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Editorial
April 28, 2026
- Hearing loss and truncating variants in Alport syndrome
- Hyung Eun Yim
- Kidney Res Clin Pract. 2026;45(3):289-292.
- Special Article
- A position statement and recommendations for sustainable kidney care
- Jihyun Yang, So Mi Kim, Eunjeong Kang, Harin Rhee, Jwa-Kyung Kim, Jung-Kook Wi, Ju-Young Moon, Yoosun Joo, Yohan Park, Young-Hwan Hwang, Kyungho Choi, Younglim Kho, Katherine Barraclough, Gangjee Ko
- Received May 14, 2025 Accepted October 16, 2025
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The Korean Society of Nephrology has embraced the principle of “Green Nephrology” and launched campaigns addressing environmental sustainability in kidney care. These include initiatives to monitor resource usage, reduce waste generation in treatment facilities, and minimize dialysis-related environmental effects. The Society aims to raise awareness about the environmental impact of kidney disease and its treatments while emphasizing the importance of... -
DOI: https://doi.org/10.23876/j.krcp.25.139 [Epub ahead of print]
- Editorials
- The role of exercise as an adjunctive therapy in patients on maintenance hemodiafiltration: clinical benefits and implications
- Moo Jun Kim, Hyo-Wook Gil
- Received January 26, 2026 Accepted February 5, 2026
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DOI: https://doi.org/10.23876/j.krcp.26.038 [Epub ahead of print]
- Interobserver reproducibility in histopathological findings of lupus nephritis: how can we improve it?
- Kyung Chul Moon
- Received June 24, 2025 Accepted July 2, 2025
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DOI: https://doi.org/10.23876/j.krcp.25.190 [Epub ahead of print]
- Lifesaving power of preparedness in dialysis units
- Kyung Don Yoo
- Received May 31, 2025 Accepted June 23, 2025
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DOI: https://doi.org/10.23876/j.krcp.25.169 [Epub ahead of print]
- Denosumab for kidney transplant recipients: clinical value and unresolved questions
- Hye-Sun Park
- Received May 12, 2025 Accepted May 13, 2025
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DOI: https://doi.org/10.23876/j.krcp.25.138 [Epub ahead of print]
- Review Articles
- Mitochondrial metabolism and dynamics in the development of diabetic kidney disease
- Gerry George Mathew
- Received November 23, 2025 Accepted December 31, 2025
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Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease worldwide, affecting over 40% of individuals with diabetes. Despite advances in glycemic control and renin-angiotensin system blockade, effective therapeutic strategies remain limited. A narrative review was synthesized from research papers using PubMed, Wiley Online Library, ScienceDirect, Cochrane Library, Springer, and other sources, published between 2000 and 2025 with... -
DOI: https://doi.org/10.23876/j.krcp.25.413 [Epub ahead of print]
- Expert opinion on the optimal use of sevelamer in clinical practice in Southeast Asia
- Bancha Satirapoj, Chong Men Leong, Christopher Thiam Seong Lim, Dung Huu Nguyen, Fariz Safhan Mohamad Nor, Kajohnsak Noppakun, Minh Tuan Nguyen, Mohamad Zaimi Abdul Wahab, Paweena Susantitaphong, Thao Ngoc Phuong Huynh, The Cuong Nguyen, Mansij Biswas
- Received July 24, 2025 Accepted November 28, 2025
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Chronic kidney disease (CKD)-mineral bone disorder (MBD) is a prevalent and serious complication in patients with advanced CKD, particularly in Southeast Asia where the disease burden is high. This condition significantly increases the risk of cardiovascular events and mortality. This review synthesizes mechanistic insights, clinical trial evidence, guideline recommendations, and expert perspectives to evaluate the role of sevelamer, a non–calcium-based... -
DOI: https://doi.org/10.23876/j.krcp.25.253 [Epub ahead of print]
- A journey through veins: discovery to modern therapy
- Muhammad Nauman Hashmi, Fayez Hejaili, Tushar J. Vachharajani, Arif Asif, Omer Siddiqui, Claudio Ronco
- Received October 19, 2025 Accepted December 31, 2025
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Vascular access is the cornerstone of successful hemodialysis, serving as the lifeline for millions of patients with end-stage kidney disease. Since the inception of maintenance dialysis in the 1960s, the development of reliable vascular access has undergone significant evolution, reflecting advancements in medical technology, surgical techniques, and an improved understanding of access-related complications. This review traces the historical progression of... -
DOI: https://doi.org/10.23876/j.krcp.25.366 [Epub ahead of print]
- Diet-microbiota-kidney axis reprogramming: mechanistic insights into microbial metabolite-driven precision nutrition for chronic kidney disease
- Xiunan Liu, Zhuoxing Li, Hao Liu, Mao Xiao, Xue Zhang, Yanyi Deng, Buyuan Tian, Yun Sun, Xiang Xiao
- Received August 19, 2025 Accepted December 31, 2025
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Medical nutrition therapy serves as the cornerstone in the management of chronic kidney disease (CKD). While conventional approaches emphasize macronutrient restriction and meal timing adjustments, research highlights the critical mediating role of gut microbiota in translating dietary patterns into physiological effects through metabolite production. Meanwhile, CKD progression is closely associated with dynamic interactions between gut microbiota and their metabolic derivatives.... -
DOI: https://doi.org/10.23876/j.krcp.25.312 [Epub ahead of print]
- Chronic kidney disease in Asia: a meta-analysis
- Guozhen Chen, Shirui Sun, Yingcong Guo, Qi He, Zepeng Li, Zhenting Zhao, Bingxuan Zheng, Haiping Liu, Wujun Xue, Chenguang Ding
- Received July 29, 2025 Accepted December 15, 2025
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The prevalence of chronic kidney disease (CKD) in Asia was determined by comparing differences in age, sex, area, and analytical methods. This meta-analysis comprised 42 studies with 2,271,169 participants from five databases that were searched until February 30, 2025. The total prevalence of CKD 1–5 was 17.0%, whereas that of stages 3–5 was 7.7% in Asia. Individuals aged >60 years... -
DOI: https://doi.org/10.23876/j.krcp.25.254 [Epub ahead of print]
- Review Article s
- Artificial intelligence virtual cells as a new paradigm in nephrology: from multiomics integration to clinical translation
- Yongzheng Hu, Yabin Wang, Xinyue Qi, Wei Jiang
- Received September 6, 2025 Accepted November 28, 2025
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Kidney diseases remain heterogeneous and mechanistically complex, and current experimental models only partially capture patient-specific dynamics. We advance artificial-intelligence virtual cells (AIVCs) as a translational framework that learns cross-modal representations of renal cell states, performs high-throughput in silico perturbations, and improves via experiment-in-the-loop updates with organoid and real-world readouts. We outline a methodological pathway—data, representation, intervention, evaluation, deployment—anchored to atlas-grade... -
DOI: https://doi.org/10.23876/j.krcp.25.316 [Epub ahead of print]
- Review Articles
- Emerging therapeutic strategies for acute kidney injury: a new dawn in renal medicine
- Hojin Jeon, Hye Ryoun Jang
- Received June 7, 2025 Accepted July 28, 2025
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Acute kidney injury (AKI) is a complex and multifactorial syndrome associated with significant morbidity, mortality, and progression to chronic kidney disease. While conventional diagnostic and therapeutic strategies have centered on serum creatinine and supportive care including kidney replacement therapy (KRT), recent advances have expanded our understanding of AKI pathophysiology and treatment. This review outlines current insights into the cellular and... -
DOI: https://doi.org/10.23876/j.krcp.25.167 [Epub ahead of print]
- Cardiovascular disease and risk management in patients with nephrotic syndrome
- Clemens Untersulzner, Philipp Gauckler, Anna Matyjek, Sayna Norouzi, Renate Pichler, Andreas Kronbichler
- Received June 20, 2025 Accepted October 1, 2025
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Nephrotic syndrome, defined by proteinuria ≥3.5 g/24 hr, hypoalbuminemia, hyperlipidemia, and edema, shows a significantly elevated risk of both arterial and venous thromboembolic complications. Large cohort studies have demonstrated an up to two-fold increase in myocardial infarction and stroke incidence and an eight-fold increase in venous thromboembolism, especially among patients with membranous nephropathy. The increased cardiovascular vulnerability in this population... -
DOI: https://doi.org/10.23876/j.krcp.25.177 [Epub ahead of print]
- Evolutionary, genetic, and mechanistic insights into uric acid regulation and sex differences
- Yan Yang, Yuwei Ji, Ziyue Zhang, Jian Yang, Xiangmei Chen, Guangyan Cai, Quan Hong
- Received March 16, 2025 Accepted October 1, 2025
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Hyperuricemia is a metabolic disorder characterized by abnormally elevated blood uric acid levels. Elevated serum uric acid levels can lead to crystal deposition in joints and tissues, causing inflammation and pain characteristic of gout and also contributing to renal dysfunction and vascular complications. It is closely associated with various health issues including gout, kidney stones, chronic kidney disease, and cardiovascular... -
DOI: https://doi.org/10.23876/j.krcp.25.074 [Epub ahead of print]
- The importance and clinical utility of reanalysis of exome and genome sequencing data
- Dongseok Moon, Go Hun Seo
- Received July 1, 2025 Accepted July 28, 2025
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Exome sequencing (ES) and genome sequencing (GS) are essential for diagnosing rare genetic disorders, yet a significant number of patients remain without a definitive diagnosis after the initial analysis. Reanalysis of existing ES and GS data has emerged as a clinically indispensable practice, offering the potential to solve previously unresolved cases by leveraging rapid advances in genomic knowledge and technology.... -
DOI: https://doi.org/10.23876/j.krcp.25.210 [Epub ahead of print]
- Transcriptional regulatory factors of the Aqp2 gene
- Hyun Jun Jung, Euijung Park, Hyo-Ju Jang, Tae-Hwan Kwon
- Received January 22, 2025 Accepted March 3, 2025
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Aquaporin-2 (AQP2), the water channel protein exclusively expressed in the kidney collecting duct, plays an essential role in water reabsorption and fluid homeostasis. Dysregulation of Aqp2 transcription and changes in protein abundance lead to water balance disorders such as nephrogenic diabetes insipidus or water overload states. Recent studies have revealed that Aqp2 transcription is highly selective, with only 35 of... -
