autoimmune disease affecting kidneys. It is characterized by the accumulation of immune complexes in the glomerular basement membrane. Renal biopsy is currently the standard procedure to confirm the diagnosis, although the presence of autoantibodies against the phospholipase A2 receptor (PLA2R) can also help diagnose. In this study, we aimed to investigate the potential... -
DOI: https://doi.org/10.23876/j.krcp.23.208 [Epub ahead of print]
- Exploring new horizons: angiotensin II, angiotensin II type 1 receptor, and renal outer medullary potassium channel interaction in distal convoluted tubule
- Kun Zhao, Tiantian Han, Linzhen Jia, Libo Wen, Renjun Gao, Xue Li
- Received January 17, 2024 Accepted May 9, 2024
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Background: This study investigates angiotensin II (Ang II)’s regulatory mechanism on renal outer medullary potassium channel (ROMK) activity in the distal convoluted tubule (DCT) during low potassium intake, focusing on the Janus kinase 2 (JAK2) pathway activation mediated by the Ang II type 1 receptor (AT1R). Methods: Utilizing a low potassium diet mouse model, various methods including patch clamping, reverse... -
DOI: https://doi.org/10.23876/j.krcp.24.023 [Epub ahead of print]
- Framingham risk score is a useful indicator of posttransplant cardiovascular events and survival among Korean kidney transplant recipients: a nationwide, prospective cohort study
- Jeonghwan Lee, Hong Suk Chang, Hyejin Mo, In Mok Jung, Boram Weon, Soie Kwon, Chun Soo Lim, Yon Su Kim, Sang-Ho Lee, Yu Ho Lee, Jeong-Hoon Lee, Jaeseok Yang, Myoung Soo Kim, Jung Pyo Lee
- Received September 10, 2023 Accepted June 3, 2024
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Background: Cardiovascular disease is an important risk factor for mortality among kidney transplant recipients. In this study, we aimed to investigate the association between cardiovascular risk score at kidney transplantation and long-term outcomes of patients. Methods: In this prospective, observational cohort study, we enrolled kidney transplant recipients who participated in the Korean Organ Transplantation Registry and underwent transplantation between April... -
DOI: https://doi.org/10.23876/j.krcp.23.237 [Epub ahead of print]
- Conventional machine learning-based prediction models did not outperform the International IgA Nephropathy Prediction Tool
- Sehoon Park, Yisak Kim, Chung Hee Baek, Hyunjeong Cho, Ji In Park, Eun Sil Koh, Jung Pyo Lee, Sun-Hee Park, Hyung Woo Kim, Seung Hyeok Han, Ho Jun Chin, Dong Ki Kim, Kyung Chul Moon, Young-Gon Kim, Hajeong Lee
- Received August 10, 2023 Accepted March 21, 2024
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Background: Immunoglobulin A nephropathy (IgAN) is a major cause of end-stage kidney disease (ESKD). The International IgA Nephropathy Prediction Tool (IIgAN-PT) predicts IgAN prognosis, but improvement in the prediction performance using machine learning (ML)-based methods is needed. Methods: We analyzed 4,425 biopsy-confirmed patients with IgAN and ≥6 months of follow-up from nine tertiary university hospitals in Korea. The study population... -
DOI: https://doi.org/10.23876/j.krcp.23.212 [Epub ahead of print]
- Impact of sex on clinical outcomes according to immunologic risk in spousal donor kidney transplantation
- Seunghyeok Choi, Hanbi Lee, Sang Hun Eum, Ji-Won Min, Hye Eun Yoon, Chul Woo Yang, Byung Ha Chung
- Received May 9, 2024 Accepted June 23, 2024
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Background: The aim of this study is to investigate the impact of sex on the clinical outcomes of spousal donor kidney transplantation. Methods: We analyzed 456 spousal donor kidney transplantation recipients and categorized them into standard or high immunological risk groups according to panel-reactive antibody ≥50% or less. There were 366 recipients in the standard-risk group and 89 recipients in... -
DOI: https://doi.org/10.23876/j.krcp.24.128 [Epub ahead of print]
- Evaluating the Safety and effectivenesS in adult KorEaN patients treated with Tolvaptan for management of autosomal domInAnt poLycystic kidney disease (ESSENTIAL): final report