DOI: https://doi.org/10.23876/j.krcp.25.016 [Epub ahead of print]
- Dreams disrupted: a comprehensive review of sleep disorders in chronic kidney disease
- Georges Kosmadakis, Clémence Deville, Aura Nécoara, Julien Baudenon, Ioana Enache, Fatima El Kanouni, Joseph El Hajal
- Received March 26, 2025 Accepted May 18, 2025
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Sleep disorders are common in chronic kidney disease (CKD), significantly affecting quality of life, morbidity, and prognosis. This review examines the classification, prevalence, pathophysiology, diagnosis, and management of insomnia, sleep-disordered breathing including obstructive and central sleep apnea (OSA/CSA), restless legs syndrome (RLS), and excessive daytime sleepiness (EDS) in CKD. Up to 80% of dialysis patients experience sleep disturbances, often underdiagnosed... -
DOI: https://doi.org/10.23876/j.krcp.25.080 [Epub ahead of print]
- Glomerular alteration in diabetic kidney disease: from morphology to metabolism
- Hasan Demirci
- Received December 1, 2024 Accepted March 4, 2025
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Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. The glomerulus is the primary site of injury in DKD progression. Pathologically, the integrity of the glomerular filtration barrier is disrupted, characterized by podocyte process fusion and detachment, glomerular basement membrane thickening, and reduction of the endothelial cell glycocalyx. These disruptions result in albuminuria due to impaired function... -
DOI: https://doi.org/10.23876/j.krcp.24.294 [Epub ahead of print]
- Original Articles
- Genetic diagnosis of hereditary kidney disease in pediatric patients through whole-exome sequencing and mitochondrial DNA analysis
- Jiyoung Oh, Keumwha Lee, Dongju Won, Young-Mock Lee, Jae Il Shin
- Received November 5, 2025 Accepted February 4, 2026
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Background: Identifying the genetic cause of hereditary kidney disease is essential for appropriate management. However, pediatric patients often present with nonspecific renal symptoms such as proteinuria, hematuria, or both, making accurate diagnosis difficult. Mitochondrial diseases are also an important but underrecognized etiology of hereditary kidney disorders. This study aimed to assess the diagnostic utility of whole-exome sequencing (WES) combined with... -
DOI: https://doi.org/10.23876/j.krcp.25.394 [Epub ahead of print]
- Associations between remnant cholesterol and cardiovascular events in patients undergoing dialysis: a nationwide cohort study
- Byung Sik Kim, Hyun-Jin Kim, Jiyeong Kim, Nayeon Choi, Jeong-Hun Shin
- Received December 7, 2025 Accepted February 23, 2026
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Background: Remnant cholesterol is a known residual risk factor for cardiovascular disease in the general population. However, its prognostic value in patients undergoing dialysis, a population at a high risk of cardiovascular events, remains unclear. We aimed to evaluate the association between remnant cholesterol levels and cardiovascular outcomes in a high-risk population. Methods: This retrospective cohort study included 21,679 patients with... -
DOI: https://doi.org/10.23876/j.krcp.25.447 [Epub ahead of print]
- Once-monthly darbepoetin alfa is non-inferior to biweekly dosing for maintaining target hemoglobin in erythropoiesis-stimulating agent-responsive Korean patients with non-dialysis chronic kidney disease: a multicenter phase 4 study
- Jung Eun Lee, Byoung-Geun Han, Jong Hyun Jhee, Hyeong Cheon Park, Hoon Young Choi
- Received June 16, 2025 Accepted February 2, 2026
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Background: Anemia is a common complication in patients with non-dialysis chronic kidney disease managed with erythropoiesis- stimulating agents. Although biweekly darbepoetin alfa administration is standard practice, extended-interval dosing may improve convenience and adherence and reduce hemoglobin overshoot risk. Methods: This prospective, single-arm, phase 4 study evaluated the non-inferiority, safety, and clinical feasibility of switching from biweekly to once-every-4-week darbepoetin alfa administration... -
DOI: https://doi.org/10.23876/j.krcp.25.187 [Epub ahead of print]
- Prevalence of polypharmacy and its association with clinical outcomes in kidney transplant recipients : results from the KNOW-KT study
- Tai Yeon Koo, Young Eun Choi, Yookyung Jang, Se Won Oh, Jaeseok Yang, Kyu Ha Huh, Kyo Won Lee, Hee-Yeon Jung, Kyung Pyo Kang, Seungyeup Han, Jung-Hwa Ryu, Sang-Kyung Jo, Myung-Gyu Kim
- Received April 2, 2025 Accepted July 14, 2025
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Background: Polypharmacy (PP) is common among kidney transplant recipients (KTRs) due to lifelong immunosuppressive therapy and comorbidity management. However, PP’s impact on clinical outcomes remains unclear. In this study, we examine the association between PP and adverse outcomes in KTRs. Methods: We analyzed data of 972 KTRs from the Korean Cohort Study for Outcomes in Patients with Kidney Transplantation (KNOW-KT). Excessive... -
DOI: https://doi.org/10.23876/j.krcp.25.091 [Epub ahead of print]
- Hypocalcemia as a nontraditional risk factor for cardiovascular events and all-cause din patients with chronic kidney disease: insights from the Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)
- Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Kook-Hwan Oh, Jayoun Kim, Suah Sung, Young Youl Hyun, Jong Cheol Jeong, Sangjun Lee, Sue K. Park, Seong Kwon Ma, Soo Wan Kim
- Received August 2, 2025 Accepted December 19, 2025
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Background: The clinical implication of hypocalcemia is elusive in patients with chronic kidney disease (CKD). The present study aimed to investigate whether low serum calcium levels increase the risk of major adverse cardiovascular events (MACEs) and cardiovascular mortality in patients with non-dialysis CKD. Methods: A total of 2,188 patients with CKD at stages 1 to 5 (pre-dialysis) were categorized by corrected... -
DOI: https://doi.org/10.23876/j.krcp.25.266 [Epub ahead of print]
- Prognostic significance of soluble urokinase-type plasminogen activator receptor in patients with glomerulonephritis: association with renal outcomes
- Ji-Young Choi, Se-Hyun Oh, Ju-Min Yook, Mingyu Kim, Jieun Yoo, You Hyun Jeon, Jeong-Hoon Lim, Hee-Yeon Jung, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
- Received August 21, 2025 Accepted December 28, 2025
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Background: We investigated the association of longitudinally assessed soluble urokinase-type plasminogen activator receptor (suPAR) levels and renal outcomes in patients with glomerulonephritis (GN). Methods: This study included 96 patients diagnosed with primary GN by renal biopsy during 2013–2020 at two tertiary hospitals. Serum suPAR levels were measured at biopsy and follow-up. The association between serum suPAR levels and renal outcomes was... -
DOI: https://doi.org/10.23876/j.krcp.25.294 [Epub ahead of print]
- Tegoprazan and the risk of end-stage kidney disease progression: a nationwide Korean study
- Yu Jeong Lee, Jinmi Kim, Dong Han Yu, Nam Kyung Je, Harin Rhee
- Received October 31, 2025 Accepted January 2, 2026
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Background: Tegoprazan, a potassium-competitive acid blocker used in South Korea since 2018, was examined in this study for its potential association with death or progression to end-stage kidney disease (ESKD) among patients with stage 3 or 4 chronic kidney disease (CKD) prescribed tegoprazan for more than 90 days. Methods: This real-world, retrospective study used national claims data from South Korea recorded... -
DOI: https://doi.org/10.23876/j.krcp.25.379 [Epub ahead of print]
- Epidemiological characteristics and treatment patterns of Alport syndrome in Korea
- Min Ji Park, Ji Hyun Kim, Keum Hwa Lee, Min Hyun Cho, Peong Gang Park
- Received September 30, 2025 Accepted January 26, 2026
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Background: Alport syndrome is the second most common inherited kidney disease, yet many patients remain undiagnosed until advanced kidney failure or receive inappropriate immunosuppressive therapy. Genetic testing indicates it is more common than recognized, but most epidemiological studies have been regional, lacking nationwide assessments. Methods: We analyzed Korean National Health Insurance data, covering the entire population. Patients were identified using the... -
DOI: https://doi.org/10.23876/j.krcp.25.348 [Epub ahead of print]
- Impact of early vs. late initiation of continuous renal replacement therapy on composite outcomes including acute kidney disease and mortality: a multicenter propensity-matched cohort study (LINKA cohort)
- Sei-hong Min, Sung Gyun Kim, Jung Nam An, Sejoong Kim
- Received November 22, 2025 Accepted January 30, 2026
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Background: The optimal timing of continuous renal replacement therapy (CRRT) initiation in acute kidney injury (AKI) remains uncertain, particularly regarding long-term kidney outcomes. This study evaluated whether early CRRT initiation improves the risk of acute kidney disease (AKD) or death. Methods: In this multicenter retrospective cohort, 852 patients with baseline creatinine ≤4 mg/dL who received CRRT at eight tertiary hospitals were... -
DOI: https://doi.org/10.23876/j.krcp.25.421 [Epub ahead of print]
- Cardiovascular health by Life’s Essential 8 and chronic kidney disease: Korea National Health and Nutrition Examination Survey 2019–2021
- Eunji Kim, Yeeun Seo, Dasom Son, Kyoung Hwa Ha, Hyeon Chang Kim, Jong Hyun Jhee, Hokyou Lee
- Received July 15, 2025 Accepted December 15, 2025
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Background: Evidence remains limited regarding the association between cardiovascular health (CVH), as defined by Life’s Essential 8 (LE8), and chronic kidney disease (CKD), particularly across its indicators and stages. Methods: We analyzed data from 12,264 adults in the Korea National Health and Nutrition Examination Survey (2019–2021). LE8 scores (range, 0–100), calculated from eight components—diet, physical activity, nicotine exposure, sleep, body mass... -
DOI: https://doi.org/10.23876/j.krcp.25.231 [Epub ahead of print]
- p-Cresyl sulfate promotes smooth muscle cell proliferation and endothelial dysfunction, leading to development of neointimal hyperplasia
- Shina Lee, EunYoung Jeon, Seung-Jung Kim
- Received June 24, 2025 Accepted December 21, 2025
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Background: Vascular access failure is a major cause of morbidity in hemodialysis patients, primarily driven by smooth muscle cell (SMC) proliferation-related neointimal hyperplasia. The uremic toxin p-cresyl sulfate (p-CS) has been linked to poor vascular access outcomes, but its pathogenic mechanisms remain unclear. This study investigated whether p-CS promotes SMC proliferation and induces endothelial dysfunction, and contributes to neointimal hyperplasia. Methods:... -
DOI: https://doi.org/10.23876/j.krcp.25.194 [Epub ahead of print]
- Xerosis elevates the risk of catheter-related infections in peritoneal dialysis patients
- Jeong Geon Lee, Jihee Lim, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hoonhee Seo, Ho-Yeon Song, Sun-Hee Park, Kook-Hwan Oh, Yong-Lim Kim, Brian A. Bieber, Ronald L. Pisoni, Eun Young Lee
- Received November 10, 2024 Accepted May 1, 2025
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Background: Catheter-related infections, such as exit-site infection and tunnel infection, are major complications in peritoneal dialysis (PD) patients, affecting their prognosis. This study investigates the association between skin conditions and catheter-related infections. Methods: Data from two distinct sources were analyzed: (1) 626 PD patients in the Korean arm of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) and (2) skin... -
DOI: https://doi.org/10.23876/j.krcp.24.275 [Epub ahead of print]
- Facility-level comorbidity burden and cardiovascular outcome in patients undergoing hemodialysis
- Hyo Jeong Kim, Seok-Jae Heo, Jung Tak Park, Ga Young Heo, Kyung Won Kim, Yong Uk Kwon, Soo Hyun Kim, Gui Ok Kim, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Hyung Woo Kim
- Received April 24, 2025 Accepted July 29, 2025
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Background: The impact of facility-level comorbidity burden on the prognosis of hemodialysis patients remains unclear. This study aimed to investigate the association between facility-level comorbidity burden and hemodialysis outcomes. Methods: We examined 15,481 participants receiving hemodialysis at primary clinics participating in the Periodic Hemodialysis Quality Assessment by Health Insurance Review and Assessment Service in Korea. Facility-level comorbidity burden, defined as the... -
DOI: https://doi.org/10.23876/j.krcp.25.118 [Epub ahead of print]
- Longitudinal triglyceride-glucose index trajectories and kidney outcomes in patients with metabolic dysfunctionassociated fatty liver disease
- Jong Hyun Jhee, Wooram Bae, Hyo Jeong Kim, Hye Sun Lee, Shinae Kang, Jung Il Lee, Hyeong Cheon Park, Hoon Young Choi
- Received July 24, 2025 Accepted December 8, 2025
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Background: Triglyceride-glucose index (TyGi), a surrogate marker of metabolic dysfunction, has not been evaluated for kidney outcomes in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). We aimed to evaluate this association in individuals with MAFLD. Methods: Totally 868 patients with MAFLD from the Gangnam Severance Medical Cohort (2006–2021) were included. TyGi trajectories were defined using latent class mixture modeling based... -
DOI: https://doi.org/10.23876/j.krcp.25.246 [Epub ahead of print]
- Early hemoglobin levels after kidney transplantation predict clinical outcomes
- Min-Gyu Kim, You Hyun Jeon, Jae Berm Park, Jung Hwan Park, Su Hyung Lee, Jaeseok Yang, Myoung Soo Kim, Yu Jin Seo, Youn-Sik Oh, Ji-Eun Yoo, Hee-Yeon Jung, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jeong-Hoon Lim, Jang-Hee Cho
- Received July 9, 2025 Accepted December 19, 2025
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Background: The impact of early hemoglobin levels following kidney transplantation (KT) on long-term outcomes remains unclear. This study evaluates the association between early posttransplant hemoglobin levels and clinical outcomes. Methods: A total of 7,501 kidney transplant recipients (KTRs) from a nationwide cohort were included. Hemoglobin levels at 6 months post-KT were analyzed. KTRs were categorized into five hemoglobin groups: <10, 10... -
DOI: https://doi.org/10.23876/j.krcp.25.215 [Epub ahead of print]
- Functional impairment as predictors of renal outcomes and mortality in elderly patients: a retrospective cohort study
- Bokeung Peun, Seunghyun Won, Kwang-il Kim, Jung-Yeon Choi, Ho Jun Chin
- Received April 13, 2025 Accepted December 16, 2025
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Background: Functional impairments in elderly patients with chronic kidney disease may affect prognosis. This study evaluated the associations between activities of daily living (ADL), instrumental activities of daily living (IADL), renal replacement therapy (RRT), and mortality. Methods: We retrospectively analyzed 6,087 adults aged ≥65 years (2,737 men and 3,350 women) who underwent geriatric assessment at Seoul National University Bundang Hospital from... -
DOI: https://doi.org/10.23876/j.krcp.25.098 [Epub ahead of print]
- Association of time-updated body mass index with initiation of kidney replacement therapy in patients with chronic kidney disease: results from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) study
- Minsang Kim, Jayoun Kim, Yunmi Kim, Geonjoo Kang, Eunjeong Kang, Suah Sung, Kyu-Beck Lee, Jong Cheol Jeong, Donghwan Lee, Kook-Hwan Oh
- Received July 16, 2025 Accepted November 27, 2025
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Background: The association between body mass index (BMI) and risk of kidney replacement therapy (KRT) initiation in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD) remains uncertain. Furthermore, controversies remain around baseline BMI as the only exposure in the analysis. Methods: A total of 2,136 patients enrolled in the KoreaN Cohort Study for Outcome in Patients With CKD were included in this... -
DOI: https://doi.org/10.23876/j.krcp.25.237 [Epub ahead of print]
- CRISPR/Cas9-based SLC12A3 gene knock in: a model for cellular feature analysis in Gitelman syndrome
- Sun Woo Lim, Xianying Fang, Sheng Cui, Hanbi Lee, Do Hyun Na, Yoo Jin Shin, Kang In Lee, Jae Young Lee, Byung Ha Chung
- Received February 21, 2025 Accepted August 22, 2025
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Background: This study aims to investigate the effects of complete SLC12A3 gene knock-in using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) in human-induced pluripotent stem cells (hiPSCs), focusing on cellular characteristics and functional implications in the context of Gitelman syndrome. Methods: Employing CRISPR/Cas9 gene-editing technology, the SLC12A3 gene was integrated into WTC-11 hiPSCs, resulting in the creation of... -
DOI: https://doi.org/10.23876/j.krcp.25.047 [Epub ahead of print]
- Risk factors for multidrug-resistant organisms and their outcomes in peritoneal dialysis-related peritonitis: a multicenter prospective observational study from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)-Korea
- Yohan Park, Jieun Shin, Daun Song, Ji Won Lee, Won Min Hwang, Sung-Ro Yun, Roberto Pecoits-Filho, Brian Bieber, Ronald L Pisoni, Jeffrey Perl, Sun-Hee Park, Yong-Lim Kim, Kook-Hwan Oh, Se-Hee Yoon
- Received September 17, 2025 Accepted November 24, 2025
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Background: Multidrug-resistant organisms (MDROs) present significant challenges in the treatment of peritoneal dialysis (PD)-related peritonitis. This study aimed to describe the incidence, risk factors, and outcomes of MDRO-peritonitis in a national cohort from the PDOPPS (Peritoneal Dialysis Outcomes and Practice Patterns Study)-Korea. Methods: Between July 2019 and December 2021, 147 of 292 peritonitis episodes had available data on organism sensitivity and... -
DOI: https://doi.org/10.23876/j.krcp.25.334 [Epub ahead of print]
- Ferric citrate for iron deficiency anemia in non-dialysis dependent chronic kidney disease: a randomized phase III study
- Mei-Yi Wu, Chin-Chan Lee, Chien-Te Lee, Der-Cherng Tarng, Chih-Kang Chiang, Chiz-Tzung Chang, Yi-Wen Chiu, Yuh-Mou Sue, Chih-Chin Kao, Yu-Sen Peng, Cheng-Chieh Hung, Ming-Cheng Wang, Mai-Szu Wu
- Received May 19, 2025 Accepted November 24, 2025
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Background: Ferric citrate (FC) can replenish iron stores in patients with non–dialysis-dependent chronic kidney disease (NDD-CKD) and iron deficiency anemia (IDA). This study evaluated the efficacy and safety of FC (PBF-1681, Panion & BF Biotech Inc.) in NDD-CKD Taiwanese patients. Methods: In this double-blind, placebo-controlled, randomized Phase III trial, patients were assigned 1:1 to receive either PBF-1681 or placebo for... -
DOI: https://doi.org/10.23876/j.krcp.25.146 [Epub ahead of print]
- Urine output on the day of continuous renal replacement therapy discontinuation predicts long-term outcomes in patients with severe acute kidney injury
- Sungmi Kim, Sojung Youn, Jiwon Min, Eun Jeong Ko, Eun Sil Koh, Hyung Duk Kim, Byung Ha Chung, Yu Ah Hong
- Received June 18, 2025 Accepted October 15, 2025
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Background: Continuous renal replacement therapy is crucial for treating critically ill patients with acute kidney injury. This study aimed to ascertain the association between urine output at continuous renal replacement therapy discontinuation and 1-year all-cause mortality and the development of end-stage renal disease (ESRD) in patients with acute kidney injury. Methods: This study included 851 patients with acute kidney injury who... -
DOI: https://doi.org/10.23876/j.krcp.25.200 [Epub ahead of print]
- Geographic disparities in kidney function decline: a matched cohort analysis of urban and rural populations in Korea
- Ji Eun Kim, Eun Jung Cho, Shin Young Ahn, Gang-Jee Ko, Young Joo Kwon
- Received June 4, 2024 Accepted August 22, 2025
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Background: Previous studies have shown differing chronic kidney disease (CKD) prevalence between rural and urban populations; data on longitudinal renal function decline remain limited. We compared kidney function deterioration rates between rural and urban residents in Korea. Methods: We analyzed data from the Korean Genome and Epidemiology Study (KoGES), including 60,487 urban and 14,776 rural participants. Individuals with baseline estimated... -
DOI: https://doi.org/10.23876/j.krcp.25.171 [Epub ahead of print]
- Outpatient visit intervals in chronic kidney disease: adherence to Kidney Disease: Improving Global Outcomes recommendations and determinants of variation
- Somi Kim, Ga Young Heo, Cheol Ho Park, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Song-Hee Kim, Hyung Woo Kim
- Received July 6, 2025 Accepted November 17, 2025
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Background: Chronic kidney disease (CKD) is a major global health problem owing to its progressive nature, complications, and substantial healthcare burden. The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend outpatient visit intervals based on CKD severity; however, adherence to these recommendations and the factors influencing the visit interval remain unclear. Methods: This retrospective observational study included 13,621 patients with... -