- Hayne Cho Park, Yong Chul Kim, Hyunsuk Kim, Yaerim Kim, Hyun Jin Ryu, Yong Soo Kim, Wookyung Chung, Yong-Lim Kim, Seungyeup Han, Yeonsoon Jung, Ho Sik Shin, Ki Young Na, Kyu Beck Lee, Hyeong Cheon Park, Seung Hyeok Han, Tae-Hyun Yoo, Yeong Hoon Kim, Soo Wan Kim, Kang Wook Lee, Sung Gyun Kim, Chang Hwa Lee, Kyongtae T. Bae, Kook Hwan Oh, Curie Ahn, Yun Kyu Oh
- Received March 10, 2024 Accepted June 7, 2024
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Background: Tolvaptan, a selective vasopressin V2 receptor antagonist, was first approved by the Korean Ministry of Food and Drug Safety in 2015 as a treatment option for autosomal dominant polycystic kidney disease (ADPKD). To prescribe tolvaptan safely and effectively, we designed the phase 4 clinical trial among Korean ADPKD patients with chronic kidney disease stages 1 to 3. Methods: A total... -
DOI: https://doi.org/10.23876/j.krcp.24.067 [Epub ahead of print]
- Medical costs in the peridiagnosis period of various biopsy-confirmed kidney diseases in South Korea
- Young Sun Shin, Kyungdo Han, Kwon Wook Joo, Jeong Min Cho, Yeojin Yu, Soojin Lee, Yaerim Kim, Semin Cho, Hyuk Huh, Seong Geun Kim, Eun Jeong Kang, Dong Ki Kim, Sehoon Park
- Received November 21, 2023 Accepted April 28, 2024
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Background: In-depth investigation is imperative to scrutinize medical costs associated with the periods before and after biopsies for diverse kidney diseases in South Korea. Long-term epidemiological data, including follow-up information, is essential for comparing risks linked to various kidney diseases and their adverse outcomes. Methods: Patients diagnosed with glomerulonephritis (GN), tubulointerstitial nephritis (TIN), and acute tubular necrosis (ATN) at Seoul... -
DOI: https://doi.org/10.23876/j.krcp.23.300 [Epub ahead of print]
- Effect of the geometry and severity of left ventricular hypertrophy on cardiovascular mortality in dialysis patients
- Yi-Chen Huang, Chung-Kuan Wu
- Received November 9, 2023 Accepted April 5, 2024
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Background: Left ventricular hypertrophy (LVH) is a vital risk factor for mortality of dialysis patients. The association of the geometry and severity of LVH with cardiovascular and all-cause mortality in hemodialysis (HD) patients remains unknown. This study investigated clinical outcomes among HD patients with different LVH geometric patterns and severity. Methods: The monocentric retrospective cohort study enrolled chronic HD patients who... -
DOI: https://doi.org/10.23876/j.krcp.23.290 [Epub ahead of print]
- NLRP3 inflammasome activation and macrophage distribution in kidney tissues from patients with acute oxalate nephropathy
- Daorina Bao, Xu Zhang, Su-xia Wang, Yu Wang, Ming-hui Zhao
- Received October 17, 2023 Accepted April 24, 2024
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Background: The current study was initiated to evaluate renal nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome pathway activation and macrophage subtype distribution and their clinicopathological significance in a cohort of oxalate-induced acute kidney injury. Methods: Twelve patients with biopsy-proven acute oxalate nephropathy (AON) from January 2016 to October 2022 were retrospectively enrolled, with estimated glomerular filtration... -
DOI: https://doi.org/10.23876/j.krcp.23.266 [Epub ahead of print]
- Original Article s
- Impact of hemodialysis center accreditation on patient mortality: Korean nationwide cohort study
- Hayne Cho Park, Do Hyoung Kim, AJin Cho, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Won-Min Hwang, Jinseog Kim, Dae Joong Kim, Young-Ki Lee
- Received March 5, 2024 Accepted May 20, 2024
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Background: Since hemodialysis (HD) patients are prone to various complications and high mortality, they need to be treated in HD units with professional personnel, proper equipment, and facilities. The Korean Society of Nephrology has been conducting an HD unit accreditation program since 2016. This study was performed to evaluate whether a qualified dialysis center (QDC) reduced the mortality of HD... -
DOI: https://doi.org/10.23876/j.krcp.24.059 [Epub ahead of print]