DOI: https://doi.org/10.23876/j.krcp.25.219 [Epub ahead of print]
- KoreaN cohort study for Outcome in patients With Kidney Transplantation (KNOW-KT) study: an overview focused on cardiovascular outcomes from the Korean kidney transplant cohort
- Jung-Hwa Ryu, Myung-Gyu Kim, Kyu Ha Huh, Hee-Yeon Jung, Jae Berm Park, Seungyeup Han, Kyung Pyo Kang, Wookyung Chung, Jaeseok Yang
- Received May 14, 2025 Accepted November 3, 2025
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Background: The KoreaN cohort study for Outcome in patients With Kidney Transplantation (KNOW-KT) is a prospective multicenter observational cohort study that provides prospective information on the natural course of kidney transplantation and elucidates risk factors for posttransplant complications. We aimed to describe the baseline characteristics and long-term posttransplant outcomes focused on cardiovascular (CV) events of the KNOW-KT cohort. Methods: KNOW-KT enrolled... -
DOI: https://doi.org/10.23876/j.krcp.25.140 [Epub ahead of print]
- Renal hypouricemia is associated with a decreased glomerular filtration rate, but not with cardiovascular events or all-cause mortality: the Shizuoka Study
- Aya Shoji-Asahina, Yasuharu Tabara
- Received September 1, 2025 Accepted October 9, 2025
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Background: Renal hypouricemia is a rare inherited disorder characterized by increased uric acid excretion, causing abnormally low serum uric acid levels. Its long-term effects on cardiovascular disease (CVD) incidence, all-cause mortality, and renal function remain unclear. Methods: We included 450,204 participants (mean age, 66.3 ± 10.5 years; 37.2% male). The baseline was defined as the earliest date of participation in specific... -
DOI: https://doi.org/10.23876/j.krcp.25.304 [Epub ahead of print]
- Effectiveness and safety of tocilizumab treatment for chronic active antibody-mediated rejection in kidney transplant recipients
- Ha-Eun Lee, Hyeran Park, Hanbi Lee, Yeong Jin Choi, Eun-Jee Oh, Byung Ha Chung
- Received June 11, 2025 Accepted October 1, 2025
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Background: Chronic active antibody-mediated rejection (cABMR) is a leading cause of allograft failure in kidney transplantation (KT) recipients. However, no effective treatment has been established. This study investigated the effectiveness and safety of tocilizumab (TCZ), an anti–interleukin-6 receptor antibody, in delaying cABMR progression in KT recipients. Methods: We included 18 KT recipients with cABMR treated with TCZ (8 mg/kg/mo for 6... -
DOI: https://doi.org/10.23876/j.krcp.25.181 [Epub ahead of print]
- Tau, a microtubule-associated protein, is upregulated and promotes kidney damage in chronic kidney disease
- Seong Woo Lee, Seung Seob Son, Hee Seul Jeong, Chae-Eun Moon, Jeong Geon Lee, Jeong Suk Kang, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Ji-Hye Lee, Eun Young Lee
- Received April 28, 2025 Accepted September 20, 2025
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Background: Tau, a microtubule-associated protein, has a well-established role in neurodegenerative disorders, but its function in the kidney and contribution to chronic kidney disease (CKD) remain unclear. Although emerging data suggest the role of tau in CKD pathogenesis, the mechanisms of tau-mediated renal injury are not well defined. In this context, we investigated tau expression in CKD and its potential... -
DOI: https://doi.org/10.23876/j.krcp.25.121 [Epub ahead of print]
- Real-world trends in glucagon-like peptide-1 receptor agonists prescribing in acute kidney disease: a global federated-network study of dialysis-requiring acute kidney injury survivors
- Heng-Chih Pan, Chung-An Wang, Jui-Yi Chen, Kang-Yung Peng, Vin-Cent Wu
- Received April 14, 2025 Accepted September 15, 2025
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Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) confer cardiovascular and renal benefits in type 2 diabetes mellitus (T2DM). However, their real-world utilization in acute kidney disease (AKD) remains underexplored. Methods: Using the TriNetX Global Network, we identified adults who survived dialysis-requiring acute kidney injury and met Acute Disease Quality Initiative 16 criteria for AKD (2012–2022). Prescribing trends and determinants of GLP-1... -
DOI: https://doi.org/10.23876/j.krcp.25.104 [Epub ahead of print]
- External validation and modification of a simple prediction model for acute kidney injury after noncardiac surgeries
- Youlu Zhao, Jinwei Wang, Damin Xu, Dongliang Mu, Nan Li, Shuangling Li, Xizi Zheng, Jicheng Lv, Li Yang
- Received February 6, 2024 Accepted February 17, 2025
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Background: The Simple Postoperative AKI Risk (SPARK) index is a practical prediction model for postoperative acute kidney injury (PO-AKI) in patients after noncardiac surgery. However, previous external validation showed unsatisfactory performance, and its generalizability requires further evaluation. Methods: This retrospective study included adults who underwent noncardiac surgery under general anesthesia from 2018 to 2020 at Peking University First Hospital. The discrimination... -
DOI: https://doi.org/10.23876/j.krcp.24.040 [Epub ahead of print]
- Impact of acute kidney injury labeling strategies in hospitalized patients: suggestion for a dual-alert clinical decision support system
- Se-Jin Ahn, Nam-Jun Cho, Inyong Jeong, Yihyun Kim, Byeongsu Kim, Hyo-Wook Gil, Hwamin Lee
- Received July 23, 2025 Accepted October 20, 2025
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Background: Operational variability in defining acute kidney injury (AKI) undermines the diagnostic reliability and impairs the generalizability of machine learning (ML) models. We evaluated whether the refined criteria based on the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines enhance prognostic validity and predictive performance. Methods: Two conservative refinements to the KDIGO serum creatinine (SCr)-based criteria were proposed: 1) exclusion of transient... -
DOI: https://doi.org/10.23876/j.krcp.25.248 [Epub ahead of print]
- Frailty-related factors and 1-year renal function change after sodium-glucose cotransporter-2 inhibitors in elderly chronic kidney disease patients
- Hye-Mi Noh, Sei Hong Min, Hyung-Seok Lee, Sung Gyun Kim, Jun Goo Kang, Jwa-Kyung Kim
- Received April 16, 2025 Accepted September 1, 2025
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Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are first-line therapy for chronic kidney disease (CKD). However, evidence regarding their safety and efficacy in frail elderly patients remains limited. This study evaluated the impact of frailty-related factors on renal outcomes in elderly CKD patients treated with SGLT2i. Methods: We retrospectively analyzed 302 elderly CKD patients (≥65 years) newly prescribed SGLT2i. Four frailty-related factors included... -
DOI: https://doi.org/10.23876/j.krcp.25.110 [Epub ahead of print]
- Clinical significance of genetic mutations in adult patients with focal segmental glomerulosclerosis
- Min Min, Qiuxia Wang, Lina Zhu, Jinquan Wang, Jiong Zhang
- Received March 5, 2025 Accepted August 16, 2025
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Background: Steroid resistance (SR) and a family history of kidney disease (FH) are key indicators of genetic focal segmental glomerulosclerosis (FSGS) in adults. The diagnostic yield and prognostic implications of genetic testing in these patients remain unclear. Methods: The study was designed in two parts to address specific research objectives. Part 1 aimed to explore the diagnostic yield in adult... -
DOI: https://doi.org/10.23876/j.krcp.25.082 [Epub ahead of print]
- Temporal trends in acute kidney injury-related mortality across 43 countries, 1996–2021, with projections up to 2050: a global time series analysis and modelling study
- Hyeon Seok Hwang, Soeun Kim, Soo-Young Yoon, Hayeon Lee, Hyeon Jin Kim, Selin Woo, Lee Smith, Louis Jacob, Jinseok Lee, Dong Keon Yon
- Received July 7, 2025 Accepted August 16, 2025
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Background: Acute kidney injury (AKI) is a major global public health concern. However, a major challenge in addressing the AKI burden is the lack of global data on AKI-related mortality and its predictions, leaving significant limitations in understanding its trends over time. Therefore, we aimed to estimate AKI-related mortality rate trends and forecast future deaths. Methods: We evaluated the temporal trends... -
DOI: https://doi.org/10.23876/j.krcp.25.224 [Epub ahead of print]
- Low serum albumin levels as a predictor of increased risk of cancer in patients undergoing maintenance hemodialysis
- Minhyung Kim, So Young Park, Yu Jeong Lim, Bo Yeon Kim, Jun Young Do, Jung Eun Lee, Junseok Jeon, Seok Hui Kang
- Received May 27, 2025 Accepted September 10, 2025
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Background: While hypoalbuminemia is a marker of poor prognosis in patients with end-stage kidney disease, its association with cancer risk remains unclear. This study evaluated the relationship of serum albumin levels with cancer risk and mortality after cancer diagnosis in patients undergoing maintenance hemodialysis (HD). Methods: This retrospective cohort study analyzed HD quality assessment program data from the Korean Health Insurance... -
DOI: https://doi.org/10.23876/j.krcp.25.155 [Epub ahead of print]
- Protein-energy wasting in chronic kidney disease patients not receiving kidney replacement therapy: risk factors for all-cause death and composite outcomes: findings from KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD)
- Hojung Lee, Hyanglim Lee, Hyunjin Ryu, Minjung Kang, Eunjeong Kang, Minsang Kim, Seon Mi Kim, Ji Hye Kim, Yujin Jeong, Ji Yong Jung, Jong Cheol Jeong, Sue K. Park, Tae-Hyun Yoo, Soo Jin Yang, Kook-Hwan Oh
- Received April 15, 2025 Accepted July 9, 2025
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Background: Protein-energy wasting (PEW) is a strong indicator of adverse outcomes such as all-cause death and cardiovascular events. Although this association has been established in dialysis patients, it has not been clearly demonstrated in those with non-dialysis–dependent chronic kidney disease (NDD-CKD). This study aimed to evaluate the association between PEW and all-cause death or cardiovascular events in patients with NDD-CKD. Methods:... -
DOI: https://doi.org/10.23876/j.krcp.25.112 [Epub ahead of print]
- Advancing patient-centered care: development and validation of the Korean Hemodialysis Management Satisfaction Scale