- Evaluation of the novel ALK5 inhibitor EW-7197 on therapeutic efficacy in renal fibrosis using a three-dimensional chip model
- So Young Jang, Seong-Hye Hwang, Yunyeong Choi, Wan-Young Kim, Sung Hyuk Park, Won Mook Kim, Eun-Jeong Kwon, Sejoong Kim
- Received November 29, 2023 Accepted April 28, 2024
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Background: EW-7197, a potent oral ALK5 inhibitor, was assessed for its impact on transforming growth factor beta 1 (TGF-β1)–induced fibrosis in a three-dimensional (3D) renal fibrosis-on-a-chip and a mouse model. The evaluation included tubular epithelial-mesenchymal transition, angiogenesis, and inflammatory cytokine expression. Methods: In a 3D renal fibrosis-on-a-chip model, three cell types (kidney fibroblasts, human proximal tubular cell line, and human umbilical... -
DOI: https://doi.org/10.23876/j.krcp.23.324 [Epub ahead of print]
- Original Articles
- Investigation of current clinical practices and perceptions of patients and caregivers regarding Alport syndrome in South Korea
- Dabin Kim, Yo Han Ahn, Eunjeong Kang, Hajeong Lee, Min Hyun Cho, Hee Gyung Kang, Ji Hyun Kim
- Received October 12, 2023 Accepted March 18, 2024
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Background: Alport syndrome (AS) is a highly prevalent inherited kidney disease. Early diagnosis and intervention are crucial for improved kidney outcomes. This study evaluated awareness among Korean clinicians about AS and assessed the understanding of AS patients and caregivers. Methods: An online survey targeting registered members of the Korean Society of Nephrology, the Korean Society of Pediatric Nephrology, AS patients,... -
DOI: https://doi.org/10.23876/j.krcp.23.260 [Epub ahead of print]
- GAIT-CKD (Gait Analysis using Artificial Intelligence for digital Therapeutics of patients with Chronic Kidney Disease): design and methods
- Youngjin Song, In cheol Jeong, Semin Ryu, Sunghan Lee, Jeonghwan Koh, Seokjue Jeong, Seongmin Park, Munsang Kim, Wonjun Lee, Okhyeon Rye, Yeojin Kim, Sanggyu Lee, Mooeob Ahn, Hyunsuk Kim
- Received October 22, 2023 Accepted February 13, 2024
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Background: Digital therapeutics are emerging as treatments for diseases and disabilities. In chronic kidney disease (CKD), gait is a potential biomarker for health status and intervention effectiveness. This study aims to analyze gait characteristics in CKD patients, providing baseline data for digital therapeutics development. Methods: At baseline and after an 8-week intervention, we performed bioimpedance analysis measurements, the Timed Up and... -
DOI: https://doi.org/10.23876/j.krcp.23.273 [Epub ahead of print]
- Comparisons of clinical outcomes between hypertensive and normotensive living kidney donors: a prospective, multicenter nationwide cohort study
- Jong Ho Kim, Yu Ho Lee, Dae Kyu Kim, Jin Sug Kim, Kyung Hwan Jeong, Ku Yong Chung, Jong Cheol Jeong, Soo Jin Na Choi, Jaeseok Yang, Myoung Soo Kim, Hyeon Seok Hwang
- Received October 30, 2023 Accepted February 2, 2024
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Background: Living kidney donors with hypertension are potential candidates for solving the donor shortages in renal transplantation. However, the safety of donors with hypertension after nephrectomy has not been sufficiently confirmed. Methods: A total of 642 hypertensive and 4,848 normotensive living kidney donors who were enrolled in the Korean Organ Transplantation Registry between May 2014 and December 2020 were included in... -
DOI: https://doi.org/10.23876/j.krcp.23.283 [Epub ahead of print]
- Clinical effects of a home care program for patients with peritoneal dialysis in a tertiary care hospital
- KyungYi Kim, Hyung Woo Kim, Beom Seok Kim, Suk-Yong Jang, Jaeyong Shin, Tae Hyun Kim, Sang Gyu Lee
- Received June 12, 2023 Accepted January 3, 2024
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Background: Digital health technologies have been rapidly adopted during the coronavirus disease 2019 pandemic. In Korea, a home care program, including face-to-face educational consultation and remote patient monitoring, was initiated to improve patients’ quality of life. This study focused on patients with end-stage renal disease undergoing peritoneal dialysis to verify the long-term clinical effectiveness of this home care program. Methods: This... -