- Soo Jin Kim, Seon Ha Baek, Jung Tak Park, Kitae Bang, Doohong Choi, Jiwon Ryu, Sejoong Kim
- Received March 3, 2025 Accepted September 5, 2025
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Background: Patient satisfaction is crucial in achieving better health outcomes, particularly for individuals undergoing hemodialysis. Although many patient satisfaction scales exist, few are culturally tailored to patients undergoing hemodialysis in Korea. This study aimed to develop and validate this population’s Hemodialysis Management Satisfaction Scale. Methods: A formative research approach involving qualitative and quantitative phases was used. In-depth interviews with 12 hemodialysis... -
DOI: https://doi.org/10.23876/j.krcp.25.077 [Epub ahead of print]
- Genetically predicted vitamin D and risk of chronic kidney disease progression: a Mendelian randomization study
- Juyeon Lee, Sangjun Lee, Sungji Moon, Yaeni Kim, Soo Wan Kim, Yeong Hoon Kim, Miyeon Han, Kook-Hwan Oh, Sue K. Park
- Received February 19, 2025 Accepted July 25, 2025
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Background: Chronic kidney disease (CKD) is a global health burden, with vitamin D deficiency being a prevalent and modifiable risk factor. Vitamin D is involved in calcium-phosphate homeostasis, immune regulation, and anti-inflammatory pathways. However, its causal role in CKD progression remains uncertain. Methods: This study employed Mendelian randomization (MR) using genome-wide association study data to assess the causal effects of... -
DOI: https://doi.org/10.23876/j.krcp.25.054 [Epub ahead of print]
- Long term graft survival and rejection rate of zero-human leukocyte-antigen-mismatched deceased donor kidney transplant recipients: a retrospective multicentric cohort study
- Dong Hui Shin, Deok Gie Kim, Sung Hwa Kim, Keunryul Park, Soo Jin Na Choi, Sung Shin, Seungyeup Han, Jaeseok Yang, Myoung Soo Kim, Jun Young Lee
- Received September 27, 2024 Accepted July 4, 2025
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Background: Historically, human leukocyte antigen (HLA) matching has been a cornerstone of kidney transplantation (KT), with favorable outcomes. However, the survival benefit of KT with zero HLA mismatches appears to have decreased with the accumulation of transplantation experience and advancements in immunosuppressive therapies. Methods: This was a prospective observational cohort study based on data from the Korean Organ Transplantation Registry,... -
DOI: https://doi.org/10.23876/j.krcp.24.238 [Epub ahead of print]
- Hsa_circRNA_101015 and hsa_circRNA_104310 as novel biomarkers of childhood steroid-resistant nephrotic syndrome
- Xiao-Yi Cai, Wen-Fei Ma, Jia-Yi Zhang, Mei Tan, Xiao-Qing Lin, Ye Chen, Hui-Ying Deng, Xue-Dong Wu
- Received December 11, 2024 Accepted June 14, 2025
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Background: Nephrotic syndrome (NS) is the leading cause of glomerular diseases in pediatric patients, among whom corticosteroid responsiveness has been shown to be closely associated with prognosis. Circular RNAs (circRNAs) play crucial roles in various pathophysiological processes and hold significant promise as biomarkers. This study investigated circRNAs for their ability to discriminate patients with steroid-resistant nephrotic syndrome (SRNS) from steroid-sensitive... -
DOI: https://doi.org/10.23876/j.krcp.24.308 [Epub ahead of print]
- Lysyl oxidase-like 2 inhibition ameliorated podocyte fibrosis by inhibiting transforming growth factor-beta signaling under high-glucose conditions
- Nara Jeon, Beom Jin Lim, Hoon Young Choi
- Received April 10, 2025 Accepted May 18, 2025
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Background: Lysyl oxidase-like 2 (LOXL2) has been implicated in tissue fibrosis; however, its role in diabetic podocyte injury remains unclear. This study aimed to investigate the contribution of LOXL2 to fibrotic signaling in podocytes under high-glucose conditions and identify its downstream molecular pathways. Methods: LOXL2 expression was examined in the glomeruli of patients with diabetes using immunofluorescence staining. Human podocytes were... -
DOI: https://doi.org/10.23876/j.krcp.25.097 [Epub ahead of print]
- Kidney transplant outcomes according to matching of the Kidney Donor Profile Index and Estimated Post-Transplant Survival scores
- Omi Na, Tai Yeon Koo, Hee Byung Koh, Beom Seok Kim, Jaeseok Yang
- Received March 9, 2025 Accepted June 11, 2025
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Background: The efficient allocation of donor kidneys to appropriate candidates is mandated in Korea, with a very long waiting time for deceased donor kidney transplantation (DDKT). This study evaluated the prognostic implications of organ matching using the Korean Kidney Donor Profile Index (K-KDPI) and Korean Estimated Post-Transplant Survival (K-EPTS). Methods: We analyzed 7,443 DDKT recipients between 2008 and 2022 using national... -
DOI: https://doi.org/10.23876/j.krcp.25.083 [Epub ahead of print]
- Outcomes of continuous kidney replacement therapy versus intermittent hemodialysis in dialysis-dependent patients with acute intracerebral hemorrhage
- Hideaki Watanabe, Akira Okada, Keita Shibahashi, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
- Received December 2, 2024 Accepted June 9, 2025
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Background: This study was performed to investigate whether continuous kidney replacement therapy is more beneficial than intermittent hemodialysis in patients with acute intracerebral hemorrhage undergoing chronic dialysis, while adjusting for more clinically important variables. Methods: Dialysis-dependent patients diagnosed with acute intracerebral hemorrhage were identified using the Japanese Diagnosis Procedure Combination database. We compared the in-hospital mortality rates and improvement in modified... -
DOI: https://doi.org/10.23876/j.krcp.24.297 [Epub ahead of print]
- The impact of adolescent smoking initiation on the risk of end-stage kidney disease: a nationwide cohort study
- Seong Geun Kim, Jeong Min Cho, Soojin Lee, Semin Cho, Hyuk Huh, Sehoon Park, Minsang Kim, Eunjeong Kang, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Kyungdo Han, Dong Ki Kim, Yaerim Kim
- Received November 28, 2024 Accepted May 30, 2025
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Background: Chronic kidney disease (CKD) is a growing global health challenge, with smoking identified as a significant risk factor. This study investigates the long-term impact of adolescent smoking initiation on end-stage kidney disease (ESKD) development. Methods: A retrospective cohort study was conducted using data from the Korean National Health Insurance Service claims database. The cohort included 201,678 CKD patients aged ≥40... -
DOI: https://doi.org/10.23876/j.krcp.24.292 [Epub ahead of print]
- Efficacy of ophthalmic examinations for predicting vascular calcification in patients undergoing maintenance hemodialysis
- Woo Yeong Park, Yaerim Kim, Jin Hyuk Paek, Seungyeup Han, Kyung Tae Kang, Ji Hye Jang, Yu Cheol Kim, Kyubok Jin
- Received June 3, 2024 Accepted April 11, 2025
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Background: In maintenance hemodialysis (MHD) patients, vascular calcification can be detected not only in coronary vessels but also in ocular areas. However, ophthalmic examinations are not sufficiently validated to measure the degree of vascular calcification. Methods: This study was performed prospectively, involving 32 MHD patients. Calcium deposition in the cornea and conjunctiva was checked using a slit lamp and anterior... -
DOI: https://doi.org/10.23876/j.krcp.24.149 [Epub ahead of print]
- Machine learning-based utilization of lipid panels in predicting kidney dysfunction
- Soie Kwon, Donghwan Yoon, Changhwa Park, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Sungroh Yoon, Seung Seok Han
- Received February 17, 2025 Accepted July 31, 2025
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Background: Dyslipidemia is a risk factor for atherosclerotic cardiovascular disease, but its relationship with kidney dysfunction varies depending on the patient and kidney status. Herein, we used a machine learning model to select lipid panels to improve the predictability of kidney dysfunction. Methods: A total of 9,403 patients whose lipid panels and low-density lipoprotein subfraction scores were measured were enrolled. The... -
DOI: https://doi.org/10.23876/j.krcp.25.052 [Epub ahead of print]
- Left ventricular geometry and the risk of heavy coronary artery calcification in patients with pre-dialysis chronic kidney disease: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD)
- Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Young Youl Hyun, Jong Cheol Jeong, Seung Hyeok Han, Sue K. Park, Soo Wan Kim
- Received March 16, 2025 Accepted May 16, 2025
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Background: The association between abnormal left ventricular geometry (LVG) patterns and the presence of coronary artery calcification is unclear in patients with CKD. Methods: A total of 2,038 patients with pre-dialysis CKD at stages 1 to 5 were categorized by LVG patterns, which were echocardiographically determined by the presence or absence of left ventricular hypertrophy (LVH) and relative wall thickness (RWT):... -
DOI: https://doi.org/10.23876/j.krcp.25.070 [Epub ahead of print]
- Development of a prediction tool for kidney function decline in children with chronic kidney disease
- Sangwoo Moon, Junhyug Noh, Hee Gyung Kang, Keum Hwa Lee, Jae Il Shin, Ji Yeon Song, Hee Sun Baek, Min Hyun Cho, Jiwon Jung, Joo Hoon Lee, Heeyeon Cho, Kyoung Hee Han, Eun Mi Yang, Seong Heon Kim, Ji Hyun Kim, Eujin Park, Yo Han Ahn
- Received January 3, 2025 Accepted May 12, 2025
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Background: A paucity of literature exists on the development of predictive tools for the decline of kidney function in pediatric chronic kidney disease (CKD). The objective of this study is to develop and internally validate a tool for the short-term prediction of a kidney function decline in pediatric patients with CKD. Methods: A total of 539 patients participating in the KNOW-PedCKD... -
DOI: https://doi.org/10.23876/j.krcp.25.004 [Epub ahead of print]
- Applicability of current chronic kidney disease criteria for mortality and end-stage kidney disease in older diabetic populations
- Kyungho Lee, Subin Hwang, Jeeeun Park, Do Hee Kim, Junseok Jeon, Hye Ryoun Jang, Kyu Yeon Hur, Jae Hyeon Kim, Wooseong Huh, Jung Eun Lee
- Received December 2, 2024 Accepted February 23, 2025