DOI: https://doi.org/10.23876/j.krcp.23.160 [Epub ahead of print]
- Hospitalization among adults with chronic kidney disease: results from the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD) study
- Yeong-Won Park, Jaeseung Hwang, Minsang Kim, Seon-Mi Kim, Yujin Jeong, Minjung Kang, Eunjeong Kang, Hyunjin Ryu, Sue K. Park, Yaeni Kim, Jong Cheol Jeong, Seung Hyeok Han, Kook-Hwan Oh
- Received October 20, 2023 Accepted February 6, 2024
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Background: Chronic kidney disease (CKD) patients are hospitalized for various conditions. Hospitalization increases the readmission rate and mortality rate, seriously deteriorating patients’ quality of life. Consequently, it is crucial to analyze the reasons for hospitalization in CKD patients from a broader perspective according to CKD grade. Methods: This is a prospective cohort study of CKD patients entitled the KoreaN Cohort Study... -
DOI: https://doi.org/10.23876/j.krcp.23.263 [Epub ahead of print]
- Mortality in patients receiving renal replacement therapy in South Korea
- BeongWoo Kim, Chan Il Park, Yu Ah Hong, Hye Eun Yoon, Yong Kyun Kim, Hyunglae Kim, Kyeong Min Kim, Seun Deuk Hwang, Sun Ryoung Choi, Hajeong Lee, Ji Hyun Kim, Su Hyun Kim, Ho-Seok Koo, Chang-Yun Yoon, Kiwon Kim, Seon Ho Ahn, Seon A Jeong, Tae Hee Kim
- Received January 30, 2024 Accepted April 6, 2024
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Background: This study analyzed data from the end-stage renal disease patient registry collected by the Korean Society of Nephrology to explore trends in mortality among dialysis patients from 2001 to 2022. Methods: Mortality was analyzed in two ways: firstly, using the annual mortality rate; and secondly, by assessing survivability after a certain period of time since the initiation of dialysis. Additionally,... -
DOI: https://doi.org/10.23876/j.krcp.24.035 [Epub ahead of print]
- Impact of glycemic control on residual kidney function and technique failure associated with volume overload in diabetic patients on peritoneal dialysis
- Dong Eon Kim, Da Woon Kim, Hyo Jin Kim, Harin Rhee, Eun Young Seong, Yewon Choi, Sang Heon Song
- Received September 25, 2023 Accepted December 14, 2023
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Background: It is unclear whether poor glycemic control contributes to residual kidney function (RKF) decline and consequent volume overload in diabetic patients on peritoneal dialysis (PD). Methods: This retrospective analysis included 80 diabetic patients who started PD at a single center. The first 2 years of patient data were collected to investigate the impact of glycemic control on RKF and volume... -
DOI: https://doi.org/10.23876/j.krcp.23.251 [Epub ahead of print]
- Global burden and risk factors of chronic kidney disease in adolescents and young adults: a study from 1990 to 2019
- Hua Deng, Qin Zou, Zhe Chen, Bo Hu, Xiangping Liao
- Received November 28, 2023 Accepted March 11, 2024
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Background: Few studies have evaluated the global burden of chronic kidney disease (CKD) in adolescents and young adults (AYAs). Methods: Age-standardized rates of incidence (ASIR), mortality (ASMR), and disability-adjusted life-years (ASDR) were used to describe the CKD burden in AYAs. The estimated annual percentage changes (EAPCs) were calculated to evaluate the temporal trends from 1990 to 2019. Risk factors were... -
DOI: https://doi.org/10.23876/j.krcp.23.331 [Epub ahead of print]
- Early single session of hyperbaric oxygen therapy mitigates renal apoptosis in lipopolysaccharides-induced endotoxemia in rats
- Hyoung Youn Lee, In Jin Kim, Hong Sang Choi, Yong Hun Jung, Kyung Woon Jeung, Najmiddin Mamadjonov, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
- Received November 15, 2023 Accepted February 13, 2024