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Background: Since the glomerular filtration rate (GFR) naturally declines with age, age-adjusted chronic kidney disease diagnostic criteria have been proposed. This study aimed to investigate the prognostic impact of estimated GFR (eGFR) on mortality and progression to end-stage kidney disease (ESKD) in normoalbuminuric older adults with type 2 diabetes mellitus. Methods: We categorized patients aged ≥65 years without albuminuria who visited... -
DOI: https://doi.org/10.23876/j.krcp.24.296 [Epub ahead of print]
- Soluble receptor for advanced glycation end products attenuates sepsis-associated acute kidney injury
- Hye-Young Kang, Sun Young Park, Gyuri Kim, Bo Young Nam, Jung Tak Park, Dong Ki Kim, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo
- Received March 23, 2025 Accepted April 11, 2025
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Background: Receptor for advanced glycation end products (RAGE) has been implicated in the pathogenesis of numerous inflammatory conditions including sepsis. We investigated the possible therapeutic role of soluble RAGE (sRAGE) in septic acute kidney injury (AKI) models. Methods: sRAGE level was measured in healthy controls and patients with septic AKI. C57/BL6 mice with cecal ligation and puncture (CLP) were injected with... -
DOI: https://doi.org/10.23876/j.krcp.25.072 [Epub ahead of print]
- Association between creatinine-to-cystatin C ratio and handgrip strength in prediabetes patients: a nationwide cross-sectional study in China
- Wenjing Zhang, Xianfang Huang, Kai Zhang
- Received October 17, 2024 Accepted April 21, 2025
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Background: This study aimed to investigate the relationship between the creatinine-to-cystatin C ratio (CCR) and handgrip strength in individuals with prediabetes, to identify patients with reduced handgrip strength. Methods: This study used a nationally representative sample from the Chinese middle-aged and elderly population. The cross-sectional portion utilized data from the first wave of the 2011 China Health and Retirement Longitudinal Study... -
DOI: https://doi.org/10.23876/j.krcp.24.259 [Epub ahead of print]
- Efficacy and safety of novel polyethersulfone dialyzers: a multicenter, randomized, crossover study
- Seong Geun Kim, Semin Cho, Jin Kyung Kwon, Minsang Kim, Soojin Lee, Jeong Min Cho, Hyuk Huh, Min Woo Kang, Soie Kwon, Jung-ho Shin, Yun Kyu Oh, Dong Ki Kim
- Received April 25, 2025 Accepted May 18, 2025
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Background: The continuous rise in healthcare costs associated with hemodialysis has become a growing concern in South Korea, where hemodialysis is the predominant treatment modality for end-stage kidney disease. Currently, all dialyzers are imported, underscoring the need for domestically manufactured alternatives. This study aims to evaluate the clinical efficacy and safety of a domestically produced novel polyethersulfone dialyzer. Methods: This multicenter,... -
DOI: https://doi.org/10.23876/j.krcp.25.113 [Epub ahead of print]
- Association between polygenic risk scores for hypertension and low-density lipoprotein cholesterol with incident chronic kidney disease
- Dong Hoon Kang, Hyung Woo Kim, Byoungwhi Ko, Hee Byung Koh, Cheol Ho Park, Ga Young Heo, Tae Ik Chang, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
- Received October 18, 2024 Accepted March 9, 2025
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Background: The clinical implications of genetic risk for hypertension (HTN) and high low-density lipoprotein cholesterol (LDL-C) levels in incident chronic kidney disease (CKD) are unknown. This study aimed to examine whether polygenic risk scores (PRSs) for these two factors can predict the development of CKD. Methods: We included 245,893 participants enrolled in UK Biobank during 2006–2010 and followed up until 2022.... -
DOI: https://doi.org/10.23876/j.krcp.24.255 [Epub ahead of print]
- A comparative study of oxidative stress, vascular calcification, and volume status in non-dippers and dippers receiving maintenance hemodialysis
- Hyangkyoung Kim, Jungho Shin, Jin Ho Hwang, Hye Ryoun Kim, Cheul Hong Min, Hyung-Eun Son, Semin Cho, Jeong Min Cho, Soie Kwon, Su Hyun Kim
- Received October 17, 2024 Accepted April 7, 2025
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Background: Hypertension is a leading cause of cardiovascular mortality in patients with end-stage kidney disease, with 80% to 90% of dialysis patients affected. Many patients with hypertension exhibit a non-dipper blood pressure pattern that is influenced by various factors. This study investigated the relationship between blood pressure patterns, volume status, vascular diseases, and oxidative stress markers. Methods: Forty-nine hemodialysis patients underwent... -
DOI: https://doi.org/10.23876/j.krcp.24.257 [Epub ahead of print]
- Weekend catch-up sleep and its association with chronic kidney disease and albuminuria in middle age and older adults from the National Health and Nutrition Examination Survey (2017–2020)
- Seung Hyun Han, Ara Ko, Jeonghwan Lee, Dong Ki Kim, Yon Su Kim, Yun Kyu Oh, Chun Soo Lim, Jung Pyo Lee
- Received November 21, 2024 Accepted February 27, 2025
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Background: How weekend catch-up sleep (WCS) influences chronic kidney disease (CKD) risk is unknown. We investigated the association between WCS and CKD prevalence in adults. Methods: In the National Health and Nutrition Examination Survey (NHANES, 2017–2020) participants (n = 4,961; age ≥ 40 years), we assessed the relationships of WCS (>1 hour increased sleep duration on weekends) with CKD and albuminuria... -
DOI: https://doi.org/10.23876/j.krcp.24.285 [Epub ahead of print]
- External validation of the international immunoglobulin A nephropathy (IgAN) prediction tool in Korean children with IgAN
- Peong Gang Park, Jayoun Kim, Ji Hyun Kim, Yo Han Ahn, Hee Gyung Kang, Jin-Soon Suh
- Received October 30, 2024 Accepted February 10, 2025
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Background: The International IgA nephropathy (IgAN) Prediction Tool was recently updated to predict the risk of a 30% decline in estimated glomerular filtration rate (eGFR) or kidney failure in children with IgAN. We aimed to evaluate the clinical performance of this tool in a Korean cohort of children with IgAN. Methods: We calculated the predicted risk for biopsy-proven IgAN children from... -
DOI: https://doi.org/10.23876/j.krcp.24.262 [Epub ahead of print]
- Effect of off-label vitamin D analog use for albuminuria in early nondiabetic nephropathy: a double-blind, randomized, placebo-controlled trial
- Nayoung Han, Dong Ki Kim, Hajeong Lee, Kwon Wook Joo, Sejoong Kim, Jung Pyo Lee, Yon Su Kim, Jung Mi Oh
- Received February 23, 2024 Accepted October 25, 2024
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Background: Albuminuria is one of the factors promoting the progression of chronic kidney disease (CKD). The study aimed to assess the efficacy and safety of calcitriol for the reduction of microalbuminuria in patients with nondiabetic nephropathy. Methods: In this randomized, double-blind, placebo-controlled, and multicenter study, adult patients with nondiabetic CKD stage 3 or greater and albuminuria were included. Participants were administered... -
DOI: https://doi.org/10.23876/j.krcp.24.051 [Epub ahead of print]
- Apurinic/apyrimidinic endonuclease 1/redox factor-1 deficiency exacerbates renal fibrosis in a unilateral ureteral obstruction model
- Sungmin Kim, Hao Jin, Eunju Choi, Eun-Ok Lee, Yu Ran Lee, Hee Kyoung Joo, Dae Eun Choi, Cuk-Seong Kim, Byeong Hwa Jeon
- Received November 11, 2024 Accepted April 21, 2025
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Background: The role of apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) in renal fibrosis development remains unclear. This study aimed to investigate the role of APE1/Ref-1 deficiency on renal fibrosis and elucidate the underlying mechanisms using a unilateral ureteral obstruction (UUO) mouse model and HK-2 cells in vitro. Methods: Male wild-type and heterozygous APE1/Ref-1+/− mice underwent UUO or sham surgery. Renal tissue was... -
DOI: https://doi.org/10.23876/j.krcp.24.281 [Epub ahead of print]
- Clinical significance of the time-average systemic immunoinflammatory index in primary immunoglobulin A nephropathy: a bicentric retrospective cohort study
- Ya Hu, Ziyuan Huang, Wanwan Zhao, Hong Zhang, Ganxiu Li, Sishi Lin, Fangfang Feng, Chaosheng Chen, Zewen Liu
- Received October 22, 2024 Accepted February 1, 2025
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Background: Systemic immune inflammation index (SII) is a potential marker that can reflect the systemic inflammatory response. However, the clinical significance of SII for immunoglobulin A nephropathy (IgAN) has yet to be determined. Methods: This was a retrospective analysis, covering January 2011 to December 2023, involving 1,399 IgAN patients confirmed through renal biopsy. The low TASII (L-TASII) group comprised patients with... -
DOI: https://doi.org/10.23876/j.krcp.24.260 [Epub ahead of print]
- Longitudinal association between kidney and lung function in the Korean general population
- Sinyoung Kwon, Hyung Woo Kim, Hye Jung Shin, Myeongjee Lee, Ah Young Leem, Ji Ye Jung, Young Sam Kim, Youngmok Park
- Received October 16, 2024 Accepted February 15, 2025
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Background: The longitudinal relationship between kidney and lung function remains poorly understood. We examined the longitudinal association between estimated glomerular filtration rate (eGFR) and lung function in a Korean population with normal kidney and lung function from 2005 to 2014. Methods: We recruited participants from the Ansan and Ansung cohorts of the Korean Genome and Epidemiology Study. Linear mixed-effects models... -
DOI: https://doi.org/10.23876/j.krcp.24.253 [Epub ahead of print]
- Exercise as an adjunctive therapy for patients on maintenance hemodiafiltration
- Jessica L. F. Andrade, Ayden T. Heitmann, Miguel K. Rodrigues, Dave K. Marchand, Adelson M. Rodrigues, Bruno P. Biluca, Rene Freitas, Thiago Reis, Miguel A. Goes, Mayron F. Oliveira
- Received October 2, 2024 Accepted January 13, 2025
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Background: Fatigue and sedentarism are common in kidney disease and dialysis treatment. Although hemodiafiltration effectively removes solutes and improves mortality, the influence of exercise as an adjunct therapy on maintenance hemodiafiltration programs remains understudied. Methods: A multicenter 6-month study was assessed comparing individuals with chronic kidney disease enrolled in exercise training (exercise group) during dialysis (intradialytic vs. interdialytic) compared to... -
DOI: https://doi.org/10.23876/j.krcp.24.243 [Epub ahead of print]
- Impact of prolonged elevated heart rate on sepsis-associated acute kidney injury patients: a causal inference and prediction study
- Fuxing Deng, Chunlin Zhu, Yaoyuan Cao, Shuangping Zhao
- Received August 13, 2024 Accepted January 4, 2025
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Background: This study investigates the relationship between prolonged elevated heart rate (pe-HR) and mortality among patients with sepsis-associated acute kidney injury (S-AKI) using causal inference and machine learning. Method: Pe-HR was defined as a heart rate exceeding 100 beats/min for 11 hours within a 12-hour interval. The average treatment effect (ATE) was a measure of the therapeutic effect of β-blockers. The... -
DOI: https://doi.org/10.23876/j.krcp.24.206 [Epub ahead of print]
- Physical activity and the risk of dementia in end-stage renal disease patients undergoing hemodialysis: a nationwide population-based study
- Hong Sang Choi, Bongseong Kim, Kyung-Do Han, Sang Heon Suh, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
- Received July 24, 2024 Accepted December 23, 2024
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Background: Several studies have reported that dementia has a high prevalence in end-stage kidney disease (ESKD) patients. However, the relationship between physical activity (PA) and the risk of dementia has not been elucidated for hemodialysis patients. Methods: A total of 11,724 patients aged ≥40 years who started hemodialysis between 2012 and 2017 were identified from the Korean National Health Insurance... -
DOI: https://doi.org/10.23876/j.krcp.24.197 [Epub ahead of print]
- Effect of preparedness of emergency equipment on patient survival in hemodialysis facilities: a Korean nationwide cohort study
- Se Yeon Park, Yo Seop Cha, Do Hyoung Kim, AJin Cho, Hayne Cho Park, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Jinseog Kim, Young-Ki Lee
- Received August 25, 2024 Accepted December 23, 2024
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Background: Intradialytic cardiac arrest is a serious complication of hemodialysis (HD) in patients with end-stage kidney disease. Therefore, appropriate emergency equipment should be prepared before the initiation of HD. However, little is known about the effects of preparedness of emergency equipment on the outcomes of patients undergoing HD. We aimed to evaluate the effects of preparedness of emergency equipment on... -
DOI: https://doi.org/10.23876/j.krcp.24.213 [Epub ahead of print]
- Risk factors and predictive models about false-negative urine dipstick results in albuminuria patients: population-based study from Korea National Health and Nutrition Examination Survey 2019 to 2022
- Yeonhee Lee, Suein Choi, Seungpil Jung, Yaeni Kim, In Kyung Lee, Dae-Chul Jeong
- Received October 10, 2024 Accepted January 31, 2025
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Background: Chronic kidney disease prognosis is determined based on glomerular filtration rate and albuminuria categories. However, the albumin-to-creatinine ratio (ACR) test is not performed on all patients as a screening test. The purpose of this study was to identify risk factors for patients with albuminuria confirmed by a urine dipstick negative and develop a model to predict underestimated patients. Methods: We... -
DOI: https://doi.org/10.23876/j.krcp.24.249 [Epub ahead of print]
- Referral to nephrologists is associated with the slow progression of kidney dysfunction in patients with type 2 diabetes mellitus
- Donghwan Yun, Sohyun Bae, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seung Seok Han
- Received August 26, 2024 Accepted December 9, 2024
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Background: Although treatment guidelines exist, referrals and discussions among clinicians about the disease can lead to more appropriate treatment for the patient. This study evaluated the effects of referrals from diabetes clinics to nephrologists on kidney function in type 2 diabetic patients through causal inference analysis. Methods: This study included patients with type 2 diabetes who initially visited the diabetes clinic... -
DOI: https://doi.org/10.23876/j.krcp.24.217 [Epub ahead of print]
- Quality of life, socioeconomic impact, and medical consideration of living kidney donors: a comprehensive survey in Korea
- Eunjeong Kang, Yaerim Kim, Jang Wook Lee, Seungyeup Han, Hyeong Dong Yuk, Chang Wook Jeong, Ahram Han, Sangil Min, Sehoon Park, Yong Chul Kim, Yon Su Kim, Jongwon Ha, Hajeong Lee
- Received July 15, 2024 Accepted November 8, 2024
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Background: South Korea stands out as a prominent nation relying heavily on living-donor transplants, with a high incidence of living-donor kidney transplants. This study aimed to obtain objective data on the psychological, social, and mental health status of living kidney donors in South Korea. Methods: A questionnaire was administered to living kidney donors at two tertiary hospitals between June 2020 and... -
DOI: https://doi.org/10.23876/j.krcp.24.191 [Epub ahead of print]
- A novel approach to the relation of multi-pollutant effect and kidney dysfunction: data analysis from the Korean National Environmental Health Survey Cycle 3 (2015–2017)
- Inae Lee, Junhyug Noh, Yaerim Kim, Jung Nam An, Jae Yoon Park, Yong Chul Kim, Jeonghwan Lee, Jung Pyo Lee, Jong Soo Lee, Kyungho Choi, Kyung Don Yoo
- Received July 1, 2024 Accepted December 23, 2024
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Background: Traditional statistical models for estimating the impact of multiple environmental chemicals on kidney outcomes have limitations. This study aimed to evaluate the risk prediction of kidney disease in the general population using innovative methodologies. Methods: Serum persistent organic pollutant (POP), urinary chemical, serum creatinine, and urinary albumin levels were measured in a subpopulation of adults (n = 1,266) drawn from... -
DOI: https://doi.org/10.23876/j.krcp.24.173 [Epub ahead of print]
- Emergency department visits for patients with end-stage kidney disease in Korea: registry data from the National Emergency Department Information System 2019–2021
- AJin Cho, Seon A Jeong, Hayne Cho Park, Hye Eun Yoon, Jungeon Kim, Young-Ki Lee, Kyung Don Yoo
- Received June 27, 2024 Accepted November 29, 2024
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Background: Patients with end-stage kidney disease (ESKD) frequently visit the emergency department (ED) due to complications from comorbidities and dialysis. This study aimed to investigate the clinical outcomes and patterns of ED visits, hospitalizations, and in-hospital mortality among ED visits by ESKD patients in South Korea. Methods: This study utilized data from the National Emergency Department Information System from 2019... -
DOI: https://doi.org/10.23876/j.krcp.24.170 [Epub ahead of print]
- Microstructural and functional connectivity changes of decision-related brain networks in end-stage kidney disease patients undergoing peritoneal dialysis
- Jingjing Yin, Dongxue Luo, Shuhua Ma, Chudan Cai, Xiaoyan Shi, Yanqiang Peng, Jianwei Peng, Lingyu Chen, Yanmin Zheng, Ruiwei Guo, Zelin Zhuang, Zhirong Lin, Lei Xie
- Received May 27, 2024 Accepted October 16, 2024
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Background: We aimed to explore changes in decision-related brain microstructure, brain functional activities, and functional connectivity, and their correlations with cognitive function in end-stage kidney disease (ESKD) patients undergoing peritoneal dialysis (PD). Furthermore, the impact of dialysis on these changes was examined. Methods: Thirty ESKD patients undergoing PD, 20 chronic kidney disease (CKD) stage 5 patients without dialysis (predialysis CKD... -
DOI: https://doi.org/10.23876/j.krcp.24.146 [Epub ahead of print]
- Methylcrotonyl-CoA carboxylase 2 supports leucine catabolism to promote mitochondrial biogenesis and alleviate cisplatin-induced acute kidney injury
- Hu Li, Kangqiang Weng, Hao Qi, Huiyue Qi, Linlu She, Junliang Qiu, Yingbo Dai
- Received June 26, 2024 Accepted September 16, 2024
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Background: Cisplatin is widely used in clinical practice, but its nephrotoxicity severely limits its use. Previous studies have shown that cisplatin-induced acute kidney injury (AKI) is closely related to mitochondrial damage and that alleviating mitochondrial dysfunction can alleviate cisplatin-induced AKI. Methylcrotonyl‑CoA carboxylase 2 (MCCC2) is mainly located in mitochondria, where it catalyzes the catabolism of leucine and maintains mitochondrial function;... -
DOI: https://doi.org/10.23876/j.krcp.24.169 [Epub ahead of print]
- Validation of an acute kidney injury prediction model as a clinical decision support system
- Giae Yun, Jinyeong Yi, Sangyub Han, Jihyeon Seong, Enver Menadjiev, Hyunkyung Han, Jaesik Choi, Ji Hyun Kim, Sejoong Kim
- Received June 21, 2024 Accepted October 21, 2024
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Background: Acute kidney injury (AKI) is a critical clinical condition that requires immediate intervention. We developed an artificial intelligence (AI) model called PRIME Solution to predict AKI and evaluated its ability to enhance clinicians’ predictions. Methods: The PRIME Solution was developed using convolutional neural networks with residual blocks on 183,221 inpatient admissions from a tertiary hospital (2013−2017) and externally validated with... -
DOI: https://doi.org/10.23876/j.krcp.24.163 [Epub ahead of print]
- Safety of direct oral anticoagulants in hemodialysis patients with venous thromboembolism: an analysis using the Korean National Health Insurance Service database
- Hyejin Mo, Hyangkyoung Kim, Seung Boo Yang, Young joo Kwon
- Received April 4, 2024 Accepted October 27, 2024
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Background: Limited data exist regarding the safety of direct oral anticoagulants in hemodialysis patients with venous thromboembolic disease. This study aims to investigate the safety of direct oral anticoagulants in hemodialysis patients using national data. Methods: The National Health Insurance Service database was retrospectively queried to identify chronic kidney disease patients who took direct oral anticoagulants for venous thromboembolism from 2008... -
DOI: https://doi.org/10.23876/j.krcp.24.093 [Epub ahead of print]
- Association between obstructive sleep apnea and albuminuria in Korean adults: a nationwide populationbased study
- Yeojin Yu, Kyungdo Han, Kyu-na Lee, Jung Hun Koh, Young Sun Shin, Jeong Min Cho, Minsang Kim, Min Woo Kang, Seong Geun Kim, Sehyun Jung, Semin Cho, Hyuk Huh, Eunjeong Kang, Sehoon Park, Yaerim Kim, Kwon Wook Joo, Dong Ki Kim, Soojin Lee
- Received June 10, 2024 Accepted October 18, 2024
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Background: Obstructive sleep apnea (OSA) is a sleep disorder associated with an increased risk of cardiovascular and metabolic complications. Albuminuria, an early marker of kidney damage, is a proposed risk factor for OSA and its adverse outcomes. The study explored the association between OSA and albuminuria in Korean adults. Methods: We screened participants from the cross-sectional Korean National Health and... -