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Background: Sepsis-associated acute kidney injury (SA-AKI) is a prominent sepsis complication, often resulting in adverse clinical outcomes. Hyperbaric oxygen therapy (HBOT), known for its anti-inflammatory characteristics, antioxidant effects, and ability to deliver high oxygen tension to hypo-perfused tissues, offers potential benefits for SA-AKI. This study investigated whether HBOT improved renal injury in sepsis and elucidated its underlying mechanisms. Methods: A lipopolysaccharide... -
DOI: https://doi.org/10.23876/j.krcp.23.294 [Epub ahead of print]
- Systematic metabolomics study in the serum and urine of a mouse model of Fabry disease
- Chang Seong Kim, Songjin Oh, Moongi Ji, Byeongchan Choi, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Eun Hui Bae, Seong Kwon Ma, Man-Jeong Paik, Soo Wan Kim
- Received August 14, 2023 Accepted January 2, 2024
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Background: Fabry disease (FD) is an X-linked lysosomal disorder caused by α-galactosidase A enzyme activity deficiency. Although glycosphingolipid analogs have been identified in the plasma or urine of patients with FD, there is a limited understanding of altered metabolomics profiles beyond the globotriaosylceramide accumulation in FD. Methods: Metabolomics study was performed for monitoring of biomarker and altered metabolism related with disease... -
DOI: https://doi.org/10.23876/j.krcp.23.218 [Epub ahead of print]
- Single-cell RNA sequencing revealed the role of the Th17 pathway in the development of anti- human leukocyte antigen antibodies in a highly sensitized mouse model
- Hanbi Lee, Yoo-Jin Shin, Xianying Fang, Sheng Cui, Sun Woo Lim, Seon-Yeong Lee, Sang Hun Eum, Ji-Won Min, Chang-Won Hong, Hae-Ock Lee, Mi-La Cho, Eun-Jee Oh, Chul Woo Yang, Byung Ha Chung
- Received November 26, 2023 Accepted February 28, 2024
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Background: The aim of this study is to investigate the specific pathway involved in human leukocyte antigen (HLA) sensitization using single-cell RNA-sequencing analysis and an allo-sensitized mouse model developed with an HLA.A2 transgenic mouse. Methods: For sensitization, wild-type C57BL/6 mouse received two skin grafts from C57BL/6-Tg(HLA-A2.1)1Enge/J mouse (allogeneic mouse, ALLO). For syngeneic control (SYN), skin grafts were transferred from C57BL/6... -
DOI: https://doi.org/10.23876/j.krcp.23.317 [Epub ahead of print]
- A novel allocation scheme for deceased donor kidneys to balance equity and utility
- Jin Hyeog Lee, Jun Hye Seo, Tai Yeon Koo, Jang Hee Cho, Kyung Pyo Kang, Jung Eun Lee, Kook Hwan Oh, Beom Seok Kim, Jaeseok Yang
- Received February 2, 2024 Accepted March 26, 2024
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Background: Patients with sensitization and blood type O experience increased waiting times for deceased-donor kidney transplantation (DDKT). While allocation benefits are needed to resolve inequity in DDKT opportunity, whether DDKT has comparable outcomes in this disadvantaged population requires further study. This study assessed these outcomes and developed a new allocation system that balances equity and utility. Methods: Patients from national and... -
DOI: https://doi.org/10.23876/j.krcp.24.033 [Epub ahead of print]
- Comparative analysis of the incidence and mortality of COVID-19 in Korean end-stage kidney disease patients: hemodialysis, peritoneal dialysis, and transplantation
- AJin Cho, Seon A Jeong, Hayne Cho Park, Do Hyoung Kim, Kyung Don Yoo, Hye Eun Yoon, Yang Gyun Kim, Young-Ki Lee
- Received November 8, 2023 Accepted December 26, 2023
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Background: Patients with end-stage kidney disease (ESKD) are more susceptible to viral epidemics and are known to have higher incidence and death rates of coronavirus disease 2019 (COVID-19) compared to the general population. We determined COVID-19 incidence and mortality among chronic hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) patients in Korea. Methods: We conducted a retrospective cohort study and... -
DOI: https://doi.org/10.23876/j.krcp.23.287 [Epub ahead of print]
- COVID-19 infection in patients with end-stage kidney disease undergoing renal replacement therapies in Korea
- Heejung Choi, Ah-Young Kim, Inwhee Park, Hankil Lee, Min-Jeong Lee
- Received November 2, 2023 Accepted January 18, 2024
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Background: The global coronavirus disease 2019 (COVID-19) pandemic has placed patients with end-stage kidney disease (ESKD) at heightened risk owing to their vulnerability to infections. Our study focused on patients with ESKD, examining COVID-19 incidence, hospitalization, and mortality in relation to their renal replacement therapy (RRT) type and identifying factors influencing COVID-19 hospitalization. Methods: We conducted a retrospective cohort study... -
DOI: https://doi.org/10.23876/j.krcp.23.280 [Epub ahead of print]
- Obesity exacerbates ischemia-reperfusion injury and senescence in murine kidneys and perirenal adipose tissues
- Seo Rin Kim, Young-Suk Kim, Je Min Hyeon, Su Ji Kim, Byung Min Ye, Min Jeong Kim, Byung Hyun Choi, Dongwon Yi, Il Young Kim, Soo Bong Lee, Dong Won Lee
- Received August 25, 2022 Accepted February 3, 2023
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Background: Obesity is a major worldwide health problem and can be related to cellular senescence. Along with the rise in obesity, the comorbidity of renal ischemia-reperfusion (IR) injury is increasing. Whether obesity accelerates the severity of IR injury and whether senescence contributes to these conditions remain unclear. We studied the degree of injury and cellular senescence in the IR kidneys... -
DOI: https://doi.org/10.23876/j.krcp.22.193 [Epub ahead of print]
- Impact of obesity on renal function in elderly Korean adults: a national population-based cohort study
- Jihyun Yang, Hui Seung Lee, Chi-Yeon Lim, Hyunsuk Kim, Sungjin Chung, Soon Hyo Kwon, Jang-Hee Cho, Kyung Don Yoo, Woo Yeong Park, In O Sun, Byung Chul Yu, Gang-Jee Ko, Jae Won Yang, Won Min Hwang, Sang Heon Song, Sung Joon Shin, Yu Ah Hong, Eunjin Bae, Young Youl Hyun
- Received July 14, 2023 Accepted December 1, 2023
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Background: Obesity is a well-known risk factor for chronic kidney disease and its progression. However, the impact of obesity on the renal function of the elderly population is uncertain. We investigated the association between obesity and renal outcomes in the elderly. Methods: We analyzed 130,504 participants from the Korean National Health Insurance Service-Senior cohort. Obesity was classified according to body... -
DOI: https://doi.org/10.23876/j.krcp.23.187 [Epub ahead of print]
- Intradialytic hypotension and worse outcomes in patients with acute kidney injury requiring intermittent hemodialysis
- Yeong-Won Park, Donghwan Yun, Yeojin Yu, Sang Hyun Kim, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seong Geun Kim, Seung Seok Han
- Received July 16, 2023 Accepted November 9, 2023
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Background: Intradialytic hypotension (IDH) is a critical complication related to worse outcomes in patients undergoing maintenance hemodialysis. Herein, we addressed the impact of IDH on mortality and other outcomes in patients with severe acute kidney injury (AKI) requiring intermittent hemodialysis. Methods: We retrospectively reviewed 1,009 patients who underwent intermittent hemodialysis due to severe AKI. IDH was defined as either dialysis discontinuation... -
DOI: https://doi.org/10.23876/j.krcp.23.188 [Epub ahead of print]
- Preliminary evaluation of the effect of revised reimbursement scheme in outpatient hemodialysis for medical aid recipients in Korea
- Heenyun Kim, Yongseok Choi, Soontack Kwon, Kook Young Jang, Do Kyung Ryuk, Hyejin Lee, Jin Yong Lee
- Received February 17, 2023 Accepted July 26, 2023
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Background: South Korea has universal health coverage guaranteeing equitable healthcare for all. However, equity issues have been raised regarding hemodialysis reimbursement for medical aid recipients with chronic kidney disease. Physicians and civic groups demanded a revision of the discriminatory policy, and in response, the Ministry of Health and Welfare amended the hemodialysis case payment scheme. This study aims to evaluate... -
DOI: https://doi.org/10.23876/j.krcp.23.038 [Epub ahead of print]