DOI: https://doi.org/10.23876/j.krcp.24.159 [Epub ahead of print]
- Clinical features and outcomes of immune complex-membranoproliferative glomerulonephritis and C3 glomerulopathy: a multicenter observational cohort study analyzing kidney biopsy cases
- SungYeon Kim, Young Eun Choi, Sung Gyun Kim, Dong-Ryeol Ryu, Sun-Hee Park, Tai Yeon Koo, Myung-Gyu Kim, Sang Kyung Jo, Se Won Oh
- Received May 12, 2024 Accepted September 20, 2024
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Background: Membranoproliferative glomerulonephritis (MPGN) has two subtypes based on immunofluorescence findings: complement 3 glomerulopathy (C3G) and immune complex-mediated MPGN (IC-MPGN). This study investigated the characteristics and prognosis of patients with MPGN. Methods: This retrospective study analyzed data from 18 hospitals between 1979 and 2018. Among 21,697 patients, 620 were diagnosed with MPGN, 570 with IC-MPGN, and 50 with C3G. Results: The C3G... -
DOI: https://doi.org/10.23876/j.krcp.24.129 [Epub ahead of print]
- Interobserver agreement analysis among renal pathologists in classification of lupus nephritis using a digital pathology image dataset: after a third evaluation
- Ju Yeon Pyo, Nara Jeon, Su-Jin Shin, Minsun Jung, Beom Jin Lim, Minseob Eom, Sung-Eun Choi
- Received July 11, 2024 Accepted October 11, 2024
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Background: Lupus nephritis is well-known for low concordance in classification. Furthermore, there has been no agreement analysis among Korean renal pathologists regarding lupus nephritis. Inconsistent diagnosis leads to confusion and increases medical costs, as well as failure of appropriate therapeutic interventions. This study aimed to assess the level of agreement among Korean renal pathologists regarding classification. Methods: Representative glomerular images... -
DOI: https://doi.org/10.23876/j.krcp.24.185 [Epub ahead of print]
- The importance of kidney response over hematologic response in predicting kidney outcome in amyloid light-chain amyloidosis
- Sungmi Kim, Jinyoung Yang, Kyungho Lee, Junseok Jeon, Sang Eun Yoon, Darae Kim, Jin-Oh Choi, Seok Jin Kim, Kihyun Kim, Jung Eun Lee
- Received April 15, 2024 Accepted October 9, 2024
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Background: Light chain amyloidosis, characterized by amyloid fibril deposition in multiple organs, often leads to progression to endstage kidney disease. This study aimed to identify predictors of kidney survival in patients with kidney amyloidosis, focusing on hematologic and kidney response. Methods: This retrospective study included 138 patients diagnosed with kidney amyloidosis between 2011 and 2019. Palladini criteria were applied to... -
DOI: https://doi.org/10.23876/j.krcp.24.111 [Epub ahead of print]
- Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series
- So Hyun Ki, Min Hwa Son, Hyung Eun Yim
- Received July 10, 2024 Accepted September 25, 2024
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Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions. Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed. NCS was diagnosed with renal Doppler ultrasonography, abdominal computed tomography,... -
DOI: https://doi.org/10.23876/j.krcp.24.178 [Epub ahead of print]
- Effectiveness and safety of denosumab on osteoporosis treatment in kidney transplant recipients
- Jin Kyung Kwon, Yaerim Kim, Jin Hyuk Paek, Kyubok Jin, Seungyeup Han, Woo Yeong Park
- Received June 26, 2024 Accepted September 17, 2024
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Background: Denosumab has been reported to improve bone mineral density (BMD), but the clinical impact of denosumab on osteoporosis in kidney transplant recipients (KTRs) remains controversial. Methods: We analyzed 98 KTRs who used denosumab from 2018 to 2023. We investigated the change in BMD, laboratory findings, complications of denosumab, fracture risk assessment tool (FRAX) score, acute rejection within 1 year, and... -
DOI: https://doi.org/10.23876/j.krcp.24.168 [Epub ahead of print]
- Circulating osteoprotegerin and progression of coronary artery calcification in patients with chronic kidney disease: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD)
- Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Tae-Hyun Yoo, Soo Wan Kim
- Received February 7, 2024 Accepted August 29, 2024
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Background: Coronary artery calcification (CAC) is a surrogate of cardiovascular events in patients with chronic kidney disease (CKD). To establish the role of circulating osteoprotegerin (OPG) as a cardiovascular biomarker in patients with CKD, we investigated whether an increase in serum OPG levels is associated with the risk of CAC progression. Methods: A total of 1,130 patients with CKD stage... -
DOI: https://doi.org/10.23876/j.krcp.24.039 [Epub ahead of print]
- Effects of dietary fatty acid on all-cause mortality according to the kidney function based on the nationwide population study
- Yaerim Kim, Kyungho Ha, Jeonghwan Lee, Eunjin Bae, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Dong Ki Kim, Chun Soo Lim, Jung Pyo Lee
- Received May 6, 2024 Accepted August 2, 2024
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Background: Although the relationship between fatty acids (FAs) and the risk of all-cause mortality has been long discussed, there is little evidence about the impact of each FA component on all-cause mortality by kidney function status. Methods: We used data from the U.S. National Health and Nutrition Examination Survey 1999–2016. The intake of FAs was estimated as a percentage of... -
DOI: https://doi.org/10.23876/j.krcp.24.121 [Epub ahead of print]
- Risk of cardiovascular events following hemodialysis initiation: a self-controlled case series study
- Minyoul Baik, Jimin Jeon, Joonsang Yoo, Hyo Suk Nam, Ji Hoe Heo, Jinkwon Kim, Young Dae Kim
- Received April 9, 2024 Accepted July 23, 2024
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Background: Patients with chronic kidney disease (CKD) are at high risk for cardiovascular disease (CVD). We aimed to evaluate whether hemodialysis (HD) initiation is associated with CVD risk in patients with CKD. Methods: This self-controlled case series, using data from a nationwide Korean health claims database, included patients with CKD who initiated HD between 2007 and 2019 and experienced CVD,... -
DOI: https://doi.org/10.23876/j.krcp.24.097 [Epub ahead of print]
- Comparison of clinical outcomes based on dialysis modality and icodextrin usage in patients on peritoneal dialysis
- Seok Hui Kang, Jun Young Do
- Received January 5, 2024 Accepted July 8, 2024
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Background: There is no conclusive evidence regarding the survival benefits of automated peritoneal dialysis (APD) or the use of icodextrin. This study aimed to evaluate patient and technique survival among four groups divided based on peritoneal dialysis modality and icodextrin use over 1 year. Methods: We specifically included patients who underwent a single peritoneal dialysis modality for at least 1 year... -
DOI: https://doi.org/10.23876/j.krcp.24.017 [Epub ahead of print]
- Blood osteoprotegerin is associated with arteriovenous access thrombosis in hemodialysis patients
- Tung-Ling Chung, Yi-Hsueh Liu, Pei-Yu Wu, Jiun-Chi Huang, Yi-Chun Tsai, Ya-Ling Hsu, Mei-Chuan Kuo, Yi-Wen Chiu, Ping-Hsun Wu, Szu-Chia Chen
- Received June 3, 2024 Accepted July 21, 2024
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Background: A functioning arteriovenous (AV) access is essential for hemodialysis efficiency and the quality of life in hemodialysis patients. Blood osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappa B ligand (RANKL) have been linked to cardiovascular diseases and vascular calcification. This study investigated the relationship between blood OPG, RANKL, and the occurrence of AV access thrombosis. Methods: This... -
DOI: https://doi.org/10.23876/j.krcp.24.153 [Epub ahead of print]
- Baseline characteristics and associated factors for hypertension in children with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Pediatric Chronic Kidney Disease study
- Ji Yeon Song, Keum Hwa Lee, Jae Il Shin, Hee Gyung Kang, Yo Han Ahn, Hee Sun Baek, Min Hyun Cho, Jiwon Jung, Joo Hoon Lee, Heeyeon Cho, Kyoung Hee Han, Eujin Park, Eun Mi Yang, Seong Heon Kim
- Received December 31, 2023 Accepted March 25, 2024
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Background: Hypertension is one of the most important complications of chronic kidney disease (CKD) as it exacerbates disease progression in children. The aim of this study is to identify characteristics and factors associated with hypertension in children with CKD. Methods: This is a cross-sectional study using baseline data from the 10-year ongoing cohort study named KNOW-PedCKD (Korean Cohort Study for Outcome... -
DOI: https://doi.org/10.23876/j.krcp.24.006 [Epub ahead of print]
- Artificial intelligence-powered chest computed tomography analysis unveils prognostic insights for COVID-19 mortality among prevalent hemodialysis patients
- Eunji Kim, Soo-Jin Yoon, Sungbong Yu, Eunsil Ko, Kyungjun Shon, Jooyeon Yoon, Youn Kyung Kee, Do Hyoung Kim, AJin Cho, Hayne Cho Park, Young-Ki Lee
- Received March 22, 2024 Accepted July 2, 2024
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Background: Coronavirus disease 2019 (COVID-19) has led to severe pneumonia and mortality worldwide, however, clinical outcomes in end-stage renal disease patients remain unclear. This study evaluates the prognostic value of chest computed tomography (CT) findings in predicting COVID-19-related outcomes in prevalent hemodialysis patients. Methods: We retrospectively analyzed 326 prevalent hemodialysis patients diagnosed with COVID-19 who underwent chest CT scans. Characteristics assessed... -
DOI: https://doi.org/10.23876/j.krcp.24.079 [Epub ahead of print]
- Effect of the geometry and severity of left ventricular hypertrophy on cardiovascular mortality in dialysis patients
- Yi-Chen Huang, Chung-Kuan Wu
- Received November 9, 2023 Accepted April 5, 2024
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Background: Left ventricular hypertrophy (LVH) is a vital risk factor for mortality of dialysis patients. The association of the geometry and severity of LVH with cardiovascular and all-cause mortality in hemodialysis (HD) patients remains unknown. This study investigated clinical outcomes among HD patients with different LVH geometric patterns and severity. Methods: The monocentric retrospective cohort study enrolled chronic HD patients who... -
DOI: https://doi.org/10.23876/j.krcp.23.290 [Epub ahead of print]