- Performance evaluation of Chronic Kidney Disease Epidemiology Collaboration equations for estimated glomerular filtration rate compared to inulin clearance in Koreans
- Jeong Min Cho, Ran-hui Cha, Dong Ki Kim, Ho Jun Chin
- Received May 17, 2023 Accepted September 12, 2023
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Background: A race-free glomerular filtration rate (GFR) estimation equation has recently been developed. However, the performance of the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations needs to be evaluated in Asian populations. Methods: We performed a cross-sectional study at a single center in South Korea. The measured GFR (mGFR) was determined based on systemic inulin clearance. The GFR was... -
DOI: https://doi.org/10.23876/j.krcp.23.124 [Epub ahead of print]
- Pericyte activation accompanied by peritubular capillaries dysfunction and pericyte-to-myofibroblast transition is associated with renal fibrosis in diabetic nephropathy
- Yiduo Feng, Dongli Tian, Yu Bai, Yan Li, Liling Zhang, Yiru Wu, Wenhu Liu, Zongli Diao
- Received April 19, 2023 Accepted October 2, 2023
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Background: Tubulointerstitial renal fibrosis is an essential feature of diabetic nephropathy (DN). Pericytes play a critical role in microvascular diseases and renal fibrogenesis. However, the role of pericytes in DN remains unclear. Herein, we aimed to explore the properties and possible mechanisms of pericytes in renal fibrosis in DN. Methods: We used multiplex immunofluorescence staining to evaluate the location and... -
DOI: https://doi.org/10.23876/j.krcp.23.099 [Epub ahead of print]
- Association of metformin with cardiovascular and graft outcomes in kidney transplant recipients with posttransplantation diabetes mellitus
- Dongyeon Lee, Jiyun Jung, Sichan Kim, Jaeyun Lee, Jangwook Lee, Chung Hee Baek, Hyunwook Kwon, Sung Shin, Younghoon Kim, Sung Joon Shin, Su-Kil Park, Jae Yoon Park, Hyosang Kim
- Received April 10, 2023 Accepted August 28, 2023
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Background: Posttransplantation diabetes mellitus (PTDM) is a crucial problem after kidney transplantation. We aimed to determine whether metformin affects cardiovascular and graft outcomes in patients with PTDM. Methods: This retrospective cohort study included 1,663 kidney transplant recipients without preexisting diabetes mellitus. The patients were divided into metformin and non-metformin groups, with matched propensity scores. We also estimated metformin’s effect on percutaneous... -
DOI: https://doi.org/10.23876/j.krcp.23.085 [Epub ahead of print]
- Predictive models for posttransplant diabetes mellitus in kidney transplant recipients using machine learning and deep learning approach: a nationwide cohort study from South Korea
- Seoyoung Choi, Mi Ryung Pyo, Sangwoong Kim, Jong Cheol Jeong, Yu Ho Lee, Hyejin Mo, Jeong-Hoon Lee, Jaeseok Yang, Myoung Soo Kim, Hye Eun Yoon, Sejoong Kim
- Received April 22, 2024 Accepted October 13, 2024
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Background: Posttransplant diabetes mellitus (PTDM) complicates kidney transplant recipients (KTRs) in morbidity and mortality. This study aimed to predict PTDM risk in KTRs using machine learning and deep learning models. Methods: Data were obtained from the Korea Organ Transplantation Registry, a nationwide cohort study of KTRs. Four machine learning algorithms, including eXtreme Gradient Boosting (XGBoost), CatBoost, light gradient boosting machine... -
DOI: https://doi.org/10.23876/j.krcp.24.113 [Epub ahead of print]
- Insulin resistance is associated with incident chronic kidney disease in population with normal renal function
- Su Hyun Song, Young Jin Goo, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
- Received December 23, 2022 Accepted June 20, 2023
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Background: Insulin resistance is prevalent in chronic kidney disease and may accelerate the progression of chronic kidney disease. This study aimed to investigate whether insulin resistance is associated with the development of incident chronic kidney disease in a population with normal renal function. Methods: A total of 3,331 participants from a community-based cohort with normal renal function were prospectively analyzed.... -
DOI: https://doi.org/10.23876/j.krcp.22.298 [Epub ahead of print]
- Impact of albuminuria on early-onset type 2 diabetes mellitus: a nationwide population-based study
- Soojin Lee, Semin Cho, Geum Nae Nam, Jeongmin Cho, Seong Geun Kim, Minsang Kim, Hyuk Huh, Eunjeong Kang, Sehoon Park, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Kwon Wook Joo, Kyungdo Han, Dong Ki Kim, Yaerim Kim
- Received November 25, 2022 Accepted July 11, 2023
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Background: Early-onset diabetes mellitus has a significant lifetime burden and is associated with higher morbidity and mortality. Since insulin resistance is one of the mechanisms of podocyte injury, we aimed to evaluate the effect of albuminuria on newly developed early-onset type 2 diabetes mellitus (T2DM). Methods: We screened 6,891,399 subjects aged ≥20 and <40 years without a history of prediabetes... -
DOI: https://doi.org/10.23876/j.krcp.22.278 [Epub ahead of print]
- Association of systolic blood pressure with incident chronic kidney disease estimated by marginal structural model: a nationwide population-based study
- Hyunsun Lim, Youn Nam Kim, Tae Ik Chang, Jae Young Kim
- Received March 28, 2023 Accepted July 30, 2023
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Background: We aimed to investigate the association between systolic blood pressure (SBP) and risk of incident chronic kidney disease (CKD) using marginal structural model (MSM) to reflect mutual effects of exposure and confounders on the outcome. Methods: A total of 195,970 adults with an estimated glomerular filtration rate (eGFR) of >60 mL/min/1.73 m2 and no proteinuria were included from... -
DOI: https://doi.org/10.23876/j.krcp.23.073 [Epub ahead of print]
- Smoking amplifies the risk of albuminuria in individuals with high sodium intake: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011 and 2014–2018
- Young-Bin Son, Tae-Bum Kim, Hyeon-Jin Min, Jihyun Yang, Myung-Gyu Kim, Sang Kyung Jo, Won Yong Cho, Se Won Oh
- Received June 30, 2022 Accepted April 10, 2023
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Background: Smoking and sodium intake (SI) have been evaluated as risk factors for kidney disease; however, the data are inconsistent. We assessed the association between SI and cotinine-verified smoking status and the risk of albuminuria. Methods: An observational study using the Korea National Health and Nutrition Examination Survey (2008–2011 and 2014–2018) was performed. We included 37,410 adults with an estimated... -
DOI: https://doi.org/10.23876/j.krcp.22.133 [Epub ahead of print]
- The feasibility of incremental peritoneal dialysis for older patients on peritoneal dialysis
- Ruihua Liu, Jing Guo, Hongjian Ye, Yuan Peng, Haishan Wu, Haiping Mao, Qunying Guo, Fengxian Huang, Xiao Yang
- Received September 2, 2022 Accepted April 3, 2023
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Background: This study was performed to investigate the feasibility of incremental peritoneal dialysis (iPD) in older patients. Methods: In this retrospective cohort study, we enrolled peritoneal dialysis (PD) patients with age ≥ 60 years old at our center from 2008 to 2017. The patients were divided into two groups based on the daily PD exchanges: iPD group (≤3 × 2... -
DOI: https://doi.org/10.23876/j.krcp.22.202 [Epub ahead of print]
- Factors associated with gait speed: results from the RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients (RECOVERY) study
- Miyeun Han, Sang Heon Song, Su Hyun Kim, Ran-hui Cha, Seock Hui Kang, Won Suk An, Jun Chul Kim
- Received July 6, 2022 Accepted December 25, 2022
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Background: Gait speed is an important measure of functional ability. This study aimed to investigate the factors associated with gait speed in patients with chronic kidney disease. The study focused on sarcopenic components, plasma uremic or inflammatory marker levels, and quality of life effects. Methods: The RolE of AST120 (Renamezin) in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients is... -
DOI: https://doi.org/10.23876/j.krcp.22.143 [Epub ahead of print]
